PT3735295T - Farmacêuticos peptídicos melhorados para tratamento de nash e outras disfunções - Google Patents

Farmacêuticos peptídicos melhorados para tratamento de nash e outras disfunções

Info

Publication number
PT3735295T
PT3735295T PT197048978T PT19704897T PT3735295T PT 3735295 T PT3735295 T PT 3735295T PT 197048978 T PT197048978 T PT 197048978T PT 19704897 T PT19704897 T PT 19704897T PT 3735295 T PT3735295 T PT 3735295T
Authority
PT
Portugal
Prior art keywords
nash
disorders
treatment
improved peptide
peptide pharmaceuticals
Prior art date
Application number
PT197048978T
Other languages
English (en)
Original Assignee
Mederis Diabetes Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mederis Diabetes Llc filed Critical Mederis Diabetes Llc
Publication of PT3735295T publication Critical patent/PT3735295T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT197048978T 2018-01-03 2019-01-03 Farmacêuticos peptídicos melhorados para tratamento de nash e outras disfunções PT3735295T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862613396P 2018-01-03 2018-01-03

Publications (1)

Publication Number Publication Date
PT3735295T true PT3735295T (pt) 2024-12-11

Family

ID=65409472

Family Applications (1)

Application Number Title Priority Date Filing Date
PT197048978T PT3735295T (pt) 2018-01-03 2019-01-03 Farmacêuticos peptídicos melhorados para tratamento de nash e outras disfunções

Country Status (17)

Country Link
US (3) US11541028B2 (pt)
EP (2) EP3735295B1 (pt)
JP (3) JP7817792B2 (pt)
KR (2) KR20250043579A (pt)
CN (1) CN111818971A (pt)
AU (2) AU2019205905B2 (pt)
BR (1) BR112020013644A2 (pt)
CA (1) CA3086918A1 (pt)
DK (1) DK3735295T3 (pt)
ES (1) ES3002666T3 (pt)
FI (1) FI3735295T3 (pt)
HU (1) HUE069178T2 (pt)
IL (2) IL275777B2 (pt)
MX (1) MX2020006999A (pt)
PL (1) PL3735295T3 (pt)
PT (1) PT3735295T (pt)
WO (1) WO2019136158A1 (pt)

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CN103796666B (zh) * 2011-05-18 2018-07-06 欧莫德里斯制药公司 改良的肽药物
CN104918961A (zh) * 2012-11-20 2015-09-16 梅德瑞斯糖尿病有限责任公司 用于胰岛素抗性的改良的肽药物
CN117180445A (zh) * 2014-05-28 2023-12-08 梅德瑞斯糖尿病有限责任公司 针对胰岛素抵抗的改良肽药物
BR112020013644A2 (pt) * 2018-01-03 2020-12-01 Mederis Diabetes, Llc produto de peptídeo ou sal farmaceuticamente aceitável do mesmo para uso no tratamento de síndrome de ovário policístico, um distúrbio renal ou um distúrbio hepático, e, kit.
GB2576705A (en) * 2018-08-17 2020-03-04 E Miller Norman Improvements in or relating to organic material
MX2022010320A (es) * 2020-02-21 2023-01-30 Spitfire Pharma Llc Agonistas, formulaciones y metodos de uso de glp-1r y gcgr.
CN111514276B (zh) * 2020-06-29 2021-07-27 黑龙江中医药大学 短肽Asp-His-Tyr在制备治疗多囊卵巢综合征的药物中的应用
US12171806B2 (en) 2021-09-28 2024-12-24 Spitfire Pharma Llc Therapeutic regimens and methods for lowering blood glucose and/or body weight using GLP-1R and GCGR balanced agonists
MX2023006736A (es) * 2020-12-07 2023-08-21 Spitfire Pharma Llc Regimenes y metodos terapeuticos para reducir la glucosa en sangre o el peso corporal usando agonistas balanceados de glp-1r y gcgr.
US20240148879A1 (en) * 2021-02-21 2024-05-09 Spitfire Pharma Llc Glp-1r, gip-r and/or gcgr agonists, formulations, and methods of use
CN113171446B (zh) * 2021-05-06 2022-03-29 合肥天汇孵化科技有限公司 利拉鲁肽组合物及其用途
CN114767665B (zh) * 2021-06-11 2023-10-10 同济大学 5-十四烷氧基-2-呋喃甲酸在制备用于治疗银屑病样皮炎的药物中的用途
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WO2024017964A1 (en) * 2022-07-20 2024-01-25 Actelion Pharmaceuticals Ltd Injectable pharmaceutical composition comprising a diphenylpyrazine derivative
US20260034091A1 (en) * 2022-07-29 2026-02-05 The Regents Of The University Of California Compositions and Methods for Treating Metabolic Disorders
CN115429871B (zh) * 2022-09-30 2025-03-18 中南大学湘雅二医院 司美格鲁肽新用途
WO2024194449A1 (en) * 2023-03-23 2024-09-26 Actelion Pharmaceuticals Ltd Pharmaceutical composition comprising a diphenylpyrazine derivative

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BR112020013644A2 (pt) * 2018-01-03 2020-12-01 Mederis Diabetes, Llc produto de peptídeo ou sal farmaceuticamente aceitável do mesmo para uso no tratamento de síndrome de ovário policístico, um distúrbio renal ou um distúrbio hepático, e, kit.

Also Published As

Publication number Publication date
RU2020125550A (ru) 2022-02-03
US12257229B2 (en) 2025-03-25
EP3735295B1 (en) 2024-08-21
AU2019205905A1 (en) 2020-07-30
EP4506017A2 (en) 2025-02-12
US20230218564A1 (en) 2023-07-13
HUE069178T2 (hu) 2025-02-28
JP2025118652A (ja) 2025-08-13
BR112020013644A2 (pt) 2020-12-01
IL275777A (en) 2020-08-31
JP7817792B2 (ja) 2026-02-19
IL275777B1 (en) 2024-05-01
IL311775A (en) 2024-05-01
AU2025200349A1 (en) 2025-03-27
PL3735295T4 (pl) 2025-01-20
JP2021509892A (ja) 2021-04-08
IL275777B2 (en) 2024-09-01
MX2020006999A (es) 2020-12-10
EP3735295A1 (en) 2020-11-11
JP7670749B2 (ja) 2025-04-30
WO2019136158A1 (en) 2019-07-11
US20250281450A1 (en) 2025-09-11
PL3735295T3 (pl) 2025-01-20
AU2019205905B2 (en) 2024-12-12
US11541028B2 (en) 2023-01-03
FI3735295T3 (fi) 2024-11-20
US20200352900A1 (en) 2020-11-12
ES3002666T3 (en) 2025-03-07
DK3735295T3 (da) 2024-11-25
KR20250043579A (ko) 2025-03-28
CA3086918A1 (en) 2019-07-11
KR102784507B1 (ko) 2025-03-19
EP4506017A3 (en) 2025-05-14
JP2023153115A (ja) 2023-10-17
CN111818971A (zh) 2020-10-23
KR20200106173A (ko) 2020-09-11

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