PT994880E - Macrolidos cristalinos e processos para a sua preparacao - Google Patents

Macrolidos cristalinos e processos para a sua preparacao

Info

Publication number: PT994880E
Authority: PT; Portugal
Prior art keywords: formula; compound; preparation; macrolids; crystal
Prior art date: 1997-06-30

Application number

PT98936392T

Other languages

English (en)

Inventor

Maximilian Grassberger

Gerhard Penn

Dosenbach Cornelia

Hartmann Otto

Horvath Amarylla

Mutz Jean-Paul

Pfeffer Sabine

Wieckhusen Dierk

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-30

Filing date

1998-06-26

Publication date

2005-06-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10815103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT994880(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-06-26 Application filed by Novartis Ag filed Critical Novartis Ag

2005-06-30 Publication of PT994880E publication Critical patent/PT994880E/pt

Links

238000002360 preparation method Methods 0.000 title abstract 3
239000013078 crystal Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 4
238000002425 crystallisation Methods 0.000 abstract 2
230000008025 crystallization Effects 0.000 abstract 2
230000001939 inductive effect Effects 0.000 abstract 2
239000006071 cream Substances 0.000 abstract 1
239000000839 emulsion Substances 0.000 abstract 1
239000002674 ointment Substances 0.000 abstract 1
KASDHRXLYQOAKZ-OLHLVPFQSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C\C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-OLHLVPFQSA-N 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Crystallography & Structural Chemistry (AREA)
Metallurgy (AREA)
Materials Engineering (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT98936392T 1997-06-30 1998-06-26 Macrolidos cristalinos e processos para a sua preparacao PT994880E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9713730.1A GB9713730D0 (en)	1997-06-30	1997-06-30	Organic compounds

Publications (1)

Publication Number	Publication Date
PT994880E true PT994880E (pt)	2005-06-30

Family

ID=10815103

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98936392T PT994880E (pt)	1997-06-30	1998-06-26	Macrolidos cristalinos e processos para a sua preparacao

Country Status (31)

Country	Link
US (1)	US6423722B1 (pt)
EP (1)	EP0994880B1 (pt)
JP (2)	JP3880634B2 (pt)
KR (1)	KR100399765B1 (pt)
CN (1)	CN1139595C (pt)
AR (1)	AR017754A1 (pt)
AT (1)	ATE287410T1 (pt)
AU (1)	AU739211B2 (pt)
BR (1)	BR9810956A (pt)
CA (1)	CA2290412C (pt)
CO (1)	CO4940463A1 (pt)
CZ (1)	CZ297244B6 (pt)
DE (1)	DE69828692T2 (pt)
DK (1)	DK0994880T3 (pt)
ES (1)	ES2236922T3 (pt)
GB (1)	GB9713730D0 (pt)
HU (1)	HU227755B1 (pt)
ID (1)	ID24897A (pt)
IL (1)	IL132761A0 (pt)
MY (1)	MY118718A (pt)
NO (1)	NO312765B1 (pt)
NZ (1)	NZ500994A (pt)
PE (1)	PE97699A1 (pt)
PL (1)	PL192761B1 (pt)
PT (1)	PT994880E (pt)
RU (1)	RU2219181C2 (pt)
SK (1)	SK285665B6 (pt)
TR (1)	TR199903189T2 (pt)
TW (1)	TW552264B (pt)
WO (1)	WO1999001458A1 (pt)
ZA (1)	ZA985655B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9713730D0 (en) *	1997-06-30	1997-09-03	Ciba Geigy Ag	Organic compounds
GB9826656D0 (en)	1998-12-03	1999-01-27	Novartis Ag	Organic compounds
GB0125443D0 (en) *	2001-10-23	2001-12-12	Novartis Ag	Organic Compounds
EP2181995A3 (en) *	2003-09-03	2010-06-16	Glaxo Group Limited	Salts and crystalline form of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-sufanyl)-acetate
AU2005230401B2 (en) *	2004-04-08	2008-11-27	Meda Pharma S.A.R.L.	Pimecrolimus foam composition containing hexylene glycol, optionally oleyl alcohol, dimethylisosorbide and/or medium chain triglycerides
CA2584358A1 (en)	2004-12-01	2006-06-08	Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag	Non-hygroscopic and powdery amorphous pimecrolimus
TW200837067A (en) *	2006-11-06	2008-09-16	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
JP2010512333A (ja) *	2006-12-07	2010-04-22	ヘルシンヘルスケアソシエテアノニム	塩酸パロノセトロンの結晶及び非晶質形
US9192697B2 (en)	2007-07-03	2015-11-24	Hemoteq Ag	Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
EP2944332B1 (en)	2009-07-10	2016-08-17	Boston Scientific Scimed, Inc.	Use of nanocrystals for a drug delivery balloon
EP2453938B1 (en)	2009-07-17	2015-08-19	Boston Scientific Scimed, Inc.	Nucleation of drug delivery balloons to provide improved crystal size and density
EP2611476B1 (en)	2010-09-02	2016-08-10	Boston Scientific Scimed, Inc.	Coating process for drug delivery balloons using heat-induced rewrap memory
WO2013022458A1 (en) *	2011-08-05	2013-02-14	Boston Scientific Scimed, Inc.	Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en)	2011-08-25	2015-06-16	Boston Scientific Scimed, Inc.	Medical device with crystalline drug coating
WO2014145780A1 (en)	2013-03-15	2014-09-18	Biosensors International Group, Ltd.	Purification of rapamycin derivatives
EP3178824A1 (en)	2015-12-08	2017-06-14	Medichem, S.A.	Process for preparing pimecrolimus
WO2018202733A1 (en) *	2017-05-01	2018-11-08	Meda Pharma Gmbh & Co. Kg	Process to convert crude ascomycin into purified pimecrolimus
EP3741367A1 (en)	2019-05-21	2020-11-25	Premark Pharma GmbH	Treatment of ocular disease
EP4687895A1 (en)	2023-04-06	2026-02-11	Premark Pharma GmbH	Use of pimecrolimus for the treatment of dry eye in patients characterized by a corneal staining score of 4 or 5 on the oxford grading scale

