PT87366A - Processo para a preparacao de derivados de 3-alil e 3-butenil-3-cefem e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de derivados de 3-alil e 3-butenil-3-cefem e de composicoes farmaceuticas que os contem

Info

Publication number: PT87366A
Authority: PT; Portugal
Prior art keywords: cephem; cpd; phosphine; tri; halomethyl
Prior art date: 1988-04-29

Application number

PT87366A

Other languages

English (en)

Other versions

PT87366B (pt

Inventor

Stephen Richard Baker

Chester Sapino Jr

Vittorio Farina

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-29

Filing date

1988-04-29

Publication date

1989-11-10

1988-04-29 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1988-04-29 Priority to PT87366A priority Critical patent/PT87366B/pt

1989-11-10 Publication of PT87366A publication Critical patent/PT87366A/pt

1994-05-31 Publication of PT87366B publication Critical patent/PT87366B/pt

Links

-1 methyl 3-cephem Chemical compound 0.000 title abstract 3
239000003880 polar aprotic solvent Substances 0.000 title abstract 2
229910000080 stannane Inorganic materials 0.000 title abstract 2
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 title 2
XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 title 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title 1
230000008878 coupling Effects 0.000 title 1
238000010168 coupling process Methods 0.000 title 1
238000005859 coupling reaction Methods 0.000 title 1
125000000623 heterocyclic group Chemical group 0.000 title 1
125000001183 hydrocarbyl group Chemical group 0.000 title 1
229910052763 palladium Inorganic materials 0.000 title 1
229910000073 phosphorus hydride Inorganic materials 0.000 title 1
229930186147 Cephalosporin Natural products 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229940124587 cephalosporin Drugs 0.000 abstract 2
150000001780 cephalosporins Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
229920002554 vinyl polymer Polymers 0.000 abstract 2
FZEVMBJWXHDLDB-ZCFIWIBFSA-N (6r)-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical group S1CC=CN2C(=O)C[C@H]21 FZEVMBJWXHDLDB-ZCFIWIBFSA-N 0.000 abstract 1
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
WXHIJDCHNDBCNY-UHFFFAOYSA-N palladium dihydride Chemical compound [PdH2] WXHIJDCHNDBCNY-UHFFFAOYSA-N 0.000 abstract 1
KXCAEQNNTZANTK-UHFFFAOYSA-N stannane Chemical compound [SnH4] KXCAEQNNTZANTK-UHFFFAOYSA-N 0.000 abstract 1
DLQYXUGCCKQSRJ-UHFFFAOYSA-N tris(furan-2-yl)phosphane Chemical compound C1=COC(P(C=2OC=CC=2)C=2OC=CC=2)=C1 DLQYXUGCCKQSRJ-UHFFFAOYSA-N 0.000 abstract 1
KUCPTMZJPDVWJL-UHFFFAOYSA-N trithiophen-2-ylphosphane Chemical compound C1=CSC(P(C=2SC=CC=2)C=2SC=CC=2)=C1 KUCPTMZJPDVWJL-UHFFFAOYSA-N 0.000 abstract 1

Landscapes

Cephalosporin Compounds (AREA)

PT87366A 1988-04-29 1988-04-29 Processo para a preparacao de derivados de 3-alil e 3-butenil-3-cefem e de composicoes farmaceuticas que os contem PT87366B (pt)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
PT87366A PT87366B (pt)	1988-04-29	1988-04-29	Processo para a preparacao de derivados de 3-alil e 3-butenil-3-cefem e de composicoes farmaceuticas que os contem

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PT87366A PT87366B (pt)	1988-04-29	1988-04-29	Processo para a preparacao de derivados de 3-alil e 3-butenil-3-cefem e de composicoes farmaceuticas que os contem

Publications (2)

Publication Number	Publication Date
PT87366A true PT87366A (pt)	1989-11-10
PT87366B PT87366B (pt)	1994-05-31

Family

ID=20084216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87366A PT87366B (pt)	1988-04-29	1988-04-29	Processo para a preparacao de derivados de 3-alil e 3-butenil-3-cefem e de composicoes farmaceuticas que os contem

Country Status (1)

Country	Link
PT (1)	PT87366B (pt)

1988
- 1988-04-29 PT PT87366A patent/PT87366B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT87366B (pt)	1994-05-31

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Legal Events

Date

Code

Title

Description

1994-05-31

FG3A

Patent granted, date of granting

Effective date: 19931108

2008-05-21

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20080508

2008-11-21

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20081108