PT971739E - Composicoes aquosas de adjuvante imunologico de monofosforil lipido a - Google Patents
Composicoes aquosas de adjuvante imunologico de monofosforil lipido aInfo
- Publication number
- PT971739E PT971739E PT98915239T PT98915239T PT971739E PT 971739 E PT971739 E PT 971739E PT 98915239 T PT98915239 T PT 98915239T PT 98915239 T PT98915239 T PT 98915239T PT 971739 E PT971739 E PT 971739E
- Authority
- PT
- Portugal
- Prior art keywords
- surfactant
- lipid
- derivative
- attenuated
- antigen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83107397A | 1997-04-01 | 1997-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT971739E true PT971739E (pt) | 2004-12-31 |
Family
ID=25258229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98915239T PT971739E (pt) | 1997-04-01 | 1998-04-01 | Composicoes aquosas de adjuvante imunologico de monofosforil lipido a |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0971739B1 (pt) |
| JP (1) | JP5019494B2 (pt) |
| KR (1) | KR100603884B1 (pt) |
| CN (2) | CN1259052A (pt) |
| AT (1) | ATE278419T1 (pt) |
| AU (1) | AU743114B2 (pt) |
| BR (1) | BR9811262A (pt) |
| CA (1) | CA2284586C (pt) |
| DE (1) | DE69826842T2 (pt) |
| ES (1) | ES2227825T3 (pt) |
| HU (1) | HUP0001403A3 (pt) |
| IL (2) | IL132126A0 (pt) |
| NO (1) | NO994760L (pt) |
| NZ (1) | NZ338101A (pt) |
| PL (1) | PL190237B1 (pt) |
| PT (1) | PT971739E (pt) |
| TR (1) | TR199902437T2 (pt) |
| WO (1) | WO1998043670A2 (pt) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6491919B2 (en) | 1997-04-01 | 2002-12-10 | Corixa Corporation | Aqueous immunologic adjuvant compostions of monophosphoryl lipid A |
| GB9706957D0 (en) | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
| GB9820525D0 (en) | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
| GB0000891D0 (en) * | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
| DK1889630T3 (da) | 2000-10-18 | 2012-03-05 | Glaxosmithkline Biolog Sa | Vacciner omfattende MAGE-antigen koblet til protein D-fragment |
| DE60239594D1 (de) | 2001-02-23 | 2011-05-12 | Glaxosmithkline Biolog Sa | Influenza vakzinzusammensetzungen zur intradermaler verabreichung |
| US20030031684A1 (en) | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
| GB0109297D0 (en) | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
| TWI228420B (en) | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
| US20100221284A1 (en) | 2001-05-30 | 2010-09-02 | Saech-Sisches Serumwerk Dresden | Novel vaccine composition |
| GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
| PT1828378E (pt) * | 2004-12-17 | 2014-10-10 | Staat Der Nederlanden Vert Door De Minister Van Vws Ministerie Van Volksgezondheid Welzijn En Sport | Deacilação de lps em bactérias de gram negativo |
| GB0503337D0 (en) | 2005-02-17 | 2005-03-23 | Glaxosmithkline Biolog Sa | Compositions |
| GB0504436D0 (en) | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
| SI2457926T1 (sl) | 2005-04-29 | 2015-01-30 | Glaxosmithkline Biologicals S.A. | Nov postopek za preprečevanje ali zdravljenje infekcije z M. tuberculosis |
| AU2006274647B2 (en) * | 2005-08-02 | 2013-01-10 | Novartis Vaccines And Diagnostics Srl | Reducing interference between oil-containing adjuvants and surfactant-containing antigens |
