PT83109A - Procede de preparation de nouveaux derives de phenylpiperazine - Google Patents

Procede de preparation de nouveaux derives de phenylpiperazine

Info

Publication number: PT83109A
Authority: PT; Portugal
Prior art keywords: phenylpiperazine; formula; alkyl; group; see diagramm
Prior art date: 1985-07-31

Application number

PT83109A

Other languages

English (en)

French (fr)

Other versions

PT83109B (pt

Inventor

Louis Lafon

Original Assignee

Lafon Labor

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-31

Filing date

1986-07-30

Publication date

1986-08-01

1986-07-30 Application filed by Lafon Labor filed Critical Lafon Labor

1986-08-01 Publication of PT83109A publication Critical patent/PT83109A/pt

1989-02-28 Publication of PT83109B publication Critical patent/PT83109B/pt

Links

238000000034 method Methods 0.000 title abstract 3
YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
229910052801 chlorine Inorganic materials 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
DLCHHOUUUHBPTB-UHFFFAOYSA-N 1,2,4-trimethyl-3-phenylpiperazine Chemical compound CN1CCN(C)C(C)C1C1=CC=CC=C1 DLCHHOUUUHBPTB-UHFFFAOYSA-N 0.000 abstract 1
ITYRNNPBHAPPDY-UHFFFAOYSA-N 1-ethyl-2-methyl-3-phenylpiperazine Chemical compound CC1N(CC)CCNC1C1=CC=CC=C1 ITYRNNPBHAPPDY-UHFFFAOYSA-N 0.000 abstract 1
WISXSZAVLBTQKR-UHFFFAOYSA-N 2-methyl-3-phenyl-1-propan-2-ylpiperazine Chemical compound CC1N(C(C)C)CCNC1C1=CC=CC=C1 WISXSZAVLBTQKR-UHFFFAOYSA-N 0.000 abstract 1
FGMBXZFXOUIKOT-UHFFFAOYSA-N 2-methyl-3-phenylpiperazine Chemical compound CC1NCCNC1C1=CC=CC=C1 FGMBXZFXOUIKOT-UHFFFAOYSA-N 0.000 abstract 1
REMUSKKHPCZIGD-UHFFFAOYSA-N 2-phenyl-1,2-dihydropyrazine Chemical compound N1C=CN=CC1C1=CC=CC=C1 REMUSKKHPCZIGD-UHFFFAOYSA-N 0.000 abstract 1
RIMRLBGNCLMSNH-UHFFFAOYSA-N 2-phenylpiperazine Chemical compound C1NCCNC1C1=CC=CC=C1 RIMRLBGNCLMSNH-UHFFFAOYSA-N 0.000 abstract 1
GFQHZHMRYXWCBK-UHFFFAOYSA-N 3-phenyl-1-propan-2-ylpiperazine Chemical compound C1N(C(C)C)CCNC1C1=CC=CC=C1 GFQHZHMRYXWCBK-UHFFFAOYSA-N 0.000 abstract 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
229910010084 LiAlH4 Inorganic materials 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
239000012280 lithium aluminium hydride Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
239000012279 sodium borohydride Substances 0.000 abstract 1
229910000033 sodium borohydride Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Luminescent Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT83109A 1985-07-31 1986-07-30 Processo para a preparacao de novos derivados da fenilpiperazina PT83109B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8511684A FR2585702B1 (fr)	1985-07-31	1985-07-31	Derives de phenyl-piperazine, procede de preparation et utilisation en therapeutique

Publications (2)

Publication Number	Publication Date
PT83109A true PT83109A (fr)	1986-08-01
PT83109B PT83109B (pt)	1989-02-28

Family

ID=9321805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT83109A PT83109B (pt)	1985-07-31	1986-07-30	Processo para a preparacao de novos derivados da fenilpiperazina

Country Status (13)

Country	Link
US (1)	US4912110A (pt)
EP (1)	EP0211746B1 (pt)
JP (1)	JPH0730047B2 (pt)
AT (1)	ATE53026T1 (pt)
AU (1)	AU580179B2 (pt)
CA (1)	CA1263392A (pt)
DE (1)	DE3671445D1 (pt)
DK (1)	DK165876C (pt)
FR (1)	FR2585702B1 (pt)
GR (1)	GR862010B (pt)
IE (1)	IE59320B1 (pt)
PT (1)	PT83109B (pt)
ZA (1)	ZA865685B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2699533A1 (fr) *	1992-12-21	1994-06-24	Mouhtaram Mohamed	Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.
HK1042696A1 (zh) *	1999-04-19	2002-08-23	Teva Pharmaceutical Industries Ltd.	哌嗪环的新合成方法
ES2190305B1 (es) *	2000-05-24	2004-07-01	Medichem S.A.	Compuestos intermedios para la preparacion de mirtazapina y sus procedimientos de obtencion.
IN190478B (pt)	2000-11-07	2003-08-02	Sun Pharmaceutical Ind Ltd
US7265223B2 (en)	2001-09-14	2007-09-04	Medichem, S.A.	Intermediate compounds for the preparation of mirtazapine and production methods thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA919590A (en) *	1967-05-24	1973-01-23	Neher Robert	Process for the manufacture of thyrocalcitonin
GB1181322A (en) *	1967-06-29	1970-02-11	Chugai Pharmaceutical Co Ltd	Piperazine Derivatives and processes for preparing the same
JPS52139085A (en) *	1976-05-13	1977-11-19	Hokuriku Pharmaceutical	22allylpiperazine derivative and method for its preparation
DE3420782A1 (de) *	1984-06-04	1985-12-05	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von 2-cyclohexylpiperazinen

