PT973546E - Formulacoes estabilizadas de virus de papiloma humano - Google Patents

Formulacoes estabilizadas de virus de papiloma humano

Info

Publication number: PT973546E
Authority: PT; Portugal
Prior art keywords: stabilized formulations; papiloma virus; human papiloma; formulations; human
Prior art date: 1997-04-08

Application number

PT98915319T

Other languages

English (en)

Inventor

Gautum Sanyal

David B Volkin

Li Shi

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-08

Filing date

1998-04-07

Publication date

2004-06-30

1997-05-07 Priority claimed from GBGB9709351.2A external-priority patent/GB9709351D0/en

1998-04-07 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2004-06-30 Publication of PT973546E publication Critical patent/PT973546E/pt

Links

239000000203 mixture Substances 0.000 title abstract 3
241000700605 Viruses Species 0.000 title 1
241000701806 Human papillomavirus Species 0.000 abstract 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
238000009472 formulation Methods 0.000 abstract 2
239000000427 antigen Substances 0.000 abstract 1
102000036639 antigens Human genes 0.000 abstract 1
108091007433 antigens Proteins 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000002736 nonionic surfactant Substances 0.000 abstract 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 1
229920000136 polysorbate Polymers 0.000 abstract 1
229920000053 polysorbate 80 Polymers 0.000 abstract 1
229940068968 polysorbate 80 Drugs 0.000 abstract 1
230000002035 prolonged effect Effects 0.000 abstract 1
230000004845 protein aggregation Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Microbiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Biochemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Plant Substances (AREA)

PT98915319T 1997-04-08 1998-04-07 Formulacoes estabilizadas de virus de papiloma humano PT973546E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4280897P	1997-04-08	1997-04-08
GBGB9709351.2A GB9709351D0 (en)	1997-05-07	1997-05-07	Stabilized human papillomavirus formulations

Publications (1)

Publication Number	Publication Date
PT973546E true PT973546E (pt)	2004-06-30

Family

ID=26311501

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98915319T PT973546E (pt)	1997-04-08	1998-04-07	Formulacoes estabilizadas de virus de papiloma humano

Country Status (18)

Country	Link
EP (1)	EP0973546B1 (pt)
JP (1)	JP4598201B2 (pt)
KR (1)	KR20010006169A (pt)
CN (1)	CN1259051A (pt)
AT (1)	ATE261734T1 (pt)
AU (1)	AU739829B2 (pt)
CA (1)	CA2286294A1 (pt)
DE (1)	DE69822452T2 (pt)
DK (1)	DK0973546T3 (pt)
EE (1)	EE9900612A (pt)
ES (1)	ES2216280T3 (pt)
IL (1)	IL132201A0 (pt)
NO (1)	NO994879L (pt)
NZ (1)	NZ500028A (pt)
PL (1)	PL336715A1 (pt)
PT (1)	PT973546E (pt)
SK (1)	SK138199A3 (pt)
WO (1)	WO1998044944A2 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AUPP765398A0 (en) *	1998-12-11	1999-01-14	University Of Queensland, The	Treatment of papillomavirus infections
DE60040727D1 (de) *	1999-02-05	2008-12-18	Merck & Co Inc	Menschliche papillomavirus impfstoff-formulierungen
US6245568B1 (en) *	1999-03-26	2001-06-12	Merck & Co., Inc.	Human papilloma virus vaccine with disassembled and reassembled virus-like particles
DE10137102A1 (de)	2001-07-30	2003-02-27	Deutsches Krebsforsch	Polyvalente Vakzine gegen durch Papillomaviren verursachte Erkrankungen, Verfahren zu deren Herstellung und deren Verwendung
GB0206360D0 (en)	2002-03-18	2002-05-01	Glaxosmithkline Biolog Sa	Viral antigens
TW200806315A (en) *	2006-04-26	2008-02-01	Wyeth Corp	Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
SG10202012986SA (en)	2006-09-29	2021-01-28	Ligocyte Pharmaceuticals Inc	Norovirus vaccine formulations
JP2010539192A (ja)	2007-09-18	2010-12-16	リゴサイトファーマスーティカルズ，インコーポレイテッド	ノロウイルスに対して防御免疫応答を付与する方法
WO2009092113A2 (en) *	2008-01-19	2009-07-23	Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methods and compositions for the delivery of vaccines to disrupted epithelium
PL2651436T3 (pl) *	2010-12-14	2016-10-31		Kompozycja antygenów mykobakteryjnych
CN102085354A (zh) *	2010-12-30	2011-06-08	重庆大学	一种治疗人乳头瘤病毒16型引发的肿瘤的多肽药物
CA2841356C (en)	2011-07-11	2022-03-01	Takeda Vaccines, Inc.	Parenteral norovirus vaccine formulations
CN105177025B (zh) *	2013-12-03	2022-11-01	北京康乐卫士生物技术股份有限公司	18型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN107002085A (zh) *	2014-09-11	2017-08-01	卡迪拉保健有限公司	具有优异免疫学特性的优异的人乳头瘤病毒抗原和含有其的疫苗
CN106399329B (zh) *	2015-08-12	2021-06-11	北京康乐卫士生物技术股份有限公司	33型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN106701797B (zh) *	2015-08-12	2021-06-15	北京康乐卫士生物技术股份有限公司	31型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN108201623A (zh) *	2016-12-19	2018-06-26	无锡鑫连鑫生物医药科技有限公司	人乳头瘤病毒重组四价疫苗、其制备方法及其应用
CN113347987A (zh) *	2018-11-28	2021-09-03	总医院公司	针对共生病毒的t细胞导向的抗癌疫苗

