RO91262B - Procedeu pentru prepararea stearatului de acetileritromicina - Google Patents

Procedeu pentru prepararea stearatului de acetileritromicina

Info

Publication number
RO91262B
RO91262B RO117230A RO11723085A RO91262B RO 91262 B RO91262 B RO 91262B RO 117230 A RO117230 A RO 117230A RO 11723085 A RO11723085 A RO 11723085A RO 91262 B RO91262 B RO 91262B
Authority
RO
Romania
Prior art keywords
erythromycin
compound
acetyl
stearate
ester
Prior art date
Application number
RO117230A
Other languages
English (en)
Other versions
RO91262A (ro
Inventor
Martti Lauri Antero Marvola
Esko Veikko Marttila
Antero Uotila Jaakko
Aino Kyllikki Pippuri
Juhani Kairisalo Peka
Erkki Juhani Honkanen
Original Assignee
Orion-Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion-Yhtyma Oy filed Critical Orion-Yhtyma Oy
Publication of RO91262A publication Critical patent/RO91262A/ro
Publication of RO91262B publication Critical patent/RO91262B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Coloring (AREA)

Abstract

Inventia se refera la un compus antibiotic, stearatul de acetil-eritromicina cu formula : (vezi formula). Compusul, conform inventiei, se absoarbe repede în tractul alimentar. Acidul gastric nu-l converteste într-o forma ineficienta, cum se întâmpla cu alti antibiotici de eritromicina. Absorbtia este de asemenea buna cînd pacientul asocieaza luarea medicamentului cu mîncarea. Compusul, conform inventiei, se prepara prin reactia dintre eritromicina baza cu o halogenura de acetil într-un solvent organic în prezenta unui acceptator de acid. Sarea de stearat se separa din esterul obtinut fara a separa esterul într-o faza intermediara.
RO117230A 1984-01-06 1985-01-07 Procedeu pentru prepararea stearatului de acetileritromicina RO91262B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK5884A DK149776C (da) 1984-01-06 1984-01-06 Antibiotisk virksom erytromycinforbindelse og praeparat indeholdende forbindelsen

Publications (2)

Publication Number Publication Date
RO91262A RO91262A (ro) 1987-06-30
RO91262B true RO91262B (ro) 1987-07-01

Family

ID=8089251

Family Applications (1)

Application Number Title Priority Date Filing Date
RO117230A RO91262B (ro) 1984-01-06 1985-01-07 Procedeu pentru prepararea stearatului de acetileritromicina

Country Status (38)

Country Link
US (1) US4599326A (ro)
JP (1) JPS60158197A (ro)
KR (1) KR900006237B1 (ro)
AT (1) AT386414B (ro)
AU (1) AU565688B2 (ro)
BE (1) BE901411A (ro)
BG (1) BG43189A3 (ro)
CA (1) CA1224461A (ro)
CH (1) CH666275A5 (ro)
CS (1) CS247191B2 (ro)
CY (1) CY1462A (ro)
DE (1) DE3500179A1 (ro)
DK (1) DK149776C (ro)
ES (1) ES8605818A1 (ro)
FI (1) FI77249C (ro)
FR (1) FR2557878B1 (ro)
GB (1) GB2152502B (ro)
HK (1) HK11590A (ro)
HU (1) HU196221B (ro)
IE (1) IE57967B1 (ro)
IL (1) IL73885A (ro)
IS (1) IS2968A7 (ro)
IT (1) IT1184304B (ro)
KE (1) KE3841A (ro)
LU (1) LU85721A1 (ro)
MA (1) MA20316A1 (ro)
MX (1) MX156277A (ro)
NL (1) NL8403979A (ro)
NO (1) NO160263C (ro)
NZ (1) NZ210606A (ro)
PH (1) PH22471A (ro)
PL (1) PL144349B1 (ro)
PT (1) PT79777B (ro)
RO (1) RO91262B (ro)
SE (1) SE461854B (ro)
SU (1) SU1410866A3 (ro)
YU (1) YU44485B (ro)
ZA (1) ZA8410143B (ro)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863741A (en) * 1985-03-25 1989-09-05 Abbott Laboratories Tablet composition for drug combinations
US4874614A (en) * 1985-03-25 1989-10-17 Abbott Laboratories Pharmaceutical tableting method
JP3382159B2 (ja) * 1998-08-05 2003-03-04 株式会社東芝 情報記録媒体とその再生方法及び記録方法
WO2004004693A1 (en) * 2002-07-05 2004-01-15 Collgegium Pharmaceutical Abuse-deterrent pharmaceutical compositions of opiods and other drugs
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8840928B2 (en) 2002-07-05 2014-09-23 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
RU2006118801A (ru) * 2003-10-31 2007-12-10 Алза Корпорейшн (Us) Композиции и лекарственные формы для усиления всасывания габапентина и прегабалина
ES2653568T3 (es) 2004-06-12 2018-02-07 Collegium Pharmaceutical, Inc. Formulaciones de fármacos para la prevención del abuso
EP1789075A4 (en) 2004-08-25 2009-07-01 Uab Research Foundation ABSORPTION ENHANCER FOR DRUG ADMINISTRATION
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
EP2158898A1 (en) 2006-06-23 2010-03-03 Aegis Therapeutics LLC Stabilizing alkylglycoside compositions and method thereof
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
EP4286400A3 (en) 2011-05-18 2024-06-05 Eumederis Pharmaceuticals, Inc. Improved peptide pharmaceuticals
EP2922877B1 (en) 2012-11-20 2018-09-05 Eumederis Pharmaceuticals, Inc. Improved peptide pharmaceuticals
WO2014081872A1 (en) 2012-11-20 2014-05-30 Mederis Diabetes, Llc Improved peptide pharmaceuticals for insulin resistance
WO2014140699A1 (en) * 2013-03-13 2014-09-18 Calyx Chemicals And Pharmaceuticals Ltd A novel process of liberation of erythromycin and preparation of its salts
CN117582516A (zh) 2014-05-28 2024-02-23 梅德瑞斯糖尿病有限责任公司 针对胰岛素抵抗的改良肽药物
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
JP6938682B2 (ja) 2017-05-19 2021-09-22 ルネラ・バイオテック・インコーポレーテッド アンチミトシン：癌幹細胞を根絶するためのミトコンドリア生合成の標的阻害薬
CA3083487A1 (en) 2017-12-01 2019-06-06 Lunella Biotech, Inc. Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
JP6941224B2 (ja) 2018-02-06 2021-09-29 イージス セラピューティクス，エルエルシー 疾患の処置のための鼻腔内エピネフリン製剤及び方法
ES2791775B2 (es) 2018-02-06 2023-01-20 Aegis Therapeutics Llc Formulaciones de epinefrina intranasal y metodos para el tratamiento de enfermedades
PE20211551A1 (es) * 2018-12-17 2021-08-16 Lunella Biotech Inc Terapias de combinacion triple para fijar como objetivo mitocondrias y aniquilar celulas madre cancerosas
CA3123850A1 (en) * 2018-12-17 2020-06-25 Lunella Biotech, Inc. Triple combination therapies for anti-aging

