PT994880E - Macrolidos cristalinos e processos para a sua preparacao - Google Patents

Macrolidos cristalinos e processos para a sua preparacao

Info

Publication number: PT994880E
Authority: PT; Portugal
Prior art keywords: formula; compound; preparation; macrolids; crystal
Prior art date: 1997-06-30

Application number

PT98936392T

Other languages

English (en)

Inventor

Maximilian Grassberger

Gerhard Penn

Dosenbach Cornelia

Hartmann Otto

Horvath Amarylla

Mutz Jean-Paul

Pfeffer Sabine

Wieckhusen Dierk

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-30

Filing date

1998-06-26

Publication date

2005-06-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10815103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT994880(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-06-26 Application filed by Novartis Ag filed Critical Novartis Ag

2005-06-30 Publication of PT994880E publication Critical patent/PT994880E/pt

Links

238000002360 preparation method Methods 0.000 title abstract 3
239000013078 crystal Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 4
238000002425 crystallisation Methods 0.000 abstract 2
230000008025 crystallization Effects 0.000 abstract 2
230000001939 inductive effect Effects 0.000 abstract 2
239000006071 cream Substances 0.000 abstract 1
239000000839 emulsion Substances 0.000 abstract 1
239000002674 ointment Substances 0.000 abstract 1
KASDHRXLYQOAKZ-OLHLVPFQSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C\C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-OLHLVPFQSA-N 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Crystallography & Structural Chemistry (AREA)
Metallurgy (AREA)
Materials Engineering (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT98936392T 1997-06-30 1998-06-26 Macrolidos cristalinos e processos para a sua preparacao PT994880E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9713730.1A GB9713730D0 (en)	1997-06-30	1997-06-30	Organic compounds

Publications (1)

Publication Number	Publication Date
PT994880E true PT994880E (pt)	2005-06-30

Family

ID=10815103

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98936392T PT994880E (pt)	1997-06-30	1998-06-26	Macrolidos cristalinos e processos para a sua preparacao

Country Status (31)

Country	Link
US (1)	US6423722B1 (pt)
EP (1)	EP0994880B1 (pt)
JP (2)	JP3880634B2 (pt)
KR (1)	KR100399765B1 (pt)
CN (1)	CN1139595C (pt)
AR (1)	AR017754A1 (pt)
AT (1)	ATE287410T1 (pt)
AU (1)	AU739211B2 (pt)
BR (1)	BR9810956A (pt)
CA (1)	CA2290412C (pt)
CO (1)	CO4940463A1 (pt)
CZ (1)	CZ297244B6 (pt)
DE (1)	DE69828692T2 (pt)
DK (1)	DK0994880T3 (pt)
ES (1)	ES2236922T3 (pt)
GB (1)	GB9713730D0 (pt)
HU (1)	HU227755B1 (pt)
ID (1)	ID24897A (pt)
IL (1)	IL132761A0 (pt)
MY (1)	MY118718A (pt)
NO (1)	NO312765B1 (pt)
NZ (1)	NZ500994A (pt)
PE (1)	PE97699A1 (pt)
PL (1)	PL192761B1 (pt)
PT (1)	PT994880E (pt)
RU (1)	RU2219181C2 (pt)
SK (1)	SK285665B6 (pt)
TR (1)	TR199903189T2 (pt)
TW (1)	TW552264B (pt)
WO (1)	WO1999001458A1 (pt)
ZA (1)	ZA985655B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9713730D0 (en) *	1997-06-30	1997-09-03	Ciba Geigy Ag	Organic compounds
GB9826656D0 (en)	1998-12-03	1999-01-27	Novartis Ag	Organic compounds
GB0125443D0 (en) *	2001-10-23	2001-12-12	Novartis Ag	Organic Compounds
EP1663220B1 (en) *	2003-09-03	2009-12-02	Glaxo Group Limited	Novel process for the preparation of pleuromutilin derivatives
PT1734927E (pt) *	2004-04-08	2012-09-05	Meda Pharma S A R L	Composição em espuma de pimecrolimus contendo hexilenoglicol, opcionalmente álcool oleílico, dimetilisossorbida e/ou triglicéridos de cadeia média
CA2584430A1 (en) *	2004-12-01	2006-06-08	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Methods for preparing pimecrolimus
TW200837067A (en) *	2006-11-06	2008-09-16	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
JP2010512333A (ja) *	2006-12-07	2010-04-22	ヘルシンヘルスケアソシエテアノニム	塩酸パロノセトロンの結晶及び非晶質形
US9192697B2 (en)	2007-07-03	2015-11-24	Hemoteq Ag	Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
EP2944332B1 (en)	2009-07-10	2016-08-17	Boston Scientific Scimed, Inc.	Use of nanocrystals for a drug delivery balloon
EP2453938B1 (en)	2009-07-17	2015-08-19	Boston Scientific Scimed, Inc.	Nucleation of drug delivery balloons to provide improved crystal size and density
EP2611476B1 (en)	2010-09-02	2016-08-10	Boston Scientific Scimed, Inc.	Coating process for drug delivery balloons using heat-induced rewrap memory
US8669360B2 (en) *	2011-08-05	2014-03-11	Boston Scientific Scimed, Inc.	Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en)	2011-08-25	2013-02-28	Boston Scientific Scimed, Inc.	Medical device with crystalline drug coating
WO2014145780A1 (en)	2013-03-15	2014-09-18	Biosensors International Group, Ltd.	Purification of rapamycin derivatives
EP3178824A1 (en)	2015-12-08	2017-06-14	Medichem, S.A.	Process for preparing pimecrolimus
ES2906158T3 (es) *	2017-05-01	2022-04-13	Meda Pharma Gmbh & Co Kg	Proceso para convertir ascomicina bruta en pimecrolimus purificado
EP3741367A1 (en)	2019-05-21	2020-11-25	Premark Pharma GmbH	Treatment of ocular disease
WO2024209038A1 (en)	2023-04-06	2024-10-10	Premark Pharma Gmbh	Use of pimecrolimus for the treatment of dry eye in patients characterized by a corneal staining score of 4 or 5 on the oxford grading scale

