PT3409660T - Derivado de amina cíclica e utilização farmacêutica do mesmo - Google Patents

Derivado de amina cíclica e utilização farmacêutica do mesmo

Info

Publication number: PT3409660T
Authority: PT; Portugal
Prior art keywords: amine derivative; pharmaceutical use; cyclic amine; cyclic; pharmaceutical
Prior art date: 2016-01-29

Application number

PT177443868T

Other languages

English (en)

Original Assignee

Toray Industries

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-01-29

Filing date

2017-01-27

Publication date

2020-07-31

2017-01-27 Application filed by Toray Industries filed Critical Toray Industries

2020-07-31 Publication of PT3409660T publication Critical patent/PT3409660T/pt

Links

-1 Cyclic amine Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Transplantation (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Toys (AREA)
Portable Nailing Machines And Staplers (AREA)

PT177443868T 2016-01-29 2017-01-27 Derivado de amina cíclica e utilização farmacêutica do mesmo PT3409660T (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2016015512		2016-01-29
JP2016212629		2016-10-31

Publications (1)

Publication Number	Publication Date
PT3409660T true PT3409660T (pt)	2020-07-31

Family

ID=59398579

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT177443868T PT3409660T (pt)	2016-01-29	2017-01-27	Derivado de amina cíclica e utilização farmacêutica do mesmo

Country Status (22)

Country	Link
US (1)	US10364222B2 (pt)
EP (1)	EP3409660B1 (pt)
JP (1)	JP6807054B2 (pt)
KR (1)	KR102721463B1 (pt)
CN (1)	CN108473426B (pt)
AU (1)	AU2017210685B2 (pt)
CA (1)	CA3009971C (pt)
DK (1)	DK3409660T3 (pt)
ES (1)	ES2822606T3 (pt)
HU (1)	HUE050744T2 (pt)
IL (1)	IL260230B (pt)
MX (1)	MX377867B (pt)
MY (1)	MY195416A (pt)
PH (1)	PH12018501434B1 (pt)
PL (1)	PL3409660T3 (pt)
PT (1)	PT3409660T (pt)
RU (1)	RU2696862C1 (pt)
SG (1)	SG11201805474PA (pt)
TR (1)	TR201912580U5 (pt)
TW (1)	TWI691486B (pt)
WO (1)	WO2017131156A1 (pt)
ZA (1)	ZA201804325B (pt)

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Publication number	Priority date	Publication date	Assignee	Title
WO2019022234A1 (ja) *	2017-07-27	2019-01-31	東レ株式会社	炎症性腸疾患の治療剤又は予防剤
CA3071235A1 (en) *	2017-07-27	2019-01-31	Toray Industries, Inc.	Therapeutic agent or preventive agent for alopecia areata
TW201910312A (zh) *	2017-07-28	2019-03-16	日商東麗股份有限公司	環狀胺衍生物及其醫藥用途
JPWO2019044940A1 (ja) *	2017-08-31	2020-08-13	東レ株式会社	環状アミン誘導体及びその医薬用途
BR112020013438A2 (pt)	2018-01-31	2020-12-01	Toray Industries, Inc.	derivado de amina cíclico, medicamento, antagonista de receptor órfão gama relacionado a retinoide, e, agentes terapêuticos ou agentes preventivos para uma doença autoimune, para psoríase ou alopecia areata, para uma doença alérgica, para dermatite alérgica e para dermatite de contato ou dermatite atópica
JP2021517563A (ja) *	2018-03-12	2021-07-26	エスカリアバイオサイエンシーズ，ビーブイ	二環式ＲＯＲγモジュレーター
KR20210060367A (ko)	2018-03-12	2021-05-26	에스칼리에 바이오사이언시스, 비브이	스피로사이클릭 ror-감마 조절제
CN111548303A (zh) *	2020-06-28	2020-08-18	山东美泰医药有限公司	一种盐酸左布比卡因的杂质及其制备和分析方法
CN113252831B (zh) *	2021-05-20	2022-08-26	京博农化科技有限公司	N-氯甲酰基-n-[4-（三氟甲氧基）苯基]氨基甲酸甲酯超高效液相色谱分析方法
CN120383557A (zh) *	2024-01-26	2025-07-29	上海医药集团股份有限公司	一种乙磺酰苯基乙酰胺类化合物的晶型、其制备方法及应用

