PT968722E - Vacina viva melhorada contra brsv. - Google Patents

Vacina viva melhorada contra brsv. Download PDF

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Publication number
PT968722E
PT968722E PT99115633T PT99115633T PT968722E PT 968722 E PT968722 E PT 968722E PT 99115633 T PT99115633 T PT 99115633T PT 99115633 T PT99115633 T PT 99115633T PT 968722 E PT968722 E PT 968722E
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PT
Portugal
Prior art keywords
virus
adjuvants
vet
adjuvant
immunity
Prior art date
Application number
PT99115633T
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English (en)
Inventor
Hsien-Jue Chu
Original Assignee
Wyeth Corp
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Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PT968722E publication Critical patent/PT968722E/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
    • C12N2760/18634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (5)

  1. ΡΕ968722 1 REIVINDICAÇÕES 1. Utilização de um Vírus Sincitial Respiratório de Bovinos modificado vivo e de um ou mais adjuvantes em combinação com um ou mais estabilizadores, veículos e adjuvantes aceitáveis do ponto de vista farmacêutico, seleccionados de entre os adjuvantes que proporcionem uma resposta imunológica multifacetada contra o BRSV modificado, sendo os adjuvantes referidos seleccionados de entre aqueles que proporcionem imunidade mediada por células e imunidade local (IgA segregado) e que para além disso sejam elementos do conjunto constituído por: esqualano e o esqualeno (ou outros óleos de origem animal); copolímeros em blocos, de preferência Pluronic® (L121); Saponina; detergentes ou tensioactivos não iónicos, de preferência mono-oleato de polioxietileno(20)-sorbitano Tween®- -80; Quil® A, óleos minerais, de preferência Drakeol® ou Marcol®, óleos vegetais; adjuvantes provenientes de Corynebacterium como por exemplo de Corynebacterium parvum; adjuvantes provenientes de Propionibacterium, de preferência de Propionibacterium acne; Mycobacterium bovis (Bacíllus Calmette e Guerinn, ou BCG); interleuquinas seleccionadas de entre a interleuqina 2 e a interleuquina-12; monoquinas, de preferência a interleuquina 1; factor de necrose tumoral; interferões de preferência interferões gama; combinações de saponina com hidróxido de alumínio ou 2 ΡΕ968722 de Quil® com hidróxido de alumínio; lipossomas; adjuvante iscom; extracto de paredes celulares de micobactérias; glicopéptidos sintéticos, de preferência dipéptidos muramílicos ou outros derivados; Avridina; Lípido A; sulfato de dextrano; DEAE-Dextrano ou DEAE-Dextrano com fosfato de alumínio; carboxipolimetilenos, de preferência o Carbopol®; EMA; emulsões de copolímeros acrílicos, de preferência Neocryl® A640; proteínas de vaccinia ou de vírus de varíola; adjuvantes que sejam partículas subvirais. de preferência o orbivirus; toxina da cólera; brometo de dimetildiocledecilmónio; ou misturas destes, na preparação de uma vacina de Vírus Sincitial Respiratório de Bovinos de dose única, de tal forma que a vacina origine uma imunidade positiva contra a infecção por BRSV após uma única administração.
  2. 2. A utilização de acordo com a reivindicação 1, em que o adjuvante inclua também um tensioactivo.
  3. 3. A utilização de acordo com a reivindicação 2, em que o adjuvante também inclua um tensioactivo presente numa concentração final de cerca de 0,0015 a 0,20 % (em volume).
  4. 4. A utilização de acordo com a reivindicação 2 ou a 3, em que o tensioactivo seja mono-oleato de poli-oxietileno-sorbitano. 3 ΡΕ968722
  5. 5. A utilização de acordo com qualquer uma das reivindicações 1 a 4, em que a vacina também inclua Virus de Rino-traqueite de Bovinos (BHV-IV), Virus de Diarreia de Bovinos (BVDV), e Virus de Parainfluenza 3 (PI-3V). Lisboa, 27 de Agosto de 2007 ι ΡΕ968722 BIBLIOGRAFIA CITADA NA DESCRIÇÃO A lista da bibliografia citada pela requerente destina-se unicamente ao leitor. Ela não integra o documento de patente Europeia. Ainda que se tenha tido grande cuidado na compilação da bibliografia, não se podem excluir erros nem omissões, e o EPO rejeita qualquer responsabilidade a este respeito. Documentos de patentes citados na descrição • EP 129923 A • US 4772466 A • US 5047238 A Outra literatura citada na descrição • KIMMAN e tal. J. Clin. • Vet. Immunol. Immunopathol., 1989, Microbiol., 1987, 25, 1097- 22(2), 145-160. 1106 . • Bovine Respiratory Syncytial Vírus • STOTT et al. J. Hyg. Camb. and the effect of the amount of 1984, 93, 251-261. vírus, vírus replication, route of • THOMAS et al. Agri-Practice, administration and maternal 1986, 5. antibodies, J. Clin. Microbiol., • SYVRUD et al. Vet. Med., 1987, 25(6), 1.097-1.106 1988, 83, 429-430. • Bovine Respiratory Syncytial Virus • Veterinary Pharmaceuticals & infection, and re-infection in cal- Biologicals. 1993, 78, 484, ves with and without maternal anti 740-741, 956-960, 982-983. bodies. Vet Q., 1991, 13(1), 47-59 • Agri-Practice. Vet. Med. • BAKER, Human and Bovine Respiratory Outubro 1983, 78, 1599-1604. Syncytial Virus immunopathologic • Bovine Vet. Fórum 1, 16 de mechanisms. Semin. Immunol. 1990, Fevereiro de 1986, 2. 2(5), 369-374, • SVYRUD et al. Vet. Med., • THOMAS et al., Agri-Practice 7(5), 1988, 429-430 26-30
PT99115633T 1994-05-10 1995-05-08 Vacina viva melhorada contra brsv. PT968722E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24037394A 1994-05-10 1994-05-10