| TWI457133B (zh) * | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| US8018440B2 (en) | 2005-12-30 | 2011-09-13 | Microsoft Corporation | Unintentional touch rejection |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| KR101378872B1 (ko) | 2006-09-26 | 2014-04-11 | 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) | 합성 애주번트를 함유하는 백신 조성물 |
| US8836648B2 (en) | 2009-05-27 | 2014-09-16 | Microsoft Corporation | Touch pull-in gesture |
| SI2437753T1 (sl) | 2009-06-05 | 2016-12-30 | Infectious Disease Research Institute | Sintetični glukopiranozil-lipidni adjuvansi in cepivni sestavki, ki jih vsebujejo |
| FR2954703B1 (fr) | 2009-12-28 | 2013-12-13 | Chu Nantes | Agonistes des recepteurs tlr 4 et 9 pour prevenir les complications septiques de l'immunodepression post-traumatique chez les patients hospitalises pour traumatismes severes |
| US8261213B2 (en) | 2010-01-28 | 2012-09-04 | Microsoft Corporation | Brush, carbon-copy, and fill gestures |
| US9411504B2 (en) | 2010-01-28 | 2016-08-09 | Microsoft Technology Licensing, Llc | Copy and staple gestures |
| US9519356B2 (en) | 2010-02-04 | 2016-12-13 | Microsoft Technology Licensing, Llc | Link gestures |
| US8799827B2 (en) | 2010-02-19 | 2014-08-05 | Microsoft Corporation | Page manipulations using on and off-screen gestures |
| US9310994B2 (en) | 2010-02-19 | 2016-04-12 | Microsoft Technology Licensing, Llc | Use of bezel as an input mechanism |
| US9367205B2 (en) | 2010-02-19 | 2016-06-14 | Microsoft Technolgoy Licensing, Llc | Radial menus with bezel gestures |
| US9454304B2 (en) | 2010-02-25 | 2016-09-27 | Microsoft Technology Licensing, Llc | Multi-screen dual tap gesture |
| US9075522B2 (en) | 2010-02-25 | 2015-07-07 | Microsoft Technology Licensing, Llc | Multi-screen bookmark hold gesture |
| US8751970B2 (en) | 2010-02-25 | 2014-06-10 | Microsoft Corporation | Multi-screen synchronous slide gesture |
| US8707174B2 (en) | 2010-02-25 | 2014-04-22 | Microsoft Corporation | Multi-screen hold and page-flip gesture |
| US8689123B2 (en) | 2010-12-23 | 2014-04-01 | Microsoft Corporation | Application reporting in an application-selectable user interface |
| US8612874B2 (en) | 2010-12-23 | 2013-12-17 | Microsoft Corporation | Presenting an application change through a tile |
| US9423951B2 (en) | 2010-12-31 | 2016-08-23 | Microsoft Technology Licensing, Llc | Content-based snap point |
| US9383917B2 (en) | 2011-03-28 | 2016-07-05 | Microsoft Technology Licensing, Llc | Predictive tiling |
| GB201106357D0 (en) | 2011-04-14 | 2011-06-01 | Pessi Antonello | Composition and uses thereof |
| AU2012243039B2 (en) | 2011-04-08 | 2017-07-13 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| US9158445B2 (en) | 2011-05-27 | 2015-10-13 | Microsoft Technology Licensing, Llc | Managing an immersive interface in a multi-application immersive environment |
| US9104307B2 (en) | 2011-05-27 | 2015-08-11 | Microsoft Technology Licensing, Llc | Multi-application environment |
| US9104440B2 (en) | 2011-05-27 | 2015-08-11 | Microsoft Technology Licensing, Llc | Multi-application environment |
| US9658766B2 (en) | 2011-05-27 | 2017-05-23 | Microsoft Technology Licensing, Llc | Edge gesture |
| US9557909B2 (en) | 2011-09-09 | 2017-01-31 | Microsoft Technology Licensing, Llc | Semantic zoom linguistic helpers |
