PT3237597T - Dispositivos para agregação de alto rendimento e manipulação de células de mamífero - Google Patents

Dispositivos para agregação de alto rendimento e manipulação de células de mamífero

Info

Publication number
PT3237597T
PT3237597T PT148308885T PT14830888T PT3237597T PT 3237597 T PT3237597 T PT 3237597T PT 148308885 T PT148308885 T PT 148308885T PT 14830888 T PT14830888 T PT 14830888T PT 3237597 T PT3237597 T PT 3237597T
Authority
PT
Portugal
Prior art keywords
manipulation
devices
mammalian cells
throughput aggregation
aggregation
Prior art date
Application number
PT148308885T
Other languages
English (en)
Original Assignee
Ecole Polytechnique Fed Lausanne Epfl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecole Polytechnique Fed Lausanne Epfl filed Critical Ecole Polytechnique Fed Lausanne Epfl
Publication of PT3237597T publication Critical patent/PT3237597T/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/26—Inoculator or sampler
    • C12M1/32—Inoculator or sampler multiple field or continuous type
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/20—Material Coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/06—Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Water Supply & Treatment (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
PT148308885T 2014-12-22 2014-12-22 Dispositivos para agregação de alto rendimento e manipulação de células de mamífero PT3237597T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2014/067242 WO2016103002A1 (en) 2014-12-22 2014-12-22 Devices for high-throughput aggregation and manipulation of mammalian cells

Publications (1)

Publication Number Publication Date
PT3237597T true PT3237597T (pt) 2021-03-12

Family

ID=52424070

Family Applications (1)

Application Number Title Priority Date Filing Date
PT148308885T PT3237597T (pt) 2014-12-22 2014-12-22 Dispositivos para agregação de alto rendimento e manipulação de células de mamífero

Country Status (9)

