PT96142A - Processo para a preparacao de derivados de 3-fenilglutarimida antagonistas de receptores muscarinicos - Google Patents

Processo para a preparacao de derivados de 3-fenilglutarimida antagonistas de receptores muscarinicos

Info

Publication number: PT96142A
Authority: PT; Portugal
Prior art keywords: alkyl; pct; independently; phenylglutarimide; preparation
Prior art date: 1989-12-12

Application number

PT96142A

Other languages

English (en)

Other versions

PT96142B (pt

Inventor

Peter Edward Cross

Alexander Roderick Mackenzie

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-12

Filing date

1990-12-10

Publication date

1991-09-30

1990-12-10 Application filed by Pfizer filed Critical Pfizer

1991-09-30 Publication of PT96142A publication Critical patent/PT96142A/pt

1997-05-28 Publication of PT96142B publication Critical patent/PT96142B/pt

Links

LIEGIQPEUGHGAI-UHFFFAOYSA-N 4-phenylpiperidine-2,6-dione Chemical class C1C(=O)NC(=O)CC1C1=CC=CC=C1 LIEGIQPEUGHGAI-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
210000003205 muscle Anatomy 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 9
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
-1 -(CH2)nOH Chemical group 0.000 abstract 1
229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

PT96142A 1989-12-12 1990-12-10 Processo para a preparacao de derivados de 3-fenilglutarimida antagonistas de receptores muscarinicos PT96142B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898928043A GB8928043D0 (en)	1989-12-12	1989-12-12	Muscarinic receptor antagonists

Publications (2)

Publication Number	Publication Date
PT96142A true PT96142A (pt)	1991-09-30
PT96142B PT96142B (pt)	1997-05-28

Family

ID=10667814

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96142A PT96142B (pt)	1989-12-12	1990-12-10	Processo para a preparacao de derivados de 3-fenilglutarimida antagonistas de receptores muscarinicos

Country Status (13)

Country	Link
US (1)	US5300516A (pt)
EP (1)	EP0505379B1 (pt)
JP (1)	JPH0686428B2 (pt)
AT (1)	ATE108776T1 (pt)
CA (1)	CA2067759C (pt)
DE (1)	DE69010917T2 (pt)
DK (1)	DK0505379T3 (pt)
ES (1)	ES2057601T3 (pt)
FI (1)	FI96024C (pt)
GB (1)	GB8928043D0 (pt)
IE (1)	IE63421B1 (pt)
PT (1)	PT96142B (pt)
WO (1)	WO1991009014A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9602516D0 (en) *	1996-02-08	1996-04-10	Chiroscience Ltd	Racemisation
DE19843793C2 (de) *	1998-09-24	2000-08-03	Gruenenthal Gmbh	Substituierte Benzamide
DE10002509A1 (de) *	2000-01-21	2001-07-26	Gruenenthal Gmbh	Substituierte Glutarimide
AU2016371762A1 (en) *	2015-12-14	2018-06-21	Cyclerion Therapeutics, Inc.	Use of sGC stimulators for the treatment of gastrointestinal sphincter dysfunction

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2664424A (en) *		1953-12-29		Dioxo-piperidines
US2848455A (en) *	1955-07-18	1958-08-19	Ciba Pharm Prod Inc	Alpha-(p-amino-phenyl)-alpha-lower alkyl glutarimides
US3125578A (en) *	1962-05-17	1964-03-17		xxviii
GB1455687A (en) *	1972-12-28	1976-11-17	Aspro Nicholas Ltd	Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
GB8716338D0 (en) *	1987-07-10	1987-08-19	Nat Res Dev	Anti-anxiogenic compositions

1989
- 1989-12-12 GB GB898928043A patent/GB8928043D0/en active Pending
1990
- 1990-11-28 CA CA002067759A patent/CA2067759C/en not_active Expired - Fee Related
- 1990-11-28 AT AT90917103T patent/ATE108776T1/de not_active IP Right Cessation
- 1990-11-28 JP JP2515783A patent/JPH0686428B2/ja not_active Expired - Fee Related
- 1990-11-28 EP EP90917103A patent/EP0505379B1/en not_active Expired - Lifetime
- 1990-11-28 US US07/859,728 patent/US5300516A/en not_active Expired - Fee Related
- 1990-11-28 WO PCT/EP1990/002040 patent/WO1991009014A1/en not_active Ceased
- 1990-11-28 DK DK90917103.5T patent/DK0505379T3/da active
- 1990-11-28 ES ES90917103T patent/ES2057601T3/es not_active Expired - Lifetime
- 1990-11-28 DE DE69010917T patent/DE69010917T2/de not_active Expired - Fee Related
- 1990-12-10 PT PT96142A patent/PT96142B/pt not_active IP Right Cessation
- 1990-12-11 IE IE446190A patent/IE63421B1/en not_active IP Right Cessation
1992
- 1992-05-22 FI FI922342A patent/FI96024C/fi active

Also Published As

Publication number	Publication date
US5300516A (en)	1994-04-05
ES2057601T3 (es)	1994-10-16
IE904461A1 (en)	1991-06-19
DK0505379T3 (da)	1994-09-12
ATE108776T1 (de)	1994-08-15
JPH04505926A (ja)	1992-10-15
CA2067759A1 (en)	1991-06-13
EP0505379B1 (en)	1994-07-20
FI96024B (fi)	1996-01-15
IE63421B1 (en)	1995-04-19
EP0505379A1 (en)	1992-09-30
PT96142B (pt)	1997-05-28
FI96024C (fi)	1996-04-25
CA2067759C (en)	1996-09-10
DE69010917D1 (de)	1994-08-25
JPH0686428B2 (ja)	1994-11-02
WO1991009014A1 (en)	1991-06-27
FI922342A7 (fi)	1992-05-22
DE69010917T2 (de)	1994-11-03
GB8928043D0 (en)	1990-02-14
FI922342A0 (fi)	1992-05-22

Legal Events

Date

Code

Title

Description

1991-09-30

BB1A

Laying open of patent application

Effective date: 19910509

1997-05-30

FG3A

Patent granted, date of granting

Effective date: 19970307

2004-11-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040907

Publication	Publication Date	Title
DK0505376T3 (da)	1995-02-13	Muscarinreceptorantagonister
CA2067816A1 (en)	1991-06-13	Muscarinic receptor antagonists
WO1992005172A3 (en)	1992-05-29	Muscarinic receptor antagonists
GR3036394T3 (en)	2001-11-30	Naphthalene derivatives
PT96421A (pt)	1991-10-15	Processo para a preparacao de derivados de piperidina e de pirrolidina antagonistas de receptores muscarinicos
YU240690A (sh)	1992-12-21	Fenil supstituisani derivati rodanina
PT96419A (pt)	1991-10-15	Processo para a preparacao de derivados de piperidina e de pirrolidina antagonistas de receptores muscarinicos
PT91871A (pt)	1990-04-30	Processo para a preparacao de amidas antagonistas de receptores muscarinicos
PT96142A (pt)	1991-09-30	Processo para a preparacao de derivados de 3-fenilglutarimida antagonistas de receptores muscarinicos
PT92158A (pt)	1990-05-31	Processo para a preparacao de derivados de piperidina 3-substituida
PT96420A (pt)	1991-10-15	Processo para a preparacao de derivados de benzodiazepinona antagonistas de receptores muscarinicos