PT90362A - Metodo para o tratamento de doencas muco-epiteliais e da pele em mamiferos que utiliza acidos 4-quinolinocarboxilicos e seus derivados e processo para a preparacao de composicoes farmaceuticas que contem os mesmos compostos - Google Patents

Metodo para o tratamento de doencas muco-epiteliais e da pele em mamiferos que utiliza acidos 4-quinolinocarboxilicos e seus derivados e processo para a preparacao de composicoes farmaceuticas que contem os mesmos compostos

Info

Publication number: PT90362A
Authority: PT; Portugal
Prior art keywords: muco; derivatives; treatment; acids; epithelial
Prior art date: 1988-04-26

Application number

PT90362A

Other languages

English (en)

Other versions

PT90362B (pt

Inventor

Richard Russell Harris

Neil Richard Ackerman

Scott Edward Loveless

Russell Howard Neubauer

Original Assignee

Du Pont Merck Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-26

Filing date

1989-04-24

Publication date

1989-11-10

1989-04-24 Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma

1989-11-10 Publication of PT90362A publication Critical patent/PT90362A/pt

1994-07-29 Publication of PT90362B publication Critical patent/PT90362B/pt

Links

239000002253 acid Substances 0.000 title 2
238000000034 method Methods 0.000 title 2
241000124008 Mammalia Species 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
208000017520 skin disease Diseases 0.000 title 1
JIPUGCBCIYYRSB-UHFFFAOYSA-N 3-phenylquinoline-2-carboxylic acid Chemical class OC(=O)C1=NC2=CC=CC=C2C=C1C1=CC=CC=C1 JIPUGCBCIYYRSB-UHFFFAOYSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PT90362A 1988-04-26 1989-04-24 Metodo para o tratamento de doencas muco-epiteliais e da pele em mamiferos que utiliza acidos 4-quinolinocarboxilicos e seus derivados e processo para a preparacao de composicoes farmaceuticas que contem os mesmos compostos PT90362B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/186,242 US4861783A (en)	1988-04-26	1988-04-26	4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases

Publications (2)

Publication Number	Publication Date
PT90362A true PT90362A (pt)	1989-11-10
PT90362B PT90362B (pt)	1994-07-29

Family

ID=22684175

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT90362A PT90362B (pt)	1988-04-26	1989-04-24	Metodo para o tratamento de doencas muco-epiteliais e da pele em mamiferos que utiliza acidos 4-quinolinocarboxilicos e seus derivados e processo para a preparacao de composicoes farmaceuticas que contem os mesmos compostos

Country Status (16)

Country	Link
US (1)	US4861783A (pt)
EP (1)	EP0339484B1 (pt)
JP (1)	JP2650756B2 (pt)
KR (1)	KR0124817B1 (pt)
AT (1)	ATE84716T1 (pt)
AU (1)	AU610469B2 (pt)
CA (1)	CA1336263C (pt)
DE (1)	DE68904462T2 (pt)
DK (1)	DK199789A (pt)
ES (1)	ES2053856T3 (pt)
IE (1)	IE64285B1 (pt)
IL (1)	IL90056A (pt)
MY (1)	MY104006A (pt)
NZ (1)	NZ228894A (pt)
PT (1)	PT90362B (pt)
ZA (1)	ZA893086B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5102883A (en) *	1989-10-31	1992-04-07	Du Pont Merck Pharmaceutical Company	Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents
US5204329A (en) *	1990-06-11	1993-04-20	Du Pont Merck Pharmaceutical Company	Treatment of organ transplantation rejection
US5135934A (en) *	1990-07-06	1992-08-04	Du Pont Merck Pharmaceutical Company	3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5281196A (en) *	1992-05-22	1994-01-25	Sultenfuss Thomas J	Skin treatment composition and method of use
US5409886A (en) *	1993-02-18	1995-04-25	Mitsui Toatsu Chemicals, Incorporated	3-pyrroline-2-one derivatives and herbicidal compositions containing same
US5578609A (en) *	1994-03-25	1996-11-26	The Dupont Merck Pharmaceutical Company	2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents
US6103905A (en) *	1997-06-19	2000-08-15	Sepracor, Inc.	Quinoline-indole antimicrobial agents, uses and compositions related thereto
AU757059B2 (en)	1997-06-19	2003-01-30	Sepracor, Inc.	Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en)	1997-06-19	2001-03-27	Sepracor, Inc.	Antimicrobial agents uses and compositions related thereto
US6376670B1 (en)	1997-06-19	2002-04-23	Sepracor Inc.	Quinoline-indole antimicrobial agents, uses and compositions related thereto
CA2591399C (en) *	2004-12-13	2014-05-20	Ono Pharmaceutical Co., Ltd.	Aminocarboxylic acid derivative and medicinal use thereof
CA3153463A1 (en)	2012-10-29	2014-05-08	The University Of North Carolina At Chapel Hill	Methods and compositions for treating mucosal tissue disorders
WO2015077535A2 (en)	2013-11-22	2015-05-28	Genzyme Corporation	Novel methods for treating neurodegenerative diseases
CN110198728A (zh)	2016-11-17	2019-09-03	莱诺翁股份有限公司	用谷胱甘肽组合物治疗呼吸道疾病和感染
CN111615395B (zh)	2017-11-17	2024-08-06	莱诺翁股份有限公司	稳定的抗坏血酸组合物及其使用方法
KR20240131358A (ko)	2022-01-04	2024-08-30	레노비온, 아이엔씨.	글루타치온 염을 포함하는 수용액

