PT3473621T - Método de produção de derivados de difenilmetano - Google Patents
Método de produção de derivados de difenilmetanoInfo
- Publication number
- PT3473621T PT3473621T PT17813615T PT17813615T PT3473621T PT 3473621 T PT3473621 T PT 3473621T PT 17813615 T PT17813615 T PT 17813615T PT 17813615 T PT17813615 T PT 17813615T PT 3473621 T PT3473621 T PT 3473621T
- Authority
- PT
- Portugal
- Prior art keywords
- diphenylmethane derivative
- producing diphenylmethane
- producing
- derivative
- diphenylmethane
- Prior art date
Links
- CZZYITDELCSZES-UHFFFAOYSA-N diphenylmethane Chemical class C=1C=CC=CC=1CC1=CC=CC=C1 CZZYITDELCSZES-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B51/00—Introduction of protecting groups or activating groups, not provided for in the preceding groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160075910 | 2016-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3473621T true PT3473621T (pt) | 2021-10-04 |
Family
ID=60664449
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT201529591T PT3663292T (pt) | 2016-06-17 | 2017-06-15 | Derivado de difenilmetano em forma cristalina |
| PT17813615T PT3473621T (pt) | 2016-06-17 | 2017-06-15 | Método de produção de derivados de difenilmetano |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT201529591T PT3663292T (pt) | 2016-06-17 | 2017-06-15 | Derivado de difenilmetano em forma cristalina |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US10640496B2 (pt) |
| EP (2) | EP3473621B1 (pt) |
| JP (4) | JP6763978B2 (pt) |
| KR (2) | KR102233229B1 (pt) |
| CN (2) | CN113651803B (pt) |
| AU (1) | AU2017285813B2 (pt) |
| CA (2) | CA3026756C (pt) |
| CL (1) | CL2018003645A1 (pt) |
| CO (1) | CO2018014018A2 (pt) |
| DK (2) | DK3663292T3 (pt) |
| DO (1) | DOP2018000287A (pt) |
| EC (1) | ECSP19000185A (pt) |
| ES (2) | ES2898336T3 (pt) |
| HR (1) | HRP20211670T8 (pt) |
| HU (1) | HUE056428T2 (pt) |
| MA (2) | MA44545B2 (pt) |
| MX (2) | MX392177B (pt) |
| MY (1) | MY203941A (pt) |
| NZ (1) | NZ749398A (pt) |
| PE (2) | PE20240590A1 (pt) |
| PH (1) | PH12018550206A1 (pt) |
| PL (2) | PL3663292T3 (pt) |
| PT (2) | PT3663292T (pt) |
| RS (1) | RS62550B1 (pt) |
| SA (2) | SA521422474B1 (pt) |
| SG (2) | SG10201911782RA (pt) |
| SI (1) | SI3663292T1 (pt) |
| TN (1) | TN2018000437A1 (pt) |
| WO (1) | WO2017217792A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011054773A1 (de) | 2011-10-25 | 2013-04-25 | Vb Autobatterie Gmbh & Co. Kgaa | Anschlusspol für einen Akkumulator, Akkumulatorgehäuse und Maschine zur Herstellung eines Anschlusspols |
| EP3838894B1 (en) | 2018-08-13 | 2024-03-13 | Daewoong Pharmaceutical Co., Ltd. | Method for producing intermediate useful for synethesis of sglt inhibitor |
| CN112341416A (zh) * | 2019-08-09 | 2021-02-09 | 天津津艺医药科技发展有限责任公司 | 一种制备苯并含氧脂杂环衍生物的方法 |
| EP4112612B1 (en) | 2020-02-27 | 2025-10-22 | Daewoong Pharmaceutical Co., Ltd. | Intermediate useful for synthesis of sglt inhibitor and method for preparing sglt inhibitor using same |
