PT3530649T - Processo para a preparação de um análogo de prostaglandina que doa óxido nítrico - Google Patents

Processo para a preparação de um análogo de prostaglandina que doa óxido nítrico

Info

Publication number
PT3530649T
PT3530649T PT181578881T PT18157888T PT3530649T PT 3530649 T PT3530649 T PT 3530649T PT 181578881 T PT181578881 T PT 181578881T PT 18157888 T PT18157888 T PT 18157888T PT 3530649 T PT3530649 T PT 3530649T
Authority
PT
Portugal
Prior art keywords
preparation
nitric oxide
prostaglandin analogue
oxide donating
donating prostaglandin
Prior art date
Application number
PT181578881T
Other languages
English (en)
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of PT3530649T publication Critical patent/PT3530649T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT181578881T 2018-02-21 2018-02-21 Processo para a preparação de um análogo de prostaglandina que doa óxido nítrico PT3530649T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18157888.1A EP3530649B1 (en) 2018-02-21 2018-02-21 Process for the preparation of a nitric oxide donating prostaglandin analogue

Publications (1)

Publication Number Publication Date
PT3530649T true PT3530649T (pt) 2020-12-04

Family

ID=61563114

Family Applications (1)

Application Number Title Priority Date Filing Date
PT181578881T PT3530649T (pt) 2018-02-21 2018-02-21 Processo para a preparação de um análogo de prostaglandina que doa óxido nítrico

Country Status (15)

Country Link
US (1) US10988438B2 (pt)
EP (2) EP3757089B1 (pt)
JP (2) JP7365349B2 (pt)
KR (1) KR102945338B1 (pt)
CN (1) CN111757868B (pt)
AR (1) AR114262A1 (pt)
CA (1) CA3089530A1 (pt)
ES (2) ES2836118T3 (pt)
HU (1) HUE052204T2 (pt)
MY (1) MY201321A (pt)
PH (1) PH12020551320A1 (pt)
PT (1) PT3530649T (pt)
SG (1) SG11202007113XA (pt)
TW (1) TWI805692B (pt)
WO (1) WO2019162149A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE064405T2 (hu) * 2019-08-05 2024-03-28 Nicox Sa Eljárás nitrogén-oxid donor prosztaglandin analóg elõállítására
ES3017242T3 (en) * 2021-02-03 2025-05-12 Nicox Sa Process for the preparation of a nitric oxide donating prostaglandin analogue
CN117979973A (zh) 2021-09-20 2024-05-03 尼科斯股份有限公司 作为神经保护剂的释放一氧化氮的前列腺酰胺
MA71652A (fr) 2022-07-07 2025-05-30 Nicox S.A. Procédé industriel pour la préparation d'acide hexanoique, 6-(nitrooxy)-, (1s,2e)-3-(1r,2r,3s,5r)-2- (2z)-7-(éthylamino)-7-oxo-2-hepten-1-yl)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
CN103288698A (zh) * 2013-05-07 2013-09-11 北京洛斯顿精细化工有限公司 一种合成前列素类似物的新方法
JP6279409B2 (ja) * 2014-06-02 2018-02-14 株式会社ダイセル ポスト処理を行ったスズ置換ゼオライト・ベータを用いたケトン類のエステル類への酸化
WO2016155906A1 (en) 2015-03-31 2016-10-06 Nicox S.A. Nitric oxide donating derivatives of fluprostenol

Also Published As

Publication number Publication date
TW202000643A (zh) 2020-01-01
TWI805692B (zh) 2023-06-21
US10988438B2 (en) 2021-04-27
CN111757868A (zh) 2020-10-09
EP3757089A1 (en) 2020-12-30
KR20200123151A (ko) 2020-10-28
EP3530649B1 (en) 2020-09-30
ES2923623T3 (es) 2022-09-29
EP3530649A1 (en) 2019-08-28
PH12020551320A1 (en) 2021-04-26
ES2836118T3 (es) 2021-06-24
CN111757868B (zh) 2023-03-14
JP2024009896A (ja) 2024-01-23
JP7661437B2 (ja) 2025-04-14
MY201321A (en) 2024-02-16
HUE052204T2 (hu) 2021-04-28
WO2019162149A1 (en) 2019-08-29
EP3757089B1 (en) 2022-05-11
SG11202007113XA (en) 2020-09-29
AR114262A1 (es) 2020-08-12
CA3089530A1 (en) 2019-08-29
JP2021514371A (ja) 2021-06-10
KR102945338B1 (ko) 2026-03-26
US20210040032A1 (en) 2021-02-11
JP7365349B2 (ja) 2023-10-19

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