Publications (1)

Publication Number Publication Date
PT968722E true PT968722E (pt) 2007-09-06

Family

ID=22906268

Family Applications (3)

Application Number Title Priority Date Filing Date
PT95918442T PT759780E (pt) 1994-05-10 1995-05-08 Vacina melhorada de vsrb vivo modificado
PT99115633T PT968722E (pt) 1994-05-10 1995-05-08 Vacina viva melhorada contra brsv.
PT70083787T PT1820512E (pt) 1994-05-10 1995-05-08 Vacina viva modificada melhorada contra brsv

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT95918442T PT759780E (pt) 1994-05-10 1995-05-08 Vacina melhorada de vsrb vivo modificado

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT70083787T PT1820512E (pt) 1994-05-10 1995-05-08 Vacina viva modificada melhorada contra brsv

Country Status (19)

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US (2) US5733555A (pt)
EP (4) EP0968722B1 (pt)
JP (3) JP3993230B2 (pt)
KR (1) KR100374434B1 (pt)
CN (1) CN1268393C (pt)
AT (2) ATE195255T1 (pt)
AU (1) AU711350B2 (pt)
BR (1) BR9507717A (pt)
CA (1) CA2189979C (pt)
DE (2) DE69535520T2 (pt)
DK (2) DK0968722T3 (pt)
ES (3) ES2149361T3 (pt)
GR (1) GR3034402T3 (pt)
MY (1) MY111829A (pt)
NZ (1) NZ285324A (pt)
PT (3) PT759780E (pt)
SI (2) SI0968722T1 (pt)
WO (1) WO1995030437A1 (pt)
ZA (1) ZA953703B (pt)

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US5958423A (en) 1999-09-28
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ATE195255T1 (de) 2000-08-15
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AU711350B2 (en) 1999-10-14
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CA2189979A1 (en) 1995-11-16
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