RS59896B1 - Kompozicije nanočestica bez priona i postupci povezani sa njima - Google Patents
Kompozicije nanočestica bez priona i postupci povezani sa njimaInfo
- Publication number
- RS59896B1 RS59896B1 RS20191601A RSP20191601A RS59896B1 RS 59896 B1 RS59896 B1 RS 59896B1 RS 20191601 A RS20191601 A RS 20191601A RS P20191601 A RSP20191601 A RS P20191601A RS 59896 B1 RS59896 B1 RS 59896B1
- Authority
- RS
- Serbia
- Prior art keywords
- heater
- electrode
- liquid
- electrodes
- prion
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
- A61K38/385—Serum albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S210/00—Liquid purification or separation
- Y10S210/902—Materials removed
- Y10S210/903—Nitrogenous
- Y10S210/905—Protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Optics & Photonics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Medical Informatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
Description
II OPIS PRONALASKA
NAZIV PRONALASKA: ELEKTRODNI TROFAZNI GREJAČ
a) Oblast tehnike na koju se pronalazak odnosi
Pronalazak se odnosi na oblast termotehnike koja se bavi zagrevanjem elektro
provodnih tečnosti u polju naizmenične struje.
b) Tehnički problem
Potrebno je zagrejati elektro provodnu tečnost za: grejanje, procesnu
opremu, toplu potrošnu vodu i paru trofaznom naizmeničnom strujom.
c) Stanje tehnike
Sadašnji nivo tehnike za grejanje elektro provodnih tečnosti je takozvani
potopljeni grejač koji se sastoji od: elektrootporne žice koja se zagreva proticanjem naizmenične struje, a toplotu prenosi na šamotno brašno u koje je utopljena i na cev sa kojim je grejač oplašten. Ovakva konstrukcija ima sledeće nedostatke: sporo zagrevanje, pregorevanje grejača kada nema tečnosti, utrošak veće količine energije zbog zagrevanja samog grejača.
d) Izlaganje suštine pronalaska
Elektroprovodna tečnost ulazi kroz otvore 9, zatim zalazi izmedju
elektroda 1 gde se u polju naizmenične struje zagreva i zatim izlazi kroz otvore 8. Ukoliko je položaj montaže elektrodnog trofaznog grejača drugačiji od onog na slici 1. tada su ulazni otvori 8, a izlazni otvori su 9-
e) Kratak opis slika nacrta
Pronalazak je detaljno opis na primeru načina izvodjenja prikazanom na
nacrtu u kome:
Slika 1. - Prikazuje vertikalni presek elektrodnog trofaznog grejača;
Slika 2. - Prikazuje horizonltalni presek A-A elektrodnog trofaznog
grejača;
Slika 3-- Prikazuje horizontalni presek B-B elektrodnog trofaznog grejača;
f) Detaljan opis pronalska
Elektroprovodna tečnost koja ulazi kroz pet otvora 9 kape od plastičnog
materijala 6 zalazi izmedju tri komada elektroda 1 u obliku nezatvorenih pravouglih profila koji zalaze jedan u drugi. Ove tri elektrode 1 ulivene su u plastično telo 5. U polju naizmenične struje izmedju elektroda 1 elektrootporna tečnost se zagreva i izlazi kroz otvore 8 plastične kape 6.
Tri elektrode 1 su preko kontakt zavrtnja 3 i klema 4, vezane za tri
faze naizmenične struje.
Telo od plastike 5 ima navoj sa kojim se navrče na sud u kome greje elektro-otpornu tečnost i ima zaptivni gumeni prsten 7 kojim se onemogučava isticanje tečnosti van suda.
