PT96096A - Processo de estabilizacao de uma mistura aquosa de um composto heterociclico de azoto e de preparacao de composicoes estabilizadas com metionina - Google Patents

Processo de estabilizacao de uma mistura aquosa de um composto heterociclico de azoto e de preparacao de composicoes estabilizadas com metionina

Info

Publication number: PT96096A
Authority: PT; Portugal
Prior art keywords: methionine; stabilizing; nitrogen; preparation; stabilized
Prior art date: 1989-12-06

Application number

PT96096A

Other languages

English (en)

Other versions

PT96096B (pt

Inventor

Petrus Johannes Maria Oetelaar

Maria Martina Francisc Mentink

Original Assignee

Akzo Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-06

Filing date

1990-12-05

Publication date

1991-09-30

1990-12-05 Application filed by Akzo Nv filed Critical Akzo Nv

1991-09-30 Publication of PT96096A publication Critical patent/PT96096A/pt

1998-02-27 Publication of PT96096B publication Critical patent/PT96096B/pt

Links

238000002360 preparation method Methods 0.000 title abstract 3
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
229930182817 methionine Natural products 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
230000000087 stabilizing effect Effects 0.000 title abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
150000002391 heterocyclic compounds Chemical class 0.000 title 1
229910052757 nitrogen Inorganic materials 0.000 title 1
FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 abstract 2
239000000935 antidepressant agent Substances 0.000 abstract 2
229940005513 antidepressants Drugs 0.000 abstract 2
FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 abstract 1
229930182818 D-methionine Natural products 0.000 abstract 1
239000004470 DL Methionine Substances 0.000 abstract 1
229930195722 L-methionine Natural products 0.000 abstract 1
UEQUQVLFIPOEMF-UHFFFAOYSA-N Mianserin Chemical compound C1C2=CC=CC=C2N2CCN(C)CC2C2=CC=CC=C21 UEQUQVLFIPOEMF-UHFFFAOYSA-N 0.000 abstract 1
229960000836 amitriptyline Drugs 0.000 abstract 1
KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
229960004452 methionine Drugs 0.000 abstract 1
235000006109 methionine Nutrition 0.000 abstract 1
229960003955 mianserin Drugs 0.000 abstract 1
229960001785 mirtazapine Drugs 0.000 abstract 1
RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 abstract 1
150000002978 peroxides Chemical class 0.000 abstract 1
-1 septiline Chemical compound 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

PT96096A 1989-12-06 1990-12-05 Processo de estabilizacao de uma mistura aquosa de um composto heterociclico de azoto e de preparacao de composicoes estabilizadas com metionina PT96096B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP89203092		1989-12-06

Publications (2)

Publication Number	Publication Date
PT96096A true PT96096A (pt)	1991-09-30
PT96096B PT96096B (pt)	1998-02-27

Family

ID=8202518

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96096A PT96096B (pt)	1989-12-06	1990-12-05	Processo de estabilizacao de uma mistura aquosa de um composto heterociclico de azoto e de preparacao de composicoes estabilizadas com metionina

Country Status (15)

