PT968182E - Derivados de acidos hidroxamicos e carboxilicos com actividade inibidora da mpm e do fnt - Google Patents

Derivados de acidos hidroxamicos e carboxilicos com actividade inibidora da mpm e do fnt

Info

Publication number: PT968182E
Authority: PT; Portugal
Prior art keywords: hydroxamic; carboxylic acid; acid derivatives; mpm; inhibiting activity
Prior art date: 1996-08-07

Application number

PT97935666T

Other languages

English (en)

Inventor

John Gary Montana

Andrew Douglas Baxter

David Alan Owen

Robert John Watson

John Fraser Keily

Original Assignee

Darwin Discovery Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-07

Filing date

1997-08-07

Publication date

2004-08-31

1996-08-07 Priority claimed from GBGB9616599.8A external-priority patent/GB9616599D0/en

1997-04-11 Priority claimed from GBGB9707427.2A external-priority patent/GB9707427D0/en

1997-08-07 Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd

2004-08-31 Publication of PT968182E publication Critical patent/PT968182E/pt

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
150000001732 carboxylic acid derivatives Chemical class 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title 1
102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)
Indole Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Quinoline Compounds (AREA)
Furan Compounds (AREA)
Pyridine Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Hydrogenated Pyridines (AREA)

PT97935666T 1996-08-07 1997-08-07 Derivados de acidos hidroxamicos e carboxilicos com actividade inibidora da mpm e do fnt PT968182E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9616599.8A GB9616599D0 (en)	1996-08-07	1996-08-07	Compounds
GBGB9707427.2A GB9707427D0 (en)	1997-04-11	1997-04-11	Compounds having mmp and tnf inhibitory activity

Publications (1)

Publication Number	Publication Date
PT968182E true PT968182E (pt)	2004-08-31

Family

ID=26309836

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97935666T PT968182E (pt)	1996-08-07	1997-08-07	Derivados de acidos hidroxamicos e carboxilicos com actividade inibidora da mpm e do fnt

Country Status (17)

Country	Link
US (1)	US6118001A (pt)
EP (1)	EP0968182B1 (pt)
JP (1)	JP2000517297A (pt)
KR (1)	KR20000029858A (pt)
CN (1)	CN1227540A (pt)
AT (1)	ATE266000T1 (pt)
AU (1)	AU730464B2 (pt)
BR (1)	BR9711027A (pt)
CA (1)	CA2263154A1 (pt)
CZ (1)	CZ297278B6 (pt)
DE (1)	DE69729007T2 (pt)
DK (1)	DK0968182T3 (pt)
ES (1)	ES2217425T3 (pt)
NO (1)	NO314452B1 (pt)
PL (1)	PL193829B1 (pt)
PT (1)	PT968182E (pt)
WO (1)	WO1998005635A1 (pt)

