PT3115367T - Composto intermediário para preparar rosuvastatina cálcica e método para preparar rosuvastatina cálcica a partir deste - Google Patents
Composto intermediário para preparar rosuvastatina cálcica e método para preparar rosuvastatina cálcica a partir desteInfo
- Publication number
- PT3115367T PT3115367T PT148850589T PT14885058T PT3115367T PT 3115367 T PT3115367 T PT 3115367T PT 148850589 T PT148850589 T PT 148850589T PT 14885058 T PT14885058 T PT 14885058T PT 3115367 T PT3115367 T PT 3115367T
- Authority
- PT
- Portugal
- Prior art keywords
- rosuvastatin calcium
- preparing rosuvastatin
- intermediate compound
- therefrom
- preparing
- Prior art date
Links
- 229960004796 rosuvastatin calcium Drugs 0.000 title 2
- LALFOYNTGMUKGG-BGRFNVSISA-L rosuvastatin calcium Chemical compound [Ca+2].CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O.CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O LALFOYNTGMUKGG-BGRFNVSISA-L 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14885058.9A EP3115367B1 (en) | 2014-03-07 | 2014-03-07 | Intermediate compound for preparing rosuvastatin calcium and method for preparing rosuvastatin calcium therefrom |
| PCT/CN2014/073079 WO2015131405A1 (zh) | 2014-03-07 | 2014-03-07 | 用于制备瑞舒伐他汀钙的中间体化合物以及由其制备瑞舒伐他汀钙的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3115367T true PT3115367T (pt) | 2018-01-04 |
Family
ID=54054408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT148850589T PT3115367T (pt) | 2014-03-07 | 2014-03-07 | Composto intermediário para preparar rosuvastatina cálcica e método para preparar rosuvastatina cálcica a partir deste |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9926283B2 (pt) |
| EP (1) | EP3115367B1 (pt) |
| JP (1) | JP6240346B2 (pt) |
| ES (1) | ES2655062T3 (pt) |
| HU (1) | HUE037976T2 (pt) |
| PT (1) | PT3115367T (pt) |
| WO (1) | WO2015131405A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106674281B (zh) * | 2016-12-31 | 2019-05-07 | 安徽美诺华药物化学有限公司 | 一种瑞舒伐他汀中间体化合物、制备方法及其用途 |
| WO2019008593A1 (en) * | 2017-07-05 | 2019-01-10 | Melody Healthcare Pvt. Ltd | PROCESS FOR THE PRODUCTION OF AMORPHOUS CALCIUM ROSUVASTATIN |
| CN111548312A (zh) * | 2020-06-01 | 2020-08-18 | 雅本化学股份有限公司 | 一种瑞舒伐他汀钙片及其制备工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| GB9903472D0 (en) * | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
| WO2004103977A2 (en) * | 2003-05-21 | 2004-12-02 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of pyrimidine derivatives |
| WO2005054207A1 (en) | 2003-12-04 | 2005-06-16 | Glenmark Pharmaceuticals Limited | Process for the preparation of pyrimidine derivatives |
| CN102351901A (zh) * | 2011-08-15 | 2012-02-15 | 上海皓元化学科技有限公司 | 25-羟基维生素d2系列药物侧链及其制备方法 |
| CN102643302A (zh) * | 2012-04-06 | 2012-08-22 | 上海皓元化学科技有限公司 | 25-羟基维生素D2和1α,25-二羟基维生素D2合成中间体的制备方法 |
| CN103804414B (zh) * | 2014-03-07 | 2016-04-13 | 凯莱英医药集团(天津)股份有限公司 | 用于制备瑞舒伐他汀钙的中间体化合物以及由其制备瑞舒伐他汀钙的方法 |
-
2014
- 2014-03-07 US US15/124,083 patent/US9926283B2/en not_active Expired - Fee Related
- 2014-03-07 WO PCT/CN2014/073079 patent/WO2015131405A1/zh not_active Ceased
- 2014-03-07 JP JP2016572868A patent/JP6240346B2/ja not_active Expired - Fee Related
- 2014-03-07 ES ES14885058.9T patent/ES2655062T3/es active Active
- 2014-03-07 HU HUE14885058A patent/HUE037976T2/hu unknown
- 2014-03-07 PT PT148850589T patent/PT3115367T/pt unknown
- 2014-03-07 EP EP14885058.9A patent/EP3115367B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015131405A1 (zh) | 2015-09-11 |
| EP3115367B1 (en) | 2017-11-01 |
| JP6240346B2 (ja) | 2017-11-29 |
| ES2655062T3 (es) | 2018-02-16 |
| EP3115367A1 (en) | 2017-01-11 |
| HUE037976T2 (hu) | 2018-09-28 |
| US9926283B2 (en) | 2018-03-27 |
| US20170022169A1 (en) | 2017-01-26 |
| JP2017508790A (ja) | 2017-03-30 |
| EP3115367A4 (en) | 2017-01-11 |
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