RU2002107441A - Применение тиенопиримидинов - Google Patents
Применение тиенопиримидинов Download PDFInfo
- Publication number
- RU2002107441A RU2002107441A RU2002107441/14A RU2002107441A RU2002107441A RU 2002107441 A RU2002107441 A RU 2002107441A RU 2002107441/14 A RU2002107441/14 A RU 2002107441/14A RU 2002107441 A RU2002107441 A RU 2002107441A RU 2002107441 A RU2002107441 A RU 2002107441A
- Authority
- RU
- Russia
- Prior art keywords
- thieno
- pyrimidin
- benzo
- acid
- methylenedioxybenzylamino
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 201000009961 allergic asthma Diseases 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 206010006451 bronchitis Diseases 0.000 claims 2
- 208000023819 chronic asthma Diseases 0.000 claims 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000001881 impotence Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 210000001147 pulmonary artery Anatomy 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- XRNQSOGCDORRGQ-UHFFFAOYSA-N 2-[4-[4-(1,3-benzodioxol-5-ylmethylamino)-[1]benzothiolo[2,3-d]pyrimidin-2-yl]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=NC(NCC=2C=C3OCOC3=CC=2)=C2C3=CC=CC=C3SC2=N1 XRNQSOGCDORRGQ-UHFFFAOYSA-N 0.000 claims 1
- KBWPAGXDPUXKIT-UHFFFAOYSA-N 2-[4-[4-[(3-chloro-4-methoxyphenyl)methylamino]-[1]benzothiolo[2,3-d]pyrimidin-2-yl]cyclohexylidene]acetic acid Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(C2CCC(CC2)=CC(O)=O)=NC2=C1C1=CC=CC=C1S2 KBWPAGXDPUXKIT-UHFFFAOYSA-N 0.000 claims 1
- YKNCNWFUQFZYCW-UHFFFAOYSA-N 3-[4-[(3-chloro-4-methoxyphenyl)methylamino]-[1]benzothiolo[2,3-d]pyrimidin-2-yl]propanoic acid Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(CCC(O)=O)=NC2=C1C1=CC=CC=C1S2 YKNCNWFUQFZYCW-UHFFFAOYSA-N 0.000 claims 1
- AFUYBPXWBNFSNJ-UHFFFAOYSA-N 4-[4-(1,3-benzodioxol-5-ylmethylamino)-[1]benzothiolo[2,3-d]pyrimidin-2-yl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C1=NC(NCC=2C=C3OCOC3=CC=2)=C2C3=CC=CC=C3SC2=N1 AFUYBPXWBNFSNJ-UHFFFAOYSA-N 0.000 claims 1
- IUQLCYAQFPLIOX-UHFFFAOYSA-N 4-[4-(1,3-benzodioxol-5-ylmethylamino)-[1]benzothiolo[2,3-d]pyrimidin-2-yl]butanoic acid Chemical compound C1=CC=C2C3=C(NCC=4C=C5OCOC5=CC=4)N=C(CCCC(=O)O)N=C3SC2=C1 IUQLCYAQFPLIOX-UHFFFAOYSA-N 0.000 claims 1
- CYJGZDCCKXCNOF-UHFFFAOYSA-N 4-[4-(1,3-benzodioxol-5-ylmethylamino)-[1]benzothiolo[2,3-d]pyrimidin-2-yl]cyclohexane-1-carboxylic acid Chemical compound C1CC(C(=O)O)CCC1C1=NC(NCC=2C=C3OCOC3=CC=2)=C2C3=CC=CC=C3SC2=N1 CYJGZDCCKXCNOF-UHFFFAOYSA-N 0.000 claims 1
- VXCPPJWBHMZOCM-UHFFFAOYSA-N 5-[4-[(3-chloro-4-methoxyphenyl)methylamino]-[1]benzothiolo[2,3-d]pyrimidin-2-yl]pentanoic acid Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(CCCCC(O)=O)=NC2=C1C1=CC=CC=C1S2 VXCPPJWBHMZOCM-UHFFFAOYSA-N 0.000 claims 1
- QVHPHQZZUULWAS-UHFFFAOYSA-N 7-[4-(1,3-benzodioxol-5-ylmethylamino)-[1]benzothiolo[2,3-d]pyrimidin-2-yl]heptanoic acid Chemical compound C1=CC=C2C3=C(NCC=4C=C5OCOC5=CC=4)N=C(CCCCCCC(=O)O)N=C3SC2=C1 QVHPHQZZUULWAS-UHFFFAOYSA-N 0.000 claims 1
- OGMKXSIWCDVZCH-UHFFFAOYSA-N 7-[4-[(3-chloro-4-methoxyphenyl)methylamino]-[1]benzothiolo[2,3-d]pyrimidin-2-yl]heptanoic acid Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(CCCCCCC(O)=O)=NC2=C1C1=CC=CC=C1S2 OGMKXSIWCDVZCH-UHFFFAOYSA-N 0.000 claims 1
- -1 COOA Chemical group 0.000 claims 1
- FZGGYQRBEGBYPI-UHFFFAOYSA-N ClC=1C=C(CNC=2C3=C(N=C(N=2)C2CCC(CC2)=C2C(CCCC2)C(=O)O)SC2=C3C=CC=C2)C=CC=1OC Chemical compound ClC=1C=C(CNC=2C3=C(N=C(N=2)C2CCC(CC2)=C2C(CCCC2)C(=O)O)SC2=C3C=CC=C2)C=CC=1OC FZGGYQRBEGBYPI-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (2)
