PT93947A - Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem

Info

Publication number: PT93947A
Authority: PT; Portugal
Prior art keywords: maleinimids; pharmaceutical compositions; compositions containing; preparing new; new dentures
Prior art date: 1989-05-05

Application number

PT93947A

Other languages

English (en)

Other versions

PT93947B (pt

Inventor

Hans-Jurgen Betche

Hubert Barth

Johannes Hartenstein

Claus Rudolph

Christoph Schachtele

Hartmut Obwald

Reinhard Reck

Original Assignee

Goedecke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-05

Filing date

1990-05-03

Publication date

1991-01-08

1989-05-05 Priority claimed from DE3914764A external-priority patent/DE3914764A1/de

1989-12-27 Priority claimed from DE19893942991 external-priority patent/DE3942991A1/de

1990-05-03 Application filed by Goedecke Ag filed Critical Goedecke Ag

1991-01-08 Publication of PT93947A publication Critical patent/PT93947A/pt

1996-11-29 Publication of PT93947B publication Critical patent/PT93947B/pt

Links

238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
206010003210 Arteriosclerosis Diseases 0.000 abstract 1
DQYBRTASHMYDJG-UHFFFAOYSA-N Bisindolylmaleimide Chemical class C1=CC=C2C(C=3C(=O)NC(C=3C=3C4=CC=CC=C4NC=3)=O)=CNC2=C1 DQYBRTASHMYDJG-UHFFFAOYSA-N 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000003412 degenerative effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
208000019622 heart disease Diseases 0.000 abstract 1
210000000987 immune system Anatomy 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
208000019553 vascular disease Diseases 0.000 abstract 1
230000003612 virological effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Aerodynamic Tests, Hydrodynamic Tests, Wind Tunnels, And Water Tanks (AREA)
Image Processing (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)

PT93947A 1989-05-05 1990-05-03 Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem PT93947B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3914764A DE3914764A1 (de)	1989-05-05	1989-05-05	Maleinimid-derivate und deren verwendung als arzneimittel
DE19893942991 DE3942991A1 (de)	1989-12-27	1989-12-27	Maleinimid-derivate und deren verwendung als arzneimittel

Publications (2)

Publication Number	Publication Date
PT93947A true PT93947A (pt)	1991-01-08
PT93947B PT93947B (pt)	1996-11-29

Family

ID=25880591

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT93947A PT93947B (pt)	1989-05-05	1990-05-03	Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem

Country Status (16)