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ATE292622T1 (de)	1997-01-22	2005-04-15	Aventis Pharma Inc	Substituierte beta-thiocarbonsäuren
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EP0965592A1 (en)	1998-06-18	1999-12-22	F. Hoffmann-La Roche Ag	Process for preparing 3-arylsulfur hydroxamic acids
FR2780402B1 (fr)	1998-06-30	2001-04-27	Adir	Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
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GB9911073D0 (en) *	1999-05-12	1999-07-14	Darwin Discovery Ltd	Hydroxamic and carboxylic acid derivatives
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GB9916562D0 (en)	1999-07-14	1999-09-15	Pharmacia & Upjohn Spa	3-Arylsulfonyl-2-(substituted-methyl) propanoic acid derivatives as matrix metalloproteinase inhibitora
GB9922825D0 (en) *	1999-09-25	1999-11-24	Smithkline Beecham Biolog	Medical use
US6667316B1 (en) *	1999-11-12	2003-12-23	Celgene Corporation	Pharmaceutically active isoindoline derivatives
JP2003524008A (ja) *	2000-02-21	2003-08-12	アストラゼネカ・アクチエボラーグ	アリールピペラジンおよびアリールピペリジン、およびそれらのメタロプロテイナーゼ阻害剤としての使用
GB0009760D0 (en)	2000-04-19	2000-06-07	Oxford Biomedica Ltd	Method
EP1286994A1 (en) *	2000-05-15	2003-03-05	Darwin Discovery Limited	Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
WO2001087870A1 (en)	2000-05-15	2001-11-22	Darwin Discovery Limited	Hydroxamic acid derivatives
JP2003533513A (ja)	2000-05-15	2003-11-11	ダーウィン・ディスカバリー・リミテッド	Ｍｍｐおよびｔｎｆ阻害活性を有するヒドロキサム酸およびカルボン酸誘導体
GB0020498D0 (en)	2000-08-18	2000-10-11	Sterix Ltd	Compound
US7842727B2 (en)	2001-03-27	2010-11-30	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
CA2344208A1 (en)	2001-04-30	2002-10-30	Oxford Biomedica (Uk) Limited	Method
GB0119474D0 (en)	2001-08-09	2001-10-03	Astrazeneca Ab	Compounds
WO2003099272A1 (en)	2002-05-22	2003-12-04	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
AU2003247390A1 (en) *	2002-05-22	2003-12-12	Errant Gene Therapeutics, Llc.	Histone deacetylase inhibitors based on alphachalcogenmethylcarbonyl compounds
DE10226370B4 (de)	2002-06-13	2008-12-11	Polyic Gmbh & Co. Kg	Substrat für ein elektronisches Bauteil, Verwendung des Substrates, Verfahren zur Erhöhung der Ladungsträgermobilität und Organischer Feld-Effekt Transistor (OFET)
DE10233085B4 (de)	2002-07-19	2014-02-20	Dendron Gmbh	Stent mit Führungsdraht
US8425549B2 (en)	2002-07-23	2013-04-23	Reverse Medical Corporation	Systems and methods for removing obstructive matter from body lumens and treating vascular defects
WO2004012663A2 (en)	2002-08-01	2004-02-12	Bristol-Myers Squibb Company	Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
US20040225077A1 (en)	2002-12-30	2004-11-11	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
GB0411562D0 (en)	2004-05-24	2004-06-23	Sterix Ltd	Compound
GB0412492D0 (en)	2004-06-04	2004-07-07	Sterix Ltd	Compound
US20050277897A1 (en) *	2004-06-14	2005-12-15	Ghannoum Ziad R	Handpiece tip
DE102005019181A1 (de) *	2005-04-25	2006-10-26	Novartis Ag	Peptid-Deformylase (PDF) Inhibitoren 1
CN101166740B (zh) *	2005-04-25	2010-12-29	诺瓦提斯公司	用作肽脱甲酰基酶(pdf)抑制剂的咪唑并[1,2-a]吡啶衍生物
ES2564823T3 (es)	2005-05-27	2016-03-29	Ospedale San Raffaele S.R.L.	Vector génico que comprende miARN
GB0513702D0 (en)	2005-07-04	2005-08-10	Sterix Ltd	Compound
GB0526210D0 (en)	2005-12-22	2006-02-01	Oxford Biomedica Ltd	Vectors
GB0604142D0 (en)	2006-03-01	2006-04-12	Sterix Ltd	Compound
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JP2010504281A (ja) *	2006-07-27	2010-02-12	エミスフェアー・テクノロジーズ・インク	アリールスルファニル化合物、および活性薬剤を送達するための組成物
GB0706072D0 (en)	2007-03-28	2007-05-09	Sterix Ltd	Compound
US11337714B2 (en)	2007-10-17	2022-05-24	Covidien Lp	Restoring blood flow and clot removal during acute ischemic stroke
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CN103549986B (zh)	2008-02-22	2015-12-09	泰科保健集团有限合伙公司	可去除的结合的血栓装置团块
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US9938540B2 (en)	2008-11-12	2018-04-10	Ospedale San Raffaele S.R.L.	Gene vector for inducing transgene-specific immune tolerance
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GB0914767D0 (en)	2009-08-24	2009-09-30	Sterix Ltd	Compound
US9039749B2 (en)	2010-10-01	2015-05-26	Covidien Lp	Methods and apparatuses for flow restoration and implanting members in the human body
WO2012156839A2 (en)	2011-05-19	2012-11-22	Ospedale San Raffaele S.R.L.	New generation of splice-less lentiviral vectors for safer gene therapy applications
CN104955806B (zh)	2013-02-06	2018-09-14	默克专利股份公司	用于治疗骨关节炎的作为聚蛋白聚糖酶抑制剂的取代羧酸衍生物
WO2014140934A2 (en)	2013-03-11	2014-09-18	Life Science Nutrition As	Natural lipids containing non-oxidizable fatty acids
US10076399B2 (en)	2013-09-13	2018-09-18	Covidien Lp	Endovascular device engagement
WO2015059674A1 (en)	2013-10-24	2015-04-30	Ospedale San Raffaele S.R.L.	Method
GB201322798D0 (en)	2013-12-20	2014-02-05	Oxford Biomedica Ltd	Production system
GB201407322D0 (en)	2014-04-25	2014-06-11	Ospedale San Raffaele	Gene therapy
GB201412494D0 (en)	2014-07-14	2014-08-27	Ospedale San Raffaele And Fond Telethon	Vector production
GB201418965D0 (pt)	2014-10-24	2014-12-10	Ospedale San Raffaele And Fond Telethon
GB201608944D0 (en)	2016-05-20	2016-07-06	Ospedale San Raffaele And Fond Telethon	Gene Tharapy
GB201706394D0 (en)	2017-04-21	2017-06-07	Ospedale San Raffaele Srl	Gene Therapy
DE102017211110A1 (de) *	2017-06-30	2019-01-03	Continental Reifen Deutschland Gmbh	Verfahren zur Herstellung eines Silans, Verfahren zur Modifizierung einer Kieselsäure mit dem Silan und modifizierte Kieselsäure
GB201807944D0 (en)	2018-05-16	2018-06-27	Ospedale San Raffaele Srl	Compositions and methods for haematopoietic stem cell transplantation
GB201807945D0 (en)	2018-05-16	2018-06-27	Ospedale San Raffaele Srl	Vector production
CN112601812A (zh)	2018-06-25	2021-04-02	圣拉斐尔医院有限责任公司	基因疗法
AU2019358519A1 (en)	2018-10-11	2021-05-27	Fondazione Telethon Ets	Selection by means of artificial transactivators
CA3126190A1 (en)	2019-01-18	2020-07-23	Societe Des Produits Nestle S.A.	Agents and methods for increasing stem cell function
KR20220097492A (ko)	2019-11-12	2022-07-07	옥스포드 바이오메디카(유케이) 리미티드	생산 시스템
JP2023513303A (ja)	2020-02-13	2023-03-30	オックスフォードバイオメディカ（ユーケー）リミテッド	レンチウイルスベクターの製造
US20230118587A1 (en)	2020-03-13	2023-04-20	Oxford Biomedica (Uk) Limited	Lentiviral Vectors
GB202007106D0 (en)	2020-05-14	2020-07-01	Ucl Business Plc	Cyclosporine analogues
GB202007199D0 (en)	2020-05-15	2020-07-01	Oxford Biomedica Ltd	Viral vector production
CN116391031A (zh)	2020-09-28	2023-07-04	雀巢产品有限公司	用于增加干细胞功能的组合物和方法
WO2022064061A1 (en)	2020-09-28	2022-03-31	Société des Produits Nestlé S.A.	Compositions and methods for increasing stem cell function
GB202017725D0 (en)	2020-11-10	2020-12-23	Oxford Biomedica Ltd	Method
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AU2021202658A1 (en)	2021-04-28	2022-11-17	Fondazione Telethon	Gene therapy
JP2024516187A (ja)	2021-05-05	2024-04-12	ソシエテ・デ・プロデュイ・ネスレ・エス・アー	幹細胞機能を向上させるためのウロリチン
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EP4514364A1 (en)	2022-04-28	2025-03-05	Ospedale San Raffaele S.r.l.	Methods for haematopoietic stem cell transplantation
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GB202211935D0 (en)	2022-08-16	2022-09-28	Oxford Biomedica Ltd	envelope proteins
EP4602153A1 (en)	2022-10-11	2025-08-20	Fondazione Telethon ETS	3d cell culture methods
IT202300011790A1 (it)	2023-06-08	2024-12-08	Fond Telethon Ets	Protocolli di manipolazione genica in cellule immunitarie