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS51118816A (en) *	1975-04-08	1976-10-19	Meiji Seika Kaisha Ltd	A process for stabilizing non-crystalloidal solid
US4127647A (en) *	1975-04-08	1978-11-28	Meiji Seika Kaisha, Ltd.	Process for preparation of stable amorphous macrolide antibiotic solids
CY1306A (en)	1980-10-01	1985-12-06	Glaxo Group Ltd	Aminoalkyl furan derivative
JP2728482B2 (ja) *	1989-01-26	1998-03-18	協和醗酵工業株式会社	マクロライド系抗生物質の精製法
ES2023560A6 (es)	1989-07-10	1992-01-16	Gema Sa	Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida.
DK0427680T3 (da) *	1989-11-09	1995-12-18	Sandoz Ltd	Heteroatom-holdige cykliske forbindelser
EP0594600A1 (en) *	1990-03-13	1994-05-04	FISONS plc	Immunosuppressive macrocyclic compounds
EP0480623A1 (en) *	1990-10-11	1992-04-15	Merck & Co. Inc.	New halomacrolides and derivatives having immunosuppressive activity
US5143918A (en) *	1990-10-11	1992-09-01	Merck & Co., Inc.	Halomacrolides and derivatives having immunosuppressive activity
DE10199058I2 (de)	1991-07-30	2006-04-27	Alcm Co	Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
US5247076A (en)	1991-09-09	1993-09-21	Merck & Co., Inc.	Imidazolidyl macrolides having immunosuppressive activity
US5221740A (en)	1992-01-16	1993-06-22	American Home Products Corporation	Oxepane isomers of rapamycin useful as immunosuppressive agents
UA41884C2 (uk) *	1993-11-05	2001-10-15	Амерікан Хоум Продактс Корпорейшн	Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
US5626757A (en) *	1994-02-22	1997-05-06	Advanced Separation Technologies Inc.	Macrocyclic antibiotics as separation agents
CA2229718A1 (en) *	1995-08-24	1997-03-06	David J. Mathre	Process for the preparation of imidazolyl macrolide immunosuppressants
GB9713730D0 (en) *	1997-06-30	1997-09-03	Ciba Geigy Ag	Organic compounds

