PT87322A - Novel 11-aryloestrane and 11-arylpregnane derivates - Google Patents

Novel 11-aryloestrane and 11-arylpregnane derivates

Info

Publication number: PT87322A
Authority: PT; Portugal
Prior art keywords: group; acyloxy; hydroxyl; carbon atoms; hydrocarbon radical
Prior art date: 1987-04-24

Application number

PT87322A

Other languages

English (en)

Other versions

PT87322B (pt

Inventor

Marinus Bernard Groen

Hendrik Paul De Jongh

Original Assignee

Akzo Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-24

Filing date

1988-04-22

Publication date

1988-05-01

1988-04-22 Application filed by Akzo Nv filed Critical Akzo Nv

1988-05-01 Publication of PT87322A publication Critical patent/PT87322A/pt

1992-08-31 Publication of PT87322B publication Critical patent/PT87322B/pt

Links

125000004423 acyloxy group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
239000004215 Carbon black (E152) Substances 0.000 abstract 2
229930195733 hydrocarbon Natural products 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000000708 anti-progestin effect Effects 0.000 abstract 1
239000003418 antiprogestin Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002560 nitrile group Chemical group 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT87322A 1987-04-24 1988-04-22 Processo de preparacao de derivados 11-arilestrano e 11-arilpregnano e de composicoes farmaceuticas que os contem PT87322B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL8700970		1987-04-24

Publications (2)

Publication Number	Publication Date
PT87322A true PT87322A (pt)	1988-05-01
PT87322B PT87322B (pt)	1992-08-31

Family

ID=19849909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87322A PT87322B (pt)	1987-04-24	1988-04-22	Processo de preparacao de derivados 11-arilestrano e 11-arilpregnano e de composicoes farmaceuticas que os contem

Country Status (17)

Country	Link
US (1)	US4871724A (pt)
EP (1)	EP0289073B1 (pt)
JP (1)	JP2655676B2 (pt)
KR (1)	KR970005318B1 (pt)
CN (1)	CN1019978C (pt)
AT (1)	ATE69820T1 (pt)
AU (1)	AU608831B2 (pt)
CA (1)	CA1297472C (pt)
DE (1)	DE3866410D1 (pt)
DK (1)	DK168294B1 (pt)
ES (1)	ES2045082T3 (pt)
FI (1)	FI88396C (pt)
GR (1)	GR3003363T3 (pt)
IE (1)	IE60783B1 (pt)
NZ (1)	NZ224355A (pt)
PT (1)	PT87322B (pt)
ZA (1)	ZA882643B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE59010853D1 (de) *	1989-08-04	1998-12-03	Schering Ag	11 Beta-Aryl-gona-4,9-dien-3-one
US5407928A (en) *	1990-08-15	1995-04-18	Schering Aktiengesellschaft	11β-aryl-gona-4,9-dien-3-ones
ZA929315B (en) *	1991-12-20	1993-05-24	Akzo Nv	17-spirofuran-3'-ylidene steroids.
CA2100514C (en) *	1992-07-29	2005-03-29	Johannes A. M. Hamersma	17-spiromethylene steroids
DE4332283A1 (de) *	1993-09-20	1995-04-13	Jenapharm Gmbh	Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4434488A1 (de)	1994-09-14	1996-03-21	Schering Ag	Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US5576310A (en) *	1994-09-20	1996-11-19	Jenapharm Gmbh	11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
ZA9510926B (en)	1994-12-23	1996-07-03	Schering Ag	Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
US6020328A (en) *	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) *	1998-05-29	1999-10-05	Research Triangle Institute	17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en)	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
CN1117759C (zh) *	1999-09-02	2003-08-13	上海中西药业股份有限公司	甾体化合物,其制备方法和其药物组合物及其应用
TW200531977A (en)	2004-03-25	2005-10-01	Akzo Nobel Nv	Progesterone receptor modulators
HUE036870T2 (hu)	2006-10-24	2018-08-28	Repros Therapeutics Inc	Az endometriális proliferáció elnyomására szolgáló készítmények és módszerek
TWI539953B (zh)	2008-04-28	2016-07-01	瑞波若斯治療學公司	用於治療乳癌之組成物和方法
EP3865502A1 (en)	2010-03-22	2021-08-18	Allergan Pharmaceuticals International Limited	Compositions and methods for non-toxic delivery of cdb-2914
US9096641B2 (en)	2013-06-05	2015-08-04	Evestra, Inc.	Imidazolyl progesterone antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3424769A (en) *	1966-04-04	1969-01-28	Syntex Corp	Process for the preparation of novel 6alpha-methyl-delta4,9(10)- diene steroids
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
EP0116974B1 (de) *	1983-02-18	1986-10-29	Schering Aktiengesellschaft	11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE3347126A1 (de) *	1983-12-22	1985-07-11	Schering AG, 1000 Berlin und 4709 Bergkamen	11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
AU580843B2 (en) *	1985-02-07	1989-02-02	Schering Aktiengesellschaft	11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
US4678282A (en) *	1985-02-19	1987-07-07	Ovonic Imaging Systems, Inc.	Active display matrix addressable without crossed lines on any one substrate and method of using the same
GB8513723D0 (en) *	1985-05-31	1985-07-03	Erba Farmitalia	11-beta substituted steroids

