PT86859A - Process for the preparation of 9-ethyl-6,9-di-hydro-4,6-dioxo-10-propyl-4h-pyrano]3,2-g"-quinoline-2,8-calcium dicarboxilate and of pharmaceutical compounds containing it - Google Patents

Process for the preparation of 9-ethyl-6,9-di-hydro-4,6-dioxo-10-propyl-4h-pyrano]3,2-g"-quinoline-2,8-calcium dicarboxilate and of pharmaceutical compounds containing it

Info

Publication number: PT86859A
Authority: PT; Portugal
Prior art keywords: pyrano; dioxo; dihydro; propyl; calcium
Prior art date: 1987-02-28

Application number

PT86859A

Other languages

English (en)

Other versions

PT86859B (pt

Inventor

Michael Arnold Nassim

Richard Anthony Raphael

Original Assignee

Fisons Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-28

Filing date

1988-02-26

Publication date

1988-03-01

1988-02-26 Application filed by Fisons Plc filed Critical Fisons Plc

1988-03-01 Publication of PT86859A publication Critical patent/PT86859A/pt

1992-05-29 Publication of PT86859B publication Critical patent/PT86859B/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
229910052791 calcium Inorganic materials 0.000 title 1
239000011575 calcium Substances 0.000 title 1
208000027771 Obstructive airways disease Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
FGUNXXYEYHFDNX-UHFFFAOYSA-L nedocromil calcium Chemical compound [Ca+2].CCN1C(C([O-])=O)=CC(=O)C2=C1C(CCC)=C1OC(C([O-])=O)=CC(=O)C1=C2 FGUNXXYEYHFDNX-UHFFFAOYSA-L 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000002441 reversible effect Effects 0.000 abstract 1
206010039083 rhinitis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT86859A 1987-02-28 1988-02-26 Processo para a preparacao de 9-etil-6,9-di-hidro-4,6-dioxo-10-propil-4h-pirano{3,2-g}-quinolina-2,8-dicarboxilato de calcio e de composicoes farmaceuticas que o contem PT86859B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878704773A GB8704773D0 (en)	1987-02-28	1987-02-28	Compounds

Publications (2)

Publication Number	Publication Date
PT86859A true PT86859A (pt)	1988-03-01
PT86859B PT86859B (pt)	1992-05-29

Family

ID=10613143

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT86859A PT86859B (pt)	1987-02-28	1988-02-26	Processo para a preparacao de 9-etil-6,9-di-hidro-4,6-dioxo-10-propil-4h-pirano{3,2-g}-quinolina-2,8-dicarboxilato de calcio e de composicoes farmaceuticas que o contem

Country Status (23)

Country	Link
US (1)	US4849427A (pt)
EP (1)	EP0285246B1 (pt)
JP (1)	JPS63225380A (pt)
KR (1)	KR880009975A (pt)
AT (1)	ATE71099T1 (pt)
AU (1)	AU597795B2 (pt)
DE (1)	DE3867281D1 (pt)
DK (1)	DK102788A (pt)
ES (1)	ES2038750T3 (pt)
FI (1)	FI87566C (pt)
GB (1)	GB8704773D0 (pt)
GR (1)	GR3003709T3 (pt)
HU (1)	HU199477B (pt)
IL (1)	IL85559A (pt)
MX (1)	MX10554A (pt)
MY (1)	MY103216A (pt)
NO (1)	NO166282C (pt)
NZ (1)	NZ223646A (pt)
PH (1)	PH24496A (pt)
PT (1)	PT86859B (pt)
WO (1)	WO1990002128A1 (pt)
YU (2)	YU37988A (pt)
ZA (1)	ZA881343B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5192528A (en) *	1985-05-22	1993-03-09	Liposome Technology, Inc.	Corticosteroid inhalation treatment method
EP0279121B1 (en) *	1986-12-23	1993-09-01	FISONS plc	Pharmaceutical compositions comprising an aqueous solution of a pyranoquinoline derivative
USRE38628E1 (en) *	1986-12-23	2004-10-19	Fisons Plc	Pharmaceutical compositions
GB8704773D0 (en) *	1987-02-28	1987-04-01	Fisons Plc	Compounds
GB8820267D0 (en) *	1988-08-26	1988-09-28	Fisons Plc	Pharmaceutical formulation
US5248493A (en) *	1988-08-27	1993-09-28	Fisons Plc	Pharmaceutical composition
US5198221A (en) *	1989-05-17	1993-03-30	Fisons Plc	Pharmaceutical composition
GB8921222D0 (en) *	1989-09-20	1989-11-08	Riker Laboratories Inc	Medicinal aerosol formulations
GB9323132D0 (en) *	1993-11-10	1994-01-05	Fisons Plc	New pharmaceutical use
US20050026880A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a cromone for treatment of asthma or chronic obstructive pulmonary disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA782473B (en) *	1977-05-04	1979-04-25	Fisons Ltd	Benzo pyrano-quinolinones
US4471119A (en) *	1981-10-10	1984-09-11	Fisons Plc	Certain hydrolysis or reductive cleavage reaction involving 4h-pyrano(3,2-g) quinoline-2,8-dicarboxylic acid derivatives
DE3571439D1 (en) *	1984-01-26	1989-08-17	Fisons Plc	Benzopyran derivatives, compositions containing them and processes for their preparation
DE3411319C2 (de) *	1984-03-28	1986-12-04	Boehringer Ingelheim KG, 6507 Ingelheim	Verwendung von Citronensäureestern als Treib- und/oder Nucleierungsmittel zur Herstellung thermoplastischer Kunststoffschäume
EP0162556B1 (en) *	1984-04-13	1991-11-06	FISONS plc	Novels forms and formulations of nedocromil sodium
EP0279121B1 (en) *	1986-12-23	1993-09-01	FISONS plc	Pharmaceutical compositions comprising an aqueous solution of a pyranoquinoline derivative
GB8704773D0 (en) *	1987-02-28	1987-04-01	Fisons Plc	Compounds