Plastična kapa 6 sa svojim otvorima 8 i 9 usmerava proticanje tečnosti
za grejanje i onemogućava mehaničkim nečistoćama da dodju izmedju elektroda. Plastična kapa 6 ima naglavne zube sa kojima se vezuje za plastično telo 5-Trofazni elektrodni grejač može da se montira u bilo kom položaju. Način uzemljenja ovih elektrodnih grejača je isti kao kod klasičnih grejača.
g) Način industrijske ili druge primene pronalaska
Elektordni trofazni grejač može da se primeni za zagrevanje elektroprovodnih
tečnosti ili proizvodnju pare kod sledečih uredjaja:
- kotlova,
- radijatora,
- bojlera, - reakcionih posuda,
- konvektora i kalorifera,
- fen-coill-a itd
Claims (1)
- Elektrodni trofazni grejač karakterisan je time što se električno naizmenično polje uspostavlja izmedju elektroda kroz elektroprovodnu tečnost što u slučaju smanjenja nivoa tečnosti (ili nestanka tečnosti) izaziva smanjenje kapaciteta grejača (ili potpuni prestanak njegovog rada). Elektrodni trofazni grejač karakterisan je time što su mu elektrode izvedene u obliku nezatvorenih pravougaonih profila koji zalaze jedan u drugi, čime je maksimalno povečana medjusobna površina tj. naizmenično električno polje, a dimenzije grejača su smanjene na minimum.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16966509P | 2009-04-15 | 2009-04-15 | |
| US23805209P | 2009-08-28 | 2009-08-28 | |
| EP10765167.1A EP2419732B1 (en) | 2009-04-15 | 2010-04-15 | Prion-free nanoparticle compositions and methods |
| PCT/US2010/031197 WO2010121000A1 (en) | 2009-04-15 | 2010-04-15 | Prion-free nanoparticle compositions and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS59896B1 true RS59896B1 (sr) | 2020-03-31 |
Family
ID=42982852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20191601A RS59896B1 (sr) | 2009-04-15 | 2010-04-15 | Kompozicije nanočestica bez priona i postupci povezani sa njima |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20100297243A1 (sr) |
| EP (2) | EP3626233A1 (sr) |
| JP (3) | JP5781500B2 (sr) |
| KR (1) | KR20120044279A (sr) |
| CN (1) | CN102460167B (sr) |
| AU (1) | AU2010236382B2 (sr) |
| BR (1) | BRPI1012525A2 (sr) |
| CA (1) | CA2758913A1 (sr) |
| CY (1) | CY1122617T1 (sr) |
| DK (1) | DK2419732T3 (sr) |
| ES (1) | ES2764100T3 (sr) |
| HR (1) | HRP20192259T1 (sr) |
| HU (1) | HUE047376T2 (sr) |
| IL (1) | IL215765A (sr) |
| LT (1) | LT2419732T (sr) |
| ME (1) | ME03596B (sr) |
| MX (2) | MX340055B (sr) |
| MY (1) | MY175260A (sr) |
| PL (1) | PL2419732T3 (sr) |
| PT (1) | PT2419732T (sr) |
| RS (1) | RS59896B1 (sr) |
| RU (1) | RU2559570C2 (sr) |
| SG (1) | SG175239A1 (sr) |
| SI (1) | SI2419732T1 (sr) |
| SM (1) | SMT201900751T1 (sr) |
| WO (1) | WO2010121000A1 (sr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070092563A1 (en) * | 1996-10-01 | 2007-04-26 | Abraxis Bioscience, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
| DK1585548T3 (en) | 2002-12-09 | 2018-09-03 | Abraxis Bioscience Llc | COMPOSITIONS AND PROCEDURES FOR THE DELIVERY OF PHARMACOLOGICAL AGENTS |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| CN103169729A (zh) | 2005-02-18 | 2013-06-26 | 阿布拉科斯生物科学有限公司 | 治疗剂的组合和给予方式以及联合治疗 |
| US7771751B2 (en) | 2005-08-31 | 2010-08-10 | Abraxis Bioscience, Llc | Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents |
| US9675578B2 (en) | 2006-12-14 | 2017-06-13 | Abraxis Bioscience, Llc | Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane |
| EP3417859A1 (en) | 2007-03-07 | 2018-12-26 | Abraxis BioScience, LLC | Nanoparticle comprising rapamycin and albumin as anticancer agent |
| WO2008137148A2 (en) * | 2007-05-03 | 2008-11-13 | Abraxis Bioscience, Llc | Methods and compositions for treating pulmonary hypertension |
| AU2008260447B2 (en) | 2007-06-01 | 2013-10-10 | Abraxis Bioscience, Llc | Methods and compositions for treating recurrent cancer |
| CA2721153C (en) * | 2008-04-10 | 2018-10-02 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
| HRP20192259T1 (hr) * | 2009-04-15 | 2020-03-06 | Abraxis Bioscience, Llc | Pripravci nanočestica bez priona i metode njihove proizvodnje |
| CA3051495A1 (en) | 2010-03-26 | 2011-09-29 | Abraxis Bioscience, Llc | Use of nanoparticles comprising a taxane and albumin in the treatment of hepatocellular carcinoma |
| US9393318B2 (en) | 2010-03-29 | 2016-07-19 | Abraxis Bioscience, Llc | Methods of treating cancer |
| KR20130028727A (ko) | 2010-03-29 | 2013-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
| KR20130088116A (ko) | 2010-06-04 | 2013-08-07 | 아브락시스 바이오사이언스, 엘엘씨 | 췌장암의 치료 방법 |
| WO2012129371A2 (en) | 2011-03-22 | 2012-09-27 | Nant Holdings Ip, Llc | Reasoning engines |
| AU2012249371B2 (en) | 2011-04-28 | 2017-06-08 | Abraxis Bioscience, Llc | Intravascular delivery of nanoparticle compositions and uses thereof |
| PL2790675T3 (pl) | 2011-12-14 | 2019-12-31 | Abraxis Bioscience, Llc | Zastosowanie polimerowych rozczynników do liofilizacji lub zamrażania cząstek |
| WO2013115559A1 (ko) * | 2012-01-30 | 2013-08-08 | 성균관대학교 산학협력단 | 수난용성 약물을 내부에 포함하는 알부민 나노입자 제조방법 |
| US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
| US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
| JP6349381B2 (ja) | 2013-03-12 | 2018-06-27 | アブラクシス バイオサイエンス， エルエルシー | 肺がんを処置する方法 |
| JP6309610B2 (ja) | 2013-03-14 | 2018-04-11 | アブラクシス バイオサイエンス， エルエルシー | 膀胱がんを処置する方法 |
| US10705070B1 (en) | 2015-03-05 | 2020-07-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
| US10527604B1 (en) | 2015-03-05 | 2020-01-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel |
| SMT202100642T1 (it) | 2015-06-29 | 2022-03-21 | Abraxis Bioscience Llc | Nanoparticelle comprendenti sirolimus e un'albumina per l'uso nel trattamento di tumori a cellule epitelioidi |
| AU2019239953B2 (en) | 2018-03-20 | 2025-01-02 | Abraxis Bioscience, Llc | Methods of treating central nervous system disorders via administration of nanoparticles of an mtor inhibitor and an albumin |
| IL292439B2 (en) * | 2019-10-28 | 2026-05-01 | Abraxis Bioscience Llc | Pharmaceutical preparations of albumin and rapamycin |
| US12329765B2 (en) * | 2021-04-28 | 2025-06-17 | New Jersey Institute Of Technology | Targeted nanoparticle for the treatment of traumatic brain injury and other CNS diseases |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1256110B (it) * | 1992-11-23 | 1995-11-28 | Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata | |
| US5665383A (en) | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of immunostimulating agents for in vivo delivery |
| US6096331A (en) | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
