PT87268A - Stabile loesungsmitteladdukte von z-1-(p-beta-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en - Google Patents

Stabile loesungsmitteladdukte von z-1-(p-beta-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en

Info

Publication number
PT87268A
PT87268A PT87268A PT8726888A PT87268A PT 87268 A PT87268 A PT 87268A PT 87268 A PT87268 A PT 87268A PT 8726888 A PT8726888 A PT 8726888A PT 87268 A PT87268 A PT 87268A
Authority
PT
Portugal
Prior art keywords
loesungsmitteladdukte
dimethylaminoethoxyphenyl
phenylbut
stabile
hydroxyphenyl
Prior art date
Application number
PT87268A
Other languages
English (en)
Other versions
PT87268B (pt
Inventor
Ingomar Grafe
Helmut Schickaneder
Peter W Jungblut
Kurt Henning Ahrens
Original Assignee
Heumann Pharma Gmbh & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma Gmbh & Co filed Critical Heumann Pharma Gmbh & Co
Publication of PT87268A publication Critical patent/PT87268A/pt
Publication of PT87268B publication Critical patent/PT87268B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PT87268A 1987-04-21 1988-04-19 Processo para a preparacao de aductos em dissolventes, estaveis, de z-1-(p-b-dimetilaminoetoxifenil)-1-(p-hidroxifenil)-2-fenilbuta-1-eno e de composicoes farmaceuticas que os contem PT87268B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87105803A EP0287690B1 (de) 1987-04-21 1987-04-21 Stabile Lösungsmitteladdukte von Z-1-(p-beta-Dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en

Publications (2)

Publication Number Publication Date
PT87268A true PT87268A (pt) 1988-05-01
PT87268B PT87268B (pt) 1992-08-31

Family

ID=8196934

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87268A PT87268B (pt) 1987-04-21 1988-04-19 Processo para a preparacao de aductos em dissolventes, estaveis, de z-1-(p-b-dimetilaminoetoxifenil)-1-(p-hidroxifenil)-2-fenilbuta-1-eno e de composicoes farmaceuticas que os contem

Country Status (18)

