PT3102565T - Processos para a preparação de intermediários de raltegravir - Google Patents

Processos para a preparação de intermediários de raltegravir

Info

Publication number
PT3102565T
PT3102565T PT15708328T PT15708328T PT3102565T PT 3102565 T PT3102565 T PT 3102565T PT 15708328 T PT15708328 T PT 15708328T PT 15708328 T PT15708328 T PT 15708328T PT 3102565 T PT3102565 T PT 3102565T
Authority
PT
Portugal
Prior art keywords
raltegravir
intermediates
processes
preparation
Prior art date
Application number
PT15708328T
Other languages
English (en)
Inventor
Ram Prasad VELLANKI Siva
Babu Balusu Raja
Mitchanagatla Kiran
Original Assignee
Mylan Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Ltd filed Critical Mylan Laboratories Ltd
Publication of PT3102565T publication Critical patent/PT3102565T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT15708328T 2014-02-03 2015-02-03 Processos para a preparação de intermediários de raltegravir PT3102565T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN471CH2014 2014-02-03

Publications (1)

Publication Number Publication Date
PT3102565T true PT3102565T (pt) 2019-04-01

Family

ID=52629638

Family Applications (1)

Application Number Title Priority Date Filing Date
PT15708328T PT3102565T (pt) 2014-02-03 2015-02-03 Processos para a preparação de intermediários de raltegravir

Country Status (6)

Country Link
US (1) US20170253585A1 (pt)
EP (1) EP3102565B1 (pt)
CA (1) CA2938387C (pt)
ES (1) ES2713686T3 (pt)
PT (1) PT3102565T (pt)
WO (1) WO2015114608A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3119773A1 (en) 2014-03-21 2017-01-25 Mylan Laboratories Ltd. A premix of crystalline raltegravir potassium salt and a process for the preparation thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE201021T1 (de) * 1995-07-28 2001-05-15 Dainippon Pharmaceutical Co (r)-5-bromo-n-(1-ethyl-4-methylhexahydro-1h-1,4 diazepin-6-yl)-2-methoxy-6-methylamino-3- pyridincarboxamid, verfahren zu seinerherstellung und dieses enthaltende medizinische zubereitung
DE60209381T2 (de) 2001-10-26 2006-10-05 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. N-substituierte hydroxypyrimidinoncarboxamid-hemmer der hiv-integrase
UA87884C2 (uk) 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
CA2710987A1 (en) 2008-01-08 2009-07-16 Merck Sharp & Dohme Corp. Process for preparing n-substituted hydroxypyrimidinone carboxamides
ES2549387T3 (es) 2009-06-02 2015-10-27 Hetero Research Foundation Procedimiento de preparación de raltegravir potásico amorfo
WO2011024192A2 (en) 2009-07-27 2011-03-03 Matrix Laboratories Ltd Novel polymorphs of raltegravir
WO2012103105A1 (en) * 2011-01-24 2012-08-02 Assia Chemical Industries Ltd. Processes for preparing raltegravir and intermediates in the processes
EP2804607B1 (en) * 2011-12-26 2020-09-16 Emcure Pharmaceuticals Limited Synthesis of raltegravir
EP3119773A1 (en) * 2014-03-21 2017-01-25 Mylan Laboratories Ltd. A premix of crystalline raltegravir potassium salt and a process for the preparation thereof
WO2016075605A1 (en) * 2014-11-10 2016-05-19 Aurobindo Pharma Ltd An improved process for the preparation of raltegravir

Also Published As

Publication number Publication date
CA2938387C (en) 2021-03-02
CA2938387A1 (en) 2015-08-06
ES2713686T3 (es) 2019-05-23
WO2015114608A1 (en) 2015-08-06
EP3102565A1 (en) 2016-12-14
EP3102565B1 (en) 2019-01-02
US20170253585A1 (en) 2017-09-07

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