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS51118816A (en) *	1975-04-08	1976-10-19	Meiji Seika Kaisha Ltd	A process for stabilizing non-crystalloidal solid
US4127647A (en) *	1975-04-08	1978-11-28	Meiji Seika Kaisha, Ltd.	Process for preparation of stable amorphous macrolide antibiotic solids
CY1306A (en)	1980-10-01	1985-12-06	Glaxo Group Ltd	Aminoalkyl furan derivative
JP2728482B2 (ja) *	1989-01-26	1998-03-18	協和醗酵工業株式会社	マクロライド系抗生物質の精製法
JPH089630B2 (ja)	1989-07-10	1996-01-31	ヘマ・ソシエダード・アノニマ	有機化合物の、または関連する改善
DK0427680T3 (da) *	1989-11-09	1995-12-18	Sandoz Ltd	Heteroatom-holdige cykliske forbindelser
EP0594600A1 (en) *	1990-03-13	1994-05-04	FISONS plc	Immunosuppressive macrocyclic compounds
EP0480623A1 (en) *	1990-10-11	1992-04-15	Merck & Co. Inc.	New halomacrolides and derivatives having immunosuppressive activity
US5143918A (en) *	1990-10-11	1992-09-01	Merck & Co., Inc.	Halomacrolides and derivatives having immunosuppressive activity
ES2100291T3 (es)	1991-07-30	1997-06-16	Ajinomoto Kk	Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos.
US5247076A (en)	1991-09-09	1993-09-21	Merck & Co., Inc.	Imidazolidyl macrolides having immunosuppressive activity
US5221740A (en)	1992-01-16	1993-06-22	American Home Products Corporation	Oxepane isomers of rapamycin useful as immunosuppressive agents
UA41884C2 (uk) *	1993-11-05	2001-10-15	Амерікан Хоум Продактс Корпорейшн	Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
JP3808500B2 (ja) *	1994-02-22	2006-08-09	キューレータズオブディユニバーシティオブミズーリ	分離剤としての大環状抗生物質
CA2229718A1 (en) *	1995-08-24	1997-03-06	David J. Mathre	Process for the preparation of imidazolyl macrolide immunosuppressants
GB9713730D0 (en) *	1997-06-30	1997-09-03	Ciba Geigy Ag	Organic compounds

