PT87688A - Hybrid protein c and method for its preparation - Google Patents

Hybrid protein c and method for its preparation

Info

Publication number
PT87688A
PT87688A PT87688A PT8768888A PT87688A PT 87688 A PT87688 A PT 87688A PT 87688 A PT87688 A PT 87688A PT 8768888 A PT8768888 A PT 8768888A PT 87688 A PT87688 A PT 87688A
Authority
PT
Portugal
Prior art keywords
preparation
hybrid protein
hybrid
protein
Prior art date
Application number
PT87688A
Other languages
English (en)
Other versions
PT87688B (pt
Inventor
Wakako Iwasaki
Mikiko Takahashi
Tamotsu Hashimoto
Original Assignee
Hoechst Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Japan filed Critical Hoechst Japan
Publication of PT87688A publication Critical patent/PT87688A/pt
Publication of PT87688B publication Critical patent/PT87688B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT87688A 1987-06-12 1988-06-09 Processo para a preparacao de proteina hibrida c PT87688B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14529387 1987-06-12

Publications (2)

Publication Number Publication Date
PT87688A true PT87688A (pt) 1988-07-01
PT87688B PT87688B (pt) 1992-09-30

Family

ID=15381791

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87688A PT87688B (pt) 1987-06-12 1988-06-09 Processo para a preparacao de proteina hibrida c

Country Status (7)

Country Link
EP (1) EP0296413A2 (pt)
JP (1) JP2799316B2 (pt)
KR (1) KR890000517A (pt)
AU (1) AU1756588A (pt)
DK (1) DK317288A (pt)
FI (1) FI882746L (pt)
PT (1) PT87688B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516650A (en) * 1985-06-27 1996-05-14 Zymogenetics, Inc. Production of activated protein C
JP2728240B2 (ja) * 1988-07-26 1998-03-18 ヘキスト薬品工業株式会社 ヒトプロテインｃ変異体及びその製造方法
US5298599A (en) * 1988-12-30 1994-03-29 Oklahoma Medical Research Foundation Expression and purification of recombinant soluble tissue factor
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
JP3153236B2 (ja) * 1989-12-22 2001-04-03 ザイモジェネティクス，インコーポレイティド 端が切り取られた軽鎖を有する組換えプロテインｃ
JP3270462B2 (ja) * 1989-12-29 2002-04-02 ザイモジェネティクス，インコーポレイティド ハイブリッドプロテインｃ
US5225537A (en) * 1989-12-29 1993-07-06 Zymogenetics, Inc. Methods for producing hybrid phospholipid-binding proteins
JP3330932B2 (ja) * 1990-01-29 2002-10-07 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 抗凝固剤タンパク質
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
AU730133B2 (en) * 1996-11-08 2001-02-22 Oklahoma Medical Research Foundation Modified protein C and methods of use thereof
SE9701228D0 (sv) * 1997-04-03 1997-04-03 Bjoern Dahlbaeck Rekombinanta protein-C-och protein-S-varianter
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6017882A (en) * 1997-10-23 2000-01-25 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6693075B1 (en) 1997-10-23 2004-02-17 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6998122B1 (en) 1999-04-30 2006-02-14 Eli Lilly And Company Protein C derivatives
US6841371B2 (en) 2000-02-02 2005-01-11 Eli Lilly And Company Protein C derivatives
JP2003521938A (ja) 2000-02-11 2003-07-22 イーライ・リリー・アンド・カンパニー プロテインｃ誘導体
EP1982732A3 (en) 2000-02-11 2011-06-08 Bayer HealthCare LLC Factor VII or VIIA-like conjugates
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
US7700733B2 (en) 2002-04-30 2010-04-20 Bayer Healthcare Llc Factor VII or VIIa polypeptide variants
DK2085470T3 (da) 2003-03-20 2012-08-06 Bayer Healthcare Llc FVII- eller FVIIa-varianter
DK1644504T3 (da) 2003-06-19 2010-05-25 Bayer Healthcare Llc Faktor VII- eller -VIIA-Gla-domænevarianter

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
CA1341228C (en) * 1985-06-27 2001-05-15 Mark J. Murray Expression of protein c
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C

Also Published As

Publication number Publication date
DK317288A (da) 1988-12-13
PT87688B (pt) 1992-09-30
KR890000517A (ko) 1989-03-15
FI882746A7 (fi) 1988-12-13
EP0296413A2 (en) 1988-12-28
JP2799316B2 (ja) 1998-09-17
FI882746A0 (fi) 1988-06-09
JPS6485096A (en) 1989-03-30
DK317288D0 (da) 1988-06-10
AU1756588A (en) 1988-12-15
FI882746L (fi) 1988-12-13

Similar Documents

Publication Publication Date Title
FI884051L (fi) Menetelmä stabiloitujen humaaniproteiinivalmisteiden valmistamiseksi
FI882746A7 (fi) Hybridiproteiini C ja menetelmä sen valmistamiseksi.
FI864654L (fi) Menetelmä modifioidun ihmisen t-PA-proteiinin valmistamiseksi
FI90346C (fi) Menetelmä terapeuttisesti käyttökelpoisten nor-statiini- ja nor-syklostatiinipolypeptidien valmistamiseksi
FI885816L (fi) Menetelmä taikinan parantamiseksi
FI881743L (fi) Menetelmä bifunktionaalisten proteiinien valmistamiseksi
DK299087D0 (da) Proteins and derivatives thereof
NO172447C (no) Fremgangsmaate for fremstilling av b-avermectiner
FI861662L (fi) Menetelmä liuenneen valkuaisaineen immobilisoimiseksi
FI893724A7 (fi) Hybridiproteiini C:n rakenteet ja menetelmät niiden valmistamiseksi
DK275788D0 (da) Protein
FI881303A7 (fi) Menetelmä ibuprofeenin valmistamiseksi
FI875518L (fi) Menetelmä kudosproteiini PP4:n puhdistamiseksi
FI884885A7 (fi) Menetelmä esineiden liittämiseksi
FI871522L (fi) Menetelmä proteiinien renaturoimiseksi
FI891129A7 (fi) Menetelmä buteeni-I:n valmistamiseksi
FI885692L (fi) Karboksimetyylisulfoetyyliselluloosa ja menetelmä sen valmistamiseksi
FI885942L (fi) Propoksibentseenijohdannaisia ja menetelmä niiden valmistamiseksi
NO164392C (no) Fremgangsmaate for forbedring av hydrolysert protein.
FI885154A7 (fi) Sialosyyliglyserolipidejä ja menetelmä niiden valmistamiseksi
FI893545A7 (fi) Ihmisen proteiini C:n mutantteja ja menetelmä niiden valmistamiseksi
FI900550A7 (fi) Hybridiproteiineja
FI904357A7 (fi) Menetelmä proteiinin C aktivoimiseksi
DK345087D0 (da) Protein
GB8701160D0 (en) Hybrid proteins

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920313

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19930930