Country	Link
US (1)	US5082864A (pt)
EP (1)	EP0431663B1 (pt)
JP (1)	JP2977912B2 (pt)
KR (1)	KR0185377B1 (pt)
AT (1)	ATE99943T1 (pt)
AU (1)	AU628768B2 (pt)
CA (1)	CA2030773C (pt)
DE (1)	DE69005992T2 (pt)
DK (1)	DK0431663T3 (pt)
ES (1)	ES2062310T3 (pt)
FI (1)	FI97689C (pt)
IE (1)	IE63985B1 (pt)
NZ (1)	NZ236332A (pt)
PT (1)	PT96096B (pt)
ZA (1)	ZA909568B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USH1591H (en) *	1992-10-09	1996-09-03	Fulcher; John	Preparation of flavor-enhanced reduced calorie fried foods
IL107887A (en) *	1992-12-08	2003-07-06	Ambi Inc	Stabilized lanthionine containing bacteriocin compositions
US6197830B1 (en)	1995-09-22	2001-03-06	Bruce M. Frome	Method for achieving relief from sympathetically mediated pain
EP0813873B1 (en) *	1996-06-19	2002-02-13	Akzo Nobel N.V.	Pharmaceutical composition comprising mirtazapine and one or more selective serotonin reuptake inhibitors
IL121076A (en) *	1996-06-19	2000-10-31	Akzo Nobel Nv	Pharmaceutical combinations comprising mirtazapine and one or more selective serotonin reuptake inhibitors
TW587938B (en) *	1997-03-27	2004-05-21	Akzo Nobel Nv	Pharmaceutical composition for the treatment and/or prophylaxis of psychotic disorder
DE69913116T2 (de) *	1998-04-02	2004-06-03	Akzo Nobel N.V.	Orale flüssige lösung enthaltend das antidepressivum mirtazapine
US6211171B1 (en)	1998-05-19	2001-04-03	Dalhousie University	Use of antidepressants for local analgesia
US6495534B2 (en) *	2000-05-15	2002-12-17	Pharmacia & Upjohn Spa	Stabilized aqueous suspensions for parenteral use
DE60224078T2 (de) *	2001-02-12	2008-12-04	N.V. Organon	Verwendung von Mirtazapin zur Verbesserung der Behandlung von Menschen mit starken Depressionen, welche Träger des Gens für Apolipoprotein E4 sind.
US6399310B1 (en)	2001-02-12	2002-06-04	Akzo Nobel N.V.	Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
US20030105082A1 (en) *	2001-12-03	2003-06-05	Murphy Greer Marechal	Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
US20050215552A1 (en) *	2002-05-17	2005-09-29	Gadde Kishore M	Method for treating obesity
HUE034290T2 (en)	2003-04-29	2018-02-28	Orexigen Therapeutics Inc	Preparations containing opioid antagonist and bupropion to affect weight loss
US7838029B1 (en) *	2003-07-31	2010-11-23	Watson Laboratories, Inc.	Mirtazapine solid dosage forms
US7429580B2 (en) *	2004-01-13	2008-09-30	Orexigen Therapeutics, Inc.	Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss
US20060039866A1 (en) *	2004-08-20	2006-02-23	Cypress Bioscience, Inc.	Method for treating sleep-related breathing disorders
US20060058390A1 (en) *	2004-09-14	2006-03-16	Molecular Therapeutics, Inc.	D-methionine formulation with improved biopharmaceutical properties
EP1827450A4 (en) *	2004-11-17	2009-04-22	Cypress Bioscience Inc	METHOD FOR REDUCING THE SIDE EFFECTS OF TREATMENT WITH MIRTAZAPINE
CA2630624C (en) *	2005-11-22	2013-08-06	Orexigen Therapeutics, Inc.	Compositions and methods for increasing insulin sensitivity
AU2007207606A1 (en) *	2006-01-17	2007-07-26	Regents Of The University Of Colorado	Central administration of stable formulations of therapeutic agents for CNS conditions
US8916195B2 (en) *	2006-06-05	2014-12-23	Orexigen Therapeutics, Inc.	Sustained release formulation of naltrexone
KR20170077291A (ko)	2006-11-09	2017-07-05	오렉시젠 세러퓨틱스 인크.	단위 용량 팩키지
TWI609702B (zh)	2006-11-09	2018-01-01	歐瑞根治療有限公司	層狀醫藥調配物
EP2167096A4 (en) *	2007-06-13	2010-07-14	Cypress Bioscience Inc	IMPROVING TOLERANCE TO MIRTAZAPINE AND A SECOND ACTIVE INGREDIENT BY THE COMBINED USE OF THEM
JP2011521973A (ja) *	2008-05-30	2011-07-28	オレキシジェン・セラピューティクス・インコーポレーテッド	内臓脂肪の状態を処置するための方法
ES2762113T3 (es)	2010-01-11	2020-05-22	Nalpropion Pharmaceuticals Inc	Métodos de proporcionar terapia de pérdida de peso en pacientes con depresión mayor
LT3730132T (lt)	2012-06-06	2022-08-25	Nalpropion Pharmaceuticals Llc	Kompozicija, skirta panaudoti pacientų su didele širdies ir kraujagyslių ligų rizika antsvorio ir nutukimo gydymo būde
KR101652081B1 (ko)	2014-12-30	2016-08-30	김인호	전극보일러 급탕시스템
WO2016138357A1 (en)	2015-02-27	2016-09-01	Kindred Biosciences, Inc.	Stimulation of appetite, management of weight loss, and treatment of anorexia in dogs and cats
KR20170001494A (ko)	2015-06-26	2017-01-04	김인호	전극보일러 전류제어시스템
CN108853042B (zh) *	2018-09-20	2021-03-26	北京哈三联科技有限责任公司	一种米氮平冻干口崩片及其制备方法和应用
GR1009883B (el) *	2019-06-07	2020-12-11	Λαμδα Φαρμακευτικα Εργαστηρια Εφαρμοσμενης Ερευνας Και Αναπτυξης Α.Ε.	Ποσιμα φαρμακευτικα διαλυματα που περιλαμβανουν υδροχλωρικη νορτριπτυλινη

