PT89955A - Processo para a preparacao de acidos 1-ciclopropil-quinolonocarboxilicos e seus derivados, e de n-ciclopropilanilinas utilizadas nesse processo - Google Patents

Processo para a preparacao de acidos 1-ciclopropil-quinolonocarboxilicos e seus derivados, e de n-ciclopropilanilinas utilizadas nesse processo

Info

Publication number
PT89955A
PT89955A PT89955A PT8995589A PT89955A PT 89955 A PT89955 A PT 89955A PT 89955 A PT89955 A PT 89955A PT 8995589 A PT8995589 A PT 8995589A PT 89955 A PT89955 A PT 89955A
Authority
PT
Portugal
Prior art keywords
quinolonocarboxylic
cyclopopilanilins
cyclopropyl
derivatives
acids
Prior art date
Application number
PT89955A
Other languages
English (en)
Inventor
Uwe Petersen
Michael Schriewer
Klaus Grohe
Andreas Krebs
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PT89955A publication Critical patent/PT89955A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT89955A 1988-03-11 1989-03-09 Processo para a preparacao de acidos 1-ciclopropil-quinolonocarboxilicos e seus derivados, e de n-ciclopropilanilinas utilizadas nesse processo PT89955A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3808117A DE3808117A1 (de) 1988-03-11 1988-03-11 N-cyclopropylaniline und deren verwendung in verfahren zur herstellung von 1-cyclopropyl-chinoloncarbonsaeuren und deren derivaten

Publications (1)

Publication Number Publication Date
PT89955A true PT89955A (pt) 1989-11-10

Family

ID=6349470

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89955A PT89955A (pt) 1988-03-11 1989-03-09 Processo para a preparacao de acidos 1-ciclopropil-quinolonocarboxilicos e seus derivados, e de n-ciclopropilanilinas utilizadas nesse processo

Country Status (9)

Country Link
EP (1) EP0332033A2 (pt)
JP (1) JPH024778A (pt)
KR (1) KR890014486A (pt)
CN (1) CN1037147A (pt)
DE (1) DE3808117A1 (pt)
FI (1) FI891122A7 (pt)
HU (1) HUT50781A (pt)
IL (1) IL89534A0 (pt)
PT (1) PT89955A (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2046091B1 (es) * 1991-09-24 1994-09-01 Elmuquimica Farm Sl Nuevo procedimiento de obtencion del acido 1-ciclopropil-6-fluoro-1,4-dihidro-4-oxo-7-(1-piperacinil)-3-quinolin carboxilico.
ES2050613B1 (es) * 1992-10-16 1996-03-16 Iteve S A Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico.
HUT67395A (en) * 1993-07-13 1995-04-28 Somfai Method for the n-cyclopropylation of primary and secondary aromatic amines
DE19720541A1 (de) 1997-05-16 1998-11-19 Bayer Ag Verfahren zur kontinuierlichen Herstellung von Dihydroxydiphenylalkanen
DE19720540A1 (de) 1997-05-16 1998-11-19 Bayer Ag Verfahren zur Aufarbeitung von Mutterlaugen aus der Bisphenolsynthese
JP2000229946A (ja) * 1998-12-10 2000-08-22 Toyama Chem Co Ltd キノロンカルボン酸の製造法およびその中間体
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CN101891680B (zh) 2004-06-24 2014-10-29 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
DK3219705T3 (da) 2005-12-28 2020-04-14 Vertex Pharma Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
EP2370411A4 (en) * 2008-12-05 2012-10-24 Univ Oregon Health & Science COMPOUNDS HAVING ANTIPARASITIC OR ANTI-INFECTIOUS ACTIVITY
US8598354B2 (en) 2008-12-05 2013-12-03 University Of South Florida Compounds having antiparasitic or anti-infectious activity
KR101727762B1 (ko) 2009-03-20 2017-04-17 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
JP2015511583A (ja) 2012-02-27 2015-04-20 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 薬学的組成物およびその投与
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶

Also Published As

Publication number Publication date
FI891122L (fi) 1989-09-12
EP0332033A2 (de) 1989-09-13
CN1037147A (zh) 1989-11-15
FI891122A0 (fi) 1989-03-09
JPH024778A (ja) 1990-01-09
IL89534A0 (en) 1989-09-10
KR890014486A (ko) 1989-10-24
FI891122A7 (fi) 1989-09-12
HUT50781A (en) 1990-03-28
DE3808117A1 (de) 1989-09-21

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Legal Events

Date Code Title Description
FC3A Refusal

Effective date: 19940408