1. Применение соединений формулы I
в которой R1, R2 в каждом случае независимо друг от друга представляют собой Н, А, ОА, ОН или Hal, R1 и R2 совместно также представляют собой алкилен из 3-5 атомов углерода, -О-СН2-СН2-, -CH2-O-CH2-, -О-СН2-О- или -O-СН2-СН2-O-;
X представляет собой R4, R5 или R6, монозамещенный R7;
R4 представляет собой линейный или разветвленный алкилен из 1-10 атомов углерода, в котором одна или две группы СН2 могут быть замещены группами -СН=СН-;
R5 представляет собой циклоалкил или циклоалкилалкилен из 5-12 атомов углерода;
R6 представляет собой фенил или фенилметил;
R7 представляет собой СООН, СООА, CONH2, CONHA, CON(А)2 или CN;
А представляет собой алкил из 1-6 атомов углерода;
Hal представляет собой F, Cl, Br или I,
а также их физиологически приемлемые соли и/или сольваты для получения лекарственного препарата для лечения ангины, высокого кровяного давления, высокого давления в легочной артерии, застойной сердечной недостаточности, атеросклероза, состояний сниженной циркуляции через сердечные сосуды, заболевания периферийных сосудов, удара, бронхита, аллергической астмы, хронической астмы, аллергического ринита, глаукомы, синдрома повышенной раздражимости кишки, опухолей, почечной недостаточности и цирроза печени и для лечения женской импотенции.
2. Применение соединений формулы I по п.1
(a) 3-[4-(3-хлоро-4-метоксибензиламино)бензо[4,5]тиено[2,3-d]пиримидин-2-ил]пропионовая кислота;
(b) 4-[4-(3,4-метилендиоксибензиламино)бензо[4,5]тиено[2,3-d]пиримидин-2-ил]масляная кислота;
(c) 7-[4-(3,4-метилендиоксибензиламино)бензо[4,5]тиено[2,3-d]пиримидин-2-ил]гептановая кислота;
(d) 7-[4-(3-хлоро-4-метоксибензиламино)бензо[4,5]тиено[2,3-d]пиримидин-2-ил]гептановая кислота;
(e) 5-[4-(3-хлоро-4-метоксибензиламино)бензо[4,5]тиено[2,3-d]пиримидин-2-ил]валериановая кислота;
(f) 2-{4-[4-(3-хлоро-4-метоксибензиламино)бензо[4,5]тиено[2,3-d]пиримидин-2-ил]-циклогексил-1-ил}уксусная кислота;
(g) 4-[4-(3,4-метилендиоксибензиламино)бензо[4,5]тиено[2,3-d]пиримидин-2-ил]циклогексанкарбоновая кислота;
(h) 4-[4-(3,4-метилендиоксибензиламино)бензо[4,5]тиено[2,3-d]пиримидин-2-ил]бензойная кислота;
(i) 4-[4-(3,4-метилендиоксибензиламино)бензо[4,5]тиено[2,3-d]пиримидин-2-ил]фенилуксусная кислота;
(k) 2-{4-[4-(3-хлоро-4-метоксибензиламино)бензо[4,5]тиено[2,3-d]пиримидин-2-ил]-циклогексил-1-ил} циклогексанкарбоновая кислота,
а также их физиологически приемлемые соли и/или сольваты для получения лекарственного препарата для лечения ангины, высокого кровяного давления, высокого давления в легочной артерии, застойной сердечной недостаточности, атеросклероза, состояний сниженной циркуляции через сердечные сосуды, заболевания периферийных сосудов, удара, бронхита, аллергической астмы, хронической астмы, аллергического ринита, глаукомы, синдрома повышенной раздражимости кишки, опухолей, почечной недостаточности и цирроза печени и для лечения женской импотенции.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19943815A DE19943815A1 (de) | 1999-09-14 | 1999-09-14 | Verwendung von Thienopyrimidinen |
| DE19943815.3 | 1999-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002107441A true RU2002107441A (ru) | 2003-11-20 |
Family
ID=7921854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002107441/14A RU2002107441A (ru) | 1999-09-14 | 2000-08-24 | Применение тиенопиримидинов |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1212062A1 (ru) |
| JP (1) | JP2003509370A (ru) |
| KR (1) | KR20020026011A (ru) |