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2949031A1 (de) *	1978-12-15	1980-07-17	Sandoz Ag	Vakzine
US4606918A (en) *	1983-08-22	1986-08-19	Syntex (U.S.A.) Inc.	Polyoxypropylene-polyoxyethylene block polymer based adjuvants
JPS63239234A (ja) *	1988-01-14	1988-10-05	Green Cross Corp:The	ワクチン製剤
JPH085803B2 (ja) *	1988-11-10	1996-01-24	武田薬品工業株式会社	日本脳炎ワクチンの製造法
AU1218295A (en) *	1993-12-09	1995-06-27	Heinrich Exner	Adjuvant for antigens, process for producing the same and its use
AUPM566794A0 (en) *	1994-05-17	1994-06-09	University Of Queensland, The	Process and product
AR004464A1 (es) *	1994-11-14	1998-12-16	Merck Sharp & Dohme	Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) *	1995-03-22	2005-11-20	Merck & Co Inc	Dna encoding human papillomavirus type 18
IL117591A0 (en) *	1995-03-30	1996-07-23	Merck & Co Inc	Synthetic DNA encoding human papillomavirus type 11 L1 protein
US5718904A (en) *	1995-06-02	1998-02-17	American Home Products Corporation	Adjuvants for viral vaccines

1998
- 1998-04-07 JP JP54301498A patent/JP4598201B2/ja not_active Expired - Fee Related
- 1998-04-07 DK DK98915319T patent/DK0973546T3/da active
- 1998-04-07 DE DE69822452T patent/DE69822452T2/de not_active Expired - Lifetime
- 1998-04-07 AT AT98915319T patent/ATE261734T1/de not_active IP Right Cessation
- 1998-04-07 WO PCT/US1998/006825 patent/WO1998044944A2/en not_active Ceased
- 1998-04-07 KR KR1019997009248A patent/KR20010006169A/ko not_active Withdrawn
- 1998-04-07 EE EEP199900612A patent/EE9900612A/xx unknown
- 1998-04-07 CA CA002286294A patent/CA2286294A1/en not_active Abandoned
- 1998-04-07 PL PL98336715A patent/PL336715A1/xx unknown
- 1998-04-07 CN CN98805728A patent/CN1259051A/zh active Pending
- 1998-04-07 PT PT98915319T patent/PT973546E/pt unknown
- 1998-04-07 NZ NZ500028A patent/NZ500028A/en unknown
- 1998-04-07 SK SK1381-99A patent/SK138199A3/sk unknown
- 1998-04-07 EP EP98915319A patent/EP0973546B1/en not_active Expired - Lifetime
- 1998-04-07 AU AU69533/98A patent/AU739829B2/en not_active Ceased
- 1998-04-07 IL IL13220198A patent/IL132201A0/xx unknown
- 1998-04-07 ES ES98915319T patent/ES2216280T3/es not_active Expired - Lifetime
1999
- 1999-10-07 NO NO994879A patent/NO994879L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE69822452D1 (de)	2004-04-22
AU739829B2 (en)	2001-10-18
AU6953398A (en)	1998-10-30
PL336715A1 (en)	2000-07-03
NO994879L (no)	1999-12-07
WO1998044944A2 (en)	1998-10-15
ES2216280T3 (es)	2004-10-16
NZ500028A (en)	2001-08-31
NO994879D0 (no)	1999-10-07
IL132201A0 (en)	2001-03-19
SK138199A3 (en)	2000-06-12
EP0973546B1 (en)	2004-03-17
ATE261734T1 (de)	2004-04-15
DK0973546T3 (da)	2004-06-28
KR20010006169A (ko)	2001-01-26
EP0973546A2 (en)	2000-01-26
DE69822452T2 (de)	2006-04-20
CA2286294A1 (en)	1998-10-15
JP2001519814A (ja)	2001-10-23
CN1259051A (zh)	2000-07-05
WO1998044944A3 (en)	1998-12-30
EE9900612A (et)	2000-08-15
JP4598201B2 (ja)	2010-12-15

