PT852585E - Metodo de tratamento da doenca de alzheimer utilizando um produto proteico de factor neurotrofico derivado de uma linha de celulas gliais. - Google Patents
Metodo de tratamento da doenca de alzheimer utilizando um produto proteico de factor neurotrofico derivado de uma linha de celulas gliais.Info
- Publication number
- PT852585E PT852585E PT96932325T PT96932325T PT852585E PT 852585 E PT852585 E PT 852585E PT 96932325 T PT96932325 T PT 96932325T PT 96932325 T PT96932325 T PT 96932325T PT 852585 E PT852585 E PT 852585E
- Authority
- PT
- Portugal
- Prior art keywords
- treating
- disease
- alzheimer
- neurotrophic factor
- line
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 108010025020 Nerve Growth Factor Proteins 0.000 title 1
- 102000007072 Nerve Growth Factors Human genes 0.000 title 1
- 210000004498 neuroglial cell Anatomy 0.000 title 1
- 239000003900 neurotrophic factor Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 abstract 2
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 abstract 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 210000002932 cholinergic neuron Anatomy 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 210000004129 prosencephalon Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/535,682 US5731284A (en) | 1995-09-28 | 1995-09-28 | Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT852585E true PT852585E (pt) | 2005-04-29 |
Family
ID=24135315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96932325T PT852585E (pt) | 1995-09-28 | 1996-09-23 | Metodo de tratamento da doenca de alzheimer utilizando um produto proteico de factor neurotrofico derivado de uma linha de celulas gliais. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5731284A (pt) |
| EP (1) | EP0852585B1 (pt) |
| JP (1) | JP4761409B2 (pt) |
| AT (1) | ATE288447T1 (pt) |
| AU (1) | AU711053B2 (pt) |
| CA (1) | CA2232789C (pt) |
| DE (1) | DE69634301T2 (pt) |
| DK (1) | DK0852585T3 (pt) |
| ES (1) | ES2237775T3 (pt) |
| NZ (1) | NZ319040A (pt) |
| PT (1) | PT852585E (pt) |
| SI (1) | SI0852585T1 (pt) |
| WO (1) | WO1997011965A1 (pt) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6184200B1 (en) * | 1995-09-28 | 2001-02-06 | Amgen Inc. | Truncated glial cell line-derived neurotrophic factor |
| US6677135B1 (en) | 1996-05-08 | 2004-01-13 | Biogen, Inc. | Ret ligand (RetL) for stimulating neutral and renal growth |
| AU728037B2 (en) * | 1997-05-22 | 2001-01-04 | Cephalon, Inc. | Vitamin D analogues and their neuronal effects |
| CA2301693A1 (en) | 1997-09-19 | 1999-04-01 | Klaus Unsicker | Cytokines having neurotrophic activity |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US20050059802A1 (en) * | 1998-04-07 | 2005-03-17 | Neuralab Ltd | Prevention and treatment of amyloidogenic disease |
| CA2327444A1 (en) | 1998-04-29 | 1999-11-04 | Oklahoma Medical Research Foundation | Construction of retroviral producer cells from adenoviral and retroviral vectors |
| AU1822000A (en) * | 1998-11-20 | 2000-06-13 | Yale University | Effects of gdnf and ngf on sodium channels in drg neurons |
| DE60137414D1 (de) | 2000-05-05 | 2009-03-05 | Univ City | Zusammensetzungen zur stimulierung der regeneration und der wiederherstellung des nervensystems durch regulierung der arginase 1- und polyamin-synthese |
| WO2002005634A2 (en) | 2000-07-13 | 2002-01-24 | University Of South Florida | Transgenic animal and methods |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| KR20050021026A (ko) * | 2001-06-15 | 2005-03-07 | 주식회사 장생도라지 | 장생도라지 추출물을 포함하는 면역계의 이상으로부터발생하는 질병의 예방 및 치료용 약제학적 조성물 |
| US7150737B2 (en) * | 2001-07-13 | 2006-12-19 | Sci/Med Life Systems, Inc. | Methods and apparatuses for navigating the subarachnoid space |
| US7455666B2 (en) * | 2001-07-13 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and apparatuses for navigating the subarachnoid space |
| MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| US20060246036A1 (en) * | 2002-09-06 | 2006-11-02 | The General Hospital Corporation | Delivery of therapeutics to the brain and spinal cord |
| MXPA05008156A (es) * | 2003-02-01 | 2005-09-30 | Neuralab Ltd | Inmunizacion activa para generar anticuerpos para beta-a soluble. |
| US20040209810A1 (en) * | 2003-02-24 | 2004-10-21 | Gill Steven S. | Method of treating Parkinson's disease in humans by intraputaminal infusion of glial cell-line derived neurotrophic factor |
| US8946151B2 (en) * | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
| PE20050627A1 (es) * | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| US20050225165A1 (en) * | 2004-04-13 | 2005-10-13 | Naik Sanjeev M | Brake by-wire control system |
| GB2414934A (en) * | 2004-06-11 | 2005-12-14 | Gill Steven Streatfield | Treatment of Parkinson's disease with GDNF |
| WO2006066089A1 (en) * | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
| TW200636066A (en) | 2004-12-15 | 2006-10-16 | Elan Pharm Inc | Humanized antibodies that recognize beta amyloid peptide |
| EP1838349A1 (en) * | 2004-12-15 | 2007-10-03 | Neuralab, Ltd. | Amyloid beta antibodies for use in improving cognition |
| JP2009513584A (ja) * | 2005-10-28 | 2009-04-02 | エヌエスゲーネ・アクティーゼルスカブ | Gdnfの送達のための移植可能な生体適合性免疫隔離ビヒクル |
| US20090181008A1 (en) * | 2005-11-10 | 2009-07-16 | Satoris, Inc. | Methods of treating alzheimer's disease |