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2082910A (en) *	1980-08-28	1982-03-17	Berk Pharmaceuticals Ltd	Anti-depressant compositions
US4603131A (en) *	1982-04-26	1986-07-29	Bernstein Joel E	Method and composition for treating and preventing irritation of the mucous membranes of the nose
DE3247676A1 (de) *	1982-12-23	1984-06-28	A. Nattermann & Cie GmbH, 5000 Köln	Galenische form fuer amitriptylinoxid und verfahren zur herstellung

1990
- 1990-11-20 DK DK90203064.2T patent/DK0431663T3/da active
- 1990-11-20 AT AT90203064T patent/ATE99943T1/de not_active IP Right Cessation
- 1990-11-20 EP EP90203064A patent/EP0431663B1/en not_active Expired - Lifetime
- 1990-11-20 DE DE90203064T patent/DE69005992T2/de not_active Expired - Lifetime
- 1990-11-20 ES ES90203064T patent/ES2062310T3/es not_active Expired - Lifetime
- 1990-11-22 IE IE422690A patent/IE63985B1/en not_active IP Right Cessation
- 1990-11-23 CA CA002030773A patent/CA2030773C/en not_active Expired - Fee Related
- 1990-11-28 ZA ZA909568A patent/ZA909568B/xx unknown
- 1990-12-03 US US07/621,480 patent/US5082864A/en not_active Expired - Lifetime
- 1990-12-04 NZ NZ236332A patent/NZ236332A/en unknown
- 1990-12-05 PT PT96096A patent/PT96096B/pt not_active IP Right Cessation
- 1990-12-05 KR KR1019900019904A patent/KR0185377B1/ko not_active Expired - Fee Related
- 1990-12-05 FI FI906008A patent/FI97689C/fi active IP Right Grant
- 1990-12-05 AU AU67798/90A patent/AU628768B2/en not_active Ceased
- 1990-12-06 JP JP2413592A patent/JP2977912B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0431663A1 (en)	1991-06-12
FI97689C (fi)	1997-02-10
KR910011250A (ko)	1991-08-07
ZA909568B (en)	1991-09-25
NZ236332A (en)	1992-07-28
DK0431663T3 (da)	1994-03-07
IE904226A1 (en)	1991-06-19
EP0431663B1 (en)	1994-01-12
DE69005992T2 (de)	1994-05-05
ES2062310T3 (es)	1994-12-16
FI906008A0 (fi)	1990-12-05
JPH05262651A (ja)	1993-10-12
US5082864A (en)	1992-01-21
AU628768B2 (en)	1992-09-17
DE69005992D1 (de)	1994-02-24
PT96096B (pt)	1998-02-27
JP2977912B2 (ja)	1999-11-15
FI97689B (fi)	1996-10-31
KR0185377B1 (ko)	1999-05-01
AU6779890A (en)	1991-06-13
ATE99943T1 (de)	1994-01-15
CA2030773A1 (en)	1991-06-07
IE63985B1 (en)	1995-06-28
CA2030773C (en)	2001-07-24
FI906008L (fi)	1991-06-07