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1997
- 1997-08-07 PT PT97935666T patent/PT968182E/pt unknown
- 1997-08-07 KR KR1019997001020A patent/KR20000029858A/ko not_active Ceased
- 1997-08-07 DE DE69729007T patent/DE69729007T2/de not_active Expired - Fee Related
- 1997-08-07 CN CN97197048A patent/CN1227540A/zh active Pending
- 1997-08-07 US US08/908,397 patent/US6118001A/en not_active Expired - Fee Related
- 1997-08-07 JP JP10507741A patent/JP2000517297A/ja not_active Ceased
- 1997-08-07 AT AT97935666T patent/ATE266000T1/de not_active IP Right Cessation
- 1997-08-07 PL PL97331598A patent/PL193829B1/pl not_active IP Right Cessation
- 1997-08-07 WO PCT/GB1997/002129 patent/WO1998005635A1/en not_active Ceased
- 1997-08-07 AU AU38564/97A patent/AU730464B2/en not_active Ceased
- 1997-08-07 DK DK97935666T patent/DK0968182T3/da active
- 1997-08-07 BR BR9711027A patent/BR9711027A/pt unknown
- 1997-08-07 CA CA002263154A patent/CA2263154A1/en not_active Abandoned
- 1997-08-07 EP EP97935666A patent/EP0968182B1/en not_active Expired - Lifetime
- 1997-08-07 CZ CZ0036899A patent/CZ297278B6/cs not_active IP Right Cessation
- 1997-08-07 ES ES97935666T patent/ES2217425T3/es not_active Expired - Lifetime
1999
- 1999-02-05 NO NO19990543A patent/NO314452B1/no unknown