1987
- 1987-02-28 GB GB878704773A patent/GB8704773D0/en active Pending
1988
- 1988-02-18 ES ES198888301383T patent/ES2038750T3/es not_active Expired - Lifetime
- 1988-02-18 DE DE8888301383T patent/DE3867281D1/de not_active Expired - Fee Related
- 1988-02-18 AT AT88301383T patent/ATE71099T1/de active
- 1988-02-18 EP EP88301383A patent/EP0285246B1/en not_active Expired - Lifetime
- 1988-02-24 US US07/159,841 patent/US4849427A/en not_active Expired - Lifetime
- 1988-02-24 PH PH36552A patent/PH24496A/en unknown
- 1988-02-24 AU AU12142/88A patent/AU597795B2/en not_active Ceased
- 1988-02-25 MX MX1055488A patent/MX10554A/es unknown
- 1988-02-25 NZ NZ223646A patent/NZ223646A/xx unknown
- 1988-02-25 MY MYPI88000185A patent/MY103216A/en unknown
- 1988-02-25 ZA ZA881343A patent/ZA881343B/xx unknown
- 1988-02-26 DK DK102788A patent/DK102788A/da not_active Application Discontinuation
- 1988-02-26 HU HU88925A patent/HU199477B/hu not_active IP Right Cessation
- 1988-02-26 YU YU00379/88A patent/YU37988A/xx unknown
- 1988-02-26 JP JP63042419A patent/JPS63225380A/ja active Pending
- 1988-02-26 NO NO880845A patent/NO166282C/no unknown
- 1988-02-26 IL IL85559A patent/IL85559A/xx not_active IP Right Cessation
- 1988-02-26 FI FI880900A patent/FI87566C/fi not_active IP Right Cessation
- 1988-02-26 PT PT86859A patent/PT86859B/pt not_active IP Right Cessation
- 1988-02-27 KR KR1019880002074A patent/KR880009975A/ko not_active Ceased
- 1988-08-26 WO PCT/GB1988/000703 patent/WO1990002128A1/en not_active Ceased
1989
- 1989-06-26 YU YU01300/89A patent/YU130089A/xx unknown
1992
- 1992-02-04 GR GR920400142T patent/GR3003709T3/el unknown

Also Published As

Publication number	Publication date
AU1214288A (en)	1988-09-01
GR3003709T3 (pt)	1993-03-16
NO880845D0 (no)	1988-02-26
WO1990002128A1 (en)	1990-03-08
PT86859B (pt)	1992-05-29
ES2038750T3 (es)	1993-08-01
DE3867281D1 (de)	1992-02-13
HU199477B (en)	1990-02-28
FI87566B (fi)	1992-10-15
IL85559A (en)	1991-11-21
NO166282B (no)	1991-03-18
YU37988A (en)	1989-12-31
HUT47581A (en)	1989-03-28
GB8704773D0 (en)	1987-04-01
ATE71099T1 (de)	1992-01-15
AU597795B2 (en)	1990-06-07
NO880845L (no)	1988-08-29
FI880900L (fi)	1988-08-29
EP0285246B1 (en)	1992-01-02
YU130089A (en)	1991-02-28
ZA881343B (en)	1989-01-25
JPS63225380A (ja)	1988-09-20
NO166282C (no)	1991-06-26
PH24496A (en)	1990-07-18
EP0285246A1 (en)	1988-10-05
US4849427A (en)	1989-07-18
FI87566C (fi)	1993-01-25
MY103216A (en)	1993-05-29
MX10554A (es)	1993-04-01
KR880009975A (ko)	1988-10-06
NZ223646A (en)	1990-05-28
IL85559A0 (en)	1988-08-31
DK102788D0 (da)	1988-02-26
FI880900A0 (fi)	1988-02-26
DK102788A (da)	1988-08-29

Legal Events

Date

Code

Title

Description

1992-05-29

FG3A

Patent granted, date of granting

Effective date: 19911126

1995-10-20

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19950531

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IL89807A (en)	1993-08-18	Topical preparation containing ofloxacin for treating otopathy
FI880900A0 (fi)	1988-02-26	Foerfarande.
DE68904462D1 (de)	1993-03-04	4-chinolincarbonsaeure-derivate, brauchbar zur behandlung von haut- und muco-epithelial-gewebekrankheiten.
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ATE40687T1 (de)	1989-02-15	Neue pyridinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
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