PT96398A - Processo de preparacao de uma composicao poli-hemoglobina estabilizada por meio de derivados da purina e de glutationa, e de substituto do sangue. - Google Patents

Processo de preparacao de uma composicao poli-hemoglobina estabilizada por meio de derivados da purina e de glutationa, e de substituto do sangue.

Info

Publication number: PT96398A
Authority: PT; Portugal
Prior art keywords: blood substitute; glutathe; polyhemoglobin; purine; derivatives
Prior art date: 1989-12-29

Application number

PT96398A

Other languages

English (en)

Other versions

PT96398B (pt

Inventor

Mario Feola

Jan S Simoni

Peter C Canizaro

Original Assignee

Univ Texas Tech

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-29

Filing date

1990-12-28

Publication date

1991-10-31

1990-12-28 Application filed by Univ Texas Tech filed Critical Univ Texas Tech

1991-10-31 Publication of PT96398A publication Critical patent/PT96398A/pt

1998-12-31 Publication of PT96398B publication Critical patent/PT96398B/pt

Links

239000003633 blood substitute Substances 0.000 title abstract 2
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title 2
239000000203 mixture Substances 0.000 title 1
108010050918 polyhemoglobin Proteins 0.000 title 1
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 3
239000002126 C01EB10 - Adenosine Substances 0.000 abstract 2
102000001554 Hemoglobins Human genes 0.000 abstract 2
108010054147 Hemoglobins Proteins 0.000 abstract 2
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
229960005305 adenosine Drugs 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
241000283690 Bos taurus Species 0.000 abstract 1
108010024636 Glutathione Proteins 0.000 abstract 1
208000032843 Hemorrhage Diseases 0.000 abstract 1
206010047139 Vasoconstriction Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229960003180 glutathione Drugs 0.000 abstract 1
230000002688 persistence Effects 0.000 abstract 1
230000002035 prolonged effect Effects 0.000 abstract 1
230000025033 vasoconstriction Effects 0.000 abstract 1
229940124549 vasodilator Drugs 0.000 abstract 1
239000003071 vasodilator agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Cosmetics (AREA)
Medicinal Preparation (AREA)
Hydrogenated Pyridines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrane Compounds (AREA)

PT96398A 1989-12-29 1990-12-28 Processo de preparacao de uma composicao poli-hemoglobina estabilizada por meio de derivados da purina e de glutationa, e de substituto do sangue. PT96398B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US45907189A	1989-12-29	1989-12-29

Publications (2)

Publication Number	Publication Date
PT96398A true PT96398A (pt)	1991-10-31
PT96398B PT96398B (pt)	1998-12-31

Family

ID=23823294

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96398A PT96398B (pt)	1989-12-29	1990-12-28	Processo de preparacao de uma composicao poli-hemoglobina estabilizada por meio de derivados da purina e de glutationa, e de substituto do sangue.

Country Status (15)