Country Link
US (1) US4973755A (pt)
EP (1) EP0287690B1 (pt)
JP (1) JP2596446B2 (pt)
KR (1) KR940010274B1 (pt)
AR (1) AR243494A1 (pt)
AT (1) ATE80152T1 (pt)
AU (1) AU607198B2 (pt)
CA (1) CA1305972C (pt)
DE (1) DE3781546D1 (pt)
DK (1) DK171748B1 (pt)
ES (1) ES2044860T3 (pt)
GR (1) GR3005582T3 (pt)
HU (1) HU204501B (pt)
IE (1) IE62488B1 (pt)
IL (1) IL85804A (pt)
NZ (1) NZ224296A (pt)
PT (1) PT87268B (pt)
ZA (1) ZA882016B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
WO1996040098A2 (en) 1995-06-07 1996-12-19 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
DE69435137D1 (de) * 1993-05-13 2008-10-16 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
CA2150230C (en) * 1993-10-25 1998-10-27 Taiho Pharmaceutical Co., Ltd. Process for producing acid-addition salt of z-isomer of triphenylethylene compound
DE4407742C1 (de) * 1994-03-08 1995-06-22 Hexal Pharma Gmbh Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat
US5650425A (en) * 1994-04-04 1997-07-22 Pharmos Corporation Permanently ionic derivatives of steroid hormones and their antagonists
GB9601167D0 (en) * 1996-01-20 1996-03-20 Univ Bradford Tamoxifen and analogues thereof
AU725286B2 (en) 1996-01-20 2000-10-12 Bradford University Tamoxifen and analogues thereof
US6083990A (en) 1997-04-02 2000-07-04 Pharmos Corporation Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
WO1998046588A2 (en) * 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
GB9715479D0 (en) * 1997-07-23 1997-10-01 Univ Bradford Tamoxifen and analogues thereof
AU2513899A (en) * 1997-12-23 1999-07-19 Hexal Ag Mixture and pharmaceutical composition comprising z-4-hydroxytamoxifen and cyclodextrin
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
EP1572178B1 (en) * 2002-12-18 2006-05-03 Laboratoires Besins International Treatment of mastalgia with 4-hydroxy tamoxifen
EP2050443B1 (en) * 2002-12-18 2017-05-24 Besins Healthcare Luxembourg SARL Reduction of breast density with 4-hydroxy tamoxifen
CA2519980C (en) * 2003-04-01 2012-04-10 Laboratoires Besins International Prevention and treatment of breast cancer with 4-hydroxy tamoxifen
DE602004013439T2 (de) * 2003-06-09 2009-06-04 Ascend Therapeutics, Inc. Behandlung und prävention von übermässiger narbenbildung mit 4-hydroxy tamoxifen
WO2004112724A2 (en) * 2003-06-20 2004-12-29 Viral Genomix, Inc. Compositions for and methods for treating hiv
US7968532B2 (en) * 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
US7507769B2 (en) * 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
AU2005227072B2 (en) * 2004-03-22 2010-08-19 Besins Healthcare Luxembourg Sarl Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
EP1579856A1 (en) * 2004-03-22 2005-09-28 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE637389A (pt) * 1962-09-13
GB1099093A (en) * 1965-09-03 1968-01-17 Ici Ltd Alkene derivatives
GB1560274A (en) * 1977-02-28 1980-02-06 Ici Ltd Phenylbut 1-ene derivatives having antiostrogenicactivity
EP0002097B1 (en) * 1977-08-22 1981-08-05 Imperial Chemical Industries Plc Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
DE3046719C2 (de) * 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
DE3239610A1 (de) * 1982-10-26 1984-04-26 Klinge Pharma GmbH, 8000 München Neue 1,1,2-triphenyl-but-l-en-derivate, sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
DK171748B1 (da) 1997-05-05
IL85804A0 (en) 1988-09-30
EP0287690A1 (de) 1988-10-26
KR880012528A (ko) 1988-11-28
NZ224296A (en) 1990-02-26
IE62488B1 (en) 1995-02-08
AU607198B2 (en) 1991-02-28
HUT50318A (en) 1990-01-29
GR3005582T3 (pt) 1993-06-07
DK189888A (da) 1988-10-22
EP0287690B1 (de) 1992-09-02
HU204501B (en) 1992-01-28
AR243494A1 (es) 1993-08-31
ATE80152T1 (de) 1992-09-15
JPS6445347A (en) 1989-02-17
PT87268B (pt) 1992-08-31
ES2044860T3 (es) 1994-01-16
US4973755A (en) 1990-11-27
JP2596446B2 (ja) 1997-04-02
KR940010274B1 (ko) 1994-10-22
CA1305972C (en) 1992-08-04
IL85804A (en) 1991-07-18
ZA882016B (en) 1988-12-28
DK189888D0 (da) 1988-04-07
DE3781546D1 (de) 1992-10-08
AU1379888A (en) 1988-10-20

Similar Documents

Publication Publication Date Title
DK177088A (da) Substitueret di-t-butylphenyl
ATE80152T1 (de) Stabile loesungsmitteladdukte von z-1-(p-betadimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl) 2-phenylbut-1-en.
DK439688A (da) Quinoloner
IT1180022B (it) Manipolo dentistico
DE3860139D1 (de) Schnurklemme.
IT1180021B (it) Manipolo dentistico
DK440884A (da) Fungicid
DK604788D0 (da) Fungicide pyridylcyklopropancarboxamidiner
IT1177372B (it) Biocida polimero
DE3478743D1 (de) 1-(2-aryl-2-halo-1-ethenyl)-1h-azoles
DK237887D0 (da) Fungicid
DK604988A (da) Fungicide pyridylamider
DK439084D0 (da) Fungicide midler
DK251788A (da) Stabile creatinamidinohydrolasemutanter
DK237987A (da) Fungicid
DK604688D0 (da) Fungicide pyridyliminocarbonater
DK30184D0 (da) Pyrrolidiner
DK424684D0 (da) Fungicide triazolethanoler
DK23884A (da) Azetidinforbindelser
MD38B1 (ro) Remediu fungicid
KR880021523U (ko) 쇠톱대
DK605088D0 (da) Fungicide n-pyridylimider
SE8301032D0 (sv) Likkista
KR850002288U (ko) 수목지지대
DK595288A (da) Azetidinonforbindelser

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920203

MM3A Annulment or lapse

Effective date: 20060803