PT4335511T - Indução do gene trail de pequenas moléculas por células normais e tumorais enquanto terapia anticancro - Google Patents

Indução do gene trail de pequenas moléculas por células normais e tumorais enquanto terapia anticancro

Info

Publication number
PT4335511T
PT4335511T PT232067702T PT23206770T PT4335511T PT 4335511 T PT4335511 T PT 4335511T PT 232067702 T PT232067702 T PT 232067702T PT 23206770 T PT23206770 T PT 23206770T PT 4335511 T PT4335511 T PT 4335511T
Authority
PT
Portugal
Prior art keywords
induction
normal
tumor cells
small molecule
anticancer therapy
Prior art date
Application number
PT232067702T
Other languages
English (en)
Original Assignee
Penn State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47068061&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT4335511(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Penn State Res Found filed Critical Penn State Res Found
Publication of PT4335511T publication Critical patent/PT4335511T/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT232067702T 2011-04-29 2012-04-30 Indução do gene trail de pequenas moléculas por células normais e tumorais enquanto terapia anticancro PT4335511T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161480743P 2011-04-29 2011-04-29

Publications (1)

Publication Number Publication Date
PT4335511T true PT4335511T (pt) 2026-02-20

Family

ID=47068061

Family Applications (3)

Application Number Title Priority Date Filing Date
PT127760734T PT2701708T (pt) 2011-04-29 2012-04-30 Indução de gene trail de moléculas pequenas através de células tumorais e normais como uma terapia anticancro
PT232067702T PT4335511T (pt) 2011-04-29 2012-04-30 Indução do gene trail de pequenas moléculas por células normais e tumorais enquanto terapia anticancro
PT201523172T PT3679934T (pt) 2011-04-29 2012-04-30 Indução do gene trail de pequenas moléculas por células normais e tumorais enquanto terapia anticancro

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT127760734T PT2701708T (pt) 2011-04-29 2012-04-30 Indução de gene trail de moléculas pequenas através de células tumorais e normais como uma terapia anticancro

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT201523172T PT3679934T (pt) 2011-04-29 2012-04-30 Indução do gene trail de pequenas moléculas por células normais e tumorais enquanto terapia anticancro

Country Status (18)

Country Link
US (9) US8673923B2 (pt)
EP (4) EP3679934B1 (pt)
JP (7) JP6132833B2 (pt)
CA (1) CA2832342C (pt)
CY (1) CY1123010T1 (pt)
DK (3) DK4335511T3 (pt)
ES (3) ES2992934T3 (pt)
FI (2) FI3679934T3 (pt)
HR (3) HRP20241214T1 (pt)
HU (2) HUE068623T2 (pt)
LT (3) LT4335511T (pt)
MX (2) MX379539B (pt)
PL (3) PL4335511T3 (pt)
PT (3) PT2701708T (pt)
RS (3) RS60186B1 (pt)
SI (3) SI4335511T1 (pt)
SM (3) SMT202000272T1 (pt)
WO (1) WO2012149546A2 (pt)

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KR20220123335A (ko) * 2013-03-13 2022-09-06 온코슈틱스 인코포레이티드 7-벤질-10-(2-메틸벤질)-2,6,7,8,9,10-헥사하이드로이미다조[1,2-a]피리도[4,3-d]피리미딘-5(3h)-온과의 조합 치료요법
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MD3805222T2 (ro) * 2015-01-30 2025-04-30 Oncoceutics Inc Derivați de 7-benzil-4-(2-metilbenzil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1H)-ona, sărurile acestora și utilizarea acestora în terapie
CA2978109A1 (en) 2015-03-31 2016-10-06 The University Of North Carolina At Chapel Hill Delivery vehicles for stem cells and uses thereof
CN104860948B (zh) * 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
US11007251B2 (en) 2015-12-17 2021-05-18 The Johns Hopkins University Ameliorating systemic sclerosis with death receptor agonists
DK3408298T3 (en) 2016-01-29 2025-03-03 Oncoceutics Inc G protein-coupled receptor (gpcr) modulation by imipridones
AU2017248264B2 (en) 2016-04-07 2020-01-30 The Johns Hopkins University Compositions and methods for treating pancreatitis and pain with death receptor agonists
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US11767353B2 (en) 2020-06-05 2023-09-26 Theraly Fibrosis, Inc. Trail compositions with reduced immunogenicity
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WO2024102447A1 (en) * 2022-11-10 2024-05-16 Emory University Uses of hydroimidazopyridopyrimidinone derivatives for managing aneurysms or other vascular conditions or diseases