| CN (1) | CN1377271A (ru) |
| AR (1) | AR025645A1 (ru) |
| AU (1) | AU6703200A (ru) |
| BR (1) | BR0013957A (ru) |
| CA (1) | CA2387123A1 (ru) |
| CZ (1) | CZ2002818A3 (ru) |
| DE (1) | DE19943815A1 (ru) |
| HU (1) | HUP0202614A3 (ru) |
| MX (1) | MXPA02002746A (ru) |
| NO (1) | NO20021234L (ru) |
| PL (1) | PL353343A1 (ru) |
| RU (1) | RU2002107441A (ru) |
| SK (1) | SK3322002A3 (ru) |
| WO (1) | WO2001019369A1 (ru) |
| ZA (1) | ZA200202868B (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03005441A (es) * | 2000-12-19 | 2003-09-10 | Merck Patent Gmbh | Formulacion farmaceutica que contiene tienopirimidinas y antitromboticos, antagonistas de calcio, prostaglandinas o derivados de prostaglandina (2). |
| DE10135815A1 (de) * | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869486A (en) * | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
| HU228446B1 (en) * | 1996-04-12 | 2013-03-28 | Warner Lambert Co | Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof |
| DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| DE19819023A1 (de) * | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
| US5948911A (en) * | 1998-11-20 | 1999-09-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives |
| EP1167367A4 (en) * | 1999-03-30 | 2002-04-24 | Nippon Soda Co | THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF, AND PROCESS FOR THE PREPARATION THEREOF |
-
1999
- 1999-09-14 DE DE19943815A patent/DE19943815A1/de not_active Withdrawn
-
2000
- 2000-08-24 CZ CZ2002818A patent/CZ2002818A3/cs unknown
- 2000-08-24 SK SK332-2002A patent/SK3322002A3/sk unknown
- 2000-08-24 EP EP00954650A patent/EP1212062A1/de not_active Withdrawn
- 2000-08-24 CN CN00813731A patent/CN1377271A/zh active Pending
- 2000-08-24 MX MXPA02002746A patent/MXPA02002746A/es not_active Application Discontinuation
- 2000-08-24 RU RU2002107441/14A patent/RU2002107441A/ru not_active Application Discontinuation
- 2000-08-24 AU AU67032/00A patent/AU6703200A/en not_active Abandoned
- 2000-08-24 BR BR0013957-2A patent/BR0013957A/pt not_active IP Right Cessation
- 2000-08-24 HU HU0202614A patent/HUP0202614A3/hu unknown
- 2000-08-24 KR KR1020027003303A patent/KR20020026011A/ko not_active Withdrawn
- 2000-08-24 WO PCT/EP2000/008258 patent/WO2001019369A1/de not_active Ceased
- 2000-08-24 PL PL00353343A patent/PL353343A1/xx unknown
- 2000-08-24 CA CA002387123A patent/CA2387123A1/en not_active Abandoned
- 2000-08-24 JP JP2001523002A patent/JP2003509370A/ja active Pending
- 2000-09-13 AR ARP000104796A patent/AR025645A1/es not_active Application Discontinuation
-
2002
- 2002-03-13 NO NO20021234A patent/NO20021234L/no not_active Application Discontinuation
- 2002-04-11 ZA ZA200202868A patent/ZA200202868B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6703200A (en) | 2001-04-17 |
| ZA200202868B (en) | 2003-11-26 |
| CZ2002818A3 (cs) | 2002-06-12 |
| HUP0202614A2 (hu) | 2002-12-28 |
| BR0013957A (pt) | 2002-05-21 |
| NO20021234D0 (no) | 2002-03-13 |
| WO2001019369A1 (de) | 2001-03-22 |
| PL353343A1 (en) | 2003-11-17 |
| NO20021234L (no) | 2002-03-13 |
| KR20020026011A (ko) | 2002-04-04 |
| SK3322002A3 (en) | 2002-07-02 |
| JP2003509370A (ja) | 2003-03-11 |
| CA2387123A1 (en) | 2001-03-22 |
| CN1377271A (zh) | 2002-10-30 |
| DE19943815A1 (de) | 2001-03-15 |
| AR025645A1 (es) | 2002-12-04 |
| HUP0202614A3 (en) | 2004-11-29 |
| EP1212062A1 (de) | 2002-06-12 |
| MXPA02002746A (es) | 2002-10-23 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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