PT3320102T - Processo para a síntese de pentostatina - Google Patents

Processo para a síntese de pentostatina

Info

Publication number
PT3320102T
PT3320102T PT167347061T PT16734706T PT3320102T PT 3320102 T PT3320102 T PT 3320102T PT 167347061 T PT167347061 T PT 167347061T PT 16734706 T PT16734706 T PT 16734706T PT 3320102 T PT3320102 T PT 3320102T
Authority
PT
Portugal
Prior art keywords
pentostatin
synthesis
Prior art date
Application number
PT167347061T
Other languages
English (en)
Inventor
Matviienko Iaroslav
Sypchenko Volodymyr
Schickaneder Christian
Zabudkin Oleksandr
Original Assignee
Synbias Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synbias Pharma Ag filed Critical Synbias Pharma Ag
Publication of PT3320102T publication Critical patent/PT3320102T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02006—Nucleoside deoxyribosyltransferase (2.4.2.6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
PT167347061T 2015-07-07 2016-07-06 Processo para a síntese de pentostatina PT3320102T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15175659.0A EP3115461A1 (en) 2015-07-07 2015-07-07 Method for the synthesis of pentostatin

Publications (1)

Publication Number Publication Date
PT3320102T true PT3320102T (pt) 2019-12-06

Family

ID=53524658

Family Applications (1)

Application Number Title Priority Date Filing Date
PT167347061T PT3320102T (pt) 2015-07-07 2016-07-06 Processo para a síntese de pentostatina

Country Status (19)

Country Link
US (1) US20180201966A1 (pt)
EP (2) EP3115461A1 (pt)
JP (1) JP2018522884A (pt)
KR (1) KR20180026738A (pt)
CN (1) CN107849593A (pt)
AR (1) AR105264A1 (pt)
AU (1) AU2016289854A1 (pt)
BR (1) BR112018000331A2 (pt)
DK (1) DK3320102T3 (pt)
ES (1) ES2764136T3 (pt)
HU (1) HUE046553T2 (pt)
MX (1) MX366715B (pt)
PL (1) PL3320102T3 (pt)
PT (1) PT3320102T (pt)
RU (1) RU2017145984A (pt)
SI (1) SI3320102T1 (pt)
TW (1) TWI648287B (pt)
UY (1) UY36775A (pt)
WO (1) WO2017005784A1 (pt)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117229A (en) * 1977-10-11 1978-09-26 Warner-Lambert Company 2-amino-1-(5-amino-1h-imidazol-4-yl)ethanone and method of preparation
CN101343302B (zh) 2003-09-15 2012-07-04 梅恩医药有限公司 喷司他丁及其前体、类似物和衍生物的合成和制造
US20090012288A1 (en) 2007-07-03 2009-01-08 Hai-Ren Zhang Process for preparation of pentostatin (R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidaz[4,5-d][1,3] diazepin-8-ol
EP2992107B1 (en) * 2013-04-29 2019-12-11 Plasmia Biotech, S.L. Biocatalytic production of nucleoside analogues as active pharmaceutical ingredients

Also Published As

Publication number Publication date
PL3320102T3 (pl) 2020-04-30
WO2017005784A1 (en) 2017-01-12
MX2017017021A (es) 2018-08-15
SI3320102T1 (sl) 2020-02-28
RU2017145984A (ru) 2019-08-07
CN107849593A (zh) 2018-03-27
ES2764136T3 (es) 2020-06-02
RU2017145984A3 (pt) 2019-09-09
KR20180026738A (ko) 2018-03-13
TWI648287B (zh) 2019-01-21
UY36775A (es) 2016-12-30
DK3320102T3 (da) 2019-12-02
US20180201966A1 (en) 2018-07-19
HUE046553T2 (hu) 2020-03-30
AU2016289854A1 (en) 2018-01-18
BR112018000331A2 (pt) 2018-09-11
JP2018522884A (ja) 2018-08-16
EP3320102A1 (en) 2018-05-16
MX366715B (es) 2019-07-18
TW201706283A (zh) 2017-02-16
AR105264A1 (es) 2017-09-20
EP3320102B1 (en) 2019-09-04
EP3115461A1 (en) 2017-01-11

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