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SMT202000272T1 (it) 2011-04-29 2020-07-08 Penn State Res Found Induzione del gene trail da parte di cellule normali e tumorali mediante una piccola molecola come terapia anticancro
KR20220123335A (ko) 2013-03-13 2022-09-06 온코슈틱스 인코포레이티드 7-벤질-10-(2-메틸벤질)-2,6,7,8,9,10-헥사하이드로이미다조[1,2-a]피리도[4,3-d]피리미딘-5(3h)-온과의 조합 치료요법

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SI2701708T1 (sl) 2020-07-31
SMT202400421T1 (it) 2024-11-15
LT4335511T (lt) 2026-02-25
US20170224690A1 (en) 2017-08-10
EP4335511A2 (en) 2024-03-13
MX379539B (es) 2025-03-11
PL4335511T3 (pl) 2026-03-30
US20170000790A1 (en) 2017-01-05
EP4706682A2 (en) 2026-03-11
EP2701708B1 (en) 2020-01-22
US20240415841A1 (en) 2024-12-19
USRE46290E1 (en) 2017-01-31
HUE049207T2 (hu) 2020-09-28
MX365365B (es) 2019-05-30
SMT202000272T1 (it) 2020-07-08
DK4335511T3 (da) 2026-02-02
LT3679934T (lt) 2024-11-11
EP3679934A1 (en) 2020-07-15
CA2832342C (en) 2019-12-31
HRP20241214T1 (hr) 2024-11-22
ES3063552T3 (en) 2026-04-17
ES2786033T3 (es) 2020-10-08
ES2992934T3 (en) 2024-12-19
JP2025159099A (ja) 2025-10-17
MX2019006379A (es) 2019-09-04
HRP20200636T1 (hr) 2020-07-10
US20220288079A1 (en) 2022-09-15
WO2012149546A2 (en) 2012-11-01
LT2701708T (lt) 2020-05-25
RS60186B1 (sr) 2020-06-30
MX2013012346A (es) 2014-08-22
SI3679934T1 (sl) 2025-04-30
EP4335511A3 (en) 2024-05-15
SMT202600075T1 (it) 2026-03-09
JP2021185210A (ja) 2021-12-09
JP2019019145A (ja) 2019-02-07
PT3679934T (pt) 2024-09-05
JP2023060196A (ja) 2023-04-27
US9452165B2 (en) 2016-09-27
PL2701708T3 (pl) 2020-11-02
FI3679934T3 (fi) 2024-07-08
RS65813B1 (sr) 2024-08-30
JP6132833B2 (ja) 2017-05-24
US20140248264A1 (en) 2014-09-04
PL3679934T3 (pl) 2025-01-07
SI4335511T1 (sl) 2026-03-31
HUE068623T2 (hu) 2025-01-28
DK3679934T3 (en) 2024-07-22
HRP20260228T1 (hr) 2026-03-27
JP7600286B2 (ja) 2024-12-16
JP2016199580A (ja) 2016-12-01
FI4335511T3 (fi) 2026-01-29
EP2701708A4 (en) 2015-01-07
PT2701708T (pt) 2020-05-08
US9061032B2 (en) 2015-06-23
EP2701708A2 (en) 2014-03-05
JP2014514326A (ja) 2014-06-19
EP4335511B1 (en) 2025-11-26
JP2024051080A (ja) 2024-04-10
US12036223B2 (en) 2024-07-16
US8673923B2 (en) 2014-03-18
EP4706682A3 (en) 2026-05-20
WO2012149546A3 (en) 2013-01-03
DK2701708T3 (da) 2020-04-27
US9072744B1 (en) 2015-07-07
CA2832342A1 (en) 2012-11-01
EP3679934B1 (en) 2024-06-05
RS67757B1 (sr) 2026-03-31
US20150202206A1 (en) 2015-07-23
US20120276088A1 (en) 2012-11-01
CY1123010T1 (el) 2021-10-29
US9629842B2 (en) 2017-04-25
US20150265619A1 (en) 2015-09-24

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