Country Link
US (1) US11583860B2 (pt)
EP (1) EP3237597B1 (pt)
JP (1) JP7089240B2 (pt)
CN (1) CN107257850A (pt)
CA (1) CA2972057C (pt)
DK (1) DK3237597T3 (pt)
ES (1) ES2858600T3 (pt)
PT (1) PT3237597T (pt)
WO (1) WO2016103002A1 (pt)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
CN106062181A (zh) * 2014-02-27 2016-10-26 公立大学法人横滨市立大学 自发组织用细胞集合体的制作方法
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
EP3296018A1 (en) 2016-09-19 2018-03-21 Ecole Polytechnique Fédérale de Lausanne (EPFL) Organoid arrays
JP6779483B2 (ja) 2016-09-29 2020-11-04 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法
JP6518985B2 (ja) * 2016-09-29 2019-05-29 住友ゴム工業株式会社 がん細胞捕捉方法
US10941374B2 (en) * 2016-09-29 2021-03-09 Sumitomo Rubber Industries, Ltd. Medical analysis device and cell analysis method
JP6485783B2 (ja) * 2016-09-29 2019-03-20 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3323882A1 (en) * 2016-11-18 2018-05-23 Ecole Polytechnique Fédérale de Lausanne Organoid tissue engineering
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
JP2018108038A (ja) * 2016-12-28 2018-07-12 クアーズテック株式会社 細胞培養担体
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
US11643625B2 (en) * 2017-12-22 2023-05-09 Institut Pasteur Hydrogel-based organ-on-chip microfluidic device
KR20210047268A (ko) * 2018-01-23 2021-04-29 바-일란 유니버시티 세포 배양 장치 및 방법
JP7109719B2 (ja) 2018-02-14 2022-08-01 住友ゴム工業株式会社 特定細胞捕捉方法
JP7158671B2 (ja) 2018-02-14 2022-10-24 住友ゴム工業株式会社 特定細胞捕捉方法
FR3079524B1 (fr) * 2018-03-27 2020-12-18 Univ Claude Bernard Lyon Plaques de micropuits en hydrogel biocompatible
FR3081168B1 (fr) * 2018-05-21 2022-03-11 Univ Bordeaux Systeme de culture cellulaire en bioreacteur
CA3102043A1 (en) * 2018-05-30 2019-12-05 Sun Bioscience Sa Well for cultivating biological material
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
JP7348586B2 (ja) * 2019-01-18 2023-09-21 東洋製罐グループホールディングス株式会社 培養容器、培養方法、及び培養装置
US11614440B2 (en) 2019-01-24 2023-03-28 Sumitomo Rubber Industries, Ltd. Specific cell fractionating and capturing methods
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
CA3135365A1 (en) * 2019-03-29 2020-10-08 Nanyang Technological University Therapeutic hydrogel device
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
EP3750982A1 (en) * 2019-06-10 2020-12-16 UPM-Kymmene Corporation Cell culture plate, method for preparing thereof and method for detecting a substance
CN112680313B (zh) * 2019-10-17 2024-12-20 苏州新格元生物科技有限公司 一种用于高通量分离单个细胞微颗粒的通孔型密封盖
EP4065693A4 (en) * 2019-11-26 2025-01-15 Stemcell Technologies Canada Inc. DEVICES, METHODS AND TESTS FOR BIOLOGICAL MATERIALS
US11845084B2 (en) * 2020-05-04 2023-12-19 The Board Of Trustees Of The University Of Illinois Microchip high density hanging drop three-dimension culture platform
EP4253516A3 (en) 2020-06-25 2023-12-06 Next & Bio Inc. Method for mass proliferation of stem cells without using hydrogel
US12606783B2 (en) 2020-06-25 2026-04-21 Next & Bio Inc. Well plate and 3D culture plate comprising the same
WO2021261622A1 (ko) * 2020-06-25 2021-12-30 주식회사 넥스트앤바이오 표준형 오가노이드 제조방법
WO2021261623A1 (ko) * 2020-06-25 2021-12-30 주식회사 넥스트앤바이오 뇌 오가노이드 제작방법
US20220333084A1 (en) * 2020-06-25 2022-10-20 Next & Bio Inc. Method for preparing induced pluripotent stem cell without using hydrogel
CN113930337B (zh) * 2020-06-29 2023-03-17 清华大学 用于制备细胞团簇的装置及其构建方法及应用
US20220090000A1 (en) * 2020-09-24 2022-03-24 University Of Wyoming Apparatus and processes for isolating biological material
EP4029934A1 (en) * 2021-01-18 2022-07-20 Universite De Geneve Methods of producing cell spheroids and tool therefore
CN113215076A (zh) * 2021-04-13 2021-08-06 华南理工大学 一种用于三维细胞球培养的半球微孔阵列基底及其制备方法
KR102746473B1 (ko) 2021-07-09 2024-12-26 주식회사 넥스트앤바이오 가상 오가노이드를 이용한 촬영 이미지 데이터 생성 방법
KR102746470B1 (ko) 2021-07-09 2024-12-26 주식회사 넥스트앤바이오 가상 오가노이드 생성 방법
CN113667603B (zh) * 2021-08-13 2023-12-22 合肥燃音生物科技有限公司 一种肝脏类器官培养芯片及其制备方法与应用
CN119365521A (zh) * 2022-02-14 2025-01-24 知名医药公司 三维细胞培养系统和方法
WO2023230596A1 (en) * 2022-05-27 2023-11-30 Satellite Biosciences, Inc. Devices and methods for cell aggregation
WO2024168428A1 (en) 2023-02-13 2024-08-22 The University Of British Columbia Well plate for imaging
CN116622503A (zh) * 2023-04-20 2023-08-22 法国介观科技有限责任公司 基于水凝胶微井薄膜和电阻抗监测的微流装置及其应用
WO2025151957A1 (en) * 2024-01-16 2025-07-24 Sunnybrook Research Institute 3d cell culture encapsulation, methods and uses thereof
WO2025172324A1 (en) 2024-02-13 2025-08-21 Universite De Strasbourg Devices and methods for the preparation of an array of reproducible and homogeneous organoids
WO2026047083A1 (en) 2024-08-29 2026-03-05 F. Hoffmann-La Roche Ag Single lumen neuroepithelial cyst derived organoids

