PT86892A - Verfahren zur herstellung von ifosfamid mit verbesserten eigenschaften - Google Patents
Verfahren zur herstellung von ifosfamid mit verbesserten eigenschaftenInfo
- Publication number
- PT86892A PT86892A PT86892A PT8689288A PT86892A PT 86892 A PT86892 A PT 86892A PT 86892 A PT86892 A PT 86892A PT 8689288 A PT8689288 A PT 8689288A PT 86892 A PT86892 A PT 86892A
- Authority
- PT
- Portugal
- Prior art keywords
- ifosfamid
- zur herstellung
- verfahren zur
- herstellung von
- eigenschaften
- Prior art date
Links
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001101 ifosfamide Drugs 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Materials For Medical Uses (AREA)
- Detergent Compositions (AREA)
- External Artificial Organs (AREA)
- Cephalosporin Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3707154 | 1987-03-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT86892A true PT86892A (pt) | 1988-04-01 |
| PT86892B PT86892B (pt) | 1992-05-29 |
Family
ID=6322382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT86892A PT86892B (pt) | 1987-03-06 | 1988-03-03 | Processo para a preparacao de ifosfamida com propriedades melhoradas |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4882452A (pt) |
| EP (1) | EP0281832B1 (pt) |
| JP (1) | JPS63230697A (pt) |
| AT (1) | ATE63121T1 (pt) |
| CA (1) | CA1305970C (pt) |
| DE (1) | DE3862595D1 (pt) |
| DK (1) | DK168822B1 (pt) |
| ES (1) | ES2021771B3 (pt) |
| FI (1) | FI86187C (pt) |
| GR (1) | GR3001898T3 (pt) |
| IE (1) | IE60474B1 (pt) |
| PT (1) | PT86892B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5227373A (en) * | 1991-10-23 | 1993-07-13 | Bristol-Myers Squibb Co. | Lyophilized ifosfamide compositions |
| US5958462A (en) * | 1997-05-23 | 1999-09-28 | Mclean; Linsey | Therapeutic bath salts and method of use |
| US5972912A (en) * | 1998-12-17 | 1999-10-26 | S.P. Pharmaceuticals | Method for lyophilizing ifosfamide |
| US6613927B1 (en) | 2002-02-08 | 2003-09-02 | American Pharmaceutical Partners, Inc. | Sterile lyophilized ifosfamide and associated methods |
| ES2369776T3 (es) * | 2003-10-01 | 2011-12-05 | Baxter International Inc. | Nueva utilización, preparados farmacéuticos y procedimiento para su producción. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1645921C3 (de) * | 1966-07-11 | 1978-10-12 | Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld | 2-Oxo-13,2-osazaphosphorinane, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| US3732340A (en) * | 1966-07-11 | 1973-05-08 | Asta Werke Ag Chem Fab | N',o-propylene phosphoric acid ester diamides |
-
1988
- 1988-02-23 ES ES88102612T patent/ES2021771B3/es not_active Expired - Lifetime
- 1988-02-23 DE DE8888102612T patent/DE3862595D1/de not_active Expired - Lifetime
- 1988-02-23 EP EP88102612A patent/EP0281832B1/de not_active Expired - Lifetime
- 1988-02-23 AT AT88102612T patent/ATE63121T1/de not_active IP Right Cessation
- 1988-03-03 PT PT86892A patent/PT86892B/pt active IP Right Revival
- 1988-03-03 US US07/163,586 patent/US4882452A/en not_active Expired - Lifetime
- 1988-03-04 IE IE63588A patent/IE60474B1/en not_active IP Right Cessation
- 1988-03-04 CA CA000560639A patent/CA1305970C/en not_active Expired - Lifetime
- 1988-03-04 DK DK116988A patent/DK168822B1/da not_active IP Right Cessation
