PT757984E - Derivados de acido hidroxamico uteis para inibir a gelatinase - Google Patents
Derivados de acido hidroxamico uteis para inibir a gelatinaseInfo
- Publication number
- PT757984E PT757984E PT96305805T PT96305805T PT757984E PT 757984 E PT757984 E PT 757984E PT 96305805 T PT96305805 T PT 96305805T PT 96305805 T PT96305805 T PT 96305805T PT 757984 E PT757984 E PT 757984E
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- hydrogen
- diseases
- acid derivatives
- hydroxamic acid
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
- 102000013382 Gelatinases Human genes 0.000 title abstract 2
- 108010026132 Gelatinases Proteins 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 241000282414 Homo sapiens Species 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 208000028006 Corneal injury Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010014561 Emphysema Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010029113 Neovascularisation Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000021386 Sjogren Syndrome Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- 230000007882 cirrhosis Effects 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 201000006334 interstitial nephritis Diseases 0.000 abstract 1
- 230000009545 invasion Effects 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22267395 | 1995-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT757984E true PT757984E (pt) | 2003-02-28 |
Family
ID=16786144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96305805T PT757984E (pt) | 1995-08-08 | 1996-08-07 | Derivados de acido hidroxamico uteis para inibir a gelatinase |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6022893A (pt) |
| EP (1) | EP0757984B1 (pt) |
| KR (1) | KR100231230B1 (pt) |
| AT (1) | ATE226936T1 (pt) |
| DE (1) | DE69624536T2 (pt) |
| DK (1) | DK0757984T3 (pt) |
| ES (1) | ES2185750T3 (pt) |
| PT (1) | PT757984E (pt) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6500948B1 (en) | 1995-12-08 | 2002-12-31 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof |
| DE69633947T2 (de) * | 1995-12-08 | 2005-12-01 | Agouron Pharmaceuticals, Inc., San Diego | Zwischenprodukte zur Herstellung von Metallproteinasehemmern |
| CA2242416C (en) * | 1996-01-23 | 2006-03-21 | Shionogi & Co., Ltd. | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
| US6919375B1 (en) | 1996-01-23 | 2005-07-19 | Shionogi & Co., Ltd. | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
| EP0950656B1 (en) | 1996-01-23 | 2007-04-11 | Shionogi & Co., Ltd. | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
| US5962481A (en) * | 1996-10-16 | 1999-10-05 | American Cyanamid Company | Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| US5977408A (en) * | 1996-10-16 | 1999-11-02 | American Cyanamid Company | Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
| US6228869B1 (en) | 1996-10-16 | 2001-05-08 | American Cyanamid Company | Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
| US5929097A (en) * | 1996-10-16 | 1999-07-27 | American Cyanamid Company | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| US6548524B2 (en) | 1996-10-16 | 2003-04-15 | American Cyanamid Company | Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
| JP2001503400A (ja) * | 1996-10-22 | 2001-03-13 | ファルマシア・アンド・アップジョン・カンパニー | マトリックス・メタロプロテイナーゼ阻害剤としてのα―アミノスルホニルヒドロキサム酸類 |
| US6174915B1 (en) | 1997-03-25 | 2001-01-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| US6008243A (en) * | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
| ES2234103T3 (es) * | 1997-03-04 | 2005-06-16 | Pharmacia Corporation | Compuestos de acido tioarilsulfonamidohidroxamico. |
| US6087359A (en) * | 1997-03-04 | 2000-07-11 | Getman; Daniel P. | Thioaryl sulfonamide hydroxamic acid compounds |
| GB9706255D0 (en) * | 1997-03-26 | 1997-05-14 | Smithkline Beecham Plc | Novel compounds |
| US5985900A (en) * | 1997-04-01 | 1999-11-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| CA2285372A1 (en) * | 1997-04-01 | 1998-10-08 | Melwyn A. Abreo | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| WO1998050348A1 (en) * | 1997-05-09 | 1998-11-12 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| SK262000A3 (en) * | 1997-07-22 | 2001-01-18 | Shionogi & Co | Therapeutic or prophylactic agent for glomerulopathy |
