PT88643A - Method for the preparation of non-nucleotide reagents to subst itution terminal of oligonucleotides - Google Patents

Method for the preparation of non-nucleotide reagents to subst itution terminal of oligonucleotides

Info

Publication number: PT88643A
Authority: PT; Portugal
Prior art keywords: oligonucleotides; preparation; terminal; nucleotide reagents; itution
Prior art date: 1987-10-02

Application number

PT88643A

Other languages

English (en)

Other versions

PT88643B (pt

Inventor

Lyle John Arnold

Ram Saroop Bhatt

Original Assignee

Ml Technology Ventures

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-02

Filing date

1988-09-30

Publication date

1988-10-01

1988-09-30 Application filed by Ml Technology Ventures filed Critical Ml Technology Ventures

1988-10-01 Publication of PT88643A publication Critical patent/PT88643A/pt

1992-12-31 Publication of PT88643B publication Critical patent/PT88643B/pt

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
239000003153 chemical reaction reagent Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000002773 nucleotide Substances 0.000 title 1
238000006467 substitution reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Physics & Mathematics (AREA)
Immunology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

PT88643A 1987-10-02 1988-09-30 Metodo para a preparacao de reagentes nao nucleotidicos para a substituicao terminal de oligonucleotideos PT88643B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10433087A	1987-10-02	1987-10-02

Publications (2)

Publication Number	Publication Date
PT88643A true PT88643A (pt)	1988-10-01
PT88643B PT88643B (pt)	1992-12-31

Family

ID=22299923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT88643A PT88643B (pt)	1987-10-02	1988-09-30	Metodo para a preparacao de reagentes nao nucleotidicos para a substituicao terminal de oligonucleotideos

Country Status (8)

Country	Link
EP (1)	EP0310312A3 (pt)
JP (1)	JPH02502284A (pt)
KR (1)	KR890701767A (pt)
AU (1)	AU2608388A (pt)
DK (1)	DK267789A (pt)
FI (1)	FI892691A0 (pt)
PT (1)	PT88643B (pt)
WO (1)	WO1989002933A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT88665B (pt) *	1987-10-05	1992-12-31	Ml Tecnology Ventures Lp	Metodo para a marcacao com ester de acridinio e purificacao de sondas nucleotidicas
US5324829A (en) *	1988-12-16	1994-06-28	Ortho Diagnostic Systems, Inc.	High specific activity nucleic acid probes having target recognition and signal generating moieties
EP0602524A1 (de) *	1992-12-15	1994-06-22	Hoechst Aktiengesellschaft	Chemilumineszenzmarkierte Gensonden und ihre Verwendung in Gensondentesten
DE19534122A1 (de) *	1995-09-14	1997-03-20	Behringwerke Ag	Homogener Gensondentest mit einem gegen das Label gerichteten Rezeptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4500707A (en) *	1980-02-29	1985-02-19	University Patents, Inc.	Nucleosides useful in the preparation of polynucleotides
US4762779A (en) *	1985-06-13	1988-08-09	Amgen Inc.	Compositions and methods for functionalizing nucleic acids
US4757141A (en) *	1985-08-26	1988-07-12	Applied Biosystems, Incorporated	Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US4855225A (en) *	1986-02-07	1989-08-08	Applied Biosystems, Inc.	Method of detecting electrophoretically separated oligonucleotides
IL86164A0 (en) *	1987-04-28	1988-11-15	Tamir Biotechnology Ltd	Improved dna probes

1988
- 1988-09-23 EP EP88308877A patent/EP0310312A3/en not_active Withdrawn
- 1988-09-26 JP JP63508671A patent/JPH02502284A/ja active Pending
- 1988-09-26 KR KR1019890700983A patent/KR890701767A/ko not_active Withdrawn
- 1988-09-26 WO PCT/US1988/003275 patent/WO1989002933A1/en not_active Ceased
- 1988-09-26 AU AU26083/88A patent/AU2608388A/en not_active Abandoned
- 1988-09-30 PT PT88643A patent/PT88643B/pt not_active IP Right Cessation
1989
- 1989-06-01 DK DK267789A patent/DK267789A/da not_active Application Discontinuation
- 1989-06-01 FI FI892691A patent/FI892691A0/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
JPH02502284A (ja)	1990-07-26
WO1989002933A1 (en)	1989-04-06
DK267789A (da)	1989-08-01
EP0310312A3 (en)	1990-08-16
EP0310312A2 (en)	1989-04-05
PT88643B (pt)	1992-12-31
FI892691A7 (fi)	1989-06-01
AU2608388A (en)	1989-04-18
DK267789D0 (da)	1989-06-01
KR890701767A (ko)	1989-12-21
FI892691A0 (fi)	1989-06-01

Legal Events

Date

Code

Title

Description

1992-12-31

FG3A

Patent granted, date of granting

Effective date: 19920616

1994-05-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19931231

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PT88643A (pt)	1988-10-01	Method for the preparation of non-nucleotide reagents to subst itution terminal of oligonucleotides
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