| US9244802B2 (en) | 2011-09-10 | 2016-01-26 | Microsoft Technology Licensing, Llc | Resource user interface |
| US9146670B2 (en) | 2011-09-10 | 2015-09-29 | Microsoft Technology Licensing, Llc | Progressively indicating new content in an application-selectable user interface |
| AU2012308149A1 (en) | 2011-09-12 | 2014-03-27 | Sheena Mary Geraldine MCCORMACK | Methods and compositions for raising an immune response to HIV |
| PT2850431T (pt) | 2012-05-16 | 2018-07-23 | Immune Design Corp | Vacinas para hsv-2 |
| EP2666785A1 (en) | 2012-05-23 | 2013-11-27 | Affiris AG | Complement component C5a-based vaccine |
| EP2703483A1 (en) | 2012-08-29 | 2014-03-05 | Affiris AG | PCSK9 peptide vaccine |
| WO2014043189A1 (en) | 2012-09-14 | 2014-03-20 | The Regents Of The University Of Colorado, A Body Corporate | Conditionally replication deficient herpes viruses and use thereof in vaccines |
| US9582122B2 (en) | 2012-11-12 | 2017-02-28 | Microsoft Technology Licensing, Llc | Touch-sensitive bezel techniques |
| EP3711768A1 (en) | 2013-04-18 | 2020-09-23 | Immune Design Corp. | Gla monotherapy for use in cancer treatment |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| US9477337B2 (en) | 2014-03-14 | 2016-10-25 | Microsoft Technology Licensing, Llc | Conductive trace routing for display and bezel sensors |
| AU2015238512B2 (en) * | 2014-03-26 | 2018-02-01 | Glaxosmithkline Biologicals S.A. | Mutant staphylococcal antigens |
| EP3169699A4 (en) | 2014-07-18 | 2018-06-20 | The University of Washington | Cancer vaccine compositions and methods of use thereof |
| EP3138579A1 (en) | 2015-09-05 | 2017-03-08 | Biomay Ag | Fusion protein for use in the treatment of a hepatitis b virus infection |
| GB201614799D0 (en) | 2016-09-01 | 2016-10-19 | Glaxosmithkline Biologicals Sa | Compositions |
| EP3295956A1 (en) | 2016-09-20 | 2018-03-21 | Biomay Ag | Polypeptide construct comprising fragments of allergens |
| CN111315406A (zh) | 2017-09-08 | 2020-06-19 | 传染病研究所 | 包括皂苷的脂质体调配物及其使用方法 |
| WO2019175145A1 (en) | 2018-03-12 | 2019-09-19 | Janssen Vaccines & Prevention B.V. | Vaccines against urinary tract infections |
| EP3569612A1 (en) | 2018-05-18 | 2019-11-20 | Biomay Ag | Treatment and prevention of house dust mite allergies |
| EP3941516A1 (en) | 2019-03-18 | 2022-01-26 | Janssen Pharmaceuticals, Inc. | Bioconjugates ofe col! o-antigen polysaccharides. methods of production thereof. andmethods of use thereof |
| IL286467B2 (en) | 2019-03-18 | 2026-02-01 | Janssen Pharmaceuticals Inc | Methods for producing bioconjugates of polysaccharides E. coli o-antigen, preparations thereof and methods for using them |
| IL291821A (en) | 2019-10-02 | 2022-06-01 | Janssen Vaccines & Prevention Bv | Staphylococcus peptides and methods of use |
| MY209568A (en) | 2020-01-16 | 2025-07-22 | Janssen Pharmaceuticals Inc | Fimh mutant, compositions therewith and use thereof |
| AU2021342797B2 (en) | 2020-09-17 | 2024-02-08 | Janssen Pharmaceuticals, Inc. | Multivalent vaccine compositions and uses thereof |
| JP7532672B2 (ja) | 2021-01-12 | 2024-08-13 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | FimH変異体、それを含む組成物、及びその使用 |
| KR20230164108A (ko) | 2021-04-01 | 2023-12-01 | 얀센 파마슈티칼즈, 인코포레이티드 | E. coli O18 생물접합체의 생산 |
