PT87944A - Processo para a preparacao de compostos 2-amino-5-hidroxi-4-pirimidonas - Google Patents

Processo para a preparacao de compostos 2-amino-5-hidroxi-4-pirimidonas

Info

Publication number: PT87944A
Authority: PT; Portugal
Prior art keywords: substituted; phenylalkyl; phenyl; alkyl; substituents
Prior art date: 1987-07-09

Application number

PT87944A

Other languages

English (en)

Other versions

PT87944B (pt

Inventor

Frederick J Walker

Brian T O'neill

John Lawrence La Mattina

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-09

Filing date

1988-07-08

Publication date

1989-06-30

1988-07-08 Application filed by Pfizer filed Critical Pfizer

1989-06-30 Publication of PT87944A publication Critical patent/PT87944A/pt

1995-03-01 Publication of PT87944B publication Critical patent/PT87944B/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
125000003884 phenylalkyl group Chemical group 0.000 abstract 7
125000005936 piperidyl group Chemical group 0.000 abstract 3
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000001309 chloro group Chemical group Cl* 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000006732 (C1-C15) alkyl group Chemical group 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000000172 allergic effect Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
150000002617 leukotrienes Chemical class 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
230000002685 pulmonary effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Hydrogenated Pyridines (AREA)

PT87944A 1987-07-09 1988-07-08 Processo para a preparacao de compostos 2-amino-5-hidroxi-4-pirimidonas PT87944B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1987/001608 WO1989000423A1 (en)	1987-07-09	1987-07-09	2-amino-5-hydroxy-4-pyrimidones

Publications (2)

Publication Number	Publication Date
PT87944A true PT87944A (pt)	1989-06-30
PT87944B PT87944B (pt)	1995-03-01

Family

ID=22202454

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87944A PT87944B (pt)	1987-07-09	1988-07-08	Processo para a preparacao de compostos 2-amino-5-hidroxi-4-pirimidonas

Country Status (12)

Country	Link
EP (1)	EP0303348B1 (pt)
JP (1)	JPH0629264B2 (pt)
AT (1)	ATE71370T1 (pt)
CA (1)	CA1310642C (pt)
DE (1)	DE3867563D1 (pt)
DK (1)	DK381188A (pt)
ES (1)	ES2037833T3 (pt)
FI (1)	FI883285A7 (pt)
GR (1)	GR3003908T3 (pt)
IE (1)	IE60210B1 (pt)
PT (1)	PT87944B (pt)
WO (1)	WO1989000423A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201111705D0 (en) *	2011-07-07	2011-08-24	Takeda Pharmaceutical	Compounds and their use
JO3115B1 (ar)	2011-08-22	2017-09-20	Takeda Pharmaceuticals Co	مركبات بيريدازينون واستخدامها كمثبطات daao
EP2773207B1 (en)	2011-10-31	2018-03-07	Merck Sharp & Dohme Corp.	Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
AP2014007637A0 (en)	2011-11-15	2014-05-31	Takeda Pharmaceutical	Dihydroxy aromatic heterocyclic compound
GB201222711D0 (en)	2012-12-17	2013-01-30	Takeda Pharmaceutical	Novel compounds
US12479816B2 (en)	2019-02-08	2025-11-25	University of Pittsburgh—of the Commonwealth System of Higher Education	20-HETE formation inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB756189A (en)	1954-02-01	1956-08-29	Ici Ltd	New pyrimidine derivatives
US4153793A (en) *	1973-05-03	1979-05-08	Smith Kline & French Laboratories Limited	Imidazo alkylamino pyrimidones
IN153791B (pt) *	1979-03-10	1984-08-18	Soc D Etudes Prod Chimique
FR2503162A1 (fr)	1981-04-07	1982-10-08	Pharmindustrie	Nouveaux derives de piperazino-2 pyrimidine, procedes pour leur preparation et leur utilisation comme medicaments ou comme intermediaires pour la fabrication de medicaments
US4554276A (en) *	1983-10-03	1985-11-19	Pfizer Inc.	2-Amino-5-hydroxy-4-methylpyrimidine derivatives
GB8421427D0 (en)	1984-08-23	1984-09-26	Smith Kline French Lab	Chemical compounds
DE3436380A1 (de) *	1984-10-04	1986-04-10	Bayer Ag, 5090 Leverkusen	Selektiv-fungizide mittel auf pyrimidin-derivat-basis
JPS61205260A (ja) *	1985-03-08	1986-09-11	Zeria Shinyaku Kogyo Kk	新規な２−置換アミノ−６−（２−メトキシフエニ−ル）−４（３ｈ）−ピリミドン誘導体及びその製造法

