PT94105A - Processo para a preparacao de (quinolin-2-il-metoxi)fenil-acil-sulfonamidas e -cianamidas substituidas uteis como madicamentos - Google Patents

Processo para a preparacao de (quinolin-2-il-metoxi)fenil-acil-sulfonamidas e -cianamidas substituidas uteis como madicamentos

Info

Publication number: PT94105A
Authority: PT; Portugal
Prior art keywords: quinolin; ylmethoxy; cianamides; methoxy; phenyl
Prior art date: 1989-05-23

Application number

PT94105A

Other languages

English (en)

Other versions

PT94105B (pt

Inventor

Siegfried Raddatz

Romanis Fruchtmann

Christian Kohlsdorfer

Reiner Muller-Peddinghaus

Pia Theisen-Popp

Klaus-Helmut Mohrs

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-23

Filing date

1990-05-21

Publication date

1991-01-08

1990-05-21 Application filed by Bayer Ag filed Critical Bayer Ag

1991-01-08 Publication of PT94105A publication Critical patent/PT94105A/pt

1996-11-29 Publication of PT94105B publication Critical patent/PT94105B/pt

Links

150000003456 sulfonamides Chemical class 0.000 title abstract 2
229940124530 sulfonamide Drugs 0.000 title 1
-1 quinolin-2-ylmethoxy Chemical group 0.000 abstract 5
NXTAUIVDUGDBKI-UHFFFAOYSA-N 2-(quinolin-2-ylmethoxy)benzoic acid Chemical class OC(=O)C1=CC=CC=C1OCC1=CC=C(C=CC=C2)C2=N1 NXTAUIVDUGDBKI-UHFFFAOYSA-N 0.000 abstract 1
239000000867 Lipoxygenase Inhibitor Substances 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
230000002862 amidating effect Effects 0.000 abstract 1
150000001912 cyanamides Chemical class 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

PT94105A 1989-05-23 1990-05-21 Processo para a preparacao de (quinolin-2-il-metoxi)fenil-acil-sulfonamidas e -cianamidas substituidas uteis como madicamentos PT94105B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3916663A DE3916663A1 (de)	1989-05-23	1989-05-23	Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
SG12695A SG12695G (en)	1989-05-23	1995-01-26	Substituted (quinoline-2-yl-methoxy) phenyl-acyl-sulphonamides and cyanamides process for their preparation and their use in medicines

Publications (2)

Publication Number	Publication Date
PT94105A true PT94105A (pt)	1991-01-08
PT94105B PT94105B (pt)	1996-11-29

Family

ID=25881158

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT94105A PT94105B (pt)	1989-05-23	1990-05-21	Processo para a preparacao de (quinolin-2-il-metoxi)fenil-acil-sulfonamidas e -cianamidas substituidas uteis como madicamentos

Country Status (18)