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4181725A (en) *	1977-05-02	1980-01-01	The Regents Of The University Of Michigan	Method for alleviating psoriasis
US4680299A (en) *	1984-04-30	1987-07-14	E.I. Du Pont De Nemours And Company	2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
DE3483704D1 (de) *	1983-07-22	1991-01-17	Du Pont	Phenylchinolinsaeure und derivate als antitumormittel.
US4889862A (en) *	1986-08-28	1989-12-26	E. I. Du Pont De Nemours And Company	Freeze-dried pharmaceutical compositions of phenylquinoline carboxylic acids

1988
- 1988-04-26 US US07/186,242 patent/US4861783A/en not_active Expired - Fee Related
1989
- 1989-04-20 EP EP89107098A patent/EP0339484B1/en not_active Expired - Lifetime
- 1989-04-20 AT AT89107098T patent/ATE84716T1/de not_active IP Right Cessation
- 1989-04-20 DE DE8989107098T patent/DE68904462T2/de not_active Expired - Fee Related
- 1989-04-20 ES ES89107098T patent/ES2053856T3/es not_active Expired - Lifetime
- 1989-04-21 CA CA000597449A patent/CA1336263C/en not_active Expired - Fee Related
- 1989-04-24 AU AU33318/89A patent/AU610469B2/en not_active Ceased
- 1989-04-24 PT PT90362A patent/PT90362B/pt not_active IP Right Cessation
- 1989-04-24 IL IL90056A patent/IL90056A/xx not_active IP Right Cessation
- 1989-04-25 DK DK199789A patent/DK199789A/da not_active Application Discontinuation
- 1989-04-25 JP JP1103585A patent/JP2650756B2/ja not_active Expired - Lifetime
- 1989-04-25 IE IE132989A patent/IE64285B1/en not_active IP Right Cessation
- 1989-04-25 KR KR1019890005406A patent/KR0124817B1/ko not_active Expired - Fee Related
- 1989-04-26 NZ NZ228894A patent/NZ228894A/en unknown
- 1989-04-26 MY MYPI89000546A patent/MY104006A/en unknown
- 1989-04-26 ZA ZA893086A patent/ZA893086B/xx unknown

Also Published As

Publication number	Publication date
DK199789D0 (da)	1989-04-25
ZA893086B (en)	1990-12-28
PT90362B (pt)	1994-07-29
KR900016135A (ko)	1990-11-12
CA1336263C (en)	1995-07-11
NZ228894A (en)	1992-02-25
IL90056A (en)	1993-04-04
DK199789A (da)	1989-10-27
IL90056A0 (en)	1989-12-15
DE68904462D1 (de)	1993-03-04
MY104006A (en)	1993-10-30
EP0339484A1 (en)	1989-11-02
JPH0272163A (ja)	1990-03-12
US4861783A (en)	1989-08-29
IE891329L (en)	1989-10-26
AU3331889A (en)	1989-11-02
KR0124817B1 (ko)	1997-11-25
JP2650756B2 (ja)	1997-09-03
IE64285B1 (en)	1995-07-26
DE68904462T2 (de)	1993-05-13
ATE84716T1 (de)	1993-02-15
EP0339484B1 (en)	1993-01-20
AU610469B2 (en)	1991-05-16
ES2053856T3 (es)	1994-08-01

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Legal Events

Date

Code

Title

Description

1994-07-29

FG3A

Patent granted, date of granting

Effective date: 19940107

1999-11-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19990731