| US20240180940A1 (en) * | 2021-05-27 | 2024-06-06 | Revelation Biosciences, Inc. | Mpla compositions and methods of use |
| CN121221758B (zh) * | 2025-12-02 | 2026-03-03 | 华诺泰生物医药科技(成都)有限公司 | 一种即用型稳定3d-mla佐剂溶液的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5068191A (en) * | 1989-08-31 | 1991-11-26 | The Biomembrane Institute | Purified histo-blood group a glycosyltransferase and antibodies thereto |
| US5552141A (en) * | 1991-10-30 | 1996-09-03 | Ribi; Hans O. | Polymeric immunological adjuvants |
| SG48309A1 (en) * | 1993-03-23 | 1998-04-17 | Smithkline Beecham Biolog | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a |
-
1998
- 1998-04-01 ES ES98915239T patent/ES2227825T3/es not_active Expired - Lifetime
- 1998-04-01 IL IL13212698A patent/IL132126A0/xx active IP Right Grant
- 1998-04-01 DE DE69826842T patent/DE69826842T2/de not_active Expired - Lifetime
- 1998-04-01 HU HU0001403A patent/HUP0001403A3/hu unknown
- 1998-04-01 PT PT98915239T patent/PT971739E/pt unknown
- 1998-04-01 CN CN98804685A patent/CN1259052A/zh active Pending
- 1998-04-01 PL PL98336698A patent/PL190237B1/pl not_active IP Right Cessation
- 1998-04-01 WO PCT/US1998/006528 patent/WO1998043670A2/en not_active Ceased
- 1998-04-01 CN CNB2004100713486A patent/CN1326564C/zh not_active Expired - Fee Related
- 1998-04-01 KR KR1019997008958A patent/KR100603884B1/ko not_active Expired - Fee Related
- 1998-04-01 TR TR1999/02437T patent/TR199902437T2/xx unknown
- 1998-04-01 JP JP54200198A patent/JP5019494B2/ja not_active Expired - Lifetime
- 1998-04-01 BR BR9811262-7A patent/BR9811262A/pt not_active Application Discontinuation
- 1998-04-01 NZ NZ338101A patent/NZ338101A/en unknown
- 1998-04-01 AT AT98915239T patent/ATE278419T1/de active
- 1998-04-01 CA CA2284586A patent/CA2284586C/en not_active Expired - Lifetime
- 1998-04-01 AU AU69473/98A patent/AU743114B2/en not_active Ceased
- 1998-04-01 EP EP98915239A patent/EP0971739B1/en not_active Expired - Lifetime
-
1999
- 1999-09-29 IL IL132126A patent/IL132126A/en not_active IP Right Cessation
- 1999-09-30 NO NO994760A patent/NO994760L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1026613A1 (en) | 2000-12-22 |
| CA2284586C (en) | 2011-02-08 |
| JP5019494B2 (ja) | 2012-09-05 |
| PL336698A1 (en) | 2000-07-03 |
| CN1575815A (zh) | 2005-02-09 |
| AU6947398A (en) | 1998-10-22 |
| NZ338101A (en) | 2002-03-28 |
| HUP0001403A3 (en) | 2003-05-28 |
| CN1326564C (zh) | 2007-07-18 |
| KR20010005882A (ko) | 2001-01-15 |
| EP0971739B1 (en) | 2004-10-06 |
| WO1998043670A3 (en) | 1998-12-30 |
| DE69826842D1 (de) | 2004-11-11 |
| IL132126A0 (en) | 2001-03-19 |
| IL132126A (en) | 2006-10-05 |
| BR9811262A (pt) | 2000-10-17 |
| HUP0001403A2 (hu) | 2000-09-28 |
| CN1259052A (zh) | 2000-07-05 |
| NO994760D0 (no) | 1999-09-30 |
| KR100603884B1 (ko) | 2006-07-24 |
| PL190237B1 (pl) | 2005-11-30 |
| JP2001526640A (ja) | 2001-12-18 |
| CA2284586A1 (en) | 1998-10-08 |
| WO1998043670A2 (en) | 1998-10-08 |
| AU743114B2 (en) | 2002-01-17 |
| EP0971739A2 (en) | 2000-01-19 |
| DE69826842T2 (de) | 2005-11-24 |
| ATE278419T1 (de) | 2004-10-15 |
| ES2227825T3 (es) | 2005-04-01 |
| TR199902437T2 (xx) | 2000-01-21 |
| NO994760L (no) | 1999-11-26 |
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