Also Published As

Publication number	Publication date
JP2000517297A (ja)	2000-12-26
DE69729007T2 (de)	2005-04-07
WO1998005635A1 (en)	1998-02-12
KR20000029858A (ko)	2000-05-25
CA2263154A1 (en)	1998-02-12
NO990543D0 (no)	1999-02-05
AU730464B2 (en)	2001-03-08
ATE266000T1 (de)	2004-05-15
US6118001A (en)	2000-09-12
BR9711027A (pt)	1999-08-17
AU3856497A (en)	1998-02-25
EP0968182B1 (en)	2004-05-06
NO990543L (no)	1999-04-06
CZ297278B6 (cs)	2006-10-11
NO314452B1 (no)	2003-03-24
PL331598A1 (en)	1999-08-02
DK0968182T3 (da)	2004-08-16
EP0968182A1 (en)	2000-01-05
DE69729007D1 (de)	2004-06-09
PL193829B1 (pl)	2007-03-30
ES2217425T3 (es)	2004-11-01
CZ36899A3 (cs)	1999-07-14
CN1227540A (zh)	1999-09-01

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ES2191830T3 (es)	2003-09-16	Inhibidores de trombina.
EE200000093A (et)	2000-12-15	Agrekanaasi ja maatriksmetalloproteinaaside uudsed inhibiitorid artriidi käitlemiseks
IL123431A0 (en)	1998-09-24	Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (MMP) and/or tumour necrosis factor (TNF)
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ATE226588T1 (de)	2002-11-15	Phosphinsäure-derivate
TR199802638T2 (xx)	1999-03-22	Kanser tedavisinde naaladase inhibit�rleri kullan�m�.
BR9709450A (pt)	1999-08-10	Inibidores de produção do s-cd23 e da secreção de tnt
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ES2186807T3 (es)	2003-05-16	Inhibidores de trombina.
ATE309352T1 (de)	2005-11-15	Inhibitoren der nf-kb aktivierung
FR2786100B1 (fr)	2002-03-01	Nouvelle application therapeutique de la nicergoline