PT88420A - Process for the preparation of pharmaceutical compositions containing 1-(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)-5-ethyluracil and a method for treating hepatitis virus infections by using said compositions - Google Patents

Process for the preparation of pharmaceutical compositions containing 1-(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)-5-ethyluracil and a method for treating hepatitis virus infections by using said compositions

Info

Publication number
PT88420A
PT88420A PT88420A PT8842088A PT88420A PT 88420 A PT88420 A PT 88420A PT 88420 A PT88420 A PT 88420A PT 8842088 A PT8842088 A PT 8842088A PT 88420 A PT88420 A PT 88420A
Authority
PT
Portugal
Prior art keywords
ethyluracyl
arabinofuranosyl
deoxy
fluoro
beta
Prior art date
Application number
PT88420A
Other languages
English (en)
Other versions
PT88420B (pt
Inventor
Jack J Fox
Kyoichi A Watanabe
Carlos Lopez
Christian G Trepo
Original Assignee
Sloan Kettering Inst Cancer
Inst Nat Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Inst Cancer, Inst Nat Sante filed Critical Sloan Kettering Inst Cancer
Publication of PT88420A publication Critical patent/PT88420A/pt
Publication of PT88420B publication Critical patent/PT88420B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PT88420A 1987-09-03 1988-09-02 Processo para a preparacao de composicoes farmaceuticas compreendendo 1-(2'-desoxi-2'-fluoro- beta -d-arabinofuranosil)-5-etiluracilo e metodo de tratamento de infeccoes pelo virus da hepatite utilizando estas composicoes PT88420B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9244687A 1987-09-03 1987-09-03

Publications (2)

Publication Number Publication Date
PT88420A true PT88420A (pt) 1989-07-31
PT88420B PT88420B (pt) 1993-12-31

Family

ID=22233256

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88420A PT88420B (pt) 1987-09-03 1988-09-02 Processo para a preparacao de composicoes farmaceuticas compreendendo 1-(2'-desoxi-2'-fluoro- beta -d-arabinofuranosil)-5-etiluracilo e metodo de tratamento de infeccoes pelo virus da hepatite utilizando estas composicoes

Country Status (10)

Country Link
EP (1) EP0338042B1 (pt)
JP (1) JPH02500524A (pt)
KR (1) KR970011386B1 (pt)
AU (1) AU2487688A (pt)
CA (1) CA1328865C (pt)
DE (1) DE3885090T2 (pt)
ES (1) ES2014042A6 (pt)
IL (1) IL87646A (pt)
PT (1) PT88420B (pt)
WO (1) WO1989001776A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
RU2235724C2 (ru) * 1992-02-12 2004-09-10 Эмори Юниверсити Способы разделения смеси энантиомеров
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
KR100719606B1 (ko) * 1998-02-25 2007-05-17 에모리 유니버시티 2'-플루오로뉴클레오사이드
KR20090089922A (ko) * 2000-10-18 2009-08-24 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211733A (en) * 1978-12-26 1980-07-08 Chang Shih Chih Gas-liquid mixing process and apparatus
US4666892A (en) * 1984-03-06 1987-05-19 Sloan-Kettering Memorial Cancer Center Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
AU575918B2 (en) * 1984-03-06 1988-08-11 Sloan-Kettering Institute For Cancer Research Hepatitis treatment with pyrimidine nucleoside compounds

Also Published As

Publication number Publication date
DE3885090D1 (de) 1993-11-25
EP0338042A1 (en) 1989-10-25
WO1989001776A1 (en) 1989-03-09
EP0338042A4 (en) 1990-09-26
KR890701112A (ko) 1989-12-19
PT88420B (pt) 1993-12-31
CA1328865C (en) 1994-04-26
DE3885090T2 (de) 1994-05-11
JPH02500524A (ja) 1990-02-22
IL87646A (en) 1994-07-31
EP0338042B1 (en) 1993-10-20
KR970011386B1 (ko) 1997-07-10
ES2014042A6 (es) 1990-06-16
AU2487688A (en) 1989-03-31

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19930621

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19981231