1987
- 1987-07-09 WO PCT/US1987/001608 patent/WO1989000423A1/en not_active Ceased
1988
- 1988-07-01 AT AT88306000T patent/ATE71370T1/de not_active IP Right Cessation
- 1988-07-01 ES ES198888306000T patent/ES2037833T3/es not_active Expired - Lifetime
- 1988-07-01 DE DE8888306000T patent/DE3867563D1/de not_active Expired - Lifetime
- 1988-07-01 EP EP88306000A patent/EP0303348B1/en not_active Expired - Lifetime
- 1988-07-05 JP JP63167638A patent/JPH0629264B2/ja not_active Expired - Lifetime
- 1988-07-07 CA CA000571374A patent/CA1310642C/en not_active Expired - Lifetime
- 1988-07-08 IE IE210788A patent/IE60210B1/en not_active IP Right Cessation
- 1988-07-08 PT PT87944A patent/PT87944B/pt not_active IP Right Cessation
- 1988-07-08 DK DK381188A patent/DK381188A/da not_active Application Discontinuation
- 1988-07-08 FI FI883285A patent/FI883285A7/fi not_active IP Right Cessation
1992
- 1992-02-27 GR GR920400321T patent/GR3003908T3/el unknown

Also Published As

Publication number	Publication date
IE60210B1 (en)	1994-06-15
PT87944B (pt)	1995-03-01
JPH0629264B2 (ja)	1994-04-20
DE3867563D1 (en)	1992-02-20
DK381188D0 (da)	1988-07-08
IE882107L (en)	1989-01-09
ATE71370T1 (de)	1992-01-15
WO1989000423A1 (en)	1989-01-26
ES2037833T3 (es)	1993-07-01
EP0303348B1 (en)	1992-01-08
FI883285A0 (fi)	1988-07-08
CA1310642C (en)	1992-11-24
GR3003908T3 (pt)	1993-03-16
FI883285A7 (fi)	1989-01-10
EP0303348A1 (en)	1989-02-15
DK381188A (da)	1989-02-21
JPS6429367A (en)	1989-01-31

Legal Events

Date

Code

Title

Description

1995-03-01

FG3A

Patent granted, date of granting

Effective date: 19940818

1996-06-28

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960229

Publication	Publication Date	Title
ATE117295T1 (de)	1995-02-15	4-oxochinolin-3-carbonsäure-derivate, ihre herstellung und ihre verwendung.
DK160877C (da)	1991-10-14	Fremgangsmaade til fremstilling af 2-penemforbindelser
FI904327A0 (fi)	1990-09-03	N-substituerad-4-pyrimidinaminer och -pyrimidindiaminer, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
FI892787A0 (fi)	1989-06-07	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-indolyylialkyyli-4-(substituoitu pyridinyyli)piperatsiinien valmistamiseksi
ATE103592T1 (de)	1994-04-15	Carbamoylpyrrolidonderivate, ihre verwendung und herstellung.
BR8403068A (pt)	1985-05-28	Compostos,processo para sua preparacao,composicoes farmaceuticas e uso dos ditos compostos
EP0632031A4 (pt)	1995-02-08
PT94297A (pt)	1991-02-08	Processo para a preparacao de n-hetero-aril-purin-6-aminas e de composicoes farmaceuticas que as contem
SE8802412L (sv)	1988-12-31	Tiokarbamidderivat
ATE86860T1 (de)	1993-04-15	Praeparat gegen ulcus.
ATE71370T1 (de)	1992-01-15	2-amino-5-hydroxy-4-pyrimidone.
HUT43787A (en)	1987-12-28	Process for production of medical compounds decreasing blood-pressure
DK0462933T3 (da)	1994-08-15	Hidtil ukendte N-benzyl-N1-phenyl og -phenylalkyl-thiourinstoffer
ATE149494T1 (de)	1997-03-15	Benzopyranderivate und verfahren zu deren herstellung
ES516553A0 (es)	1983-06-16	Procedimiento para preparar nuevos derivados de etenilimidazol.
PT89064A (pt)	1988-12-01	Processo para a preparacao de compostos piperidinil-1,4-dissubstituidos com accao analgesica e miorrelaxante
DE69110219D1 (de)	1995-07-13	3-(1H-Indazol-3-yl)-4-pyridiname, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
EP0230018A3 (en)	1988-06-15	Pyrethroide, process for their preparation and their use in combatting parasites as well as precursors for the preparation of these pyrethroids
ATE110367T1 (de)	1994-09-15	Kalziumantagonisten.
ES435670A1 (es)	1977-05-01	Un procedimiento para la preparacion de compuestos de acido xantona-carboxilico sustituidos.
FI932911L (fi)	1993-06-23	2,5-diatsabisyklo/2,2,1/heptaanijohdannaisia