1985
- 1985-07-31 FR FR8511684A patent/FR2585702B1/fr not_active Expired
1986
- 1986-07-23 DE DE8686401644T patent/DE3671445D1/de not_active Expired - Lifetime
- 1986-07-23 EP EP86401644A patent/EP0211746B1/fr not_active Expired - Lifetime
- 1986-07-23 AT AT86401644T patent/ATE53026T1/de not_active IP Right Cessation
- 1986-07-29 DK DK360286A patent/DK165876C/da active
- 1986-07-29 GR GR862010A patent/GR862010B/el unknown
- 1986-07-30 AU AU60691/86A patent/AU580179B2/en not_active Ceased
- 1986-07-30 ZA ZA865685A patent/ZA865685B/xx unknown
- 1986-07-30 PT PT83109A patent/PT83109B/pt not_active IP Right Cessation
- 1986-07-30 IE IE203286A patent/IE59320B1/en not_active IP Right Cessation
- 1986-07-31 JP JP61181806A patent/JPH0730047B2/ja not_active Expired - Lifetime
- 1986-07-31 CA CA000515056A patent/CA1263392A/fr not_active Expired
1988
- 1988-12-13 US US07/283,736 patent/US4912110A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPS6229576A (ja)	1987-02-07
IE59320B1 (en)	1994-02-09
AU580179B2 (en)	1989-01-05
PT83109B (pt)	1989-02-28
ZA865685B (en)	1987-03-25
DK165876B (da)	1993-02-01
JPH0730047B2 (ja)	1995-04-05
GR862010B (en)	1986-12-23
ATE53026T1 (de)	1990-06-15
DK360286D0 (da)	1986-07-29
US4912110A (en)	1990-03-27
FR2585702A1 (fr)	1987-02-06
DK165876C (da)	1993-06-21
FR2585702B1 (fr)	1989-03-03
EP0211746A1 (fr)	1987-02-25
DK360286A (da)	1987-02-01
EP0211746B1 (fr)	1990-05-23
DE3671445D1 (de)	1990-06-28
IE862032L (en)	1987-01-31
CA1263392A (fr)	1989-11-28
AU6069186A (en)	1987-02-05

Legal Events

Date

Code

Title

Description

1998-06-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19980228

Publication	Publication Date	Title
ATE15185T1 (de)	1985-09-15	Benzhydrylsulfinylacetamid-derivate und deren verwendung in der therapeutik.
GB994918A (en)	1965-06-10	Naphthoxy-substituted alkanolamines
DK136191D0 (da)	1991-07-16	1h-imidazo/4,5-c/quinolinderivat
BG50939A3 (bg)	1992-12-15	Метод за получаване на пиридазинонови производни
SE8404712D0 (sv)	1984-09-20	Azole derivatives, process for their production compositions containing them and their use
MA18956A1 (fr)	1981-04-01	Procede pour la preparation de diphenylethers
ATE19066T1 (de)	1986-04-15	1,3-dihydro 4-(1-hydroxy-2-aminoethyl)2-h-indol-2-on-deriva e, ihre saelze, verfahren zu ihrer herstellung, verwendung als heilmittel und zusammenstellungen die sie enthalten.
ATE75737T1 (de)	1992-05-15	Indenothiazolderivate und verfahren zu ihrer herstellung.
DK360286D0 (da)	1986-07-29	Substituerede phenylpiperazinderivater
HUT58270A (en)	1992-02-28	Process for producing amine derivatives and pharmaceutical compositions containing them
ES423058A1 (es)	1976-04-16	Procedimiento de preparacion de nuevos deivados de la i- soindolina.
GB1038735A (en)	1966-08-10	New condensed heterocyclic compounds, their production and compositions containing them
ATE30718T1 (de)	1987-11-15	Herstellung von 1-benzyl azetidin-3-ol und von dem entsprechenden halid acid.
ES423746A1 (es)	1976-05-01	Procedimiento para preparar derivados de 2-aminoindano.
ATE135693T1 (de)	1996-04-15	Halogeno-4-methylpyrazole und verfahren zu ihrer herstellung
ES423745A1 (es)	1976-04-16	Procedimiento para preparar derivados de 2-aminoindano.
ES387448A1 (es)	1974-01-16	Procedimiento para la preparacion de nuevos compuestos-a- zoicos.
GB1436970A (en)	1976-05-26	2-aminoindane derivatives
GB819654A (en)	1959-09-09	New quinone derivatives and a process for their preparation
ES272000A1 (es)	1962-06-16	Procedimiento para la preparación de nuevos derivados de cumarina
ES448275A1 (es)	1977-11-16	Un procedimiento para la produccion de nuevas benzo 2,4-ta- cepinas.
ES421929A1 (es)	1976-05-01	Procedimiento para la preparacion de sulfonanilidas susti- tuidas.
ES393828A1 (es)	1973-08-16	Un metodo para la produccion de derivados de benzodiazepina.
ES289533A1 (es)	1964-03-01	Procedimiento de preparaciën de nuevos compuestos biciclicos
ES293388A1 (es)	1964-04-01	Procedimiento para la obtencion de difenilalquilaminas