PT87523A - Mischkristalle aus insulin und insulinderivaten verfahren zur herstellung dieser mischkristalle diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus - Google Patents

Mischkristalle aus insulin und insulinderivaten verfahren zur herstellung dieser mischkristalle diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus

Info

Publication number: PT87523A
Authority: PT; Portugal
Prior art keywords: mischkristalle; insulin; und; diabetes mellitus; insulinderivaten
Prior art date: 1987-05-22

Application number

PT87523A

Other languages

English (en)

Other versions

PT87523B (pt

Inventor

Michael Dorschug

Rainer Obermeier

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-22

Filing date

1988-05-19

Publication date

1989-05-31

1988-05-19 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-05-31 Publication of PT87523A publication Critical patent/PT87523A/pt

1992-09-30 Publication of PT87523B publication Critical patent/PT87523B/pt

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 9
102000004877 Insulin Human genes 0.000 title abstract 4
108090001061 Insulin Proteins 0.000 title abstract 4
229940125396 insulin Drugs 0.000 title abstract 4
206010012601 diabetes mellitus Diseases 0.000 title abstract 2
239000013078 crystal Substances 0.000 abstract 3
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 2
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 2
108700007397 Arg(B31)- insulin Proteins 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
235000015278 beef Nutrition 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
235000015277 pork Nutrition 0.000 abstract 1
230000002035 prolonged effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Toxicology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Enzymes And Modification Thereof (AREA)

PT87523A 1987-05-22 1988-05-19 Processo para a preparacao de cristais mistos de insulina e derivados da insulina, e de composicoes farmaceuticas que os contem PT87523B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873717370 DE3717370A1 (de)	1987-05-22	1987-05-22	Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus

Publications (2)

Publication Number	Publication Date
PT87523A true PT87523A (pt)	1989-05-31
PT87523B PT87523B (pt)	1992-09-30

Family

ID=6328227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87523A PT87523B (pt)	1987-05-22	1988-05-19	Processo para a preparacao de cristais mistos de insulina e derivados da insulina, e de composicoes farmaceuticas que os contem

Country Status (20)

Country	Link
US (1)	US5028587A (pt)
EP (1)	EP0291863B1 (pt)
JP (1)	JPS63303930A (pt)
KR (1)	KR880013572A (pt)
AT (1)	ATE71842T1 (pt)
AU (1)	AU601280B2 (pt)
CA (1)	CA1335924C (pt)
DE (2)	DE3717370A1 (pt)
DK (1)	DK278088A (pt)
ES (1)	ES2032896T3 (pt)
FI (1)	FI93797C (pt)
GR (1)	GR3004344T3 (pt)
HU (1)	HU203840B (pt)
IE (1)	IE60649B1 (pt)
IL (1)	IL86452A (pt)
NO (1)	NO175641C (pt)
NZ (1)	NZ224715A (pt)
PH (1)	PH25587A (pt)
PT (1)	PT87523B (pt)
ZA (1)	ZA883599B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
WO1992010284A2 (en)	1990-12-07	1992-06-25	Cnc Development, Inc.	Catalytic chemical reactor
ES2108122T3 (es) *	1991-05-24	1997-12-16	Amylin Pharmaceuticals Inc	Composicion a base de amilina o de un analogo de amilina conteniendo opcionalmente insulina, para el tratamiento de la anorexia y de las patologias asociadas.
DK72793D0 (da) *	1993-06-21	1993-06-21	Novo Nordisk As	Nyt produkt
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
US5504188A (en) *	1994-06-16	1996-04-02	Eli Lilly And Company	Preparation of stable zinc insulin analog crystals
US5461031A (en) *	1994-06-16	1995-10-24	Eli Lilly And Company	Monomeric insulin analog formulations
US5547929A (en) *	1994-09-12	1996-08-20	Eli Lilly And Company	Insulin analog formulations
US5597893A (en) *	1994-10-31	1997-01-28	Eli Lilly And Company	Preparation of stable insulin analog crystals
US6004549A (en) *	1994-12-14	1999-12-21	Schering Corporation	Crystalline protein controlled release compositions
CO4970787A1 (es) *	1997-12-23	2000-11-07	Lilly Co Eli	Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
DE19903125B4 (de) *	1999-01-27	2006-01-05	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga
CN1125081C (zh) *	1999-09-08	2003-10-22	中国科学院上海生物化学研究所	重组天然和新型人胰岛素及其制备方法
DE60217066T4 (de) *	2001-02-09	2010-07-01	Genentech, Inc., South San Francisco	Kristallisierung von igf-1
US7396936B1 (en)	2004-11-09	2008-07-08	Kemia, Inc.	Modulators of calcitonin and amylin receptor activity
WO2008066899A2 (en) *	2006-11-28	2008-06-05	Marinus Pharmaceuticals	Nanoparticulate formulations and methods for the making and use thereof
WO2015084694A2 (en)	2013-12-04	2015-06-11	Merck Sharp & Dohme Corp.	Method for preparing crystalline insulin
US10124040B2 (en)	2014-08-26	2018-11-13	Merck Sharp & Dohme Corp.	Method for preparing crystalline insulin or insulin analog compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2538018A (en) *	1944-04-04	1951-01-16	Nordisk Insulinlab	Crystalline product of insulin and alkaline protein and process of making it
EG12098A (en) *	1974-04-13	1980-12-31	Hoechst Ag	New pharmaceutical insulin preparations having antidiabetic activity and process for their manufacture
DE3326472A1 (de) *	1983-07-22	1985-02-14	Hoechst Ag, 6230 Frankfurt	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) *	1983-07-22	1985-01-31	Hoechst Ag, 6230 Frankfurt	Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3333640A1 (de) *	1983-09-17	1985-04-25	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung

1987
- 1987-05-22 DE DE19873717370 patent/DE3717370A1/de not_active Withdrawn
1988
- 1988-05-13 EP EP88107667A patent/EP0291863B1/de not_active Expired - Lifetime
- 1988-05-13 DE DE8888107667T patent/DE3867903D1/de not_active Expired - Fee Related
- 1988-05-13 ES ES198888107667T patent/ES2032896T3/es not_active Expired - Lifetime
- 1988-05-13 AT AT88107667T patent/ATE71842T1/de not_active IP Right Cessation
- 1988-05-19 PT PT87523A patent/PT87523B/pt not_active IP Right Cessation
- 1988-05-19 FI FI882354A patent/FI93797C/fi not_active IP Right Cessation
- 1988-05-20 HU HU882597A patent/HU203840B/hu not_active IP Right Cessation
- 1988-05-20 IL IL86452A patent/IL86452A/xx unknown
- 1988-05-20 DK DK278088A patent/DK278088A/da not_active Application Discontinuation
- 1988-05-20 CA CA000567377A patent/CA1335924C/en not_active Expired - Fee Related
- 1988-05-20 NO NO882207A patent/NO175641C/no unknown
- 1988-05-20 US US07/196,530 patent/US5028587A/en not_active Expired - Fee Related
- 1988-05-20 NZ NZ224715A patent/NZ224715A/en unknown
- 1988-05-20 JP JP63122211A patent/JPS63303930A/ja active Pending
- 1988-05-20 IE IE152288A patent/IE60649B1/en not_active IP Right Cessation
- 1988-05-20 ZA ZA883599A patent/ZA883599B/xx unknown
- 1988-05-20 KR KR1019880005946A patent/KR880013572A/ko not_active Ceased
- 1988-05-20 AU AU16487/88A patent/AU601280B2/en not_active Ceased
- 1988-05-20 PH PH36954A patent/PH25587A/en unknown
1992
- 1992-04-15 GR GR920400389T patent/GR3004344T3/el unknown

