RO85311B1 - Procedeu pentru obtinerea unui agent de blocare beta-adrenergica - Google Patents
Procedeu pentru obtinerea unui agent de blocare beta-adrenergicaInfo
- Publication number
- RO85311B1 RO85311B1 RO108290A RO10829082A RO85311B1 RO 85311 B1 RO85311 B1 RO 85311B1 RO 108290 A RO108290 A RO 108290A RO 10829082 A RO10829082 A RO 10829082A RO 85311 B1 RO85311 B1 RO 85311B1
- Authority
- RO
- Romania
- Prior art keywords
- defined above
- general formula
- blocking agent
- beta
- obtaining
- Prior art date
Links
- 239000002876 beta blocker Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229940030611 beta-adrenergic blocking agent Drugs 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000000376 reactant Substances 0.000 abstract 2
- 238000010992 reflux Methods 0.000 abstract 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229940097320 beta blocking agent Drugs 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000002989 phenols Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la un procedeu pentru obtinerea unui agent de blocare beta afrenergica avînd formula generala I: (vezi formula) în care R este alchil inferior, alchenil inferior, haloalchil inferior sau aralalchil; n este un numar între 0 si 2; Ar este un radical fenil sau naftil, alchenil inferior; R1 este alchil inferior sau aralalchil inferior conform caruia se supune reactiei un derivat de fenol cu formula generala II: (vezi formula) în care R, n si Ar sunt definiti ca mai înainte, cu epiclorhidrina, prin încalzirea reactantilor la reflux în mediul de solvent organic, în prezenta unei baze, pentru a forma un derivat de 1,2-epoxi-3-ariloxipropan, avînd formula generala III: (vezi formula) în care R, n si Ar sunt definiti ca mai înainte, care se lasa apoi sa reactioneze cu o amina avînd formula R1-NH2, în care R1 este definit ca mai înainte, încalzind reactantii la reflux, într-un solvent organic, pentru a se obtine produsul final care poate fi eventual transformat, într-o sare farmaceutic acceptabila.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO108290A RO85311B1 (ro) | 1982-07-27 | 1982-07-27 | Procedeu pentru obtinerea unui agent de blocare beta-adrenergica |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO108290A RO85311B1 (ro) | 1982-07-27 | 1982-07-27 | Procedeu pentru obtinerea unui agent de blocare beta-adrenergica |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO85311B1 true RO85311B1 (ro) | 1984-10-30 |
Family
ID=40903496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO108290A RO85311B1 (ro) | 1982-07-27 | 1982-07-27 | Procedeu pentru obtinerea unui agent de blocare beta-adrenergica |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO85311B1 (ro) |
-
1982
- 1982-07-27 RO RO108290A patent/RO85311B1/ro unknown
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