1997
- 1997-06-30 GB GBGB9713730.1A patent/GB9713730D0/en active Pending
1998
- 1998-06-25 CO CO98036359A patent/CO4940463A1/es unknown
- 1998-06-26 PL PL336719A patent/PL192761B1/pl unknown
- 1998-06-26 PE PE1998000568A patent/PE97699A1/es not_active IP Right Cessation
- 1998-06-26 JP JP50628799A patent/JP3880634B2/ja not_active Expired - Lifetime
- 1998-06-26 DK DK98936392T patent/DK0994880T3/da active
- 1998-06-26 SK SK1866-99A patent/SK285665B6/sk not_active IP Right Cessation
- 1998-06-26 WO PCT/EP1998/003929 patent/WO1999001458A1/en not_active Ceased
- 1998-06-26 CA CA002290412A patent/CA2290412C/en not_active Expired - Lifetime
- 1998-06-26 PT PT98936392T patent/PT994880E/pt unknown
- 1998-06-26 ES ES98936392T patent/ES2236922T3/es not_active Expired - Lifetime
- 1998-06-26 TR TR1999/03189T patent/TR199903189T2/xx unknown
- 1998-06-26 BR BR9810956-1A patent/BR9810956A/pt not_active Application Discontinuation
- 1998-06-26 NZ NZ500994A patent/NZ500994A/en not_active IP Right Cessation
- 1998-06-26 AT AT98936392T patent/ATE287410T1/de active
- 1998-06-26 AU AU85409/98A patent/AU739211B2/en not_active Expired
- 1998-06-26 RU RU2000101826/04A patent/RU2219181C2/ru active
- 1998-06-26 ID IDW991682A patent/ID24897A/id unknown
- 1998-06-26 DE DE69828692T patent/DE69828692T2/de not_active Expired - Lifetime
- 1998-06-26 IL IL13276198A patent/IL132761A0/xx not_active IP Right Cessation
- 1998-06-26 KR KR10-1999-7010048A patent/KR100399765B1/ko not_active Expired - Lifetime
- 1998-06-26 HU HU0003053A patent/HU227755B1/hu unknown
- 1998-06-26 EP EP98936392A patent/EP0994880B1/en not_active Expired - Lifetime
- 1998-06-26 CN CNB988064677A patent/CN1139595C/zh not_active Expired - Lifetime
- 1998-06-26 CZ CZ0474099A patent/CZ297244B6/cs not_active IP Right Cessation
- 1998-06-26 AR ARP980103094A patent/AR017754A1/es active IP Right Grant
- 1998-06-29 ZA ZA985655A patent/ZA985655B/xx unknown
- 1998-06-29 MY MYPI98002955A patent/MY118718A/en unknown
- 1998-07-21 TW TW087111867A patent/TW552264B/zh not_active IP Right Cessation
1999
- 1999-12-02 NO NO19995909A patent/NO312765B1/no not_active IP Right Cessation
2000
- 2000-10-17 US US09/690,404 patent/US6423722B1/en not_active Expired - Lifetime
2006
- 2006-03-01 JP JP2006055107A patent/JP4504323B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SK186699A3 (en)	2000-05-16
CA2290412A1 (en)	1999-01-14
HU227755B1 (en)	2012-02-28
AR017754A1 (es)	2001-10-24
EP0994880B1 (en)	2005-01-19
US6423722B1 (en)	2002-07-23
IL132761A0 (en)	2001-03-19
HK1028597A1 (en)	2001-02-23
CN1261365A (zh)	2000-07-26
TW552264B (en)	2003-09-11
CO4940463A1 (es)	2000-07-24
CZ297244B6 (cs)	2006-10-11
HUP0003053A2 (hu)	2001-02-28
JP3880634B2 (ja)	2007-02-14
CN1139595C (zh)	2004-02-25
JP2001506279A (ja)	2001-05-15
ID24897A (id)	2000-08-31
WO1999001458A1 (en)	1999-01-14
MY118718A (en)	2005-01-31
KR20010020423A (ko)	2001-03-15
NO995909L (no)	1999-12-02
PE97699A1 (es)	1999-10-29
ZA985655B (en)	1998-12-30
ATE287410T1 (de)	2005-02-15
AU739211B2 (en)	2001-10-04
TR199903189T2 (xx)	2000-06-21
PL192761B1 (pl)	2006-12-29
JP2006151999A (ja)	2006-06-15
SK285665B6 (sk)	2007-05-03
NO995909D0 (no)	1999-12-02
KR100399765B1 (ko)	2003-09-29
NZ500994A (en)	2001-08-31
DE69828692T2 (de)	2006-01-12
GB9713730D0 (en)	1997-09-03
DK0994880T3 (da)	2005-05-30
JP4504323B2 (ja)	2010-07-14
PL336719A1 (en)	2000-07-03
NO312765B1 (no)	2002-07-01
DE69828692D1 (de)	2005-02-24
EP0994880A1 (en)	2000-04-26
HUP0003053A3 (en)	2003-03-28
ES2236922T3 (es)	2005-07-16
CZ474099A3 (cs)	2000-04-12
AU8540998A (en)	1999-01-25
RU2219181C2 (ru)	2003-12-20
CA2290412C (en)	2009-11-10
BR9810956A (pt)	2000-09-26