1997
- 1997-06-30 GB GBGB9713730.1A patent/GB9713730D0/en active Pending
1998
- 1998-06-25 CO CO98036359A patent/CO4940463A1/es unknown
- 1998-06-26 IL IL13276198A patent/IL132761A0/xx not_active IP Right Cessation
- 1998-06-26 PT PT98936392T patent/PT994880E/pt unknown
- 1998-06-26 RU RU2000101826/04A patent/RU2219181C2/ru active
- 1998-06-26 BR BR9810956-1A patent/BR9810956A/pt not_active Application Discontinuation
- 1998-06-26 AU AU85409/98A patent/AU739211B2/en not_active Expired
- 1998-06-26 AR ARP980103094A patent/AR017754A1/es active IP Right Grant
- 1998-06-26 ES ES98936392T patent/ES2236922T3/es not_active Expired - Lifetime
- 1998-06-26 EP EP98936392A patent/EP0994880B1/en not_active Expired - Lifetime
- 1998-06-26 CA CA002290412A patent/CA2290412C/en not_active Expired - Lifetime
- 1998-06-26 DK DK98936392T patent/DK0994880T3/da active
- 1998-06-26 KR KR10-1999-7010048A patent/KR100399765B1/ko not_active Expired - Lifetime
- 1998-06-26 AT AT98936392T patent/ATE287410T1/de active
- 1998-06-26 PE PE1998000568A patent/PE97699A1/es not_active IP Right Cessation
- 1998-06-26 WO PCT/EP1998/003929 patent/WO1999001458A1/en not_active Ceased
- 1998-06-26 TR TR1999/03189T patent/TR199903189T2/xx unknown
- 1998-06-26 NZ NZ500994A patent/NZ500994A/en not_active IP Right Cessation
- 1998-06-26 ID IDW991682A patent/ID24897A/id unknown
- 1998-06-26 DE DE69828692T patent/DE69828692T2/de not_active Expired - Lifetime
- 1998-06-26 HU HU0003053A patent/HU227755B1/hu unknown
- 1998-06-26 PL PL336719A patent/PL192761B1/pl unknown
- 1998-06-26 JP JP50628799A patent/JP3880634B2/ja not_active Expired - Lifetime
- 1998-06-26 CN CNB988064677A patent/CN1139595C/zh not_active Expired - Lifetime
- 1998-06-26 CZ CZ0474099A patent/CZ297244B6/cs not_active IP Right Cessation
- 1998-06-26 SK SK1866-99A patent/SK285665B6/sk not_active IP Right Cessation
- 1998-06-29 ZA ZA985655A patent/ZA985655B/xx unknown
- 1998-06-29 MY MYPI98002955A patent/MY118718A/en unknown
- 1998-07-21 TW TW087111867A patent/TW552264B/zh not_active IP Right Cessation
1999
- 1999-12-02 NO NO19995909A patent/NO312765B1/no not_active IP Right Cessation
2000
- 2000-10-17 US US09/690,404 patent/US6423722B1/en not_active Expired - Lifetime
2006
- 2006-03-01 JP JP2006055107A patent/JP4504323B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR100399765B1 (ko)	2003-09-29
EP0994880A1 (en)	2000-04-26
JP4504323B2 (ja)	2010-07-14
ID24897A (id)	2000-08-31
AR017754A1 (es)	2001-10-24
KR20010020423A (ko)	2001-03-15
CO4940463A1 (es)	2000-07-24
HUP0003053A3 (en)	2003-03-28
SK285665B6 (sk)	2007-05-03
JP2001506279A (ja)	2001-05-15
CA2290412A1 (en)	1999-01-14
NZ500994A (en)	2001-08-31
PL192761B1 (pl)	2006-12-29
CZ474099A3 (cs)	2000-04-12
CN1139595C (zh)	2004-02-25
ATE287410T1 (de)	2005-02-15
CA2290412C (en)	2009-11-10
PL336719A1 (en)	2000-07-03
TW552264B (en)	2003-09-11
EP0994880B1 (en)	2005-01-19
BR9810956A (pt)	2000-09-26
ES2236922T3 (es)	2005-07-16
WO1999001458A1 (en)	1999-01-14
RU2219181C2 (ru)	2003-12-20
CZ297244B6 (cs)	2006-10-11
IL132761A0 (en)	2001-03-19
DE69828692T2 (de)	2006-01-12
AU8540998A (en)	1999-01-25
NO995909D0 (no)	1999-12-02
MY118718A (en)	2005-01-31
SK186699A3 (en)	2000-05-16
HUP0003053A2 (hu)	2001-02-28
TR199903189T2 (xx)	2000-06-21
CN1261365A (zh)	2000-07-26
GB9713730D0 (en)	1997-09-03
NO312765B1 (no)	2002-07-01
DK0994880T3 (da)	2005-05-30
ZA985655B (en)	1998-12-30
AU739211B2 (en)	2001-10-04
NO995909L (no)	1999-12-02
DE69828692D1 (de)	2005-02-24
JP3880634B2 (ja)	2007-02-14
HU227755B1 (en)	2012-02-28
HK1028597A1 (en)	2001-02-23
JP2006151999A (ja)	2006-06-15
US6423722B1 (en)	2002-07-23
PE97699A1 (es)	1999-10-29

