PT3305770T - Processo para a produção de forma cristalina de enzalutamida - Google Patents
Processo para a produção de forma cristalina de enzalutamidaInfo
- Publication number
- PT3305770T PT3305770T PT168032480T PT16803248T PT3305770T PT 3305770 T PT3305770 T PT 3305770T PT 168032480 T PT168032480 T PT 168032480T PT 16803248 T PT16803248 T PT 16803248T PT 3305770 T PT3305770 T PT 3305770T
- Authority
- PT
- Portugal
- Prior art keywords
- producing
- crystal form
- enzalutamide
- enzalutamide crystal
- producing enzalutamide
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title 1
- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 title 1
- 229960004671 enzalutamide Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B33/00—After-treatment of single crystals or homogeneous polycrystalline material with defined structure
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Metallurgy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Glass Compositions (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015109805 | 2015-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3305770T true PT3305770T (pt) | 2023-04-26 |
Family
ID=57442345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT168032480T PT3305770T (pt) | 2015-05-29 | 2016-05-27 | Processo para a produção de forma cristalina de enzalutamida |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10118899B2 (pt) |
| EP (1) | EP3305770B1 (pt) |
| JP (1) | JP6753396B2 (pt) |
| KR (1) | KR102666017B1 (pt) |
| CN (1) | CN107635969B (pt) |
| CA (1) | CA2987563C (pt) |
| ES (1) | ES2942618T3 (pt) |
| MX (1) | MX385084B (pt) |
| PL (1) | PL3305770T3 (pt) |
| PT (1) | PT3305770T (pt) |
| WO (1) | WO2016194813A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3990435A1 (en) * | 2019-06-27 | 2022-05-04 | Synthon B.V. | Process for preparation of enzalutamide |
| WO2021064123A1 (en) | 2019-10-03 | 2021-04-08 | Synthon B.V. | Pharmaceutical composition comprising enzalutamide |
| CN111217757B (zh) * | 2020-01-06 | 2021-03-19 | 武汉大学 | 一种恩杂鲁胺化合物及其药物组合物制剂 |
| CN111303042A (zh) * | 2020-03-25 | 2020-06-19 | 北京赛思源生物医药技术有限公司 | 一种恩杂鲁胺的新晶型 |
| CN114591246A (zh) * | 2022-03-25 | 2022-06-07 | 重庆华邦制药有限公司 | 一种恩扎卢胺的纯化方法 |
| CN115536591B (zh) * | 2022-09-27 | 2024-06-25 | 爱斯特(成都)生物制药股份有限公司 | 一种连续流制备恩扎卢胺的方法 |
| WO2025125565A1 (en) | 2023-12-13 | 2025-06-19 | Krka, D.D., Novo Mesto | Tablet comprising enzalutamide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110003114B (zh) | 2005-05-13 | 2023-01-17 | 加利福尼亚大学董事会 | 二芳基乙内酰脲化合物 |
| KR101514659B1 (ko) * | 2010-02-24 | 2015-04-23 | 메디베이션 프로스테이트 테라퓨틱스 인코퍼레이티드 | 디아릴티오히단토인 및 디아릴히단토인 화합물의 합성 방법 |
| US20130090417A1 (en) * | 2010-06-14 | 2013-04-11 | Solvay Specialty Polymers Italy S.P.A. | PVDF coating compositions |
| BR112015005404A2 (pt) | 2012-09-11 | 2017-08-22 | Dr Reddys Laboratories Ltd | Formas polimórficas de enzalutamida e sua preparação |
| CN106543085A (zh) | 2013-10-14 | 2017-03-29 | 杭州普晒医药科技有限公司 | 恩杂鲁胺的固态形式及其制备方法和用途 |
| US9611225B2 (en) * | 2014-01-27 | 2017-04-04 | Cadila Healthcare Limited | Process for preparation of androgen receptor antagonist |
| WO2016005875A1 (en) * | 2014-07-11 | 2016-01-14 | Shilpa Medicare Limited | An improved process for the preparation of enzalutamide |
| CN104610158A (zh) | 2015-02-03 | 2015-05-13 | 江苏慧博生物科技有限公司 | 一种恩杂鲁胺的精制方法 |
| ITUB20151204A1 (it) * | 2015-05-28 | 2016-11-28 | Olon Spa | Procedimento per la preparazione di enzalutamide |
-
2016
- 2016-05-27 EP EP16803248.0A patent/EP3305770B1/en active Active
- 2016-05-27 ES ES16803248T patent/ES2942618T3/es active Active
- 2016-05-27 JP JP2017521901A patent/JP6753396B2/ja active Active
- 2016-05-27 WO PCT/JP2016/065729 patent/WO2016194813A1/ja not_active Ceased
- 2016-05-27 KR KR1020177037241A patent/KR102666017B1/ko active Active
- 2016-05-27 CN CN201680029674.1A patent/CN107635969B/zh active Active
- 2016-05-27 US US15/577,007 patent/US10118899B2/en active Active
- 2016-05-27 PT PT168032480T patent/PT3305770T/pt unknown
- 2016-05-27 PL PL16803248.0T patent/PL3305770T3/pl unknown
- 2016-05-27 CA CA2987563A patent/CA2987563C/en active Active
- 2016-05-27 MX MX2017014958A patent/MX385084B/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3305770B1 (en) | 2023-03-29 |
| MX2017014958A (es) | 2018-07-06 |
| JP6753396B2 (ja) | 2020-09-09 |
| EP3305770A4 (en) | 2018-12-12 |
| US10118899B2 (en) | 2018-11-06 |
| CN107635969B (zh) | 2021-08-17 |
| CA2987563A1 (en) | 2016-12-08 |
| KR20180014015A (ko) | 2018-02-07 |
| MX385084B (es) | 2025-03-14 |
| US20180148417A1 (en) | 2018-05-31 |
| PL3305770T3 (pl) | 2023-06-26 |
| WO2016194813A1 (ja) | 2016-12-08 |
| HK1251218A1 (en) | 2019-01-25 |
| KR102666017B1 (ko) | 2024-05-16 |
| EP3305770A1 (en) | 2018-04-11 |
| CA2987563C (en) | 2024-04-09 |
| CN107635969A (zh) | 2018-01-26 |
| JPWO2016194813A1 (ja) | 2018-06-07 |
| ES2942618T3 (es) | 2023-06-05 |
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