Publication	Publication Date	Title
PT994880E (pt)	2005-06-30	Macrolidos cristalinos e processos para a sua preparacao
ES2157254T3 (es)	2001-08-16	Ceftiofur (acido libre) cristalino.
NO881933L (no)	1988-11-07	Orale administreringsformer med forsinket avgivning.
BR0015836A (pt)	2002-08-06	Cristal de 4-carboxiamino-2-etil-1,2,3,4-tetra-hidroquinolina como inibidor de cetp
AR015349A1 (es)	2001-05-02	Nuevas modificaciones cristalinas del 2-amino-4-(4-fluorbencilamino)-1-etoxicarbonil-aminobenceno y procedimiento para prepararlos, utilizacion de losmismas y medicamento que las contienen
BR9809745A (pt)	2000-06-20	Sal cristalino de amina de cefdinir
FR2400045A1 (fr)	1979-03-09	Copolyesters d'acide dicarboxylique, d'hydroquinone substituee et de resorcinol, sous forme de cristaux liquides
NO965516D0 (no)	1996-12-20	Sterolderivater anvendt til regulering av meiose
AR015418A1 (es)	2001-05-02	Procedimiento para la preparacion de la forma cristalina (modificacion 1) de la n-(trifluormetil-fenil)-5-metil-isoxazol-4-carboxamida.
DE3856314D1 (de)	1999-04-15	Mesomorphische Verbindung, Flüssigkristallzusammensetzung und Flüssigkristallvorrichtung
RU2000101826A (ru)	2001-09-27	Кристаллические макролиды и способ их получения
BR9812453A (pt)	2000-11-28	Cristalização de açúcares
ES2178214T3 (es)	2002-12-16	Preparacion de zeolita l.
MX9305773A (es)	1994-05-31	5-oxo-dibenzo/a,d/ciclohepta-1,4-dienos, procedimiento para su obtencion y medicamentos que los contienen.
PT905138E (pt)	2003-03-31	Cristais de maltitol de formas particulares composicoes cristalinas que os contenham e processos para a sua preparacao
BR9910085A (pt)	2000-12-26	Processo para a cristalização de um antibiótico de beta-lactama
PT871632E (pt)	2003-08-29	Producao de um sal cristalino de amoxicilina
BR9203092A (pt)	1993-03-30	Processo para producao de aparelho de exibicao de cristal liquido
DE69608012D1 (de)	2000-06-08	Flüssigkristallines Alkenylcyclohexenderivat, Flüssigkristallzusammensetzung und Flüssigkristallanzeigeelement
TR199901363T2 (xx)	1999-08-23	Bir tetrahidro piridin t�revinin kristalle�tirilmesi i�in y�ntem ve bu �ekilde elde edilen kristal �ekiller.
BR0307880A (pt)	2004-12-28	Método para purificar um composto de nióbio e/ou um composto de tântalo altamente puro
ATE28647T1 (de)	1987-08-15	Chinazolinonderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
MY131049A (en)	2007-07-31	Crystallization of optical isomers of leukotriene antagonists
AR023479A1 (es)	2002-09-04	Formas cristalinas de la sal de sodio de 5-cloro-2-metoxi-n-(2-4-metoxi-3-metilaminotiocarbonilamino sulfonilfenil)etil)benzamida
UEDAIRA	1983	Interaction between biomembrane and water