Country	Link
US (1)	US5091392A (pt)
EP (1)	EP0399291B1 (pt)
JP (1)	JP3004678B2 (pt)
KR (1)	KR100210214B1 (pt)
AT (1)	ATE108777T1 (pt)
AU (1)	AU627579B2 (pt)
CA (1)	CA2017135C (pt)
DD (1)	DD297961A5 (pt)
DE (2)	DE3916663A1 (pt)
DK (1)	DK0399291T3 (pt)
ES (1)	ES2056294T3 (pt)
HK (1)	HK33395A (pt)
HU (1)	HU215833B (pt)
IE (1)	IE63593B1 (pt)
IL (1)	IL94465A (pt)
PT (1)	PT94105B (pt)
SG (1)	SG12695G (pt)
ZA (1)	ZA903939B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5304563A (en) *	1991-02-22	1994-04-19	Bayer Aktiengesellschaft	2-substituted quinolines, and their use in medicaments
DE4139751A1 (de) *	1991-12-03	1993-06-09	Bayer Ag, 5090 Leverkusen, De	Thiazolyl substituierte chinolylmethoxyphenylessigsaeurederivate
DE4226649A1 (de) *	1992-08-12	1994-02-17	Bayer Ag	Neue isobutylsubstituierte Methansulfonyl-chinolylmethoxyphenyl-cycloalkylessigsäureaminole
DE4105551A1 (de) *	1991-02-22	1992-08-27	Bayer Ag	2-substituierte chinoline, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE4112533A1 (de) *	1991-04-17	1992-10-22	Bayer Ag	Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren
DE4125270A1 (de) *	1991-07-31	1993-02-04	Bayer Ag	Chinolin-2-yl-methoxybenzylhydroxyharnstoffe
DE4129742A1 (de) *	1991-09-06	1993-03-11	Bayer Ag	Heterocyclisch substituierte chinolylmethoxy-phenylacetamide
US5391555A (en) *	1991-11-12	1995-02-21	Miles Inc.	Methods for treating inflammatory bowel disease with leukotriene synthesis inhibitors
DE4139749A1 (de) *	1991-12-03	1993-06-09	Bayer Ag, 5090 Leverkusen, De	Chinolylmethoxyphenyl-essigsaeureamide
DE4139750A1 (de) *	1991-12-03	1993-06-09	Bayer Ag, 5090 Leverkusen, De	Chinolylmethoxyphenylessigsaeure-acylamide und -harnstoffe
CA2092152A1 (en) *	1992-03-23	1993-09-24	Azuma Igarashi	Phenoxyacetic acid compounds and medical preparations containing them
DE4215213A1 (de) *	1992-05-09	1993-11-11	Merck Patent Gmbh	Arylacetamide
DE4226519A1 (de) *	1992-08-11	1994-02-17	Bayer Ag	3-Substituierte Chinolylmethoxy-phenylessigsäurederivate
DE4235133A1 (de) *	1992-10-19	1994-04-21	Bayer Ag	Kristallines (R)-(-)-2-Cycloheptyl-N-methylsulfonyl-[4-(2-chinolinyl-methoxy)-phenyl]-acetamid
IL109431A (en) *	1993-05-14	2001-01-11	Warner Lambert Co	Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
US5491172A (en) *	1993-05-14	1996-02-13	Warner-Lambert Company	N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents
DE4443892A1 (de) *	1994-12-09	1996-06-13	Bayer Ag	4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
DE4443891A1 (de)	1994-12-09	1996-06-13	Bayer Ag	Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide
GB2356139A (en) *	1999-11-15	2001-05-16	Bayer Ag	Use of substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphonamides and cyanamides for the treatment of diseases
PE20050676A1 (es)	2003-12-12	2005-11-02	Wyeth Corp	Quinolinas referidas a enfermedades cardiovasculares
EP2636407A3 (en) *	2007-03-30	2013-11-06	Tioga Pharmaceuticals, Inc.	Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3682160D1 (de) *	1985-10-16	1991-11-28	Merck Frosst Canada Inc	2-substituierte chinoline.
EP0309541B1 (en) *	1987-03-18	1992-01-02	American Home Products Corporation	Sulfonylcarboxamides
DE3927369A1 (de) *	1989-08-19	1991-02-21	Bayer Ag	Substituierte n-(chinolin-2-yl-methoxy)benzyl-sulfonyl-harnstoffe
DE3927931A1 (de) *	1989-08-24	1991-02-28	Bayer Ag	Disubstituierte (chinolin-2-yl-methoxy)phenylessigsaeure-derivate
DE3927930A1 (de) *	1989-08-24	1991-02-28	Bayer Ag	Cyclisch substituierte (chinolin-2-yl-methoxy)phenyl-essig-saeure-derivate

1989
- 1989-05-23 DE DE3916663A patent/DE3916663A1/de not_active Withdrawn
1990
- 1990-05-01 US US07/517,108 patent/US5091392A/en not_active Expired - Lifetime
- 1990-05-10 DE DE59006474T patent/DE59006474D1/de not_active Expired - Fee Related
- 1990-05-10 ES ES90108775T patent/ES2056294T3/es not_active Expired - Lifetime
- 1990-05-10 DK DK90108775.9T patent/DK0399291T3/da active
- 1990-05-10 EP EP90108775A patent/EP0399291B1/de not_active Expired - Lifetime
- 1990-05-10 AT AT90108775T patent/ATE108777T1/de not_active IP Right Cessation
- 1990-05-18 CA CA002017135A patent/CA2017135C/en not_active Expired - Fee Related
- 1990-05-21 PT PT94105A patent/PT94105B/pt not_active IP Right Cessation
- 1990-05-21 DD DD90340878A patent/DD297961A5/de not_active IP Right Cessation
- 1990-05-22 KR KR1019900007333A patent/KR100210214B1/ko not_active Expired - Fee Related
- 1990-05-22 IE IE185190A patent/IE63593B1/en not_active IP Right Cessation
- 1990-05-22 HU HU132/90A patent/HU215833B/hu not_active IP Right Cessation
- 1990-05-22 IL IL9446590A patent/IL94465A/en not_active IP Right Cessation
- 1990-05-22 ZA ZA903939A patent/ZA903939B/xx unknown
- 1990-05-23 JP JP2131439A patent/JP3004678B2/ja not_active Expired - Fee Related
- 1990-05-23 AU AU55867/90A patent/AU627579B2/en not_active Ceased
1995
- 1995-01-26 SG SG12695A patent/SG12695G/en unknown
- 1995-03-09 HK HK33395A patent/HK33395A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3004678B2 (ja)	2000-01-31
KR100210214B1 (ko)	1999-07-15
AU5586790A (en)	1990-11-29
JPH035459A (ja)	1991-01-11
CA2017135A1 (en)	1990-11-23
DK0399291T3 (da)	1994-11-14
PT94105B (pt)	1996-11-29
IL94465A (en)	1994-07-31
DD297961A5 (de)	1992-01-30
HUT54655A (en)	1991-03-28
ZA903939B (en)	1991-03-27
EP0399291A3 (de)	1991-03-06
DE59006474D1 (de)	1994-08-25
CA2017135C (en)	2001-07-10
IL94465A0 (en)	1991-03-10
IE901851L (en)	1990-11-23
US5091392A (en)	1992-02-25
HU903132D0 (en)	1990-10-28
HK33395A (en)	1995-03-17
EP0399291A2 (de)	1990-11-28
EP0399291B1 (de)	1994-07-20
ES2056294T3 (es)	1994-10-01
AU627579B2 (en)	1992-08-27
SG12695G (en)	1995-06-16
ATE108777T1 (de)	1994-08-15
DE3916663A1 (de)	1990-11-29
IE63593B1 (en)	1995-05-17
KR900018037A (ko)	1990-12-20
HU215833B (hu)	2001-06-28