Country	Link
EP (1)	EP0507870B1 (pt)
JP (1)	JP2954347B2 (pt)
KR (1)	KR0168866B1 (pt)
AT (1)	ATE136466T1 (pt)
AU (1)	AU650439B2 (pt)
CA (1)	CA2072081C (pt)
DE (1)	DE69026513T2 (pt)
DK (1)	DK0507870T3 (pt)
ES (1)	ES2086532T3 (pt)
FI (1)	FI105256B (pt)
GR (1)	GR3019775T3 (pt)
IE (1)	IE73248B1 (pt)
NO (1)	NO309799B1 (pt)
PT (1)	PT96398B (pt)
WO (1)	WO1991009615A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5650388A (en) *	1989-11-22	1997-07-22	Enzon, Inc.	Fractionated polyalkylene oxide-conjugated hemoglobin solutions
JP3437572B2 (ja) *	1991-02-12	2003-08-18	テキサス・テック・ユニバーシティー・ヘルス・サイエンシズ・センター	改良された人工血液
US5900477A (en) *	1992-01-30	1999-05-04	Baxter International, Inc.	Use of hemoglobin in the treatment of hemorrhagic shock
US5334706A (en) *	1992-01-30	1994-08-02	Baxter International	Administration of low dose hemoglobin to increase perfusion
US5264555A (en) *	1992-07-14	1993-11-23	Enzon, Inc.	Process for hemoglobin extraction and purification
US6242417B1 (en) *	1994-03-08	2001-06-05	Somatogen, Inc.	Stabilized compositions containing hemoglobin
US5631219A (en) *	1994-03-08	1997-05-20	Somatogen, Inc.	Method of stimulating hematopoiesis with hemoglobin
EP0767675A4 (en) *	1995-04-10	1998-08-05	Baxter Int	USE OF CROSS-LINKED HEMOGLOBIN IN THE TREATMENT OF SUBARACHNOIDAL BLEEDING
US5741894A (en) *	1995-09-22	1998-04-21	Baxter International, Inc.	Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
KR100674690B1 (ko) *	1999-07-01	2007-01-25	시스멕스 가부시키가이샤	헤모글로빈 안정화수단
CN116500111B (zh) *	2023-04-04	2026-02-10	深圳大学	一种用于检测单细胞内atp的探针型有机电化学晶体管传感器及其制备方法、检测方法
CN116941603A (zh) *	2023-07-21	2023-10-27	浙江康嘉基因技术有限公司	一种新型醛化鸡红细胞的制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4061736A (en) *	1975-02-02	1977-12-06	Alza Corporation	Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4401652A (en) *	1980-12-31	1983-08-30	Allied Corporation	Process for the preparation of stroma-free hemoglobin solutions
US4473496A (en) *	1981-09-14	1984-09-25	The United States Of America As Represented By The Secretary Of The Army	Intramolecularly crosslinked hemoglobin
US4831012A (en) *	1984-03-23	1989-05-16	Baxter International Inc.	Purified hemoglobin solutions and method for making same
GB8710598D0 (en) *	1987-05-05	1987-06-10	Star Medical Diagnostics Ltd	Hemoglobin based blood substitute
US4876241A (en) *	1987-05-22	1989-10-24	Armour Pharmaceutical Company	Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants

1990
- 1990-12-12 AT AT91902885T patent/ATE136466T1/de not_active IP Right Cessation
- 1990-12-12 DE DE69026513T patent/DE69026513T2/de not_active Expired - Lifetime
- 1990-12-12 ES ES91902885T patent/ES2086532T3/es not_active Expired - Lifetime
- 1990-12-12 WO PCT/US1990/007442 patent/WO1991009615A1/en not_active Ceased
- 1990-12-12 EP EP91902885A patent/EP0507870B1/en not_active Expired - Lifetime
- 1990-12-12 CA CA002072081A patent/CA2072081C/en not_active Expired - Lifetime
- 1990-12-12 JP JP3503266A patent/JP2954347B2/ja not_active Expired - Lifetime
- 1990-12-12 DK DK91902885.2T patent/DK0507870T3/da active
- 1990-12-12 AU AU71425/91A patent/AU650439B2/en not_active Expired
- 1990-12-28 IE IE471790A patent/IE73248B1/en not_active IP Right Cessation
- 1990-12-28 PT PT96398A patent/PT96398B/pt not_active IP Right Cessation
1992
- 1992-06-24 FI FI922937A patent/FI105256B/fi active
- 1992-06-26 NO NO922551A patent/NO309799B1/no not_active IP Right Cessation
- 1992-12-12 KR KR1019920701541A patent/KR0168866B1/ko not_active Expired - Fee Related
1996
- 1996-04-29 GR GR960401155T patent/GR3019775T3/el unknown