Also Published As

Publication number	Publication date
CA1335924C (en)	1995-06-13
PH25587A (en)	1991-08-08
GR3004344T3 (pt)	1993-03-31
NO175641B (pt)	1994-08-01
AU601280B2 (en)	1990-09-06
IE881522L (en)	1988-11-22
KR880013572A (ko)	1988-12-21
IE60649B1 (en)	1994-08-10
EP0291863A3 (en)	1990-04-04
EP0291863B1 (de)	1992-01-22
IL86452A0 (en)	1988-11-15
NO175641C (no)	1994-11-09
DE3717370A1 (de)	1988-12-01
ES2032896T3 (es)	1993-03-01
ATE71842T1 (de)	1992-02-15
HU203840B (en)	1991-10-28
NO882207D0 (no)	1988-05-20
DK278088D0 (da)	1988-05-20
FI882354L (fi)	1988-11-23
FI93797C (fi)	1995-06-12
IL86452A (en)	1993-02-21
ZA883599B (en)	1989-01-25
PT87523B (pt)	1992-09-30
DE3867903D1 (de)	1992-03-05
NZ224715A (en)	1990-04-26
DK278088A (da)	1988-11-23
JPS63303930A (ja)	1988-12-12
EP0291863A2 (de)	1988-11-23
FI882354A0 (fi)	1988-05-19
NO882207L (no)	1988-11-23
AU1648788A (en)	1988-11-24
HUT46546A (en)	1988-11-28
FI93797B (fi)	1995-02-28
US5028587A (en)	1991-07-02

Legal Events

Date

Code

Title

Description

1992-09-30

FG3A

Patent granted, date of granting

Effective date: 19920311

1998-01-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19970930

Publication	Publication Date	Title
AU601280B2 (en)	1990-09-06	Mixed crystals of insulin and insulin derivatives, a process for the preparation of these mixed crystals, pharmaceutical agents containing these mixed crystals, and the use thereof for the treatment of diabetes mellitus
DE3772429D1 (de)	1991-10-02	Pharmazeutisches praeparat zur behandlung von peridontalkrankheiten.
DK393288A (da)	1988-09-13	Praeparat til saarheling og knogleregenerering
ATE29729T1 (de)	1987-10-15	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus.
DE3768286D1 (de)	1991-04-11	Substituierte pyridinsulfonamidverbindungen, diese enthaltende herbizide zusammensetzungen und verfahren zur herstellung dieser verbindungen.
FI875533A0 (fi)	1987-12-16	Insulinpreparat foer non-parenteral dosering.
DE69033040D1 (de)	1999-05-12	Verfahren zur Herstellung von biologisch aktivem Protein (z.B. TGF)
ATE31625T1 (de)	1988-01-15	Pharmazeutisches mittel zur behandlung des diabetes mellitus.
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DE3882775D1 (de)	1993-09-09	Zusammensetzung zur behandlung von parodontaler krankheit.
DE3782028D1 (de)	1992-11-05	Verwendung von ketonderivaten zur behandlung von bewusstseinsstoerungen.
ATE94070T1 (de)	1993-09-15	Faktor xiii zur vorbeugung von intraventrikulaeren blutungen.
ATE84716T1 (de)	1993-02-15	4-chinolincarbonsaeure-derivate, brauchbar zur behandlung von haut- und muco-epithelialgewebekrankheiten.
PT83309A (de)	1986-10-01	Neue pyrrolo-benzimidazole pyrrolo-benzoxazole und pyrrolo-benzthiazole verfahren zu ihrer herstellung und diese verbindungen enthaltende arneimittel
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ATE25969T1 (de)	1987-04-15	1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten.
DE69809785D1 (de)	2003-01-09	Verwendung eines retinoidids zur in vivo erhöhung der entkopplung des ucp2 proteins
DE69025967D1 (de)	1996-04-25	Aryl- oder Heteroaryl-1-alkyl-pyrrol-2-carbonsäure-Derivate, zur Behandlung von durch Interleukin-1 hervorgerufenen Erkrankungen
DE69103294D1 (de)	1994-09-15	Verwendung der 3-Oxygermylpropionsäure zur Behandlung und Prävention von Diabetes verursacht durch Autoimmunkrankheiten.
DE3765250D1 (de)	1990-10-31	Verwendung von 24,25-dihydroxycholecalciferol zur behandlung von harnsteinen.
DE68905479D1 (de)	1993-04-22	Transdermate magensafthemmende wirkstoffe zur behandlung von magen-darm-erkrankungen.