RO97920B1 - Procedeu de preparare a acidului 1(p-clorbenzoil)-5-metoxi-2-metil-indolil-3-acetic - Google Patents
Procedeu de preparare a acidului 1(p-clorbenzoil)-5-metoxi-2-metil-indolil-3-aceticInfo
- Publication number
- RO97920B1 RO97920B1 RO129545A RO12954587A RO97920B1 RO 97920 B1 RO97920 B1 RO 97920B1 RO 129545 A RO129545 A RO 129545A RO 12954587 A RO12954587 A RO 12954587A RO 97920 B1 RO97920 B1 RO 97920B1
- Authority
- RO
- Romania
- Prior art keywords
- chlorobenzoyl
- methoxy
- acetic acid
- indolyl
- methyl
- Prior art date
Links
- 125000000242 4-chlorobenzoyl group Chemical group ClC1=CC=C(C(=O)*)C=C1 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 229940040102 levulinic acid Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- NNPXCKWGJZVCKD-UHFFFAOYSA-M sodium;n-amino-n-(4-methoxyphenyl)sulfamate Chemical compound [Na+].COC1=CC=C(N(N)S([O-])(=O)=O)C=C1 NNPXCKWGJZVCKD-UHFFFAOYSA-M 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Prezenta inventie se refera la un procedeu de preparare a acidului 1-(p-clorbenzoil)-5-metoxi-2-metil-indolil-3-acetic, substanta cu proprietati analgezice, antiinflamatoare si antipiretice, pornind de la p-metoxifenilhidrazinsulfonatul de sodiu, prin acilare directa în pozitia 1 la azot, urmata de indolizare cu acid levulinic în mediu toluenic si în prezenta de acid fosforic, fara izolarea intermediarilor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO129545A RO97920B1 (ro) | 1987-08-24 | 1987-08-24 | Procedeu de preparare a acidului 1(p-clorbenzoil)-5-metoxi-2-metil-indolil-3-acetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO129545A RO97920B1 (ro) | 1987-08-24 | 1987-08-24 | Procedeu de preparare a acidului 1(p-clorbenzoil)-5-metoxi-2-metil-indolil-3-acetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO97920B1 true RO97920B1 (ro) | 1989-10-30 |
Family
ID=40906045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO129545A RO97920B1 (ro) | 1987-08-24 | 1987-08-24 | Procedeu de preparare a acidului 1(p-clorbenzoil)-5-metoxi-2-metil-indolil-3-acetic |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO97920B1 (ro) |
-
1987
- 1987-08-24 RO RO129545A patent/RO97920B1/ro unknown
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