| US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| WO2007127803A2 (en) * | 2006-04-25 | 2007-11-08 | The Regents Of The University Of California | Administration of growth factors for the treatment of cns disorders |
| US20070259031A1 (en) * | 2006-04-26 | 2007-11-08 | The Regents Of The University Of California | Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics |
| US20080292625A1 (en) * | 2007-04-18 | 2008-11-27 | Sally Schroeter | Prevention and treatment of cerebral amyloid angiopathy |
| US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| PT2182983E (pt) | 2007-07-27 | 2014-09-01 | Janssen Alzheimer Immunotherap | Tratamento de doenças amiloidogénicas com anticorpos anti-abeta humanizados |
| JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| EP2485638B1 (en) | 2009-10-07 | 2016-11-30 | Endophys Holdings, LLC | Pressure-sensing medical device |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| JP6190723B2 (ja) | 2010-12-01 | 2017-08-30 | アルダーバイオ ホールディングス エルエルシー | 抗ngf組成物およびその使用 |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US20140302027A1 (en) * | 2011-09-26 | 2014-10-09 | University Of Louisville Research Foundation, Inc. | Methods of treating periodontal inflammation and periodontal bone loss |
| US8999927B2 (en) * | 2012-04-02 | 2015-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Glial cell line-derived neurotrophic factor (GDNF) compositions and use thereof |
| EP3538560B1 (en) | 2016-11-10 | 2026-04-08 | Keros Therapeutics, Inc. | Gdnf fusion polypeptides and methods of use thereof |
| EP3628315A1 (en) | 2018-09-28 | 2020-04-01 | Université de Caen Normandie | Combination of acetylcholinesterase inhibitor and 5-ht4 receptor agonist as neuroprotective agent in the treatment of neurodegenerative diseases |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518584A (en) * | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| EP0154316B1 (en) * | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| US5158881A (en) * | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5106627A (en) * | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
| US5011472A (en) * | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| EP0401384B1 (en) * | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
| US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
| SG59931A1 (en) * | 1989-10-16 | 1999-02-22 | Amgen Inc | Stem cell factor |
| WO1991010470A1 (en) * | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
| US5202428A (en) * | 1990-06-20 | 1993-04-13 | The Salk Institute For Biological Studies | DNA encoding neurotropic growth factor |
| US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| JP3385040B2 (ja) * | 1991-02-14 | 2003-03-10 | 武田薬品工業株式会社 | グリア活性化因子およびその製造法 |
| MX9205293A (es) * | 1991-09-20 | 1993-05-01 | Syntex Sinergen Neuroscience J | Factores neurotrofico derivado del glial |
| WO1993008828A1 (en) * | 1991-11-08 | 1993-05-13 | Syntex-Synergen Neuroscience Joint Venture | Methods for the treatment of neuronal damage associated with ischemia, hypoxia or neurodegeneration |
| ATE218893T1 (de) * | 1993-08-12 | 2002-06-15 | Neurotech Sa | Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten |
| WO1995017203A1 (en) * | 1993-12-22 | 1995-06-29 | The University Of Medicine And Dentistry Of New Jersey | Novel nucleic acid sequences isolated from glial cells |
| FR2717824B1 (fr) * | 1994-03-25 | 1996-04-26 | Rhone Poulenc Rorer Sa | Virus recombinants, préparation et utilisation en thérapie génique. |
| US5641750A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
| US5641749A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product |
-
1995
- 1995-09-28 US US08/535,682 patent/US5731284A/en not_active Expired - Lifetime
-
1996
- 1996-09-23 SI SI9630703T patent/SI0852585T1/xx unknown
- 1996-09-23 CA CA002232789A patent/CA2232789C/en not_active Expired - Lifetime
- 1996-09-23 AU AU71175/96A patent/AU711053B2/en not_active Expired
- 1996-09-23 AT AT96932325T patent/ATE288447T1/de active
- 1996-09-23 PT PT96932325T patent/PT852585E/pt unknown
- 1996-09-23 DE DE69634301T patent/DE69634301T2/de not_active Expired - Lifetime
- 1996-09-23 EP EP96932325A patent/EP0852585B1/en not_active Expired - Lifetime
- 1996-09-23 WO PCT/US1996/015305 patent/WO1997011965A1/en not_active Ceased
- 1996-09-23 NZ NZ319040A patent/NZ319040A/en not_active IP Right Cessation
- 1996-09-23 JP JP51357297A patent/JP4761409B2/ja not_active Expired - Lifetime
- 1996-09-23 ES ES96932325T patent/ES2237775T3/es not_active Expired - Lifetime
- 1996-09-23 DK DK96932325T patent/DK0852585T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11514860A (ja) | 1999-12-21 |
| EP0852585A1 (en) | 1998-07-15 |
| SI0852585T1 (en) | 2005-06-30 |
| CA2232789C (en) | 2001-02-27 |
| AU711053B2 (en) | 1999-10-07 |
| CA2232789A1 (en) | 1997-04-03 |
| DE69634301D1 (de) | 2005-03-10 |
| EP0852585B1 (en) | 2005-02-02 |
| DK0852585T3 (da) | 2005-05-09 |
| WO1997011965A1 (en) | 1997-04-03 |
| ES2237775T3 (es) | 2005-08-01 |
| NZ319040A (en) | 2001-02-23 |
| DE69634301T2 (de) | 2005-06-09 |
| ATE288447T1 (de) | 2005-02-15 |
| AU7117596A (en) | 1997-04-17 |
| US5731284A (en) | 1998-03-24 |
| JP4761409B2 (ja) | 2011-08-31 |
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