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007796A2 (en) * 2003-07-21 2005-01-27 Molecular Cytomics Ltd. Improved multiwell plate
CA2637663C (en) * 2006-01-24 2015-06-02 Brown University Cell aggregation and encapsulation device and method
WO2008106771A1 (en) * 2007-03-02 2008-09-12 Mark Ungrin Devices and methods for production of cell aggregates
CN101815782B (zh) * 2007-09-12 2014-02-05 公益财团法人北九州产业学术推进机构 细胞培养器具和使用该器具的细胞培养方法
EP2304016B1 (en) * 2008-07-16 2012-06-27 Cook Medical Technologies LLC Micro-fluidic cell manipulation and holding device
WO2010023497A1 (en) 2008-08-29 2010-03-04 Peking University A microfluidic chip for accurately controllable cell culture
US20100055733A1 (en) * 2008-09-04 2010-03-04 Lutolf Matthias P Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels
JP6120778B2 (ja) * 2011-02-03 2017-04-26 ノースイースタン ユニヴァーシティ 生物学的材料の極めて特異的な捕獲および遊離のための方法および組成物
JP5487136B2 (ja) * 2011-02-14 2014-05-07 株式会社Ｎｔｔドコモ 非周期的チャネル状態情報通知方法、無線基地局装置、ユーザ端末
KR101282926B1 (ko) 2011-07-28 2013-07-08 고려대학교 산학협력단 표면장력을 이용한 반구형 마이크로웰의 제조 및 이를 이용한 세포 집합체의 형성
WO2013030940A1 (ja) * 2011-08-29 2013-03-07 株式会社日立製作所 培養シート、培養器材、及び製造方法
WO2013042360A1 (ja) 2011-09-20 2013-03-28 株式会社クラレ 接着性細胞の培養方法
JP6113999B2 (ja) 2012-10-18 2017-04-12 株式会社クラレ 化合物のスクリーニング方法

Also Published As

Publication number Publication date
JP2018504103A (ja) 2018-02-15
WO2016103002A1 (en) 2016-06-30
EP3237597B1 (en) 2020-12-09
CN107257850A (zh) 2017-10-17
EP3237597A1 (en) 2017-11-01
DK3237597T3 (da) 2021-03-15
ES2858600T3 (es) 2021-09-30
US11583860B2 (en) 2023-02-21
CA2972057C (en) 2023-06-13
CA2972057A1 (en) 2016-06-30
JP7089240B2 (ja) 2022-06-22
US20180264465A1 (en) 2018-09-20

Similar Documents

Publication Publication Date Title
PT3237597T (pt) Dispositivos para agregação de alto rendimento e manipulação de células de mamífero
IL284235A (en) Kits and methods for preparing a microfluidic device for cell culture
ZA201606198B (en) Special handling of low priority cells
IL254734A0 (en) Modified t cells and methods for their preparation and use
IL251504B (en) car expression vector and t cells expressing car
SG11201703494PA (en) Devices and methods for generation and culture of 3d cell aggregates
PL3149025T3 (pl) Peptydy penetrujące komórkę i sposoby ich wytwarzania i stosowania
IL249970A0 (en) Gamma delta T cells and their uses
EP3157866A4 (en) Graphene and graphene-related materials for manipulation of cell membrane potential
EP3351615A4 (en) CELL CULTURE VESSEL
EP3315596A4 (en) CELL CULTURE CONTAINER
SG11201609916RA (en) Culture method and cell mass
IL249384A0 (en) Methods for producing cells using perfusate and their use
PL3865563T3 (pl) Materiały i sposoby do przedłużania pożywki do hodowli komórkowej
EP3134735A4 (en) Methods of measuring antigen-specific t cells
EP3201319A4 (en) Uses of trehalose in cell suspensions
PL3132020T3 (pl) Naczynie do hodowli komórek i jego zastosowanie
EP3124595A4 (en) Apparatus for cell culture and experiment
GB201403107D0 (en) Permeability and transformation of cells
SG11201609269TA (en) Method of culturing cells
GB201416078D0 (en) Cell culture substrate
GB201307377D0 (en) Devices and methods for culture of cells
AU2014901577A0 (en) Thermo-Electrochemical Cell and Method of Use
GB201415379D0 (en) Gamma T cells and uses thereof
GB201412175D0 (en) Gamma T cells and uses thereof