| CN112094253B (zh) * | 2020-09-10 | 2023-01-10 | 株式会社大熊制药 | 用于制备sglt抑制剂中间体的合成方法 |
| PE20231373A1 (es) | 2020-09-10 | 2023-09-07 | Daewoong Pharmaceutical Co Ltd | Metodo de sintesis para la preparacion de un intermedio de inhibidores de sglt |
| CN113200860B (zh) * | 2021-04-29 | 2024-07-30 | 爱斯特（成都）生物制药股份有限公司 | 一种sglt2抑制剂中间体的制备方法 |
| KR20230046784A (ko) * | 2021-09-30 | 2023-04-06 | 주식회사 대웅제약 | 이나보글리플로진을 포함하는 약학 조성물 |
| CN113801010A (zh) * | 2021-11-18 | 2021-12-17 | 山东诚创蓝海医药科技有限公司 | 一种5-溴-2-氯苯甲酸的制备方法 |
| CN113912487B (zh) * | 2021-11-23 | 2024-05-28 | 山东研峰新材料科技有限公司 | 一种2,5-双卤代苯甲酸的合成方法 |
| KR20230110001A (ko) * | 2022-01-14 | 2023-07-21 | 주식회사 대웅제약 | Ssglt 저해제의 합성에 유용한 중간체의 제조 방법 |
| KR20240044194A (ko) | 2022-09-28 | 2024-04-04 | 주식회사 대웅제약 | 이나보글리플로진의 신규한 공결정 |
| KR20240044190A (ko) | 2022-09-28 | 2024-04-04 | 주식회사 대웅제약 | 이나보글리플로진의 신규한 결정형 및 이의 제조방법 |
| CN119968202A (zh) | 2022-09-29 | 2025-05-09 | 株式会社大熊制药 | 用于预防或治疗心血管衰老疾病的包含依那格列净的药物组合物 |
| WO2024076177A1 (ko) | 2022-10-05 | 2024-04-11 | 주식회사 대웅제약 | 이나보글리플로진을 포함하는 신장애 및/또는 당뇨병 예방 또는 치료용 약학 조성물 |
| CN120435283A (zh) | 2022-12-21 | 2025-08-05 | 大熊治疗株式会社 | 包含依那格列净的滴眼剂形式的药物组合物 |
| KR20240107660A (ko) | 2022-12-30 | 2024-07-09 | 주식회사 대웅제약 | 이나보글리플로진 및 메트포르민을 포함하는 약학 조성물 |
| KR102837941B1 (ko) * | 2024-11-13 | 2025-07-25 | 대웅바이오(주) | Inline quenching 공정을 도입한 연속반응 공정을 이용한 이나보글리플로진 합성방법 |
| KR102853437B1 (ko) * | 2024-11-13 | 2025-09-04 | 대웅바이오(주) | 연속반응 공정을 이용한 이나보글리플로진 합성방법 |
| KR102837948B1 (ko) * | 2024-11-13 | 2025-07-25 | 대웅바이오(주) | 분배 투입법을 도입한 연속반응 공정을 이용한 이나보글리플로진 합성방법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4966907A (en) * | 1988-08-12 | 1990-10-30 | Merck & Co., Inc. | 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis |
| LT2896397T (lt) * | 2003-08-01 | 2017-11-27 | Mitsubishi Tanabe Pharma Corporation | Nauji junginiai, turintys inhibitorinį aktyvumą prieš nuo natrio priklausomą gliukozės transporterį |
| AU2008279424B2 (en) | 2007-07-26 | 2013-06-13 | Lexicon Pharmaceuticals, Inc. | Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors |
| PE20110208A1 (es) | 2008-07-30 | 2011-03-28 | Ferrer Int | Compuestos de 1,6-dihidro-2h-3-oxa-6-aza-as-indaceno |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| WO2012041898A1 (en) * | 2010-09-29 | 2012-04-05 | Celon Pharma Sp. Z O.O. | Combination of sglt2 inhibitor and a sugar compound for the treatment of diabetes |
| WO2012165914A2 (en) * | 2011-06-01 | 2012-12-06 | Green Cross Corporation | Novel diphenylmethane derivatives as sglt2 inhibitors |
| US9340521B2 (en) | 2013-03-18 | 2016-05-17 | Green Cross Corporation | Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2017
- 2017-06-15 MX MX2021008988A patent/MX392177B/es unknown
- 2017-06-15 PL PL20152959T patent/PL3663292T3/pl unknown
- 2017-06-15 KR KR1020170075799A patent/KR102233229B1/ko active Active
- 2017-06-15 DK DK20152959.1T patent/DK3663292T3/da active
