PT90792A - Processo para a preparacao de composicoes farmaceuticas apresentando boa estabilidade, particularmente adaptado a composicoes farmaceuticas contendo a pravastatina - Google Patents

Processo para a preparacao de composicoes farmaceuticas apresentando boa estabilidade, particularmente adaptado a composicoes farmaceuticas contendo a pravastatina

Info

Publication number: PT90792A
Authority: PT; Portugal
Prior art keywords: compsn; amt; corn starch; present; disintegrants
Prior art date: 1989-06-08

Application number

PT9079289A

Other languages

English (en)

Other versions

PT90792B (pt

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-08

Filing date

1989-06-08

Publication date

1991-02-08

1989-06-08 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1989-06-08 Priority to PT9079289A priority Critical patent/PT90792B/pt

1991-02-08 Publication of PT90792A publication Critical patent/PT90792A/pt

1995-05-04 Publication of PT90792B publication Critical patent/PT90792B/pt

Links

239000002610 basifying agent Substances 0.000 title abstract 3
239000011230 binding agent Substances 0.000 title abstract 3
239000007884 disintegrant Substances 0.000 title abstract 3
239000000945 filler Substances 0.000 title abstract 3
239000006185 dispersion Substances 0.000 title abstract 2
239000000314 lubricant Substances 0.000 title abstract 2
TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title 1
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title 1
229960002965 pravastatin Drugs 0.000 title 1
229920002261 Corn starch Polymers 0.000 abstract 3
229920000168 Microcrystalline cellulose Polymers 0.000 abstract 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
239000008120 corn starch Substances 0.000 abstract 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 3
239000008108 microcrystalline cellulose Substances 0.000 abstract 3
235000019813 microcrystalline cellulose Nutrition 0.000 abstract 3
229940016286 microcrystalline cellulose Drugs 0.000 abstract 3
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 abstract 2
CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical group [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 2
229920000881 Modified starch Polymers 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
239000008101 lactose Substances 0.000 abstract 2
-1 spermacoti Polymers 0.000 abstract 2
235000000346 sugar Nutrition 0.000 abstract 2
244000215068 Acacia senegal Species 0.000 abstract 1
235000006491 Acacia senegal Nutrition 0.000 abstract 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 abstract 1
229920002785 Croscarmellose sodium Polymers 0.000 abstract 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
229920000084 Gum arabic Polymers 0.000 abstract 1
229930195725 Mannitol Natural products 0.000 abstract 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
239000004698 Polyethylene Substances 0.000 abstract 1
235000010489 acacia gum Nutrition 0.000 abstract 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract 1
229910021502 aluminium hydroxide Inorganic materials 0.000 abstract 1
JIFPTBLGXRKRAO-UHFFFAOYSA-K aluminum;magnesium;hydroxide;sulfate Chemical compound [OH-].[Mg+2].[Al+3].[O-]S([O-])(=O)=O JIFPTBLGXRKRAO-UHFFFAOYSA-K 0.000 abstract 1
235000011114 ammonium hydroxide Nutrition 0.000 abstract 1
235000010216 calcium carbonate Nutrition 0.000 abstract 1
229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
239000000920 calcium hydroxide Substances 0.000 abstract 1
235000011116 calcium hydroxide Nutrition 0.000 abstract 1
229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
235000013869 carnauba wax Nutrition 0.000 abstract 1
239000004203 carnauba wax Substances 0.000 abstract 1
229940099112 cornstarch Drugs 0.000 abstract 1
229960001681 croscarmellose sodium Drugs 0.000 abstract 1
229960000913 crospovidone Drugs 0.000 abstract 1
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 abstract 1
229910001679 gibbsite Inorganic materials 0.000 abstract 1
229960004018 magaldrate Drugs 0.000 abstract 1
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 abstract 1
239000000347 magnesium hydroxide Substances 0.000 abstract 1
235000012254 magnesium hydroxide Nutrition 0.000 abstract 1
229910001862 magnesium hydroxide Inorganic materials 0.000 abstract 1
235000012245 magnesium oxide Nutrition 0.000 abstract 1
239000000395 magnesium oxide Substances 0.000 abstract 1
239000000594 mannitol Substances 0.000 abstract 1
235000010355 mannitol Nutrition 0.000 abstract 1
239000004200 microcrystalline wax Substances 0.000 abstract 1
235000019808 microcrystalline wax Nutrition 0.000 abstract 1
239000012188 paraffin wax Substances 0.000 abstract 1
229920000573 polyethylene Polymers 0.000 abstract 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 abstract 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 abstract 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
235000011118 potassium hydroxide Nutrition 0.000 abstract 1
235000011121 sodium hydroxide Nutrition 0.000 abstract 1
229920003109 sodium starch glycolate Polymers 0.000 abstract 1
229940079832 sodium starch glycolate Drugs 0.000 abstract 1
239000008109 sodium starch glycolate Substances 0.000 abstract 1
239000000600 sorbitol Substances 0.000 abstract 1
150000008163 sugars Chemical class 0.000 abstract 1
239000002023 wood Substances 0.000 abstract 1

Landscapes

Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT9079289A 1989-06-08 1989-06-08 Processo para a preparacao de composicoes farmaceuticas apresentando boa estabilidade, particularmente adaptado a composicoes farmaceuticas contendo a pravastatina PT90792B (pt)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
PT9079289A PT90792B (pt)	1989-06-08	1989-06-08	Processo para a preparacao de composicoes farmaceuticas apresentando boa estabilidade, particularmente adaptado a composicoes farmaceuticas contendo a pravastatina

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PT9079289A PT90792B (pt)	1989-06-08	1989-06-08	Processo para a preparacao de composicoes farmaceuticas apresentando boa estabilidade, particularmente adaptado a composicoes farmaceuticas contendo a pravastatina

Publications (2)

Publication Number	Publication Date
PT90792A true PT90792A (pt)	1991-02-08
PT90792B PT90792B (pt)	1995-05-04

Family

ID=20084502

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT9079289A PT90792B (pt)	1989-06-08	1989-06-08	Processo para a preparacao de composicoes farmaceuticas apresentando boa estabilidade, particularmente adaptado a composicoes farmaceuticas contendo a pravastatina

Country Status (1)

Country	Link
PT (1)	PT90792B (pt)

1989
- 1989-06-08 PT PT9079289A patent/PT90792B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT90792B (pt)	1995-05-04

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Legal Events

Date

Code

Title

Description

1995-05-04

FG3A

Patent granted, date of granting

Effective date: 19941003

2009-10-14

MM4A

Annulment/lapse due to non-payment of fees;searched & examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20091003