PT88964A - Processo de preparacao de compostos de quinoxalina e de composicoes farmaceuticas que os contem - Google Patents

Processo de preparacao de compostos de quinoxalina e de composicoes farmaceuticas que os contem

Info

Publication number: PT88964A
Authority: PT; Portugal
Prior art keywords: alkyl; halogen; hydrogen; compounds; pharmaceutical compositions
Prior art date: 1987-11-10

Application number

PT88964A

Other languages

English (en)

Other versions

PT88964B (pt

Inventor

Tage Honore

Poul Jacobsen

Flemming Elmelund Nielsen

Lars Naerum

Original Assignee

Ferrosan As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-10

Filing date

1988-11-09

Publication date

1988-12-01

1987-11-10 Priority claimed from DK586287A external-priority patent/DK586287D0/da

1988-03-16 Priority claimed from DK142288A external-priority patent/DK142288D0/da

1988-11-09 Application filed by Ferrosan As filed Critical Ferrosan As

1988-12-01 Publication of PT88964A publication Critical patent/PT88964A/pt

1993-02-26 Publication of PT88964B publication Critical patent/PT88964B/pt

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical class N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
229910052736 halogen Inorganic materials 0.000 abstract 6
150000002367 halogens Chemical class 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
150000002431 hydrogen Chemical class 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 3
-1 Heterocyclic dihydroxyquinoxaline compounds Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
102000003678 AMPA Receptors Human genes 0.000 abstract 1
108090000078 AMPA Receptors Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001408 amides Chemical group 0.000 abstract 1
150000001412 amines Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001733 carboxylic acid esters Chemical group 0.000 abstract 1
230000002964 excitative effect Effects 0.000 abstract 1
208000013403 hyperactivity Diseases 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
239000002858 neurotransmitter agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT88964A 1987-11-10 1988-11-09 Processo de preparacao de compostos de quinoxalina e de composicoes farmaceuticas que os contem PT88964B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK586287A DK586287D0 (da)	1987-11-10	1987-11-10	Quinoxalinforbindelser, deres fremstilling og anvendelse
DK142288A DK142288D0 (da)	1988-03-16	1988-03-16	Quinoxalinforbindelser, deres fremstilling og anvendelse

Publications (2)

Publication Number	Publication Date
PT88964A true PT88964A (pt)	1988-12-01
PT88964B PT88964B (pt)	1993-02-26

Family

ID=26065733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT88964A PT88964B (pt)	1987-11-10	1988-11-09	Processo de preparacao de compostos de quinoxalina e de composicoes farmaceuticas que os contem

Country Status (16)