- 2017-06-15 WO PCT/KR2017/006271 patent/WO2017217792A1/ko not_active Ceased
- 2017-06-15 EP EP17813615.6A patent/EP3473621B1/en active Active
- 2017-06-15 MY MYPI2018002498A patent/MY203941A/en unknown
- 2017-06-15 NZ NZ749398A patent/NZ749398A/en unknown
- 2017-06-15 SG SG10201911782RA patent/SG10201911782RA/en unknown
- 2017-06-15 PT PT201529591T patent/PT3663292T/pt unknown
- 2017-06-15 RS RS20211297A patent/RS62550B1/sr unknown
- 2017-06-15 AU AU2017285813A patent/AU2017285813B2/en active Active
- 2017-06-15 PE PE2023002240A patent/PE20240590A1/es unknown
- 2017-06-15 CA CA3026756A patent/CA3026756C/en active Active
- 2017-06-15 PE PE2018003162A patent/PE20190467A1/es unknown
- 2017-06-15 CA CA3081033A patent/CA3081033C/en active Active
- 2017-06-15 SG SG11201811154QA patent/SG11201811154QA/en unknown
- 2017-06-15 HU HUE20152959A patent/HUE056428T2/hu unknown
- 2017-06-15 MA MA44545A patent/MA44545B2/fr unknown
- 2017-06-15 SI SI201730944T patent/SI3663292T1/sl unknown
- 2017-06-15 HR HRP20211670TT patent/HRP20211670T8/hr unknown
- 2017-06-15 DK DK17813615.6T patent/DK3473621T3/da active
- 2017-06-15 ES ES20152959T patent/ES2898336T3/es active Active
- 2017-06-15 MX MX2018015647A patent/MX385640B/es unknown
- 2017-06-15 US US16/310,005 patent/US10640496B2/en active Active
- 2017-06-15 ES ES17813615T patent/ES2891825T3/es active Active
- 2017-06-15 MA MA50774A patent/MA50774B1/fr unknown
- 2017-06-15 CN CN202110860586.9A patent/CN113651803B/zh active Active
- 2017-06-15 PT PT17813615T patent/PT3473621T/pt unknown
- 2017-06-15 JP JP2018565754A patent/JP6763978B2/ja active Active
- 2017-06-15 CN CN201780036968.1A patent/CN109311861B/zh active Active
- 2017-06-15 PL PL17813615T patent/PL3473621T3/pl unknown
- 2017-06-15 EP EP20152959.1A patent/EP3663292B1/en active Active
- 2017-06-15 TN TNP/2018/000437A patent/TN2018000437A1/en unknown
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2018
- 2018-12-15 SA SA521422474A patent/SA521422474B1/ar unknown
- 2018-12-15 SA SA518400666A patent/SA518400666B1/ar unknown
- 2018-12-17 CL CL2018003645A patent/CL2018003645A1/es unknown
- 2018-12-17 DO DO2018000287A patent/DOP2018000287A/es unknown
- 2018-12-17 PH PH12018550206A patent/PH12018550206A1/en unknown
- 2018-12-21 CO CONC2018/0014018A patent/CO2018014018A2/es unknown
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2019
- 2019-01-04 EC ECSENADI2019185A patent/ECSP19000185A/es unknown
- 2019-08-30 US US16/557,180 patent/US10889574B2/en active Active
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2020
- 2020-04-06 JP JP2020068458A patent/JP7352509B2/ja active Active
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2021
- 2021-03-22 KR KR1020210036824A patent/KR102379584B1/ko active Active
- 2021-06-21 JP JP2021102648A patent/JP7669206B2/ja active Active
-
2023
- 2023-07-06 JP JP2023111632A patent/JP7773506B2/ja active Active
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