PT91101A - Processo de preparacao de derivados lipidos de nucleosidos antivirais, de suspensoes de lipossomas e de composicoes farmaceuticas - Google Patents

Processo de preparacao de derivados lipidos de nucleosidos antivirais, de suspensoes de lipossomas e de composicoes farmaceuticas

Info

Publication number: PT91101A
Authority: PT; Portugal
Prior art keywords: nucleoside; antiviral; compounds; liposomes; group
Prior art date: 1988-07-07

Application number

PT9110189A

Other languages

English (en)

Other versions

PT91101B (pt

Inventor

Karl Y Hostetler

Raj Kumar

Louise M Stuhmiller

Original Assignee

Peretz Glikfeld

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-07

Filing date

1989-07-07

Publication date

1990-02-08

1989-03-06 Priority claimed from US07/319,483 external-priority patent/US4884863A/en

1989-07-07 Application filed by Peretz Glikfeld filed Critical Peretz Glikfeld

1990-02-08 Publication of PT91101A publication Critical patent/PT91101A/pt

1995-01-31 Publication of PT91101B publication Critical patent/PT91101B/pt

Links

230000000840 anti-viral effect Effects 0.000 title abstract 6
239000002502 liposome Substances 0.000 title abstract 5
239000002777 nucleoside Substances 0.000 title abstract 5
150000002632 lipids Chemical class 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
125000003835 nucleoside group Chemical group 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title 1
239000000725 suspension Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
229940127073 nucleoside analogue Drugs 0.000 abstract 5
125000001805 pentosyl group Chemical group 0.000 abstract 4
150000003904 phospholipids Chemical class 0.000 abstract 3
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
QXKAIJAYHKCRRA-BXXZVTAOSA-N D-ribonic acid Chemical group OC[C@@H](O)[C@@H](O)[C@@H](O)C(O)=O QXKAIJAYHKCRRA-BXXZVTAOSA-N 0.000 abstract 2
239000003443 antiviral agent Substances 0.000 abstract 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
FTSFSHHUBPYPIE-UHFFFAOYSA-N 5-(azidomethyl)-1h-pyrimidine-2,4-dione Chemical compound [N-]=[N+]=NCC1=CNC(=O)NC1=O FTSFSHHUBPYPIE-UHFFFAOYSA-N 0.000 abstract 1
208000030507 AIDS Diseases 0.000 abstract 1
229930024421 Adenine Natural products 0.000 abstract 1
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
229930186217 Glycolipid Natural products 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 1
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
108010067390 Viral Proteins Proteins 0.000 abstract 1
208000036142 Viral infection Diseases 0.000 abstract 1
MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 abstract 1
229960004150 aciclovir Drugs 0.000 abstract 1
229960000643 adenine Drugs 0.000 abstract 1
229940124522 antiretrovirals Drugs 0.000 abstract 1
239000003903 antiretrovirus agent Substances 0.000 abstract 1
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
125000000089 arabinosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)CO1)* 0.000 abstract 1
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
229940104302 cytosine Drugs 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
238000001647 drug administration Methods 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
230000003834 intracellular effect Effects 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
125000003473 lipid group Chemical group 0.000 abstract 1
210000002540 macrophage Anatomy 0.000 abstract 1
210000001616 monocyte Anatomy 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
230000010076 replication Effects 0.000 abstract 1
230000000717 retained effect Effects 0.000 abstract 1
230000001177 retroviral effect Effects 0.000 abstract 1
150000003408 sphingolipids Chemical class 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

PT9110189A 1988-07-07 1989-07-07 Processo de preparacao de derivados lipidos de nucleosidos antivirais, de suspensoes de lipossomas e de composicoes farmaceuticas PT91101B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US21641288A	1988-07-07	1988-07-07
US07/319,483 US4884863A (en)	1989-03-06	1989-03-06	Optical fiber splicing enclosure for installation in pedestals

Publications (2)

Publication Number	Publication Date
PT91101A true PT91101A (pt)	1990-02-08
PT91101B PT91101B (pt)	1995-01-31

Family

ID=26910992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT9110189A PT91101B (pt)	1988-07-07	1989-07-07	Processo de preparacao de derivados lipidos de nucleosidos antivirais, de suspensoes de lipossomas e de composicoes farmaceuticas

Country Status (1)

Country	Link
PT (1)	PT91101B (pt)

1989
- 1989-07-07 PT PT9110189A patent/PT91101B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT91101B (pt)	1995-01-31

Legal Events

Date	Code	Title	Description
1995-01-31	FG3A	Patent granted, date of granting	Effective date: 19940721
1995-03-31	PC3A	Transfer or assignment	Free format text: 940906 VESTAR, INC. US
1997-06-30	PC3A	Transfer or assignment	Free format text: 970306 NEXSTAR PHARMACEUTICALS, INC. US
2001-12-28	PC3A	Transfer or assignment	Free format text: 20010912 CHIMERIX, INC. US
2009-07-28	MM4A	Annulment/lapse due to non-payment of fees;searched & examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20090721

Publication	Publication Date	Title
EP0350287A3 (en)	1990-08-01	Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use
US6448392B1 (en)	2002-09-10	Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US5194654A (en)	1993-03-16	Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
US5744461A (en)	1998-04-28	Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
KR100568035B1 (ko)	2006-04-07	Ｂ형 간염의 치료용 β-Ｌ-2'-데옥시-뉴클레오시드
US6599887B2 (en)	2003-07-29	Methods of treating viral infections using antiviral liponucleotides
JP2007056033A (ja)	2007-03-08	ウィルス感染を治療するための脂質アナログ
US6252060B1 (en)	2001-06-26	Antiviral liponucleosides: treatment of hepatitis B
CA2112803A1 (en)	1993-01-21	Antiviral liponucleosides: treatment of hepatitis b
WO1994001138A1 (en)	1994-01-20	Covalent polar lipid-peptide conjugates for biological targeting
US5817638A (en)	1998-10-06	Antiviral liponucleosides: treatment of hepatitis B
KR100632520B1 (ko)	2006-10-09	Β 형 간염 바이러스를 치료하기 위한 복합 요법
Jia et al.	2024	Antiviral activity of lipophilic nucleoside tetraphosphate compounds
IE83237B1 (en)		Lipid derivatives of antiviral nucleosides, lipsomal incorporation and method of use
PT91101B (pt)	1995-01-31	Processo de preparacao de derivados lipidos de nucleosidos antivirais, de suspensoes de lipossomas e de composicoes farmaceuticas