Country	Link
US (2)	US4948794A (pt)
EP (1)	EP0315959B1 (pt)
JP (1)	JP2721520B2 (pt)
KR (1)	KR970011279B1 (pt)
AT (1)	ATE102192T1 (pt)
AU (1)	AU618766B2 (pt)
CA (1)	CA1321587C (pt)
DE (1)	DE3888093T2 (pt)
ES (1)	ES2061606T3 (pt)
FI (1)	FI100181B (pt)
IE (1)	IE64320B1 (pt)
IL (1)	IL88155A0 (pt)
NO (2)	NO179551C (pt)
NZ (1)	NZ226916A (pt)
PH (1)	PH25103A (pt)
PT (1)	PT88964B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO179551C (no) *	1987-11-10	1996-10-30	Novo Nordisk As	Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
DK716188D0 (da) *	1988-12-22	1988-12-22	Ferrosan As	Quinoxalinforbindelser, deres fremstilling og anvendelse
DK715888D0 (da) *	1988-12-22	1988-12-22	Ferrosan As	Quinoxalinforbindelser, deres fremstilling og anvendelse
DK69790D0 (da) *	1990-03-16	1990-03-16	Novo Nordisk As	Heterocykliske forbindelser, deres fremstilling af anvendelse
HU221425B (en) *	1990-11-06	2002-10-28	Yamanouchi Pharma Co Ltd	Condensed pyrazine derivatives, process for their production and pharmaceutical preparations containing these compounds
PT99864B (pt)	1990-12-21	1999-06-30	Schering Ag	Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato
DK73091D0 (da) *	1991-04-22	1991-04-22	Novo Nordisk As	Quinoxalinforbindelser, deres fremstilling og anvendelse
US5196421A (en) *	1991-06-05	1993-03-23	Eli Lilly And Company	Excitatory amino acid receptor antagonists in methods for the use thereof
US5153196A (en) *	1991-06-05	1992-10-06	Eli Lilly And Company	Excitatory amino acid receptor antagonists and methods for the use thereof
DK177191D0 (da) *	1991-10-23	1991-10-23	Novo Nordisk As	Heterocyclic compounds and their preparation and use
PT101004B (pt) *	1991-10-26	1999-10-29	Schering Ag	Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem
US6057304A (en)	1992-10-26	2000-05-02	Schering Aktiengesellschaft	Quinoxaline-phosphonic acid derivatives
DE4217952A1 (de) *	1992-05-30	1993-12-02	Basf Ag	Chinoxalin-2,3(1H,4H)-dione
EP0647137B1 (en) *	1992-06-22	2008-08-13	The Regents Of The University Of California	Glycine receptor antagonists and the use thereof
FR2696466B1 (fr) *	1992-10-02	1994-11-25	Rhone Poulenc Rorer Sa	Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.
DK12293D0 (da) *	1993-02-02	1993-02-02	Novo Nordisk As	Heterocykliske forbindelser og deres fremstilling og anvendelse
IL109397A0 (en) *	1993-04-28	1994-07-31	Schering Ag	Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
DE4314592A1 (de) *	1993-04-28	1994-11-03	Schering Ag	Benzo(f)chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
US5631373A (en) *	1993-11-05	1997-05-20	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon	Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
DE4340045A1 (de) *	1993-11-24	1995-06-01	Basf Ag	Neue Chinoxaline und Arzneimittel daraus
AU688459B2 (en) *	1994-04-08	1998-03-12	Shionogi & Co., Ltd.	Oxopyridinylquinoxaline derivative
DE4428152A1 (de) *	1994-06-22	1996-01-04	Basf Ag	Neue Amido-chinoxalindione, ihrer Herstellung und Verwendung
US5597922A (en) *	1994-07-29	1997-01-28	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Glycine receptor antagonist pharmacophore
DE4436852A1 (de) *	1994-10-14	1996-04-18	Basf Ag	Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung
DE19521058A1 (de) *	1995-06-09	1996-12-12	Basf Ag	Verfahren zur Herstellung von Aromaten enthaltenden Polyetherpolyolen
DE19545251A1 (de) *	1995-11-24	1997-05-28	Schering Ag	Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19624808A1 (de)	1996-06-21	1998-01-02	Basf Ag	Pyrrolylchinoxalindione, ihre Herstellung und Verwendung
CA2269807C (en) *	1996-10-24	2007-04-10	Novartis Ag	Substituted aminoalkanephosphonic acids
US5922715A (en) *	1997-02-18	1999-07-13	American Home Products Corporation	5-aminoalkoxy-1, 4-dihydroquinoxaline-2, 3-diones
HUP0001311A3 (en) *	1997-02-18	2001-07-30	American Home Products Corp Ma	5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists and pharmaceutical compositions containing them
JP4707261B2 (ja) *	2001-05-15	2011-06-22	日本エンバイロケミカルズ株式会社	キノキサリン系化合物および工業用殺菌組成物
JP2007500245A (ja) *	2003-06-10	2007-01-11	スミスクラインビーチャムコーポレーション	化合物
EP2338492A1 (en)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Methods and compositions for the treatment of alzheimer
WO2012014910A1 (ja)	2010-07-29	2012-02-02	日本ケミファ株式会社	Ｐ２ｘ４受容体拮抗剤
EP3427729A1 (en)	2017-07-13	2019-01-16	Paris Sciences et Lettres - Quartier Latin	Probenecid for use in treating epileptic diseases, disorders or conditions
US10890033B1 (en)	2017-12-10	2021-01-12	Watson, Incorporated	Kelly bar with locking feature, related system and method
US11939302B2 (en) *	2020-10-21	2024-03-26	The Governors Of The University Of Alberta	Compounds for the treatment of Alzheimer's disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3431111A (en) *	1963-06-10	1969-03-04	Eastman Kodak Co	Cyanine dyes
US3992378A (en) *	1973-12-26	1976-11-16	Eli Lilly And Company	Fluoralkyl quinoxadinediones
EP0008864A1 (en) *	1978-08-15	1980-03-19	FISONS plc	Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them
EP0030795A3 (en) *	1979-12-06	1981-09-09	Imperial Chemical Industries Plc	Quinoxaline derivatives, processes therefor, pharmaceutical compositions, and benzene derivatives
DE3165028D1 (de) *	1980-05-09	1984-08-30	Usv Pharma Corp	Triazaloquinoxalin-1,4-diones
US4659713A (en) *	1984-10-01	1987-04-21	International Minerals & Chemical Corp.	Quinoxalinedione compounds useful for controlling coccidiosis
US4812458A (en) *	1986-09-16	1989-03-14	A/S Ferrosan	6,7-disubstituted-2,3-dihydroxyquinoxaline compounds, pharmaceutical compositions thereof, and their use as neuroleptics
DK146787A (da) *	1987-03-23	1988-09-24	Ferrosan	Heterocykliske forbindelser, deres fremstilling og anvendelse
NO179551C (no) *	1987-11-10	1996-10-30	Novo Nordisk As	Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser

1988
- 1988-10-24 NO NO884729A patent/NO179551C/no not_active IP Right Cessation
- 1988-10-25 IL IL88155A patent/IL88155A0/xx not_active IP Right Cessation
- 1988-10-25 IE IE320988A patent/IE64320B1/en not_active IP Right Cessation
- 1988-11-02 PH PH37764A patent/PH25103A/en unknown
- 1988-11-03 CA CA000582104A patent/CA1321587C/en not_active Expired - Fee Related
- 1988-11-08 DE DE3888093T patent/DE3888093T2/de not_active Expired - Fee Related
- 1988-11-08 ES ES88118592T patent/ES2061606T3/es not_active Expired - Lifetime
- 1988-11-08 EP EP88118592A patent/EP0315959B1/en not_active Expired - Lifetime
- 1988-11-08 US US07/268,939 patent/US4948794A/en not_active Expired - Lifetime
- 1988-11-08 AT AT88118592T patent/ATE102192T1/de not_active IP Right Cessation
- 1988-11-09 FI FI885151A patent/FI100181B/fi not_active IP Right Cessation
- 1988-11-09 AU AU24949/88A patent/AU618766B2/en not_active Ceased
- 1988-11-09 NZ NZ226916A patent/NZ226916A/xx unknown
- 1988-11-09 PT PT88964A patent/PT88964B/pt active IP Right Grant
- 1988-11-10 JP JP63282621A patent/JP2721520B2/ja not_active Expired - Lifetime
- 1988-11-10 KR KR1019880014744A patent/KR970011279B1/ko not_active Expired - Fee Related
1989
- 1989-12-26 US US07/456,325 patent/US5026704A/en not_active Expired - Fee Related
1996
- 1996-08-15 NO NO963412A patent/NO307252B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI885151A7 (fi)	1989-05-11
PH25103A (en)	1991-02-19
JPH01153680A (ja)	1989-06-15
IE64320B1 (en)	1995-07-26
IL88155A0 (en)	1989-06-30
NO884729D0 (no)	1988-10-24
NO307252B1 (no)	2000-03-06
NZ226916A (en)	1991-01-29
PT88964B (pt)	1993-02-26
ES2061606T3 (es)	1994-12-16
US4948794A (en)	1990-08-14
ATE102192T1 (de)	1994-03-15
FI100181B (fi)	1997-10-15
KR970011279B1 (ko)	1997-07-09
EP0315959A3 (en)	1989-12-27
AU2494988A (en)	1989-05-11
JP2721520B2 (ja)	1998-03-04
IE883209L (en)	1989-05-10
AU618766B2 (en)	1992-01-09
DE3888093T2 (de)	1994-06-09
FI885151A0 (fi)	1988-11-09
US5026704A (en)	1991-06-25
DE3888093D1 (de)	1994-04-07
KR890008113A (ko)	1989-07-08
EP0315959A2 (en)	1989-05-17
NO884729L (no)	1989-05-11
NO179551C (no)	1996-10-30
NO179551B (no)	1996-07-22
EP0315959B1 (en)	1994-03-02
NO963412L (no)	1989-05-11
CA1321587C (en)	1993-08-24

Legal Events

Date	Code	Title	Description
1993-02-26	FG3A	Patent granted, date of granting	Effective date: 19920820

Publication	Publication Date	Title
PT88964A (pt)	1988-12-01	Processo de preparacao de compostos de quinoxalina e de composicoes farmaceuticas que os contem
PT92717A (pt)	1990-06-29	Processo de preparacao de compostos de heterociclicos derivados da quinoxalina e de composicoes farmaceuticas que os contem
PT92714A (pt)	1990-06-29	Processo de preparacao de compostos de quinoxalina e de composicoes farmaceuticas que os contem
SE8406585D0 (sv)	1984-12-21	Benzoic acid derivatives
FI92582B (fi)	1994-08-31	Menetelmä uusien terapeuttisesti käyttökelpoisten kinoksaliinijohdannaisten valmistamiseksi
PT86836A (pt)	1988-03-01	Method for the preparation of indanes dihydrobenzofuranes dihydrobenzothiophenes and indolines
DE3883456D1 (de)	1993-09-30	Verfahren zur Herstellung von substituierten Indolinonderivaten.
FI873790A0 (fi)	1987-09-01	Kinoxalinfoereningar och deras framstaellning och anvaendning.
ATE125795T1 (de)	1995-08-15	Isatinderivate, ihre herstellung und verwendung.
SE7605204L (sv)	1976-11-08	Neuroleptika
ATE50247T1 (de)	1990-02-15	Herstellung von substituierten und nichtsubstituierten 2-carbamoylderivaten von nikotinsaeure und chinolin-3-carboxylsaeure.
DK620688A (da)	1989-05-11	Quinoxalinforbindelser, deres fremstilling og anvendelse
PT82593B (pt)	1988-03-03	Processo de preparacao da oxadiazolil-imidazobenzodiazepina e das composicoes farmaceuticas que a contem
AT353990B (de)	1979-12-10	Verfahren zur herstellung neuer substituierter prostaglandin-derivate, deren racemischen gemischen und enantiomeren