Legal Events

Date	Code	Title	Description
1991-09-30	BB1A	Laying open of patent application	Effective date: 19910430
1998-02-27	FG3A	Patent granted, date of granting	Effective date: 19971118
2007-01-31	PC4A	Transfer of assignment	Owner name: N.V. ORGANON, NL Effective date: 20061124
2007-01-31	PD4A	Change of proprietorship	Owner name: AKZO NOBEL N.V., NL Effective date: 20061124
2011-12-20	PC4A	Transfer of assignment	Owner name: MSD OSS B.V., NL Effective date: 20111209
2012-11-27	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20121119

Publication	Publication Date	Title
PT96096A (pt)	1991-09-30	Processo de estabilizacao de uma mistura aquosa de um composto heterociclico de azoto e de preparacao de composicoes estabilizadas com metionina
PT91602A (pt)	1990-03-08	Processo para a preparacao de compostos espiro com accao antibacteriana e de composicoes farmaceuticas que os contem
FI922141A0 (fi)	1992-05-12	Analogiamenetelmä uusien hypoglykeemisten oksatsolidiinidionien valmistamiseksi
ES2131463B1 (es)	2000-03-01	Derivados de ciclopropilglicina con propiedades farmaceuticas.
PT87912A (pt)	1989-06-30	Processo para a preparacao de composicoes herbicidas contendo uma mistura de pelo menos, um composto de 1,3-dicarbonilo acilado com um antidoto
PT89170A (pt)	1989-12-29	Processo de preparacao de compostos de imidazoquinoxalina terapeuticamente activos e de composicoes farmaceuticas que os contem
BR9907694A (pt)	2000-11-14	Agente para tingir fibras
ATE86970T1 (de)	1993-04-15	2-substituierte paraaminophenole und ihre verwendung fuer die faerbung von keratinischen fasern.
PT97286A (pt)	1992-01-31	Processo para a preparacao de novos derivados do 3-aminocromano e de composicoes farmaceuticas que os contem
NO903430L (no)	1991-02-05	Fremgangsmaate for fremstilling av aminoketonderivater.
BR8906421A (pt)	1990-08-28	Processo para preparacao de monopersulfato de piridina-3-acido peroxicarboxilico
FI870994A0 (fi)	1987-03-06	Foerfarande foer framstaellning av stabila, injekterbara farmaceutiska kompositioner, vilka innehaoller 1,4-dihydroxi-5,8-bis/2-(2-hydroxietylamino)etylamino/ antrakinondihydroklorid.
PT91576A (pt)	1990-03-08	Processo para a preparacao de de sulfonamidas contendo o radical tetrazolilo e de composicoes farmaceuticas que as contem
PT89742A (pt)	1989-10-04	Processo de preparacao de 24r-cimnol e de suas composicoes farmaceuticas
NO179072C (no)	1996-07-31	Glutarsyrederivater, samt fremstilling derav
DE69014256D1 (de)	1995-01-05	Benzopyran-Derivate.
ATE111093T1 (de)	1994-09-15	Verfahren zur herstellung von enantiomeren von 3- aminchromanderivaten.
DE68901472D1 (de)	1992-06-17	Stabilisierungsmittel und dieses mittel enthaltende injizierbare zusammensetzung.
PT95972A (pt)	1991-09-13	Processo de preparacao de novos compostos de imidazoquinoxalina e de composicoes farmaceuticas que os contem
ATE96424T1 (de)	1993-11-15	Mit einer cyanogruppe substituierte nitroanilin- farbstoffe.
DK446183D0 (da)	1983-09-29	Fremgangsmade til fremstilling af 6h-bibenz(b,e) (1,4)oxathiepiner
CO4650015A1 (es)	1998-09-03	Plaguicidas derivados de hidrazina