| JP2001513484A (ja) | 1997-07-31 | 2001-09-04 | ザ プロクター アンド ギャンブル カンパニー | 非環式メタロプロテアーゼ阻害剤 |
| US6420427B1 (en) | 1997-10-09 | 2002-07-16 | Ono Pharmaceutical Co., Ltd. | Aminobutyric acid derivatives |
| KR20010042412A (ko) | 1998-04-03 | 2001-05-25 | 가와무라 요시부미 | 술폰아미드 유도체 |
| US6200996B1 (en) | 1999-01-27 | 2001-03-13 | American Cyanamid Company | Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors |
| US6358980B1 (en) | 1999-01-27 | 2002-03-19 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
| US6340691B1 (en) | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
| US6753337B2 (en) | 1999-01-27 | 2004-06-22 | Wyeth Holdings Corporation | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
| US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| US6225311B1 (en) | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
| US6326516B1 (en) | 1999-01-27 | 2001-12-04 | American Cyanamid Company | Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors |
| US6277885B1 (en) | 1999-01-27 | 2001-08-21 | American Cyanamid Company | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
| US6946473B2 (en) | 1999-01-27 | 2005-09-20 | Wyeth Holdings Corporation | Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors |
| US6762178B2 (en) | 1999-01-27 | 2004-07-13 | Wyeth Holdings Corporation | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
| US6506936B1 (en) | 1999-02-25 | 2003-01-14 | Fibrogen, Inc. | N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of c-proteinase and for treating or preventing disorders related to unregulated collagen production |
| CN1349498A (zh) * | 1999-03-03 | 2002-05-15 | 宝洁公司 | 含有链烯基和炔基的金属蛋白酶抑制剂 |
| US6541521B1 (en) | 1999-07-12 | 2003-04-01 | Warner-Lambert Company | Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
| US6869951B1 (en) | 1999-07-16 | 2005-03-22 | Pharmacia Corporation | Method of changing conformation of a matrix metalloproteinase |
| AU6049800A (en) * | 1999-07-16 | 2001-02-05 | G.D. Searle & Co. | Method of changing conformation of a matrix metalloproteinase |
| EP1088815A1 (en) * | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
| US6465508B1 (en) | 2000-02-25 | 2002-10-15 | Wyeth | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors |
| WO2002003994A1 (en) * | 2000-07-12 | 2002-01-17 | G.D. Searle & Co. | N sulfonyl aminoacid derivatives as inhibitors of metalloproteinase |
| JP2004359546A (ja) * | 2001-03-15 | 2004-12-24 | Ono Pharmaceut Co Ltd | ヒドロキサム酸誘導体、それらの非毒性塩およびそれらのプロドラッグ体を有効成分として含有する、固形癌の予防および／または治療剤 |
| JPWO2002074298A1 (ja) * | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Ｉｌ−６産生阻害剤 |
| SG143977A1 (en) * | 2001-06-05 | 2008-07-29 | Auckland Uniservices Ltd | Methods and compositions for assessment of pulmonary function and disorders |
| ITMI20011733A1 (it) * | 2001-08-07 | 2003-02-07 | Italfarmaco Spa | Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc |
| WO2003037852A1 (en) | 2001-11-01 | 2003-05-08 | Wyeth Holdings Corporation | Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| ATE429909T1 (de) * | 2002-05-29 | 2009-05-15 | Merck & Co Inc | Nützliche verbindungen für die behandlung von anthrax und hemmung des letalen faktors |
| KR100529845B1 (ko) * | 2002-09-16 | 2005-11-22 | 한국식품연구원 | 배를 주재로 한 발효음료의 제조방법 |
| WO2005021489A2 (en) | 2002-12-23 | 2005-03-10 | Wyeth Holdings Corporation | Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors |
| ES2369498T3 (es) | 2003-04-04 | 2011-12-01 | Yeda Research And Development Co., Ltd. | Anticuerpos para inhibir la actividad de mmp-2 y mmp-9. |
| JP2007537256A (ja) * | 2004-05-11 | 2007-12-20 | メルク エンド カムパニー インコーポレーテッド | Ｎ−スルホン化アミノ酸誘導体調製のためのプロセス |
| US20100003276A1 (en) * | 2004-12-07 | 2010-01-07 | Hermes Jeffery D | Methods for treating anthrax and inhibiting lethal factor |
| US20060269946A1 (en) * | 2005-05-10 | 2006-11-30 | Young Robert P | Methods and compositions for assessment of pulmonary function and disorders |