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CN1826121B (zh)	2003-07-23	2013-05-29	幸讬制药公司	苯基与吡啶基衍生物用于制备调控钙离子释放活化钙离子通道的药物的用途
CN101203512A (zh)	2005-04-22	2008-06-18	第一三共株式会社	杂环化合物
GB0510139D0 (en)	2005-05-18	2005-06-22	Addex Pharmaceuticals Sa	Novel compounds B1
WO2007087442A2 (en)	2006-01-25	2007-08-02	Synta Pharmaceuticals Corp.	Substituted biaryl compounds for inflammation and immune-related uses
WO2009074829A1 (en) *	2007-12-12	2009-06-18	Astrazeneca Ab	Peptidyl nitriles and use thereof as dipeptidyl peptidase i inhibitors
EP2559455A1 (en)	2008-07-15	2013-02-20	Novartis AG	Heteroaryl derivatives as DGAT1 inhibitors
WO2010096371A2 (en)	2009-02-18	2010-08-26	Boehringer Ingelheim International Gmbh	Heterocyclic compounds which modulate the cb2 receptor
CA2772790C (en)	2009-09-04	2017-06-27	Benjamin Bader	Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors
US8686048B2 (en) *	2010-05-06	2014-04-01	Rhizen Pharmaceuticals Sa	Immunomodulator and anti-inflammatory compounds
WO2012027965A1 (en)	2010-09-01	2012-03-08	Glaxo Group Limited	Novel compounds
CA2816753A1 (en)	2010-11-08	2012-05-18	Lycera Corporation	N- sulfonylated tetrahydroquinolines and related bicyclic compounds inhibition of rory activity and the treatment of diseases
WO2012147916A1 (ja)	2011-04-28	2012-11-01	日本たばこ産業株式会社	アミド化合物およびその医薬用途
WO2012158784A2 (en)	2011-05-16	2012-11-22	Theodore Mark Kamenecka	Modulators of the nuclear hormone receptor ror
EP2738170B1 (en)	2011-07-29	2017-08-30	Takeda Pharmaceutical Company Limited	Heterocyclic compound
GB201207406D0 (en)	2012-04-27	2012-06-13	Glaxo Group Ltd	Novel compounds
CN107007597A (zh)	2012-05-31	2017-08-04	菲尼克斯药品股份公司	作为孤儿核受体RORγ调节物的经甲酰胺或磺酰胺取代的噻唑及相关衍生物的制药用途
MX2015011677A (es) *	2013-03-14	2016-07-08	Celtaxsys Inc	Inhibidores de leucotrieno a4 hidrolasa.
CN106061947B (zh) *	2014-01-06	2019-12-03	百时美施贵宝公司	环己基砜RORγ调节剂
WO2015103508A1 (en) *	2014-01-06	2015-07-09	Bristol-Myers Squibb Company	CARBOCYCLIC SULFONE RORγ MODULATORS
JPWO2015129853A1 (ja) *	2014-02-27	2017-03-30	東レ株式会社	環状アミン誘導体及びその医薬用途

2017
- 2017-01-25 TW TW106102788A patent/TWI691486B/zh active
- 2017-01-27 JP JP2017507454A patent/JP6807054B2/ja active Active
- 2017-01-27 ES ES17744386T patent/ES2822606T3/es active Active
- 2017-01-27 AU AU2017210685A patent/AU2017210685B2/en not_active Ceased
- 2017-01-27 MY MYPI2018000987A patent/MY195416A/en unknown
- 2017-01-27 RU RU2018126968A patent/RU2696862C1/ru active
- 2017-01-27 PT PT177443868T patent/PT3409660T/pt unknown
- 2017-01-27 US US16/072,482 patent/US10364222B2/en active Active
- 2017-01-27 KR KR1020187019685A patent/KR102721463B1/ko active Active
- 2017-01-27 HU HUE17744386A patent/HUE050744T2/hu unknown
- 2017-01-27 PH PH1/2018/501434A patent/PH12018501434B1/en unknown
- 2017-01-27 MX MX2018008454A patent/MX377867B/es unknown
- 2017-01-27 CN CN201780008139.2A patent/CN108473426B/zh active Active
- 2017-01-27 WO PCT/JP2017/002924 patent/WO2017131156A1/ja not_active Ceased
- 2017-01-27 EP EP17744386.8A patent/EP3409660B1/en active Active
- 2017-01-27 PL PL17744386T patent/PL3409660T3/pl unknown
- 2017-01-27 CA CA3009971A patent/CA3009971C/en active Active
- 2017-01-27 SG SG11201805474PA patent/SG11201805474PA/en unknown
- 2017-01-27 DK DK17744386.8T patent/DK3409660T3/da active
2018
- 2018-06-24 IL IL260230A patent/IL260230B/en active IP Right Grant
- 2018-06-27 ZA ZA2018/04325A patent/ZA201804325B/en unknown
2019
- 2019-08-21 TR TR2019/12580U patent/TR201912580U5/tr unknown

Also Published As

Publication number	Publication date
MY195416A (en)	2023-01-20
BR112018015125A2 (pt)	2019-02-26
TR201912580U5 (tr)	2020-09-21
AU2017210685B2 (en)	2020-09-24
ZA201804325B (en)	2019-09-25
US20180370916A1 (en)	2018-12-27
JP6807054B2 (ja)	2021-01-06
KR102721463B1 (ko)	2024-10-24
TW201731816A (zh)	2017-09-16
CN108473426B (zh)	2021-09-07
KR20180100573A (ko)	2018-09-11
AU2017210685A1 (en)	2018-07-05
ES2822606T3 (es)	2021-05-04
US10364222B2 (en)	2019-07-30
DK3409660T3 (da)	2020-08-31
HUE050744T2 (hu)	2021-01-28
WO2017131156A1 (ja)	2017-08-03
IL260230A (en)	2018-07-31
EP3409660B1 (en)	2020-07-01
TWI691486B (zh)	2020-04-21
JPWO2017131156A1 (ja)	2018-11-22
PH12018501434A1 (en)	2019-03-04
CN108473426A (zh)	2018-08-31
MX377867B (es)	2025-03-10
EP3409660A1 (en)	2018-12-05
SG11201805474PA (en)	2018-07-30
PL3409660T3 (pl)	2021-01-25
IL260230B (en)	2020-06-30
CA3009971A1 (en)	2017-08-03
MX2018008454A (es)	2018-08-14
CA3009971C (en)	2024-03-19
PH12018501434B1 (en)	2023-07-05
RU2696862C1 (ru)	2019-08-07
EP3409660A4 (en)	2019-06-26

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