Publication	Publication Date	Title
PT973546E (pt)	2004-06-30	Formulacoes estabilizadas de virus de papiloma humano
TR200302105T4 (tr)	2004-02-23	Siklosporin, hiyalüronik asit ve polisorbat içeren göz formülasyonları.
JO3404B1 (ar)	2019-10-20	تركيبة صيدلانية سائلة تحتوي على مشتقات اريثروبويتين
CA2478621A1 (en)	2001-08-16	Botulinum toxin pharmaceutical compositions
DE69531314D1 (de)	2003-08-21	Verwendung von metallionen chelatoren zur stabilisierung von interferon-enthaltenden pharmazeutischen zubereitungen
CY1113609T1 (el)	2015-08-05	ΔΙΑΛΥΤΟΤΗΤΑ ΙFΝ-ΒΗΤΑ-1b ΣΕ ΔΙΑΛΥΜΑΤΑ ΧΛΩΡΙΟΥΧΟΥ ΝΑΤΡΙΟΥ
NZ510887A (en)	2004-12-24	Formulations of fexofenadine for ocular and nasal delivery
DK1259226T3 (da)	2006-08-21	Anæstetiske formuleringer
DK1079803T3 (da)	2004-11-22	Proteinholdige præparater
NO922953L (no)	1992-09-04	Rekombinant fremstilt blodfaktorer og fremgangsmaate for ekspresjon av blodfaktorene, samt vacciniavirusrekombinanter
BR0110290A (pt)	2003-02-18	Preparação lìquida estabilizada
BR9809708A (pt)	2000-07-11	Composições farmacêuticas de peptìdeos tendo solubilidade baixa em meio fisiológico
CA2060560A1 (en)	1992-08-04	Method for insuring adequate intracellular glutathione in tissue
MXPA05009135A (es)	2005-10-20	Formulaciones liquidas de las proteinas de union del factor necrosis del tumor.
DE69933875D1 (de)	2006-12-14	Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt.
UY27373A1 (es)	2003-02-28	Formulaciones de interferón beta-humano
DE69736779D1 (de)	2006-11-16	Zusammensetzungen von rekombinanten papillomavirus vakzinen
ATE401394T1 (de)	2008-08-15	Verbesserte dnase flüssige lösungen
EA199900915A1 (ru)	2000-06-26	Стабилизированные композиции вируса папилломы человека
SE8402199L (sv)	1984-10-23	Farmaceutiskt preparat innehallande co-dergocrin och en kalciumantagonist
DE69926633D1 (de)	2005-09-15	Injizierbare arzneiformulierungen von partricin derivaten
RU94032143A (ru)	1996-08-20	Композиция, содержащая препарат коагуляционного фактора viii, способ ее получения и применение поверхностно-активного вещества в качестве стабилизатора
RU2003124254A (ru)	2005-02-27	Косметическое средство для ухода за кожей лица и шеи
DE60217302D1 (de)	2007-02-15	Erhaltung von körpereigenen proteinen