| US20070116761A1 (en) | 1993-02-22 | 2007-05-24 | Desai Neil P | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US5997904A (en) | 1993-02-22 | 1999-12-07 | American Bioscience, Inc. | Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof |
| CA2155947C (en) | 1993-02-22 | 2007-08-21 | Mark W. Grinstaff | Methods for in vivo delivery of biologics and compositions useful therefor |
| US5439686A (en) | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
| US5916596A (en) | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US6753006B1 (en) | 1993-02-22 | 2004-06-22 | American Bioscience, Inc. | Paclitaxel-containing formulations |
| US5362478A (en) | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
| US6528067B1 (en) | 1993-02-22 | 2003-03-04 | American Bioscience, Inc. | Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof |
| US20030068362A1 (en) | 1993-02-22 | 2003-04-10 | American Bioscience, Inc. | Methods and formulations for the delivery of pharmacologically active agents |
| WO1999000113A1 (en) | 1997-06-27 | 1999-01-07 | Vivorx Pharmaceuticals, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US6749868B1 (en) | 1993-02-22 | 2004-06-15 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US6537579B1 (en) | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| US5665382A (en) | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of pharmaceutically active agents for in vivo delivery |
| US5650156A (en) | 1993-02-22 | 1997-07-22 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of nutriceuticals and compositions useful therefor |
| JP2930421B2 (ja) * | 1994-02-28 | 1999-08-03 | メディノヴァ メディカル コンサルティング ゲゼルシャフト ミット ベシュレンクテル ハフツング | 薬剤組成物、その製造方法及びその使用方法 |
| US6565842B1 (en) | 1995-06-07 | 2003-05-20 | American Bioscience, Inc. | Crosslinkable polypeptide compositions |
| GB9519197D0 (en) | 1995-09-20 | 1995-11-22 | Affinity Chromatography Ltd | Novel affinity ligands and their use |
| US5750361A (en) | 1995-11-02 | 1998-05-12 | The Regents Of The University Of California | Formation and use of prion protein (PRP) complexes |
| US6537539B2 (en) | 1996-01-11 | 2003-03-25 | Human Genome Sciences, Inc. | Immune cell cytokine |
| US20070092563A1 (en) | 1996-10-01 | 2007-04-26 | Abraxis Bioscience, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US6719988B2 (en) * | 1997-02-21 | 2004-04-13 | The Regents Of The University Of California | Antiseptic compositions for inactivating prions |
| US6221614B1 (en) * | 1997-02-21 | 2001-04-24 | The Regents Of The University Of California | Removal of prions from blood, plasma and other liquids |
| US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US20030199425A1 (en) | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
| US6150172A (en) * | 1999-01-08 | 2000-11-21 | The United States Of America As Represented By The Secretary Of Agriculture | Method and kit for extracting prion protein |
| AU777528B2 (en) | 1999-04-22 | 2004-10-21 | Abraxis Bioscience, Llc | Long term administration of pharmacologically active agents |
| ES2241601T3 (es) | 1999-04-30 | 2005-11-01 | Krones Ag | Procedimiento y dispositivo para aplicar etiquetas tubulares sobre objetos. |