Also Published As

Publication number	Publication date
GR3019775T3 (en)	1996-07-31
KR920703087A (ko)	1992-12-17
DE69026513D1 (de)	1996-05-15
JP2954347B2 (ja)	1999-09-27
IE73248B1 (en)	1997-05-21
DE69026513T2 (de)	1996-09-12
CA2072081A1 (en)	1991-06-30
KR0168866B1 (ko)	1999-01-15
EP0507870A1 (en)	1992-10-14
EP0507870A4 (en)	1993-08-11
EP0507870B1 (en)	1996-04-10
FI922937L (fi)	1992-06-24
FI922937A0 (fi)	1992-06-24
FI105256B (fi)	2000-07-14
AU650439B2 (en)	1994-06-23
CA2072081C (en)	2002-07-30
DK0507870T3 (da)	1996-06-10
WO1991009615A1 (en)	1991-07-11
IE904717A1 (en)	1991-07-17
PT96398B (pt)	1998-12-31
NO922551D0 (no)	1992-06-26
AU7142591A (en)	1991-07-24
NO922551L (no)	1992-08-28
JPH05504766A (ja)	1993-07-22
ES2086532T3 (es)	1996-07-01
ATE136466T1 (de)	1996-04-15
NO309799B1 (no)	2001-04-02

Legal Events

Date

Code

Title

Description

1991-10-31

BB1A

Laying open of patent application

Effective date: 19910709

1998-12-31

FG3A

Patent granted, date of granting

Effective date: 19980917

2001-07-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20010331

Publication	Publication Date	Title
PT96398A (pt)	1991-10-31	Processo de preparacao de uma composicao poli-hemoglobina estabilizada por meio de derivados da purina e de glutationa, e de substituto do sangue.
CA2009637A1 (en)	1990-08-08	Substituted-1,3-oxathiolanes with antiviral properties
MX167702B (es)	1993-04-06	Composicion farmaceutica anti-retroviral de 3'azid-2',3'-dideoxiuridina y metodo para elaborarla
FI893750A0 (fi)	1989-08-09	Menetelmä valmistaa terapeuttisesti aktiivista makrosyklistä johdannaista
BRPI9506596B8 (pt)	2016-05-24	composto l-nucleosídeo.
AU578809B2 (en)	1988-11-03	Therapeutic nucleosides
AU1130988A (en)	1988-08-11	Thiazolidinone derivatives, their preparation and their use
EP0786458A3 (en)	1999-10-13	Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents
DE69019111D1 (de)	1995-06-08	Ascorbinsäure-Tocopheryl-Phosphatdiester zur Hemmung der Maillard-Reaktion.
MX9203320A (es)	1992-07-01	Composicion antialergica que contiene compuestos biciclicos switterionicos.
MY105523A (en)	1994-10-31	Substituted-1,3-oxathiolanes with antiviral properties.
ZA892284B (en)	1990-02-28	Novel fluorophosphonate nucleotide derivatives
KR0158672B1 (en)	1998-12-01	Injectable ready-to-use solutions containing an antitumour anthracycline glycoside
ATE173273T1 (de)	1998-11-15	Verbesserter blutersatz
CA2036507A1 (en)	1991-08-20	2'-deoxy-2'-methylidenecytidine dihydrate, methods for its production and compositions
EP0295350A3 (en)	1990-07-04	Use of n-û2-(diethylamino)ethyl¨-2-methoxy-4-û(1-h 4,5-dihydro-2-imidazolyl)amino¨-5-chlorobenzamide as an anxiolytic and antipsychotic agent
DZ1366A1 (fr)	2004-09-13	Nouveaux dérivés de la méthoxycarbonyl-2 n,n'-di-(triméthoxybenzoyle) pipérazine, ainsi que leur procédé de préparation.
PH27369A (en)	1993-06-21	Glutaric acid derivatives and preparations thereof
ZA906252B (en)	1991-08-28	Benzopyran derivatives
AU2601088A (en)	1989-06-01	Hypoglycaemic peptides