PT3538143T - Atenuação da virulência bacteriana por atenuação do transporte de folato bacter - Google Patents

Atenuação da virulência bacteriana por atenuação do transporte de folato bacter

Info

Publication number
PT3538143T
PT3538143T PT178079828T PT17807982T PT3538143T PT 3538143 T PT3538143 T PT 3538143T PT 178079828 T PT178079828 T PT 178079828T PT 17807982 T PT17807982 T PT 17807982T PT 3538143 T PT3538143 T PT 3538143T
Authority
PT
Portugal
Prior art keywords
mitigation
bacter
folate
transport
bacterial virulence
Prior art date
Application number
PT178079828T
Other languages
English (en)
Original Assignee
Boehringer Ingelheim Vetmedica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica Gmbh filed Critical Boehringer Ingelheim Vetmedica Gmbh
Publication of PT3538143T publication Critical patent/PT3538143T/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092Streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/542Mucosal route oral/gastrointestinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46Streptococcus ; Enterococcus; Lactococcus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT178079828T 2016-11-11 2017-11-10 Atenuação da virulência bacteriana por atenuação do transporte de folato bacter PT3538143T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16198361 2016-11-11

Publications (1)

Publication Number Publication Date
PT3538143T true PT3538143T (pt) 2022-09-06

Family

ID=57396264

Family Applications (1)

Application Number Title Priority Date Filing Date
PT178079828T PT3538143T (pt) 2016-11-11 2017-11-10 Atenuação da virulência bacteriana por atenuação do transporte de folato bacter

Country Status (21)

Country Link
US (2) US11684663B2 (pt)
EP (2) EP4159231A1 (pt)
JP (2) JP6982616B2 (pt)
KR (1) KR102674702B1 (pt)
CN (2) CN118546970A (pt)
AU (1) AU2017357813B2 (pt)
BR (1) BR112019009399A2 (pt)
CA (1) CA3043039A1 (pt)
CL (1) CL2019001275A1 (pt)
DK (1) DK3538143T3 (pt)
EA (1) EA201991126A1 (pt)
ES (1) ES2926543T3 (pt)
HU (1) HUE060176T2 (pt)
MX (2) MX2019005499A (pt)
MY (1) MY201256A (pt)
PH (1) PH12019501019A1 (pt)
PL (1) PL3538143T3 (pt)
PT (1) PT3538143T (pt)
RS (1) RS63524B1 (pt)
UA (1) UA129349C2 (pt)
WO (1) WO2018089841A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017357813B2 (en) * 2016-11-11 2024-07-25 Boehringer Ingelheim Vetmedica Gmbh Attenuating bacterial virulence by attenuating bacterial folate transport
WO2021035421A1 (en) * 2019-08-23 2021-03-04 Chifeng Pharmaceutical Co., Ltd. Folate producing strain and the preparation and application thereof
CA3169518A1 (en) 2020-06-03 2021-12-09 Mv Biotherapeutics Sa Combination of an atp-hydrolyzing enzyme and an immune checkpoint modulator and uses thereof
JP2023529399A (ja) 2020-06-08 2023-07-10 エムヴィ バイオセラピューティクス エスエー ディスバイオーシスの処置に有用なatp加水分解酵素
CN112813085B (zh) * 2021-03-05 2023-03-31 昆明理工大学 焦磷酸酶基因的用途
CN112961878B (zh) * 2021-03-08 2023-04-25 昆明理工大学 一种植物乳杆菌的基因在叶酸生物生成中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6229001B1 (en) 1997-01-03 2001-05-08 Southern Research Institute Mycobacterium fol a gene that encodes for the enzyme dihydrofolate reductase
US5882898A (en) * 1997-08-29 1999-03-16 Smithkline Beecham Corporation Streptococcus pneumoniae polynucleotides which encode folyl-polyglutamate synthetase (FPGS) polypeptides
CA2341268C (en) * 1998-07-22 2010-10-12 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Streptococcus suis vaccines and diagnostic tests
EP1205552A1 (en) * 2000-11-09 2002-05-15 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Virulence of streptococci, involving ORFs from Streptococcus suis
DE102005049527B4 (de) * 2005-10-17 2013-05-08 Forschungszentrum Jülich GmbH Verfahren zur Herstellung von L-Serin, Gensequenz, Vektoren sowie Mikroorganismus
CN106085936B (zh) * 2016-06-14 2019-02-26 华中农业大学 一种猪链球菌2型10基因缺失株及应用
AU2017357813B2 (en) * 2016-11-11 2024-07-25 Boehringer Ingelheim Vetmedica Gmbh Attenuating bacterial virulence by attenuating bacterial folate transport

Also Published As

Publication number Publication date
CN110582296A (zh) 2019-12-17
US11992522B2 (en) 2024-05-28
DK3538143T3 (da) 2022-08-29
MX2022014984A (es) 2023-01-04
KR102674702B1 (ko) 2024-06-14
KR20190084097A (ko) 2019-07-15
EP4159231A1 (en) 2023-04-05
RS63524B1 (sr) 2022-09-30
US20240115687A1 (en) 2024-04-11
EP3538143B1 (en) 2022-06-22
MX2019005499A (es) 2019-07-04
JP6982616B2 (ja) 2021-12-17
CN110582296B (zh) 2024-02-06
MY201256A (en) 2024-02-14
US20220226456A1 (en) 2022-07-21
WO2018089841A9 (en) 2018-09-07
JP2022036982A (ja) 2022-03-08
BR112019009399A2 (pt) 2019-10-08
ES2926543T3 (es) 2022-10-26
US11684663B2 (en) 2023-06-27
AU2017357813A1 (en) 2019-06-27
PL3538143T3 (pl) 2022-10-17
CL2019001275A1 (es) 2019-09-06
EP3538143A1 (en) 2019-09-18
CA3043039A1 (en) 2018-05-17
WO2018089841A1 (en) 2018-05-17
AU2017357813B2 (en) 2024-07-25
UA129349C2 (uk) 2025-03-26
CN118546970A (zh) 2024-08-27
EA201991126A1 (ru) 2019-11-29
PH12019501019A1 (en) 2019-12-16
HUE060176T2 (hu) 2023-01-28
JP2019533710A (ja) 2019-11-21

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