Country	Link
EP (1)	EP0397060B1 (pt)
JP (1)	JP2983248B2 (pt)
KR (1)	KR900018080A (pt)
AT (1)	ATE209202T1 (pt)
AU (1)	AU634541B2 (pt)
CA (1)	CA2015996C (pt)
DE (1)	DE59010927D1 (pt)
DK (1)	DK0397060T3 (pt)
ES (1)	ES2169719T3 (pt)
FI (1)	FI902251A7 (pt)
HU (1)	HU207727B (pt)
IL (1)	IL94274A0 (pt)
NO (1)	NO179748C (pt)
NZ (1)	NZ233560A (pt)
PT (1)	PT93947B (pt)
YU (1)	YU87990A (pt)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ280738B6 (cs) *	1988-02-10	1996-04-17	F. Hoffmann - La Roche And Co., Aktiengesellschaft	Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
DE4005970A1 (de) *	1990-02-26	1991-08-29	Boehringer Mannheim Gmbh	Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
CA2046801C (en) *	1990-08-07	2002-02-26	Peter D. Davis	Substituted pyrroles
US5292747A (en) *	1990-08-07	1994-03-08	Hoffman-La Roche Inc.	Substituted pyrroles
GB9123396D0 (en) *	1991-11-04	1991-12-18	Hoffmann La Roche	A process for the manufacture of substituted maleimides
WO1993018765A1 (en) *	1992-03-20	1993-09-30	The Wellcome Foundation Limited	Indole derivatives with antiviral activity
DE4243321A1 (de) *	1992-12-21	1994-06-23	Goedecke Ag	Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
US5405864A (en) *	1993-10-15	1995-04-11	Syntex (U.S.A.) Inc.	Chemotherapeutic maleimides
NO308798B1 (no) *	1993-12-07	2000-10-30	Lilly Co Eli	Proteinkinase-C-hemmere, anvendelse av samme for fremstilling av farmasøytika samt farmasøytisk formulering omfattende samme
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
US5843935A (en) *	1993-12-07	1998-12-01	Eli Lilly And Company	Protein kinase C inhibitors
DK0657411T3 (da) *	1993-12-07	1999-11-15	Lilly Co Eli	Forbedret syntese af bisindolylmaleimider
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
US5541347A (en) *	1993-12-07	1996-07-30	Eli Lilly And Company	Synthesis of bisindolylmaleimides
ES2236702T3 (es) *	1993-12-23	2005-07-16	Eli Lilly And Company	Inhibidores de la proteina quinasa c.
EP1264836B1 (en) *	1994-05-09	2004-12-01	Banyu Pharmaceutical Co., Ltd.	Processes for the preparation of indolopyrrolocarbazole derivatives
US5491242A (en) *	1994-06-22	1996-02-13	Eli Lilly And Company	Protein kinase C inhibitors
US5481003A (en) *	1994-06-22	1996-01-02	Eli Lilly And Company	Protein kinase C inhibitors
US5559228A (en) *	1995-03-30	1996-09-24	Eli Lilly And Company	Synthesis of bisindolylmaleimides
AU701659B2 (en) *	1995-11-20	1999-02-04	Eli Lilly And Company	Novel intermediates and their use to prepare n,n'-bridged bisindolylmaleimides
PE91698A1 (es) *	1996-07-29	1998-12-24	Hoffmann La Roche	Pirroles sustituidos
PE91498A1 (es) *	1996-07-29	1998-12-22	Hoffmann La Roche	Pirroles sustituidos
PE91598A1 (es) *	1996-07-29	1998-12-24	Hoffmann La Roche	Pirroles sustituidos
SE9603283D0 (sv) *	1996-09-10	1996-09-10	Astra Ab	New compounds
US5955462A (en) *	1996-10-31	1999-09-21	Harbor Branch Oceanographic Institution, Inc.	Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
AU2548699A (en) *	1998-02-23	1999-09-06	Rei Asakai	Cell death inhibitors
WO2000002857A1 (en)	1998-07-08	2000-01-20	Harbor Branch Oceanographic Institution, Inc.	Bis-indole derivatives and their use as antiinflammatory agents
AU2327700A (en)	1999-02-09	2000-08-29	Rei Asakai	Pyrrole derivatives and cell death inhibitors
US6281356B1 (en) *	1999-12-22	2001-08-28	Hoffmann-La Roche Inc.	Substituted pyrroles
CA2308994A1 (en) *	2000-05-19	2001-11-19	Aegera Therapeutics Inc.	Neuroprotective compounds
US7129250B2 (en)	2000-05-19	2006-10-31	Aegera Therapeutics Inc.	Neuroprotective and anti-proliferative compounds
DE10109280A1 (de) *	2001-02-26	2002-09-05	Peter Mayser	Indolderivate mit inhibitorischer Wirkung auf Proteinkinasen
TW201041580A (en)	2001-09-27	2010-12-01	Alcon Inc	Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
ES2269793T3 (es)	2001-10-30	2007-04-01	Novartis Ag	Derivados de estaurospina como inhibidores de la actividad de tirosina quinasa receptora flt3.
CA2393720C (en)	2002-07-12	2010-09-14	Eli Lilly And Company	Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
US20060217368A1 (en) *	2003-04-18	2006-09-28	Kyowa Hakko Kogyo Co., Ltd.	Drug for nerve regeneration
ATE486872T1 (de)	2005-02-09	2010-11-15	Arqule Inc	Maleimid-derivate, pharmazeutische zusammensetzungen und verfahren zur behandlung von krebs
AU2008268613A1 (en)	2007-06-22	2008-12-31	Arqule, Inc.	Quinazolinone compounds and methods of use thereof
EP2392574B1 (en)	2007-06-22	2013-12-18	ArQule, Inc.	Indolyl pyrrolidines for the treatment of cancer
WO2009002806A1 (en)	2007-06-22	2008-12-31	Arqule, Inc.	Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
WO2010144780A1 (en) *	2009-06-12	2010-12-16	University Of Kansas	Compositions and methods for establishing and maintaining stem cells in an undifferentiated state
JP2017524739A (ja)	2014-07-17	2017-08-31	アンセルムＩｎｓｅｒｍ	神経筋接合部関連疾患の処置方法
WO2016207366A1 (en)	2015-06-26	2016-12-29	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of viral infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4785085A (en) *	1986-11-21	1988-11-15	Bristol-Myers Company	Rebeccamycin analogs
CZ280738B6 (cs) *	1988-02-10	1996-04-17	F. Hoffmann - La Roche And Co., Aktiengesellschaft	Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi

1990
- 1990-05-03 CA CA002015996A patent/CA2015996C/en not_active Expired - Fee Related
- 1990-05-03 PT PT93947A patent/PT93947B/pt active IP Right Grant
- 1990-05-03 IL IL9094274A patent/IL94274A0/xx unknown
- 1990-05-04 NO NO901989A patent/NO179748C/no unknown
- 1990-05-04 YU YU87990A patent/YU87990A/sh unknown
- 1990-05-04 DK DK90108468T patent/DK0397060T3/da active
- 1990-05-04 AT AT90108468T patent/ATE209202T1/de not_active IP Right Cessation
- 1990-05-04 NZ NZ233560A patent/NZ233560A/xx unknown
- 1990-05-04 AU AU54666/90A patent/AU634541B2/en not_active Ceased
- 1990-05-04 KR KR1019900006359A patent/KR900018080A/ko not_active Withdrawn
- 1990-05-04 DE DE59010927T patent/DE59010927D1/de not_active Expired - Fee Related
- 1990-05-04 HU HU902681A patent/HU207727B/hu not_active IP Right Cessation
- 1990-05-04 EP EP90108468A patent/EP0397060B1/de not_active Expired - Lifetime
- 1990-05-04 ES ES90108468T patent/ES2169719T3/es not_active Expired - Lifetime
- 1990-05-04 FI FI902251A patent/FI902251A7/fi not_active Application Discontinuation
- 1990-05-07 JP JP2115916A patent/JP2983248B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO901989D0 (no)	1990-05-04
EP0397060A2 (de)	1990-11-14
AU5466690A (en)	1990-11-08
HU902681D0 (en)	1990-09-28
IL94274A0 (en)	1991-03-10
KR900018080A (ko)	1990-12-20
ATE209202T1 (de)	2001-12-15
ES2169719T3 (es)	2002-07-16
HU207727B (en)	1993-05-28
NO179748C (no)	1996-12-11
PT93947B (pt)	1996-11-29
EP0397060A3 (de)	1992-01-02
JPH02306974A (ja)	1990-12-20
NO179748B (no)	1996-09-02
JP2983248B2 (ja)	1999-11-29
NO901989L (no)	1990-11-06
CA2015996C (en)	2001-08-28
FI902251A0 (fi)	1990-05-04
NZ233560A (en)	1992-01-29
AU634541B2 (en)	1993-02-25
DK0397060T3 (da)	2002-05-21
HUT53902A (en)	1990-12-28
DE59010927D1 (de)	2002-01-03
EP0397060B1 (de)	2001-11-21
CA2015996A1 (en)	1990-11-05
YU87990A (sh)	1992-07-20
FI902251A7 (fi)	1990-11-06

Legal Events

Date	Code	Title	Description
1996-11-29	FG3A	Patent granted, date of granting	Effective date: 19960902

Publication	Publication Date	Title
PT93947A (pt)	1991-01-08	Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
PT91351A (pt)	1990-03-08	Processo para a preparacao de derivados de alcoxi-4-(1h)-piridona e de composicoes farmaceuticas que os contem
FI904204A0 (fi)	1990-08-24	Foerfarande foer framstaellning av cykliska aminosyraderivat och mellanprodukter.
PT96304A (pt)	1991-09-30	Processo para a preparacao de novos derivados de cromano e de tiocromano e de composicoes farmaceuticas que os contem
ATE140920T1 (de)	1996-08-15	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
MX163574B (es)	1992-06-02	Procedimiento para preparar una composicion farmaceutica para inhalacion conteniendo un gangliosido
ES8609312A1 (es)	1986-09-01	Procedimiento para la preparacion de silibinina exenta de isosilibina
GR920100570A (el)	1993-08-31	Παραγωγα 3(2η)-πυριδαζινονης και μεθοδος για την παρασκευη τους.
ES532322A0 (es)	1985-01-01	Procedimiento para preparar derivados de 4-oxo-tiazolidin-2-iliden-acetamida.
BG90414A (bg)	1993-12-24	2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им
PT92155A (pt)	1990-05-31	Processo para a preparacao de derivados de acidos 2-amino-carboxilicos e de composicoes farmaceuticas que os contem
ES8802506A1 (es)	1988-07-16	Procedimiento para preparar derivados de fluoralcanos.