Legal Events

Date	Code	Title	Description
1996-11-29	FG3A	Patent granted, date of granting	Effective date: 19960829
1998-06-30	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19980228
1998-10-30	NF3A	Restitutio in integrum	Effective date: 19980722
2004-05-31	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20040229

Publication	Publication Date	Title
HUT54655A (en)	1991-03-28	Process for producing substituted (quinolin-2-ylmethoxy)-phenylacyl sulfonamides and cyanamides, as well as pharmaceutical compositions comprising same
ATE61357T1 (de)	1991-03-15	Substituierte phenylsulfonamide.
BR8805440A (pt)	1989-06-27	Processo para a fabricacao de 1,1,1-trifluorodicloroetano e/ou 1,1,1,2-tetrafluorocloroetano por fluoracao de um tetrahaloetileno
BR7803712A (pt)	1979-03-20	Sutura sintetica de multifilamento,e processo para melhorar as caracteristicas de amarracao de uma sutura de multifilamento
PT84144B (pt)	1989-03-30	Processo para a preparacao de sulfonamidas heterociclicas uteis como agente antialergicos e antitromboticos
DK0414019T3 (da)	1996-10-07	Substituerede N-(quinolin-2-yl-methoxy)benzyl-sulfonylurinstoffer
BR8005621A (pt)	1981-03-31	Processo de fabricacao e aparelho para utilizacao na montagem de batentes,vigas e similares
BR7904386A (pt)	1980-03-25	Processo para a producao de um latex de borracha auto-reticulavel,livre de emulsionante e latex de borracha
BR7900376A (pt)	1979-08-14	Processo para a producao de um catalisador,catalisador assim obtido,sua aplicacao,e processo para a producao de uma poliolefina
IT8025261A0 (it)	1980-10-09	Procedimento per la produzione di teatrafluoruro di zolfo.
BR7802700A (pt)	1979-01-02	Processo para calcinacao de calcareo ou cal hidratada
BR7904618A (pt)	1980-03-25	Processo para a preparacao de uma prancha de apara de madeira e prancha de apara de madeira obtida por ligacao entre si
BR8804931A (pt)	1989-05-02	Processo para a producao de uma tetra-hidro-1,3,5-tiadiazin-4-ona,e,composicao inseticida
IT1122745B (it)	1986-04-23	Procedimento per la produzione di diciclopentilen parentesi quadra aperta 2,2'-bis(4-alchil-6-t-butilfenoli)parentesi quadra chiusa
ES2038242T3 (es)	1993-07-16	Nuevos compuestos de tiofeno y su preparacion.
IT1123138B (it)	1986-04-30	Processo per la preparazione di 2,2'-bis(fenol 4-sostituito)solfuri
DE3888543D1 (de)	1994-04-21	Zusammensetzungen zur herstellung von gasdurchlässigen kontaktlinsen.
NO823550L (no)	1983-10-27	Produkt anvendtbart som dyrefor eller gjoedning, samt fremgangsmaate for dets fremstilling
PT84011B (pt)	1989-07-31	Processo para a preparacao de novos analogos de compostos polipeptidicos e hipocalcificantes e de composicoes farmaceuticas que os contem
IT1097538B (it)	1985-08-31	Processo per la preparazione del 2,6-dimetil-4-3(3-nitrofenil)-3-metossicarbonil-1,4-didropiridin-5-carbossilati di 2(n-benzil-n-metilammino)
MX9304608A (es)	1994-02-28	Nuevas (n-metanosulfonil)-quinolilmetoxifenil-cicoalquilacetamidas sustituidas por isobutilo, procedimiento para su preparacion y medicamentos que las contienen.
PT96179A (pt)	1991-09-30	Processo para a preparacao de 2-acilamino-9-acil-6-halopurinas
BR8905403A (pt)	1990-10-16	Processo para sintetizar n,n'-ditiobis (sulfonamidas)
FI864146A0 (fi)	1986-10-14	Mitogena peptider.
IT7820684A0 (it)	1978-02-28	Processo per la preparazione di 6 isobornil 3,4 xilenolo.