PT870197E - Utilizacao de ressonancia magnetica nuclear para projectar ligandos para biomoleculas alvo - Google Patents

Utilizacao de ressonancia magnetica nuclear para projectar ligandos para biomoleculas alvo Download PDF

Info

Publication number: PT870197E
Authority: PT; Portugal
Prior art keywords: target molecule; ligand; ligands; nmr; binding
Prior art date: 1995-11-14

Application number

PT96939709T

Other languages

English (en)

Portuguese (pt)

Inventor

Stephen W Fesik

Edward T Onejniczak

Philip J Hajduk

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-14

Filing date

1996-11-13

Publication date

2001-11-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27415774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT870197(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-11-14 Priority claimed from US08/558,633 external-priority patent/US5891643A/en

1996-10-31 Priority claimed from US08/744,701 external-priority patent/US5989827A/en

1996-11-13 Application filed by Abbott Lab filed Critical Abbott Lab

2001-11-30 Publication of PT870197E publication Critical patent/PT870197E/pt

Links

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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/4633—Sequences for multi-dimensional NMR
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
High Energy & Nuclear Physics (AREA)
Spectroscopy & Molecular Physics (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Computational Biology (AREA)
Condensed Matter Physics & Semiconductors (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Investigating Or Analysing Biological Materials (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

PT96939709T 1995-11-14 1996-11-13 Utilizacao de ressonancia magnetica nuclear para projectar ligandos para biomoleculas alvo PT870197E (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/558,633 US5891643A (en)	1995-11-14	1995-11-14	Use of nuclear magnetic resonance to design ligands to target biomolecules
US67890396A	1996-07-12	1996-07-12
US08/744,701 US5989827A (en)	1995-11-14	1996-10-31	Use of nuclear magnetic resonance to design ligands to target biomolecules

Publications (1)

Publication Number	Publication Date
PT870197E true PT870197E (pt)	2001-11-30

Family

ID=27415774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96939709T PT870197E (pt)	1995-11-14	1996-11-13	Utilizacao de ressonancia magnetica nuclear para projectar ligandos para biomoleculas alvo

Country Status (12)

Country	Link
EP (1)	EP0870197B2 (da)
JP (1)	JP3300366B2 (da)
AT (1)	ATE201768T1 (da)
AU (1)	AU711092B2 (da)
DE (1)	DE69613146T3 (da)
DK (1)	DK0870197T4 (da)
ES (1)	ES2159056T5 (da)
GR (1)	GR3036454T3 (da)
IL (1)	IL123572A (da)
MX (1)	MX9803805A (da)
PT (1)	PT870197E (da)
WO (1)	WO1997018469A2 (da)

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US20010004528A1 (en) *	1995-11-14	2001-06-21	Stephen W. Fesik	Use of 13c nuclear magnetic resonance to detect binding to target molecules
US6344330B1 (en)	1998-03-27	2002-02-05	The Regents Of The University Of California	Pharmacophore recombination for the identification of small molecule drug lead compounds
WO2000005414A1 (en) *	1998-07-21	2000-02-03	Rutgers, The State University	Linking gene sequence to gene function by three dimensional (3d) protein structure determination
US6333149B1 (en) *	1999-06-04	2001-12-25	Triad Biotechnology, Inc.	NMR-solve method for rapid identification of bi-ligand drug candidates
US6677160B1 (en)	1999-09-29	2004-01-13	Pharmacia & Upjohn Company	Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
US6764858B2 (en)	1999-09-29	2004-07-20	Pharmacia & Upjohn Company	Methods for creating a compound library
GB9925677D0 (en) *	1999-10-29	1999-12-29	Pharmacia & Upjohn Spa	Use of double-quantum 1H-NMR spectroscopy for the identification of ligands interacting with target biomolecules
MXPA02008253A (es) *	2000-02-25	2002-11-29	Wyeth Corp	Metodos de diseno de farmacos basados en la estructura usando em/rmn.
JP5129424B2 (ja)	2000-09-27	2013-01-30	ユニヴェルシテイトレイデン	リガンドの発見または薬物スクリーニング手段としてのｎｍｒ利用法
US7653490B2 (en)	2001-09-10	2010-01-26	Triad Liquidating Company LLC	Nuclear magnetic resonance assembly of chemical entities
NO20025738D0 (no) *	2002-11-29	2002-11-29	Amersham Health As	Metode
JP4192078B2 (ja)	2003-11-26	2008-12-03	株式会社日立製作所	核磁気共鳴方法
US20080293150A1 (en) *	2004-02-02	2008-11-27	Toshiyuki Kohno	Nmr Signal Assignment Method
US20090239760A1 (en)	2006-03-14	2009-09-24	University Of Basel	Method for the Identification of New Leads for Drug Candidates
KR20200057071A (ko) *	2017-09-25	2020-05-25	스카이호크 테라퓨틱스, 인코포레이티드	스플라이싱 조절제의 스크리닝 및 확인을 위한 방법 및 조성물
WO2020260277A1 (en) *	2019-06-25	2020-12-30	Albert-Ludwig-Universität Freiburg	Method and kit for measuring of analytes in bi-component systems and uses thereof
CN117912601B (zh) *	2024-01-26	2024-11-01	苏州腾迈医药科技有限公司	分子构象的展示方法及装置、介质