1988
- 1988-04-12 AT AT88200689T patent/ATE69820T1/de not_active IP Right Cessation
- 1988-04-12 DE DE8888200689T patent/DE3866410D1/de not_active Expired - Lifetime
- 1988-04-12 EP EP88200689A patent/EP0289073B1/en not_active Expired - Lifetime
- 1988-04-12 ES ES88200689T patent/ES2045082T3/es not_active Expired - Lifetime
- 1988-04-14 IE IE113188A patent/IE60783B1/en not_active IP Right Cessation
- 1988-04-14 ZA ZA882643A patent/ZA882643B/xx unknown
- 1988-04-19 FI FI881826A patent/FI88396C/fi not_active IP Right Cessation
- 1988-04-20 CA CA000564606A patent/CA1297472C/en not_active Expired - Lifetime
- 1988-04-20 US US07/183,851 patent/US4871724A/en not_active Expired - Fee Related
- 1988-04-22 JP JP63100010A patent/JP2655676B2/ja not_active Expired - Lifetime
- 1988-04-22 AU AU15072/88A patent/AU608831B2/en not_active Ceased
- 1988-04-22 NZ NZ224355A patent/NZ224355A/xx unknown
- 1988-04-22 DK DK221888A patent/DK168294B1/da active IP Right Grant
- 1988-04-22 PT PT87322A patent/PT87322B/pt not_active IP Right Cessation
- 1988-04-23 KR KR1019880004653A patent/KR970005318B1/ko not_active Expired - Fee Related
- 1988-04-23 CN CN88102416A patent/CN1019978C/zh not_active Expired - Fee Related
1991
- 1991-12-17 GR GR91402004T patent/GR3003363T3/el unknown

Also Published As

Publication number	Publication date
FI881826A0 (fi)	1988-04-19
FI881826A7 (fi)	1988-10-25
DK221888A (da)	1988-10-25
EP0289073B1 (en)	1991-11-27
FI88396C (fi)	1993-05-10
AU608831B2 (en)	1991-04-18
DE3866410D1 (de)	1992-01-09
NZ224355A (en)	1990-03-27
DK168294B1 (da)	1994-03-07
KR970005318B1 (ko)	1997-04-15
CA1297472C (en)	1992-03-17
IE60783B1 (en)	1994-08-10
IE881131L (en)	1988-10-24
JP2655676B2 (ja)	1997-09-24
DK221888D0 (da)	1988-04-22
AU1507288A (en)	1988-10-27
ATE69820T1 (de)	1991-12-15
US4871724A (en)	1989-10-03
GR3003363T3 (en)	1993-02-17
CN88102416A (zh)	1988-12-14
CN1019978C (zh)	1993-03-03
ZA882643B (en)	1988-10-04
EP0289073A1 (en)	1988-11-02
PT87322B (pt)	1992-08-31
JPS63280097A (ja)	1988-11-17
KR880012637A (ko)	1988-11-28
FI88396B (fi)	1993-01-29
ES2045082T3 (es)	1994-01-16

Legal Events

Date

Code

Title

Description

1992-08-31

FG3A

Patent granted, date of granting

Effective date: 19920207

2002-11-29

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20020831

Publication	Publication Date	Title
PT87322A (pt)	1988-05-01	Novel 11-aryloestrane and 11-arylpregnane derivates
DK163307C (da)	1992-07-06	11-phenyl-14betah-steroidderivater, fremgangsmaade til fremstilling heraf samt farmaceutisk middel indeholdende disse
ES8308314A1 (es)	1983-09-01	Procedimiento para preparar derivados de 2-amino-4-hidroxiquinazolina.
DK688088A (da)	1989-06-13	11-arylsteoridforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
IL65501A (en)	1986-04-29	1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
ES8305736A1 (es)	1983-04-16	Procedimiento para la preparacion de derivados de la piridazina.
FR2517309B1 (pt)	1985-03-22
FI895937A0 (fi)	1989-12-12	Nya imidazolidinderivat, foerfaranden foer deras framstaellning samt laekemedel innehaollande dessa foereningar.
FR2530248B1 (pt)	1985-02-15
PT79158A (fr)	1984-09-01	Derives de nitrosourees leur procede de preparation et compositions pharmaceutiques les contenant
JPS6463517A (en)	1989-03-09	Antianxiety composition
MY102457A (en)	1992-06-30	Isoquinoline derivatives
FR2593810B1 (fr)	1988-04-22	Derives de la quinoleine, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
FR2444038A1 (fr)	1980-07-11	Derives de pyrazolo(1,5-c)quinazoline utiles comme medicaments et leurs procedes de preparation
DE3160549D1 (en)	1983-08-11	Process for the preparation of chlorophenols
EP0273732A3 (en)	1989-09-27	Streptovaricin c derivatives as anti-aids virus agents
JPS525724A (en)	1977-01-17	Process for preparation of 1,3,5-tri-substituted- benzene derivatives
EP0210653A3 (en)	1987-12-16	Pyrazolo [4,3-d] pyrimidine derivative, process for its production, and antihyperlipidemic or antiatheroschlerotic agent containing it
JPS53112877A (en)	1978-10-02	Compound relating to prostaglandin x and its preparaion
JPS5414998A (en)	1979-02-03	Prostaglandin i2 analog and its preparation