PT99435A - Processo para a preparacao de derivados de amino-sulfonil-ureia e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de derivados de amino-sulfonil-ureia e de composicoes farmaceuticas que os contem

Info

Publication number: PT99435A
Authority: PT; Portugal
Prior art keywords: pharmaceutical compositions; sulfonyl; amino; preparation; compositions containing
Prior art date: 1990-11-07

Application number

PT99435A

Other languages

English (en)

Other versions

PT99435B (pt

Inventor

Drago Robert Sliskovic

Joseph Armand Picard

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-07

Filing date

1991-11-06

Publication date

1992-12-31

1991-11-06 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1992-12-31 Publication of PT99435A publication Critical patent/PT99435A/pt

1999-04-30 Publication of PT99435B publication Critical patent/PT99435B/pt

Links

OJXASOYYODXRPT-UHFFFAOYSA-N sulfamoylurea Chemical class NC(=O)NS(N)(=O)=O OJXASOYYODXRPT-UHFFFAOYSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
238000009877 rendering Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/08—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/10—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT99435A 1990-11-07 1991-11-06 Processo para a preparacao de derivados de amino-sulfonil-ureia e de composicoes farmaceuticas que os contem PT99435B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US61028790A	1990-11-07	1990-11-07
US07/747,040 US5214206A (en)	1990-11-07	1991-08-19	Aminosulfonyl urea acat inhibitors

Publications (2)

Publication Number	Publication Date
PT99435A true PT99435A (pt)	1992-12-31
PT99435B PT99435B (pt)	1999-04-30

Family

ID=27086230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99435A PT99435B (pt)	1990-11-07	1991-11-06	Processo para a preparacao de derivados de amino-sulfonil-ureia e de composicoes farmaceuticas que os contem

Country Status (16)

Country	Link
US (2)	US5214206A (pt)
EP (1)	EP0556322B1 (pt)
JP (2)	JP3256541B2 (pt)
AT (1)	ATE139226T1 (pt)
AU (1)	AU657928B2 (pt)
CA (1)	CA2094806C (pt)
DE (1)	DE69120287T2 (pt)
DK (1)	DK0556322T3 (pt)
ES (1)	ES2088128T3 (pt)
GR (1)	GR3020355T3 (pt)
IE (1)	IE75379B1 (pt)
MX (1)	MX9101958A (pt)
NZ (1)	NZ240481A (pt)
PH (1)	PH30665A (pt)
PT (1)	PT99435B (pt)
WO (1)	WO1992008694A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992012144A1 (en) *	1990-12-28	1992-07-23	Teijin Limited	Condensed benzoxa ring compound, production thereof, and pharmaceutical composition containing the same
US5576335A (en) *	1994-02-01	1996-11-19	Nisshin Flour Milling Co., Ltd.	Urea derivatives and their use as ACAT inhibitors
US5491170A (en) *	1994-12-19	1996-02-13	Warner-Lambert Company	β-carboxy sulfonamide ACAT inhibitors
US6103733A (en) *	1998-09-09	2000-08-15	Bachmann; Kenneth A.	Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
CA2369967A1 (en) *	2001-02-12	2002-08-12	Joseph Anthony Cornicelli	Methods of treating nuclear factor-kappa b mediated diseases and disorders
EP1281399A3 (en) *	2001-08-01	2004-02-11	Warner-Lambert Company	Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production
ES2677668T3 (es) *	2010-11-16	2018-08-06	Texas Heart Institute	Agonistas que mejoran la unión de células que expresan integrina a receptores de integrina
CN103288749A (zh) *	2013-03-04	2013-09-11	盐城工学院	可作除草剂的氨基磺酰脲类化合物
EP3733209A1 (en) *	2014-10-03	2020-11-04	Synaffix B.V.	Sulfamide linker, conjugates thereof, and methods of preparation
JP6929792B2 (ja) *	2015-02-16	2021-09-01	ザユニバーシティオブクィーンズランド	スルホニル尿素及び関連化合物並びにその使用
BR112018016671A2 (pt) *	2016-02-16	2018-12-26	The University Of Queensland	sulfonilureias e compostos relacionados e uso do mesmo
CN110914256A (zh)	2017-07-07	2020-03-24	英夫拉索姆有限公司	新颖磺酰胺羧酰胺化合物
GB201721185D0 (en)	2017-12-18	2018-01-31	Nodthera Ltd	Sulphonyl urea derivatives
SG11202101480XA (en) *	2018-08-15	2021-03-30	Inflazome Ltd	Novel sulfonamideurea compounds
JP7661248B2 (ja)	2019-06-12	2025-04-14	ノッドセラリミテッド	スルホニル尿素誘導体及びその使用
HUE067378T2 (hu)	2019-06-12	2024-10-28	Nodthera Ltd	Szulfonilurea származékok és alkalmazásaik