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AU7034791A (en) *	1989-12-29	1991-07-24	University Technologies International Inc.	Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin
US5393669A (en) *	1993-02-05	1995-02-28	Martek Biosciences Corp.	Compositions and methods for protein structural determinations
US8558663B2 (en) †	2007-11-30	2013-10-15	Bank Of America Corporation	Integration of facial recognition into cross channel authentication
DE102008042959A1 (de) †	2008-10-20	2010-04-22	Zf Friedrichshafen Ag	Verfahren zur Steuerung eines Kraftfahrzeug-Antriebsstrangs
US8678903B1 (en) †	2012-09-13	2014-03-25	Chia-Yen Lin	Mobile device having a virtual spin wheel and virtual spin wheel control method of the same

1996
- 1996-11-13 AU AU76804/96A patent/AU711092B2/en not_active Expired
- 1996-11-13 PT PT96939709T patent/PT870197E/pt unknown
- 1996-11-13 AT AT96939709T patent/ATE201768T1/de active
- 1996-11-13 IL IL12357296A patent/IL123572A/en not_active IP Right Cessation
- 1996-11-13 JP JP51908697A patent/JP3300366B2/ja not_active Expired - Lifetime
- 1996-11-13 ES ES96939709T patent/ES2159056T5/es not_active Expired - Lifetime
- 1996-11-13 DK DK96939709T patent/DK0870197T4/da active
- 1996-11-13 DE DE69613146T patent/DE69613146T3/de not_active Expired - Lifetime
- 1996-11-13 EP EP96939709A patent/EP0870197B2/en not_active Expired - Lifetime
- 1996-11-13 WO PCT/US1996/018312 patent/WO1997018469A2/en not_active Ceased
1998
- 1998-05-13 MX MX9803805A patent/MX9803805A/es unknown
2001
- 2001-08-27 GR GR20010401304T patent/GR3036454T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU711092B2 (en)	1999-10-07
AU7680496A (en)	1997-06-05
JP3300366B2 (ja)	2002-07-08
ES2159056T3 (es)	2001-09-16
WO1997018469A3 (en)	1997-08-07
JP2002510384A (ja)	2002-04-02
IL123572A0 (en)	1998-10-30
DE69613146T2 (de)	2003-01-16
DK0870197T4 (da)	2007-02-26
GR3036454T3 (en)	2001-11-30
EP0870197B1 (en)	2001-05-30
MX9803805A (es)	1998-09-30
DE69613146T3 (de)	2007-06-14
DE69613146D1 (de)	2001-07-05
EP0870197A2 (en)	1998-10-14
DK0870197T3 (da)	2001-08-27
EP0870197B2 (en)	2006-11-08
WO1997018469A2 (en)	1997-05-22
ES2159056T5 (es)	2007-07-16
ATE201768T1 (de)	2001-06-15
IL123572A (en)	2004-06-01

Publication	Publication Date	Title
PT866967E (pt)	2000-04-28	Utilizacao da ressonancia magnetica nuclear para a identificacao de ligandos para biomoleculas alvo
US5891643A (en)	1999-04-06	Use of nuclear magnetic resonance to design ligands to target biomolecules
US5989827A (en)	1999-11-23	Use of nuclear magnetic resonance to design ligands to target biomolecules
PT870197E (pt)	2001-11-30	Utilizacao de ressonancia magnetica nuclear para projectar ligandos para biomoleculas alvo
WO1997018471A9 (en)	1997-07-31	Use of nuclear magnetic resonance to identify ligands to target biomolecules
Qi et al.	2014	Gd (III)-PyMTA label is suitable for in-cell EPR
Tugarinov et al.	2003	Quantitative NMR studies of high molecular weight proteins: application to domain orientation and ligand binding in the 723 residue enzyme malate synthase G
JP4723094B2 (ja)	2011-07-13	結合を検出するための１３ｃ−ｎｍｒの使用
WO2003038396A2 (en)	2003-05-08	Method for detecting macromolecular conformational change and binding information
US20040038216A1 (en)	2004-02-26	Method for the structural determination of ligands bound to macromolecular targets by nuclear magnetic resonance
IL149512A (en)	2004-06-01	Use of two-dimensional <15>n/<1>h nmr correlation spectroscopy in a process for designing high-affinity ligands to target molecules
Frere et al.	2022	The Application of 19 F NMR to Studies of Protein Function and Drug Screening
MXPA98003810A (en)	1998-11-16	Use of nuclear magnetic resonance to identify ligands directed to biomolecu
CA2237336C (en)	2010-08-24	Use of nuclear magnetic resonance to design ligands to target biomolecules
KR100888805B1 (ko)	2009-03-16	특정 아미노산이 표지된 단백질과 1ｄｎｍｒ 기법을이용하여 단백질의 활성 부위에 결합하는 화합물을검색하는 방법
US20010051333A1 (en)	2001-12-13	Nuclear magnetic resonance methods for identifying sites in papillomavirus E2 protein
KR20030028920A (ko)	2003-04-11	특정 아미노산이 표지된 단백질과 2ｄｎｍｒ 기법을이용하여 단백질의 활성 부위에 결합하는 화합물을검색하는 방법