PT3728252T - Compostos 4-azaindol - Google Patents

Compostos 4-azaindol

Info

Publication number
PT3728252T
PT3728252T PT188306484T PT18830648T PT3728252T PT 3728252 T PT3728252 T PT 3728252T PT 188306484 T PT188306484 T PT 188306484T PT 18830648 T PT18830648 T PT 18830648T PT 3728252 T PT3728252 T PT 3728252T
Authority
PT
Portugal
Prior art keywords
azaindole compounds
azaindole
compounds
Prior art date
Application number
PT188306484T
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PT3728252T publication Critical patent/PT3728252T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT188306484T 2017-12-18 2018-12-17 Compostos 4-azaindol PT3728252T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762599875P 2017-12-18 2017-12-18

Publications (1)

Publication Number Publication Date
PT3728252T true PT3728252T (pt) 2023-10-26

Family

ID=65003548

Family Applications (1)

Application Number Title Priority Date Filing Date
PT188306484T PT3728252T (pt) 2017-12-18 2018-12-17 Compostos 4-azaindol

Country Status (28)

Country Link
US (4) US10544143B2 (pt)
EP (1) EP3728252B1 (pt)
JP (1) JP7289301B2 (pt)
KR (1) KR102720550B1 (pt)
CN (1) CN111819176B (pt)
AR (1) AR113959A1 (pt)
AU (1) AU2018388464B2 (pt)
BR (1) BR112020011771A2 (pt)
CA (1) CA3085817A1 (pt)
CL (1) CL2020001546A1 (pt)
DK (1) DK3728252T3 (pt)
EA (1) EA202091484A1 (pt)
ES (1) ES2960411T3 (pt)
FI (1) FI3728252T3 (pt)
HR (1) HRP20231244T1 (pt)
HU (1) HUE064473T2 (pt)
IL (1) IL275344B2 (pt)
LT (1) LT3728252T (pt)
MX (1) MX2020006168A (pt)
PE (1) PE20210129A1 (pt)
PL (1) PL3728252T3 (pt)
PT (1) PT3728252T (pt)
RS (1) RS64728B1 (pt)
SG (1) SG11202005628RA (pt)
SI (1) SI3728252T1 (pt)
SM (1) SMT202300342T1 (pt)
TW (1) TWI689510B (pt)
WO (1) WO2019125977A1 (pt)

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CA3085937A1 (en) * 2017-12-20 2019-06-27 Bristol-Myers Squibb Company Diazaindole compounds
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MX2023001883A (es) * 2020-08-19 2023-03-10 Bristol Myers Squibb Co Compuestos heteroarilicos sustituidos utiles como inhibidores del receptor tipo toll 9 (tlr9).
US12486267B2 (en) 2020-08-19 2025-12-02 Bristol-Myers Squibb Company Imidazo[1,2-A]pyridine and [1,2,4]triazolo[1,5-A]pyridine derivatives as TLR9 inhibitors for the treatment of fibrosis
KR20230053645A (ko) 2020-08-19 2023-04-21 브리스톨-마이어스 스큅 컴퍼니 섬유증의 치료를 위한 tlr9 억제제로서의 1h-벤조[d]이미다졸 유도체
AU2021328577A1 (en) 2020-08-19 2023-03-23 Bristol-Myers Squibb Company 1H-pyrrolo[3,2-c]pyridine and 1H-pyrrolo[2,3-c]pyridine derivatives as TLR9 inhibitors for the treatment of fibrosis
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CN116783202A (zh) * 2021-02-09 2023-09-19 吉利德科学公司 噻吩并吡咯化合物
TWI861488B (zh) 2021-04-16 2024-11-11 美商基利科學股份有限公司 噻吩并吡咯化合物
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TWI899933B (zh) 2023-04-06 2025-10-01 美商輝瑞大藥廠 經取代吲唑丙酸衍生化合物及其用途

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Also Published As

Publication number Publication date
MX2020006168A (es) 2020-08-13
JP2021506858A (ja) 2021-02-22
KR20200100709A (ko) 2020-08-26
AU2018388464B2 (en) 2022-07-21
TW201927780A (zh) 2019-07-16
AU2018388464A1 (en) 2020-07-30
US10730877B2 (en) 2020-08-04
DK3728252T3 (da) 2023-11-13
EP3728252A1 (en) 2020-10-28
CN111819176B (zh) 2023-12-15
BR112020011771A2 (pt) 2020-11-17
US20220340555A1 (en) 2022-10-27
SG11202005628RA (en) 2020-07-29
PL3728252T3 (pl) 2023-10-23
EA202091484A1 (ru) 2021-03-25
FI3728252T3 (fi) 2023-10-18
HUE064473T2 (hu) 2024-03-28
JP7289301B2 (ja) 2023-06-09
HRP20231244T1 (hr) 2024-02-16
TWI689510B (zh) 2020-04-01
WO2019125977A1 (en) 2019-06-27
US11053244B1 (en) 2021-07-06
US10544143B2 (en) 2020-01-28
IL275344B2 (en) 2023-08-01
RS64728B1 (sr) 2023-11-30
CA3085817A1 (en) 2019-06-27
SMT202300342T1 (it) 2023-11-13
IL275344A (en) 2020-07-30
EP3728252B1 (en) 2023-08-09
US20190185469A1 (en) 2019-06-20
IL275344B1 (en) 2023-04-01
AR113959A1 (es) 2020-07-01
SI3728252T1 (sl) 2023-11-30
ES2960411T3 (es) 2024-03-04
PE20210129A1 (es) 2021-01-19
CN111819176A (zh) 2020-10-23
KR102720550B1 (ko) 2024-10-21
US11820768B2 (en) 2023-11-21
US20200095247A1 (en) 2020-03-26
CL2020001546A1 (es) 2020-10-23
LT3728252T (lt) 2023-10-25

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