Publication	Publication Date	Title
ID24897A (id)	2000-08-31	Makrolida kristalin
ES2157254T3 (es)	2001-08-16	Ceftiofur (acido libre) cristalino.
NO881933L (no)	1988-11-07	Orale administreringsformer med forsinket avgivning.
NO20022558L (no)	2002-05-29	4-karboksyamino-2-etyl-1,2,3,4-tetrahydrokinolinkrystall som CETP inhibitor
BR9809745A (pt)	2000-06-20	Sal cristalino de amina de cefdinir
ATE382598T1 (de)	2008-01-15	Flüssigkristallverbindungen
NO179867C (no)	1997-01-02	Sulfonamido- og sulfonamidokarbonyl-pyridin-2-karboksylsyreamider og anvendelse av forbindelsene som legemidler
AR029312A1 (es)	2003-06-25	Formas cristalinas de eto2c-ch2-(r)cgl-aze-pab-oh, procesos para su produccion, formulacion farmaceutica, y uso de estos compuestos para la elaboracion de un medicamento.
DE3856314D1 (de)	1999-04-15	Mesomorphische Verbindung, Flüssigkristallzusammensetzung und Flüssigkristallvorrichtung
BR9101663A (pt)	1991-12-10	Utilizacao de n-alquil-lactamas,processo para prevenir a cristalizacao de substancias ativas;e caldos de pulverizacao aquosos
RU2000101826A (ru)	2001-09-27	Кристаллические макролиды и способ их получения
BRPI0415203A (pt)	2006-12-05	pentanóis reestruturados, um processo para sua produção e seu uso como agentes antiinflamatórios
ES2191466T3 (es)	2003-09-01	Fenil-alquenoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamentos o agentes de diagnostico, asi como medicamentos que las contienen.
DE3585477D1 (de)	1992-04-09	Fluessigkristallzusammensetzung des phasentransitionstyps.
BR9812453A (pt)	2000-11-28	Cristalização de açúcares
BR9803949A (pt)	1999-12-21	Cristais de maltitol de formas particulares, composições cristalinas contendo os mesmos e processo para fabriacação dos mesmos
ES2089993T3 (es)	1997-02-16	Procedimiento y productos intermedios para la preparacion de clorhidrato de terazosina dihidrato.
DE69429224D1 (de)	2002-01-10	Zwischenprodukte für die Synthese von Cephalosporinen
PT871632E (pt)	2003-08-29	Producao de um sal cristalino de amoxicilina
BR9203092A (pt)	1993-03-30	Processo para producao de aparelho de exibicao de cristal liquido
ECSP982561A (es)	1999-04-13	Macrolidas cristalinas
ES2095184A1 (es)	1997-02-01	Procedimiento para la obtencion de una carga radial especialmente para uso en la industria papelera, producto de carga formado por cocristalizacion de sulfatos de calcio anhidro y hemihidrato y composicion util para la preparacion de dicha carga.
BR9914399A (pt)	2002-01-22	Composto de piridopirazina, processo para sua produção e seu uso
TR199901363T2 (xx)	1999-08-23	Bir tetrahidro piridin t�revinin kristalle�tirilmesi i�in y�ntem ve bu �ekilde elde edilen kristal �ekiller.
MY131049A (en)	2007-07-31	Crystallization of optical isomers of leukotriene antagonists