| CA2371912C (en) | 1999-05-21 | 2010-02-16 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| ITMI20001107A1 (it) | 2000-05-18 | 2001-11-18 | Acs Dobfar Spa | Metodo per il trattamento di tumori solici mediante microparticelle di albumina incorporanti paclitaxel |
| US7252799B2 (en) * | 2001-08-31 | 2007-08-07 | Clearant, Inc. | Methods for sterilizing preparations containing albumin |
| ITMI20020681A1 (it) | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina |
| ITMI20020680A1 (it) | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | Composizione antitumorale migliorata a base di paclitaxel e metodo per il suo ottenimento |
| US7201901B2 (en) | 2002-05-23 | 2007-04-10 | Ortho-Clinical Diagnostics, Inc. | Capture, concentration and quantitation of abnormal prion protein from biological fluids using depth filtration |
| US7438100B2 (en) | 2002-07-05 | 2008-10-21 | They Yokohama Rubber Co., Ltd. | Pneumatic tire for ice-bound or snow-covered road |
| ES2527408T3 (es) * | 2002-12-03 | 2015-01-23 | North Carolina State University | Ligandos de proteínas priones y procedimientos de uso |
| KR20140148502A (ko) | 2002-12-09 | 2014-12-31 | 아브락시스 바이오사이언스, 엘엘씨 | 약리학적 물질의 조성물 및 그 전달방법 |
| DK1585548T3 (en) | 2002-12-09 | 2018-09-03 | Abraxis Bioscience Llc | COMPOSITIONS AND PROCEDURES FOR THE DELIVERY OF PHARMACOLOGICAL AGENTS |
| JP4783727B2 (ja) | 2003-04-04 | 2011-09-28 | パソゲン リムーバル アンド ダイアグノスティック テクノロジーズ インコーポレーテッド | プリオンタンパク質結合物質と使用法 |
| US7510848B2 (en) | 2003-04-04 | 2009-03-31 | North Carolina State University | Prion protein binding materials and methods of use |
| GB0416699D0 (en) * | 2004-07-27 | 2004-09-01 | Prometic Biosciences Ltd | Prion protein ligands and methods of use |
| US20070166388A1 (en) | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
| CN103169729A (zh) * | 2005-02-18 | 2013-06-26 | 阿布拉科斯生物科学有限公司 | 治疗剂的组合和给予方式以及联合治疗 |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| US7771751B2 (en) | 2005-08-31 | 2010-08-10 | Abraxis Bioscience, Llc | Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents |
| CN101291658B (zh) | 2005-08-31 | 2014-04-16 | 阿布拉科斯生物科学有限公司 | 用于制备稳定性增加的水难溶性药物的组合物和方法 |
| US20080280987A1 (en) | 2006-08-31 | 2008-11-13 | Desai Neil P | Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases |
| AU2006347740A1 (en) | 2006-08-31 | 2008-03-06 | Abraxis Bioscience, Llc | Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases |
| US20100112077A1 (en) | 2006-11-06 | 2010-05-06 | Abraxis Bioscience, Llc | Nanoparticles of paclitaxel and albumin in combination with bevacizumab against cancer |
| US9675578B2 (en) | 2006-12-14 | 2017-06-13 | Abraxis Bioscience, Llc | Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane |
| EP3417859A1 (en) | 2007-03-07 | 2018-12-26 | Abraxis BioScience, LLC | Nanoparticle comprising rapamycin and albumin as anticancer agent |
| WO2008137148A2 (en) | 2007-05-03 | 2008-11-13 | Abraxis Bioscience, Llc | Methods and compositions for treating pulmonary hypertension |
| AU2008260447B2 (en) | 2007-06-01 | 2013-10-10 | Abraxis Bioscience, Llc | Methods and compositions for treating recurrent cancer |
| CA2721153C (en) | 2008-04-10 | 2018-10-02 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
| WO2009126175A1 (en) | 2008-04-10 | 2009-10-15 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