- 1988-03-04 FI FI881020A patent/FI86187C/fi not_active IP Right Cessation
- 1988-03-04 JP JP63049949A patent/JPS63230697A/ja active Granted
-
1991
- 1991-05-03 GR GR91400540T patent/GR3001898T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK116988A (da) | 1988-09-07 |
| FI881020L (fi) | 1988-09-07 |
| IE880635L (en) | 1988-09-06 |
| JPH0563479B2 (pt) | 1993-09-10 |
| IE60474B1 (en) | 1994-07-13 |
| ES2021771B3 (es) | 1991-11-16 |
| EP0281832A1 (de) | 1988-09-14 |
| DE3862595D1 (de) | 1991-06-06 |
| DK116988D0 (da) | 1988-03-04 |
| US4882452A (en) | 1989-11-21 |
| JPS63230697A (ja) | 1988-09-27 |
| ATE63121T1 (de) | 1991-05-15 |
| GR3001898T3 (en) | 1992-11-23 |
| PT86892B (pt) | 1992-05-29 |
| FI86187B (fi) | 1992-04-15 |
| DK168822B1 (da) | 1994-06-20 |
| CA1305970C (en) | 1992-08-04 |
| FI86187C (fi) | 1992-07-27 |
| EP0281832B1 (de) | 1991-05-02 |
| FI881020A0 (fi) | 1988-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3888647D1 (de) | Verfahren zur Herstellung von Aminopropylsilanen. | |
| AT370086B (de) | Verfahren zur herstellung des d-camphorats von l-carnitinamid | |
| DE59101703D1 (de) | Verfahren zur Herstellung von Dialkylcarbonaten. | |
| DE3889595D1 (de) | Verfahren zur Herstellung von Arylpiperidincarbinolen. | |
| ATE1241T1 (de) | Verfahren zur herstellung von 4,5-perfluor-1,3-dioxolanen. | |
| ATE8261T1 (de) | Verfahren zur herstellung von 3-jodmethylcephalosporinen. | |
| DE3862595D1 (de) | Verfahren zur herstellung von ifosfamid mit verbesserten eigenschaften. | |
| PT72724B (de) | Verfahren zur herstellung von pyrimidyl-chinazolinen | |
| DE3884272D1 (de) | Verfahren zur Herstellung von Triglyceriden. | |
| DE68921787D1 (de) | Verfahren zur Herstellung von N-Phosphonomethylglycin. | |
| ATE5812T1 (de) | Verfahren zur herstellung von chlorierten phenoxyalkansaeuren. | |
| DE3887963D1 (de) | Verfahren zur Herstellung von substituiertem Bernsteinsäureanhydrid. | |
| DE3886877D1 (de) | Verfahren zur Herstellung von Triphendioxazinen. | |
| DE3852408D1 (de) | Verfahren zur Herstellung von Acyloxialkansulfonaten. | |
| DE59006008D1 (de) | Verfahren zur Herstellung von Dialkylcarbonaten. | |
| ATE23523T1 (de) | Neue ester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen. | |
| DE3886786D1 (de) | Verfahren zur Herstellung von Cimetidin. | |
| DE3851376D1 (de) | Verfahren zur Herstellung von Triphendioxazinverbindungen. | |
| DE3888099D1 (de) | Verfahren zur Herstellung von substituiertem Bernsteinsäureanhydrid. | |
| DE69107740D1 (de) | Verfahren zur Herstellung von (Cyanofluormethyl)-Phosphonsäureestern. | |
| ATE100789T1 (de) | Verfahren zur herstellung von saeureanhydriden. | |
| ATE12233T1 (de) | Verfahren zur herstellung von penicillansaeuresulfon-estern. | |
| ATA49980A (de) | Verfahren zur herstellung von 4'-nitrobenzyl-7-phenoxyacetamido-3-hydroxy-3-c phem-4-carboxylat- solvaten | |
| PT74392A (de) | Verfahren zur herstellung von 2-oxabicyclo <3.3.o> octanderiva-ten | |
| AT383128B (de) | Verfahren zur herstellung des 1-aethoxycarbonyloxy-aethylesters von alpha-aminobenzylpenicillin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19911127 |
|
| PD3A | Change of proprietorship | ||
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20070528 |
|
| NF4A | Restitutio in integrum |
Free format text: RESTITUTIO IN INTEGRUM Effective date: 20071102 |