RO100033A2 - Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1,2,5-tiadiazolului - Google Patents

Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1,2,5-tiadiazolului

Info

Publication number: RO100033A2
Authority: RO; Romania
Prior art keywords: timolol; hidroxypropoxy; terbutylamino; tiadiazole; morpholine
Prior art date: 1988-09-26

Application number

RO135259A

Other languages

English (en)

Other versions

RO100033B1 (ro

Inventor

Gabriela Putina

Corina Ilie

Steliana Cilianu

Teodor Burghelea

M Simina Ionescu

Rodica Caproiu

Original Assignee

Inst De Cercetari Chimico Farm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-26

Filing date

1988-09-26

Publication date

1990-07-24

1988-09-26 Application filed by Inst De Cercetari Chimico Farm filed Critical Inst De Cercetari Chimico Farm

1988-09-26 Priority to RO135259A priority Critical patent/RO100033B1/ro

1990-07-24 Publication of RO100033A2 publication Critical patent/RO100033A2/ro

1990-10-30 Publication of RO100033B1 publication Critical patent/RO100033B1/ro

Links

238000004519 manufacturing process Methods 0.000 title 1
229960004605 timolol Drugs 0.000 abstract 2
TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000011975 tartaric acid Substances 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

RO135259A 1988-09-26 1988-09-26 Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1, 2, 5-tiadiazolului RO100033B1 (ro)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
RO135259A RO100033B1 (ro)	1988-09-26	1988-09-26	Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1, 2, 5-tiadiazolului

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
RO135259A RO100033B1 (ro)	1988-09-26	1988-09-26	Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1, 2, 5-tiadiazolului

Publications (2)

Publication Number	Publication Date
RO100033A2 true RO100033A2 (ro)	1990-07-24
RO100033B1 RO100033B1 (ro)	1990-10-30

Family

ID=20122524

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RO135259A RO100033B1 (ro)	1988-09-26	1988-09-26	Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1, 2, 5-tiadiazolului

Country Status (1)

Country	Link
RO (1)	RO100033B1 (ro)

1988
- 1988-09-26 RO RO135259A patent/RO100033B1/ro unknown

Also Published As

Publication number	Publication date
RO100033B1 (ro)	1990-10-30

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