| AU2009324464B2 (en) * | 2008-12-11 | 2016-05-05 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| BRPI1008955A2 (pt) | 2009-03-13 | 2015-09-01 | Abraxis Bioscience Llc | Terapia de combinação com derivados de tiocolchicina. |
| MX2011010673A (es) | 2009-04-10 | 2012-02-21 | Abraxis Bioscience Llc | Formulaciones de nanoparticulas y usos de las mismas. |
| HRP20192259T1 (hr) | 2009-04-15 | 2020-03-06 | Abraxis Bioscience, Llc | Pripravci nanočestica bez priona i metode njihove proizvodnje |
| BR112012004149A2 (pt) | 2009-08-25 | 2016-03-22 | Abraxis Bioscience Llc | terapia de combinação com composições de nanopartículas de taxano e inibidores de hedgehog |
| CA3051495A1 (en) | 2010-03-26 | 2011-09-29 | Abraxis Bioscience, Llc | Use of nanoparticles comprising a taxane and albumin in the treatment of hepatocellular carcinoma |
| US9393318B2 (en) | 2010-03-29 | 2016-07-19 | Abraxis Bioscience, Llc | Methods of treating cancer |
| KR20130028727A (ko) * | 2010-03-29 | 2013-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
| CN103221042B (zh) | 2010-06-02 | 2016-02-10 | 阿布拉科斯生物科学有限公司 | 治疗膀胱癌的方法 |
| KR20130088116A (ko) | 2010-06-04 | 2013-08-07 | 아브락시스 바이오사이언스, 엘엘씨 | 췌장암의 치료 방법 |
| CA2801891C (en) | 2010-06-07 | 2020-10-27 | Abraxis Bioscience, Llc | Combination therapy methods for treating proliferative diseases |
| AU2012249371B2 (en) | 2011-04-28 | 2017-06-08 | Abraxis Bioscience, Llc | Intravascular delivery of nanoparticle compositions and uses thereof |
| PL2790675T3 (pl) | 2011-12-14 | 2019-12-31 | Abraxis Bioscience, Llc | Zastosowanie polimerowych rozczynników do liofilizacji lub zamrażania cząstek |
| US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
| US20140186447A1 (en) | 2012-12-28 | 2014-07-03 | Abraxis Bioscience, Llc | Nanoparticle compositions of albumin and paclitaxel |
| US20140199404A1 (en) | 2013-01-11 | 2014-07-17 | Abraxis Bioscience, Llc | Method for treating cancer based on level of a nucleoside transporter |
| US20140199405A1 (en) | 2013-01-11 | 2014-07-17 | Abraxis Bioscience, Llc | Method for treating cancer based on mutation status of k-ras |
| US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
| JP6349381B2 (ja) | 2013-03-12 | 2018-06-27 | アブラクシス バイオサイエンス， エルエルシー | 肺がんを処置する方法 |
| CN105209035A (zh) | 2013-03-13 | 2015-12-30 | 阿布拉科斯生物科学有限公司 | 治疗儿童实体瘤的方法 |
| JP6309610B2 (ja) | 2013-03-14 | 2018-04-11 | アブラクシス バイオサイエンス， エルエルシー | 膀胱がんを処置する方法 |
| US20170202782A1 (en) | 2014-04-06 | 2017-07-20 | Abraxis Bioscience, Llc | Combination therapy comprising nanoparticles of a taxane and albumin with abt-263 in methods for treating cancer |
| US20180064679A1 (en) | 2015-03-05 | 2018-03-08 | Abraxis Bioscience, Llc | Method for treating cancer based on level of glucocorticoid receptor |
| JP2018521058A (ja) | 2015-06-29 | 2018-08-02 | アブラクシス バイオサイエンス， エルエルシー | ナノ粒子ｍＴＯＲ阻害剤併用治療を使用して固形腫瘍を処置する方法 |
| US20180177771A1 (en) | 2015-06-29 | 2018-06-28 | Abraxis Bioscience, Llc | Biomarkers for nanoparticle compositions |
| SMT202100642T1 (it) | 2015-06-29 | 2022-03-21 | Abraxis Bioscience Llc | Nanoparticelle comprendenti sirolimus e un'albumina per l'uso nel trattamento di tumori a cellule epitelioidi |
| US20170181988A1 (en) | 2015-12-23 | 2017-06-29 | Cipla Limited | Methods for the treatment of bladder cancer |