| AU2006248201A1 (en) * | 2005-05-19 | 2006-11-23 | Synergenz Bioscience Limited | Methods for the assesssment of risk of developing lung cancer using analysis of genetic polymorphisms |
| EP1888779A4 (en) * | 2005-05-20 | 2009-06-10 | Synergenz Bioscience Ltd | METHOD FOR THE ANALYSIS OF POLYMORPHISMS AND USES THEREOF |
| CN101702906B (zh) | 2007-02-23 | 2014-02-12 | 耶达研究及发展有限公司 | 用于抑制金属蛋白活性的抗体和含有所述抗体的药物组合物 |
| EP2212303A1 (en) * | 2007-11-26 | 2010-08-04 | NeuroSearch AS | Novel benzamide derivatives useful as potassium channel modulators |
| US20100120013A1 (en) * | 2008-11-07 | 2010-05-13 | Mb Research Laboratories, Inc. | Procedure for long term corneal culture |
| KR102632439B1 (ko) * | 2022-10-31 | 2024-02-05 | 나리찬주식회사 농업회사법인 | 백김치 음료의 제조방법 및 이에 따라 제조된 백김치 음료 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE555319A (pt) * | 1956-03-21 | 1900-01-01 | ||
| US3095355A (en) * | 1961-10-12 | 1963-06-25 | Revlon | Aerosol composition |
| DE1251765B (de) * | 1963-07-23 | 1967-10-12 | Dr Karl Thomae Gesellschaft mit beschrankter Haftung Biberach/Riß | Verfahren zur Herstellung von neuen 5H - Dihydrothiopyrano [4 3 d] pynmidinen |
| GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| ZA782648B (en) * | 1977-05-23 | 1979-06-27 | Ici Australia Ltd | The prevention,control or eradication of infestations of ixodid ticks |
| FI824314A7 (fi) * | 1981-12-16 | 1983-06-17 | Sankyo Co | Thienopyrimidiinijohdannaiset, niiden valmistus ja niiden lääketieteellinen käyttö. |
| NL8300656A (nl) * | 1982-02-25 | 1983-09-16 | Maruko Pharmaceutical Co | Thiopyranopyrimidineverbindingen en zuuradditiezouten daarvan. |
| DD228811A1 (de) * | 1984-04-17 | 1985-10-23 | Hydrierwerk Rodleben Veb | Verfahren zur herstellung von neuen triazolopyrimidinen |
| AU593109B2 (en) * | 1986-06-05 | 1990-02-01 | Merrell Dow Pharmaceuticals Inc. | 2,3-dihydro-1-(8-methyl-1,2,4-triazolo-{4,3-b}pyridazin-6-YL )-4(1H)-pyridinone |
| US5017610A (en) * | 1988-06-13 | 1991-05-21 | Ono Pharmaceutical Co., Ltd. | Derivatives of p-substituted phenyl ester of pivalic acid |
| DE68908786T2 (de) * | 1988-06-16 | 1994-03-17 | Smith Kline French Lab | Condensierte Pyrimidinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen. |
| US5011835A (en) * | 1990-02-07 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Substituted triazolopyridazines, pharmaceutical compositions and use |
| DE4008726A1 (de) * | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
| EP0452002A3 (en) * | 1990-03-30 | 1992-02-26 | Dowelanco | Thienopyrimidine derivatives |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | ４−アミノキナゾリン誘導体およびそれを含有する医薬品 |
| US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| PH31122A (en) * | 1993-03-31 | 1998-02-23 | Eisai Co Ltd | Nitrogen-containing fused-heterocycle compounds. |
| DK0822186T3 (da) * | 1994-01-20 | 2000-06-26 | British Biotech Pharm | L-tert-leucin-2-pyridylamid |
| NZ288299A (en) * | 1994-06-22 | 1998-06-26 | British Biotech Pharm | Substituted (hetero)aryl-sulphonylaminomethyl-hydroxamic acid and medicaments |
-
1996
- 1996-08-07 EP EP96305805A patent/EP0757984B1/en not_active Expired - Lifetime
- 1996-08-07 DK DK96305805T patent/DK0757984T3/da active
- 1996-08-07 AT AT96305805T patent/ATE226936T1/de not_active IP Right Cessation
- 1996-08-07 PT PT96305805T patent/PT757984E/pt unknown
- 1996-08-07 DE DE69624536T patent/DE69624536T2/de not_active Expired - Fee Related
- 1996-08-07 KR KR1019960032819A patent/KR100231230B1/ko not_active Expired - Fee Related
- 1996-08-07 ES ES96305805T patent/ES2185750T3/es not_active Expired - Lifetime
- 1996-08-07 US US08/694,473 patent/US6022893A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0757984B1 (en) | 2002-10-30 |
| DE69624536T2 (de) | 2003-06-05 |
| US6022893A (en) | 2000-02-08 |
| ATE226936T1 (de) | 2002-11-15 |
| KR970010741A (ko) | 1997-03-27 |
| EP0757984A1 (en) | 1997-02-12 |
| KR100231230B1 (ko) | 1999-11-15 |
| ES2185750T3 (es) | 2003-05-01 |
| DE69624536D1 (de) | 2002-12-05 |
| DK0757984T3 (da) | 2003-03-03 |
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