RO72511B - Procedeu de hidrogenare a grupei metilen-exociclice din 6-metilen-tetraciclice - Google Patents
Procedeu de hidrogenare a grupei metilen-exociclice din 6-metilen-tetracicliceInfo
- Publication number
- RO72511B RO72511B RO77638A RO7763874A RO72511B RO 72511 B RO72511 B RO 72511B RO 77638 A RO77638 A RO 77638A RO 7763874 A RO7763874 A RO 7763874A RO 72511 B RO72511 B RO 72511B
- Authority
- RO
- Romania
- Prior art keywords
- methylene
- hydrogenation
- atom
- carbon atoms
- general formula
- Prior art date
Links
- 238000005984 hydrogenation reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000004098 Tetracycline Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 abstract 2
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 abstract 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Inorganic materials [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 229940040944 tetracyclines Drugs 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedeu de hidrogenare a grupei metil-exociclice din 6 metilen-tetracicline cu hidrogen gazos, în prezenta de catalizatori, caracterizat prin aceea ca se aduc în reactie tetracicline cu formula generala I: (vezi form. in desc.) în care Y reprezinta un atom de hidrogen, sau o grupa hidroxil, Z reprezinta un atom de hidrogen sau un atom de clor, cu hidrogen gazos sub presiune de 1....120 at, la temperatura de 20....85 degree C, în prezenta unui complex cu formula generala:(vezi form. in desc.) în care R1 si R2 reprezinta radicali inferioara cu 1..4 atomi de carbon, eventual, în prezenta de bromura sau iodura de potasiu în proportie de 0,25....1% greutate fata de masa complecsului, într-un solvent ales din eter-etilenglicol-monometilic, eter etilenglicol-monoetilic, N,N-dimetilformamida sau alcool cu 1....4 atomi de carbon, luat singur sau în amestec, apoi amestecul de reactie este prelucrat, în mod cunoscut, în vederea separarii produsului de reactie.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36806073A | 1973-06-08 | 1973-06-08 | |
| US42827873A | 1973-12-26 | 1973-12-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO72511A RO72511A (ro) | 1983-04-29 |
| RO72511B true RO72511B (ro) | 1983-04-30 |
Family
ID=27004030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO77638A RO72511B (ro) | 1973-06-08 | 1974-02-12 | Procedeu de hidrogenare a grupei metilen-exociclice din 6-metilen-tetraciclice |
Country Status (3)
| Country | Link |
|---|---|
| BG (1) | BG29137A3 (ro) |
| EG (1) | EG11064A (ro) |
| RO (1) | RO72511B (ro) |
-
1974
- 1974-02-12 RO RO77638A patent/RO72511B/ro unknown
- 1974-02-21 BG BG025858A patent/BG29137A3/xx unknown
- 1974-05-13 EG EG17274A patent/EG11064A/xx active
Also Published As
| Publication number | Publication date |
|---|---|
| RO72511A (ro) | 1983-04-29 |
| EG11064A (en) | 1976-11-30 |
| BG29137A3 (en) | 1980-09-15 |
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