-
2010
- 2010-04-15 HR HRP20192259TT patent/HRP20192259T1/hr unknown
- 2010-04-15 SG SG2011075264A patent/SG175239A1/en unknown
- 2010-04-15 PT PT107651671T patent/PT2419732T/pt unknown
- 2010-04-15 RU RU2011146132/15A patent/RU2559570C2/ru active
- 2010-04-15 MX MX2011010825A patent/MX340055B/es active IP Right Grant
- 2010-04-15 JP JP2012506210A patent/JP5781500B2/ja active Active
- 2010-04-15 EP EP19192486.9A patent/EP3626233A1/en not_active Withdrawn
- 2010-04-15 WO PCT/US2010/031197 patent/WO2010121000A1/en not_active Ceased
- 2010-04-15 RS RS20191601A patent/RS59896B1/sr unknown
- 2010-04-15 ME MEP-2019-364A patent/ME03596B/me unknown
- 2010-04-15 PL PL10765167T patent/PL2419732T3/pl unknown
- 2010-04-15 CA CA2758913A patent/CA2758913A1/en not_active Abandoned
- 2010-04-15 CN CN201080026604.3A patent/CN102460167B/zh active Active
- 2010-04-15 KR KR1020117027031A patent/KR20120044279A/ko not_active Ceased
- 2010-04-15 SM SM20190751T patent/SMT201900751T1/it unknown
- 2010-04-15 AU AU2010236382A patent/AU2010236382B2/en active Active
- 2010-04-15 LT LTEP10765167.1T patent/LT2419732T/lt unknown
- 2010-04-15 ES ES10765167T patent/ES2764100T3/es active Active
- 2010-04-15 DK DK10765167.1T patent/DK2419732T3/da active
- 2010-04-15 EP EP10765167.1A patent/EP2419732B1/en active Active
- 2010-04-15 HU HUE10765167A patent/HUE047376T2/hu unknown
- 2010-04-15 BR BRPI1012525-6A patent/BRPI1012525A2/pt not_active Application Discontinuation
- 2010-04-15 US US12/761,292 patent/US20100297243A1/en not_active Abandoned
- 2010-04-15 SI SI201031963T patent/SI2419732T1/sl unknown
- 2010-04-15 MY MYPI2011004956A patent/MY175260A/en unknown
- 2010-04-15 MX MX2016000853A patent/MX378130B/es unknown
-
2011
- 2011-10-23 IL IL215765A patent/IL215765A/en active IP Right Grant
-
2014
- 2014-02-26 US US14/191,279 patent/US9446003B2/en active Active
-
2015
- 2015-04-24 JP JP2015089364A patent/JP6433371B2/ja active Active
-
2016
- 2016-08-17 US US15/239,680 patent/US10206887B2/en active Active
- 2016-11-24 JP JP2016227715A patent/JP2017061537A/ja active Pending
-
2019
- 2019-12-11 CY CY20191101294T patent/CY1122617T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS59796B1 (sr) | Isparljiv materijal | |
| CN102124281A (zh) | 快速的液体加热 | |
| RU2015149575A (ru) | Спринклер с контролем срабатывания | |
| TWI604814B (zh) | Electric field processing heating processing equipment | |
| CN205535717U (zh) | 一种电加热蒸汽发生器 | |
| CN108295776B (zh) | 一种固态盐加热熔融装置及方法 | |
| CN102560578B (zh) | 一种间断式超声电镀装置及其应用 | |
| CN105371478A (zh) | 一种液体加热器 | |
| CN212339185U (zh) | 用于加热熔盐的装置 | |
| CN203618586U (zh) | 一种新型水族箱用加热装置 | |
| CN201131062Y (zh) | 搪瓷电热膜加热管 | |
| CA2952267A1 (en) | Electrode water heater | |
| CN203744531U (zh) | 一种增强型四氯化硅电加热器 | |
| CN202057027U (zh) | 用于腐蚀性液体的加热器 | |
| CN201822619U (zh) | 新型盖热式电水壶 | |
| CN204063927U (zh) | 熔炉制造中间罐炉渣加热装置 | |
| CN202752024U (zh) | 一种规定时间内提高指定温度的实验箱 | |
| CN105219232A (zh) | 一种隔热涂料及其制造方法 | |
| CN203615531U (zh) | 安全环保低功耗精密空调加湿罐 | |
| CN205491217U (zh) | 一种新型电热装置 | |
| CN201628365U (zh) | 一种新型即热式热水器 | |
| CN204311162U (zh) | 可拆卸式沥青计量泵保温装置 | |
| RU2494580C1 (ru) | Электродный нагреватель жидкости | |
| CN202968716U (zh) | 一种调节电解槽液位装置 | |
| RU76780U1 (ru) | Устройство для пастеризации жидких пищевых продуктов |