PT90743A - Processo para a preparacao de derivados de hirudina com accao retardada e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de derivados de hirudina com accao retardada e de composicoes farmaceuticas que os contem

Info

Publication number: PT90743A
Authority: PT; Portugal
Prior art keywords: preparation; derivatives; hydrudine; pharmaceutical compositions; compositions containing
Prior art date: 1988-06-04

Application number

PT90743A

Other languages

English (en)

Other versions

PT90743B (pt

Inventor

Paul Habermann

Klaus Sauber

Dominique Tripier

Peter Crause

Martin Kramer

Rainer Obermeier

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-04

Filing date

1989-06-02

Publication date

1989-12-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6355879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT90743(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-06-02 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-12-29 Publication of PT90743A publication Critical patent/PT90743A/pt

1994-10-31 Publication of PT90743B publication Critical patent/PT90743B/pt

Links

230000003111 delayed effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical class C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 2
102000007625 Hirudins Human genes 0.000 abstract 1
108010007267 Hirudins Proteins 0.000 abstract 1
101000712605 Theromyzon tessulatum Theromin Proteins 0.000 abstract 1
229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
229940006607 hirudin Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000003868 thrombin inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PT90743A 1988-06-04 1989-06-02 Processo para a preparacao de derivados de hirudina com accao retardada e de composicoes farmaceuticas que os contem PT90743B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3819079A DE3819079A1 (de)	1988-06-04	1988-06-04	Hirudin-derivate mit verzoegerter wirkung

Publications (2)

Publication Number	Publication Date
PT90743A true PT90743A (pt)	1989-12-29
PT90743B PT90743B (pt)	1994-10-31

Family

ID=6355879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT90743A PT90743B (pt)	1988-06-04	1989-06-02	Processo para a preparacao de derivados de hirudina com accao retardada e de composicoes farmaceuticas que os contem

Country Status (21)

Country	Link
US (1)	US5538946A (pt)
EP (1)	EP0345616B1 (pt)
JP (1)	JP2804514B2 (pt)
KR (1)	KR0140884B1 (pt)
AT (1)	ATE130315T1 (pt)
AU (1)	AU625215B2 (pt)
CA (1)	CA1340197C (pt)
CY (1)	CY2025A (pt)
DE (2)	DE3819079A1 (pt)
DK (1)	DK175103B1 (pt)
ES (1)	ES2080732T3 (pt)
FI (1)	FI98703C (pt)
GR (1)	GR3018364T3 (pt)
HK (1)	HK1006024A1 (pt)
HU (1)	HU204851B (pt)
IE (1)	IE72201B1 (pt)
IL (1)	IL90507A0 (pt)
NO (1)	NO177312C (pt)
NZ (1)	NZ229402A (pt)
PT (1)	PT90743B (pt)
ZA (1)	ZA894180B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2000887A1 (en) *	1988-11-01	1990-05-01	Cecilia S.L. Ku	Thromboresistant materials and methods for making same
US5663141A (en) *	1989-12-01	1997-09-02	Basf Aktiengesellschaft	Hirudin/polyalkylene glycol conjugates and hirudin muteins
JP2975632B2 (ja) *	1990-03-30	1999-11-10	生化学工業株式会社	グリコサミノグリカン修飾プロテイン
GB2247239A (en) *	1990-08-22	1992-02-26	Ciba Geigy Ag	Hirudin conjugates with polyoxyethylene
DE4041185A1 (de) *	1990-12-21	1992-06-25	Knoll Ag	Verwendung von hirudin und dessen muteinen zur kombinationsbehandlung von tumoren
DE4437502A1 (de) *	1993-12-02	1995-06-08	Basf Ag	Hirudin-Konjugate aus Hirudin und lipophilen Verbindungen
DE4342154A1 (de) *	1993-12-10	1995-06-14	Behringwerke Ag	Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
DE19533817C2 (de) *	1995-09-13	1999-12-09	Max Planck Gesellschaft	Komplex-gebundene Hemmstoffe aktivierbarer Stoffwechselenzyme als molekulare Marker zur Diagnostik und Therapieüberwachung
US7045585B2 (en)	1995-11-30	2006-05-16	Hamilton Civic Hospital Research Development Inc.	Methods of coating a device using anti-thrombin heparin
US6491965B1 (en)	1995-11-30	2002-12-10	Hamilton Civic Hospitals Research Development, Inc.	Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6562781B1 (en)	1995-11-30	2003-05-13	Hamilton Civic Hospitals Research Development Inc.	Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US5856452A (en)	1996-12-16	1999-01-05	Sembiosys Genetics Inc.	Oil bodies and associated proteins as affinity matrices
DE19915862A1 (de) *	1999-04-08	2000-10-12	Max Planck Gesellschaft	Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie
US6809076B2 (en) *	2000-03-20	2004-10-26	Abbott Gmbh & Co. Kg	Use of anticoagulant agents in the extracorporeal treatment of blood
US6818392B2 (en)	2000-12-06	2004-11-16	Abbott Laboratories	Monoclonal antibodies to human immunodeficiency virus and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55500091A (pt) *	1978-02-17	1980-02-14
DE2930542A1 (de) *	1979-07-27	1981-02-12	Hoechst Ag	Neue insulinderivate und verfahren zu ihrer herstellung
DE3586333T2 (de) *	1984-03-27	1992-12-10	Transgene Sa	Expressionsvektoren fuer hirudin, transformierte zellen und verfahren zur herstellung von hirudin.
US4666884A (en) *	1984-04-10	1987-05-19	New England Deaconess Hospital	Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3583361D1 (de) *	1984-06-14	1991-08-08	Ucp Gen Pharma Ag	Verfahren zur herstellung von thrombin-inhibitoren.
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3500268A1 (de) *	1985-01-05	1986-07-10	Hoechst Ag, 6230 Frankfurt	Praeparate mit verzoegerter wirkung, verfahren zu deren herstellung sowie entsprechende mittel zur human- bzw. veterinaermedizinischen anwendung
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
EP0209061B1 (de) *	1985-07-17	1994-01-12	Hoechst Aktiengesellschaft	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
DE3541856A1 (de) *	1985-11-27	1987-06-04	Hoechst Ag	Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens

1988
- 1988-06-04 DE DE3819079A patent/DE3819079A1/de not_active Withdrawn
1989
- 1989-05-30 DE DE58909493T patent/DE58909493D1/de not_active Expired - Lifetime
- 1989-05-30 EP EP89109772A patent/EP0345616B1/de not_active Expired - Lifetime
- 1989-05-30 AT AT89109772T patent/ATE130315T1/de not_active IP Right Cessation
- 1989-05-30 ES ES89109772T patent/ES2080732T3/es not_active Expired - Lifetime
- 1989-06-01 HU HU892808A patent/HU204851B/hu unknown
- 1989-06-01 FI FI892686A patent/FI98703C/fi active IP Right Grant
- 1989-06-01 AU AU35955/89A patent/AU625215B2/en not_active Expired
- 1989-06-02 CA CA000601593A patent/CA1340197C/en not_active Expired - Lifetime
- 1989-06-02 KR KR1019890007560A patent/KR0140884B1/ko not_active Expired - Lifetime
- 1989-06-02 NZ NZ229402A patent/NZ229402A/en unknown
- 1989-06-02 JP JP1139378A patent/JP2804514B2/ja not_active Expired - Lifetime
- 1989-06-02 DK DK198902707A patent/DK175103B1/da not_active IP Right Cessation
- 1989-06-02 NO NO892267A patent/NO177312C/no not_active IP Right Cessation
- 1989-06-02 PT PT90743A patent/PT90743B/pt not_active IP Right Cessation
- 1989-06-02 ZA ZA894180A patent/ZA894180B/xx unknown
- 1989-06-02 IL IL90507A patent/IL90507A0/xx unknown
- 1989-06-12 IE IE181589A patent/IE72201B1/en not_active IP Right Cessation
1992
- 1992-06-05 US US07/895,436 patent/US5538946A/en not_active Expired - Lifetime
1995
- 1995-12-12 GR GR950403492T patent/GR3018364T3/el unknown
1998
- 1998-02-20 CY CY202598A patent/CY2025A/xx unknown
- 1998-06-11 HK HK98105201A patent/HK1006024A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU204851B (en)	1992-02-28
NO177312B (no)	1995-05-15
NO892267D0 (no)	1989-06-02
HK1006024A1 (en)	1999-02-05
US5538946A (en)	1996-07-23
DK270789D0 (da)	1989-06-02
NO892267L (no)	1989-12-05
IE891815L (en)	1989-12-04
ZA894180B (en)	1990-02-28
KR910001041A (ko)	1991-01-30
PT90743B (pt)	1994-10-31
FI892686A0 (fi)	1989-06-01
ES2080732T3 (es)	1996-02-16
DE3819079A1 (de)	1989-12-07
DK270789A (da)	1989-12-05
IE72201B1 (en)	1997-04-09
EP0345616A2 (de)	1989-12-13
CA1340197C (en)	1998-12-15
DE58909493D1 (de)	1995-12-21
HUT51298A (en)	1990-04-28
IL90507A0 (en)	1990-01-18
EP0345616B1 (de)	1995-11-15
ATE130315T1 (de)	1995-12-15
GR3018364T3 (en)	1996-03-31
JPH0267300A (ja)	1990-03-07
FI892686L (fi)	1989-12-05
EP0345616A3 (de)	1991-03-20
FI98703C (fi)	1997-08-11
AU625215B2 (en)	1992-07-02
NZ229402A (en)	1992-05-26
CY2025A (en)	1998-02-20
JP2804514B2 (ja)	1998-09-30
DK175103B1 (da)	2004-06-01
AU3595589A (en)	1989-12-07
KR0140884B1 (ko)	1998-06-15
FI98703B (fi)	1997-04-30
NO177312C (no)	1995-08-23

Legal Events

Date

Code

Title

Description

1994-10-31

FG3A

Patent granted, date of granting

Effective date: 19940412

2001-06-29

PC3A

Transfer or assignment

Free format text: 20010322 AVENTIS PHARMA DEUTSCHLAND GMBH DE

2009-06-12

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090602

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