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2312404A (en) *	1939-11-22	1943-03-02	Haack Erich	Method of preparing n-sulphonylureas
CH396872A (de) *	1959-08-13	1965-08-15	Ciba Geigy	Verfahren zur Herstellung neuer Harnstoffe
US3242174A (en) *	1962-02-06	1966-03-22	Pfizer & Co C	1-(tertiary aminosulfonyl)-3-(hydrocarbon) ureas
GB990860A (en) *	1962-02-08	1965-05-05	Pfizer & Co C	N,n-disubstituted sulfamylureas and compositions thereof
US3245982A (en) *	1962-03-27	1966-04-12	Pfizer & Co C	Sulfamylsemicarbazides
DE1518541A1 (de) *	1965-03-16	1969-09-11	Boehringer Mannheim Gmbh	Verfahren zur Herstellung von Sulfonylharnstoffen und Sulfonylsemicarbaziden
FR2339694A1 (fr)	1976-01-30	1977-08-26	Martin Usines Fonderie Arthur	Machine a laver le linge comportant un dispositif de sechage par ventilation d'air chaud
CH649081A5 (de) *	1982-01-12	1985-04-30	Ciba Geigy Ag	Triaza-verbindungen.

1991
- 1991-08-19 US US07/747,040 patent/US5214206A/en not_active Expired - Lifetime
- 1991-11-05 CA CA002094806A patent/CA2094806C/en not_active Expired - Fee Related
- 1991-11-05 DE DE69120287T patent/DE69120287T2/de not_active Expired - Fee Related
- 1991-11-05 ES ES92900981T patent/ES2088128T3/es not_active Expired - Lifetime
- 1991-11-05 JP JP50093292A patent/JP3256541B2/ja not_active Expired - Fee Related
- 1991-11-05 EP EP92900981A patent/EP0556322B1/en not_active Expired - Lifetime
- 1991-11-05 WO PCT/US1991/008223 patent/WO1992008694A1/en not_active Ceased
- 1991-11-05 AT AT92900981T patent/ATE139226T1/de not_active IP Right Cessation
- 1991-11-05 DK DK92900981.9T patent/DK0556322T3/da active
- 1991-11-05 AU AU89597/91A patent/AU657928B2/en not_active Ceased
- 1991-11-05 NZ NZ240481A patent/NZ240481A/xx not_active IP Right Cessation
- 1991-11-06 PT PT99435A patent/PT99435B/pt not_active IP Right Cessation
- 1991-11-06 PH PH43413A patent/PH30665A/en unknown
- 1991-11-06 IE IE387491A patent/IE75379B1/en not_active IP Right Cessation
- 1991-11-06 MX MX9101958A patent/MX9101958A/es not_active IP Right Cessation
1993
- 1993-02-19 US US08/019,519 patent/US5288757A/en not_active Expired - Lifetime
1996
- 1996-06-27 GR GR960401724T patent/GR3020355T3/el unknown
2000
- 2000-06-14 JP JP2000177740A patent/JP2001026574A/ja active Pending

Also Published As

Publication number	Publication date
IE75379B1 (en)	1997-09-10
NZ240481A (en)	1994-06-27
US5288757A (en)	1994-02-22
IE913874A1 (en)	1992-05-20
US5214206A (en)	1993-05-25
MX9101958A (es)	1992-07-08
EP0556322A1 (en)	1993-08-25
GR3020355T3 (en)	1996-09-30
JPH06501707A (ja)	1994-02-24
DE69120287T2 (de)	1996-10-10
EP0556322B1 (en)	1996-06-12
ATE139226T1 (de)	1996-06-15
DK0556322T3 (da)	1996-10-14
CA2094806C (en)	2004-11-02
AU8959791A (en)	1992-06-11
DE69120287D1 (en)	1996-07-18
PT99435B (pt)	1999-04-30
JP3256541B2 (ja)	2002-02-12
CA2094806A1 (en)	1992-05-08
ES2088128T3 (es)	1996-08-01
AU657928B2 (en)	1995-03-30
PH30665A (en)	1997-09-16
WO1992008694A1 (en)	1992-05-29
JP2001026574A (ja)	2001-01-30

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Legal Events

Date	Code	Title	Description
1992-12-31	BB1A	Laying open of patent application	Effective date: 19920814
1999-04-30	FG3A	Patent granted, date of granting	Effective date: 19990119
2006-09-29	MM3A	Annulment or lapse	Effective date: 20060719