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1011117B (de) * 1953-11-16 1957-06-27 Abbott Lab Verfahren zur Herstellung von reinen stabilen Erythromycin-Saeure-Additionssalzen
FR1179208A (fr) * 1953-11-16 1959-05-21 Abbott Lab Procédé de préparation de sels d'érythromycine
GB834397A (en) * 1958-07-29 1960-05-04 Lilly Co Eli Therapeutic compositions comprising erythromycin esters
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
FR2473525A1 (fr) * 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
AU565688B2 (en) 1987-09-24
FI77249B (fi) 1988-10-31
KE3841A (en) 1989-04-07
MX156277A (es) 1988-08-04
RO91262A (ro) 1987-06-30
ES539349A0 (es) 1986-04-01
NO160263B (no) 1988-12-19
LU85721A1 (fr) 1985-07-24
NO850007L (no) 1985-07-08
PT79777A (en) 1985-01-01
NZ210606A (en) 1987-08-31
SE8406671L (sv) 1985-07-07
IT1184304B (it) 1987-10-28
GB2152502B (en) 1987-10-07
IE850022L (en) 1985-07-06
AU3705984A (en) 1985-07-11
DK149776B (da) 1986-09-29
DK149776C (da) 1987-04-21
CS247191B2 (en) 1986-12-18
IT8519012A0 (it) 1985-01-04
ATA985A (de) 1988-01-15
IL73885A0 (en) 1985-03-31
MA20316A1 (fr) 1985-10-01
PL251457A1 (en) 1985-11-05
IS2968A7 (is) 1985-04-03
DK5884A (da) 1985-07-07
PT79777B (en) 1986-10-21
HK11590A (en) 1990-02-23
FI850023A0 (fi) 1985-01-03
ES8605818A1 (es) 1986-04-01
SE8406671D0 (sv) 1984-12-28
CH666275A5 (de) 1988-07-15
HU196221B (en) 1988-10-28
BG43189A3 (en) 1988-04-15
IE57967B1 (en) 1993-06-02
AT386414B (de) 1988-08-25
BE901411A (fr) 1985-04-16
SU1410866A3 (ru) 1988-07-15
FR2557878A1 (fr) 1985-07-12
JPH029040B2 (ro) 1990-02-28
IL73885A (en) 1988-10-31
YU44485B (en) 1990-08-31
CY1462A (en) 1989-07-21
PL144349B1 (en) 1988-05-31
NL8403979A (nl) 1985-08-01
SE461854B (sv) 1990-04-02
PH22471A (en) 1988-09-12
YU2085A (en) 1987-12-31
NO160263C (no) 1989-03-29
FI850023L (fi) 1985-07-07
FR2557878B1 (fr) 1988-01-15
GB2152502A (en) 1985-08-07
DK5884D0 (da) 1984-01-06
US4599326A (en) 1986-07-08
DE3500179C2 (ro) 1989-08-24
ZA8410143B (en) 1985-08-28
KR900006237B1 (ko) 1990-08-27
DE3500179A1 (de) 1985-07-18
JPS60158197A (ja) 1985-08-19
KR850005452A (ko) 1985-08-26
GB8432368D0 (en) 1985-02-06
FI77249C (fi) 1989-02-10
HUT37628A (en) 1986-01-23
CA1224461A (en) 1987-07-21

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